Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs
To determine whether non-steroidal anti-inflammatory drug (NSAIDs) exposure prior to intensive care unit (ICU) admission affects the development of acute kidney injury (AKI) with renal replacement therapy (RRT). An administrative database is used to establish a cohort of patients who were admitted t...
- Autores:
-
Oliveros, Enrique
Buitrago, Giancarlo
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2022
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- spa
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/63790
- Acceso en línea:
- https://www.mdpi.com/1424-8247/15/11/1409
http://hdl.handle.net/10554/63790
https://doi.org/10.3390/ph15111409
- Palabra clave:
- Nefrotoxicidad
Fármacos antiinflamatorios no esteroideos
Lesión renal aguda (IRA)
Enfermedad crítica
Control negativo
Nephrotoxicity
Non-steroidal anti-inflammatory drugs
Acute kidney injury (AKI)
Critical illness
Negative control
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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|
dc.title.spa.fl_str_mv |
Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs |
dc.title.english.spa.fl_str_mv |
Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs |
title |
Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs |
spellingShingle |
Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs Nefrotoxicidad Fármacos antiinflamatorios no esteroideos Lesión renal aguda (IRA) Enfermedad crítica Control negativo Nephrotoxicity Non-steroidal anti-inflammatory drugs Acute kidney injury (AKI) Critical illness Negative control |
title_short |
Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs |
title_full |
Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs |
title_fullStr |
Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs |
title_full_unstemmed |
Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs |
title_sort |
Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs |
dc.creator.fl_str_mv |
Oliveros, Enrique Buitrago, Giancarlo |
dc.contributor.author.none.fl_str_mv |
Oliveros, Enrique Buitrago, Giancarlo |
dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Epidemiología Clínica y Bioestadística |
dc.subject.spa.fl_str_mv |
Nefrotoxicidad Fármacos antiinflamatorios no esteroideos Lesión renal aguda (IRA) Enfermedad crítica Control negativo |
topic |
Nefrotoxicidad Fármacos antiinflamatorios no esteroideos Lesión renal aguda (IRA) Enfermedad crítica Control negativo Nephrotoxicity Non-steroidal anti-inflammatory drugs Acute kidney injury (AKI) Critical illness Negative control |
dc.subject.keyword.spa.fl_str_mv |
Nephrotoxicity Non-steroidal anti-inflammatory drugs Acute kidney injury (AKI) Critical illness Negative control |
description |
To determine whether non-steroidal anti-inflammatory drug (NSAIDs) exposure prior to intensive care unit (ICU) admission affects the development of acute kidney injury (AKI) with renal replacement therapy (RRT). An administrative database is used to establish a cohort of patients who were admitted to the ICU. The exposure to NSAIDs that the patients had before admission to the ICU is determined. Demographic variables, comorbidities, AKI diagnoses requiring RRT, and pneumonia during the ICU stay are also measured. Multivariate logistic regression and inverse probability weighting (IPW) are used to calculate risks of exposure to NSAIDs for patients with AKI requiring RRT. In total, 96,235 patients were admitted to the ICU, of which 16,068 (16.7%) were exposed to NSAIDs. The incidence of AKI with RRT was 2.71% for being exposed to NSAIDs versus 2.24% for those not exposed (p < 0.001). For the outcome of AKI, the odds ratio weighted with IPW was 1.28 (95% CI: 1.15–1.43), and for the outcome of pneumonia as a negative control, the odds ratio was 1.07 (95% CI: 0.98–1.17). The impact of prior exposure to NSAIDs over critically ill patients in the development of AKI is calculated as 8 patients per 1000 exposures. The negative control with the same sources of bias did not show an association with NSAID exposure. |
publishDate |
2022 |
dc.date.created.none.fl_str_mv |
2022-11-14 |
dc.date.accessioned.none.fl_str_mv |
2023-03-15T20:07:30Z |
dc.date.available.none.fl_str_mv |
2023-03-15T20:07:30Z |
dc.type.local.spa.fl_str_mv |
Artículo de revista |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.identifier.spa.fl_str_mv |
https://www.mdpi.com/1424-8247/15/11/1409 |
dc.identifier.issn.spa.fl_str_mv |
1424-8247 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/63790 |
dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.3390/ph15111409 |
dc.identifier.instname.spa.fl_str_mv |
instname:Pontificia Universidad Javeriana |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
dc.identifier.repourl.spa.fl_str_mv |
repourl:https://repository.javeriana.edu.co |
url |
https://www.mdpi.com/1424-8247/15/11/1409 http://hdl.handle.net/10554/63790 https://doi.org/10.3390/ph15111409 |
identifier_str_mv |
1424-8247 instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
dc.language.iso.spa.fl_str_mv |
spa |
language |
spa |
dc.relation.citationstartpage.spa.fl_str_mv |
1 |
dc.relation.citationendpage.spa.fl_str_mv |
10 |
dc.relation.ispartofjournal.spa.fl_str_mv |
Pharmaceuticals |
dc.relation.citationvolume.spa.fl_str_mv |
15 |
dc.relation.citationissue.spa.fl_str_mv |
11 |
dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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PDF |
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application/pdf |
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Pontificia Universidad Javeriana |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Oliveros, EnriqueBuitrago, GiancarloPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Epidemiología Clínica y Bioestadística2023-03-15T20:07:30Z2023-03-15T20:07:30Z2022-11-14https://www.mdpi.com/1424-8247/15/11/14091424-8247http://hdl.handle.net/10554/63790https://doi.org/10.3390/ph15111409instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coTo determine whether non-steroidal anti-inflammatory drug (NSAIDs) exposure prior to intensive care unit (ICU) admission affects the development of acute kidney injury (AKI) with renal replacement therapy (RRT). An administrative database is used to establish a cohort of patients who were admitted to the ICU. The exposure to NSAIDs that the patients had before admission to the ICU is determined. Demographic variables, comorbidities, AKI diagnoses requiring RRT, and pneumonia during the ICU stay are also measured. Multivariate logistic regression and inverse probability weighting (IPW) are used to calculate risks of exposure to NSAIDs for patients with AKI requiring RRT. In total, 96,235 patients were admitted to the ICU, of which 16,068 (16.7%) were exposed to NSAIDs. The incidence of AKI with RRT was 2.71% for being exposed to NSAIDs versus 2.24% for those not exposed (p < 0.001). For the outcome of AKI, the odds ratio weighted with IPW was 1.28 (95% CI: 1.15–1.43), and for the outcome of pneumonia as a negative control, the odds ratio was 1.07 (95% CI: 0.98–1.17). The impact of prior exposure to NSAIDs over critically ill patients in the development of AKI is calculated as 8 patients per 1000 exposures. The negative control with the same sources of bias did not show an association with NSAID exposure.Q1Q1Determinar si la exposición a fármacos antiinflamatorios no esteroideos (AINE) antes del ingreso en la unidad de cuidados intensivos (UCI) afecta el desarrollo de lesión renal aguda (IRA) con terapia de reemplazo renal (TRR). Se utiliza una base de datos administrativa para establecer una cohorte de pacientes que ingresaron en la UCI. Se determina la exposición a AINE que tenían los pacientes antes del ingreso en la UCI. También se miden variables demográficas, comorbilidades, diagnósticos de FRA que requieren TRS y neumonía durante la estancia en la UCI. La regresión logística multivariante y la ponderación de probabilidad inversa (IPW) se utilizan para calcular los riesgos de exposición a los AINE para pacientes con LRA que requieren TRS. En total ingresaron en UCI 96.235 pacientes, de los cuales 16.068 (16,7%) estuvieron expuestos a AINE. La incidencia de LRA con TRS fue del 2,71% por exposición a AINE frente a 2.p < 0,001). Para el resultado de AKI, la razón de probabilidades ponderada con IPW fue de 1,28 (IC 95 %: 1,15–1,43), y para el resultado de neumonía como control negativo, la razón de probabilidades fue 1,07 (IC 95 %: 0,98–1,17). El impacto de la exposición previa a AINE en pacientes en estado crítico en el desarrollo de LRA se calcula en 8 pacientes por cada 1000 exposiciones. El control negativo con las mismas fuentes de sesgo no mostró asociación con la exposición a AINE.N/ASiPDFapplication/pdfspaNefrotoxicidadFármacos antiinflamatorios no esteroideosLesión renal aguda (IRA)Enfermedad críticaControl negativoNephrotoxicityNon-steroidal anti-inflammatory drugsAcute kidney injury (AKI)Critical illnessNegative controlAcute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugsAcute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugsArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1110Pharmaceuticals1511ORIGINALpharmaceuticals-15-01409-v2 (1).pdfpharmaceuticals-15-01409-v2 (1).pdfArtículoapplication/pdf2207649http://repository.javeriana.edu.co/bitstream/10554/63790/1/pharmaceuticals-15-01409-v2%20%281%29.pdfdb5a0e1280d8b0a78c6d8c05c2fc1a64MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/63790/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILpharmaceuticals-15-01409-v2 (1).pdf.jpgpharmaceuticals-15-01409-v2 (1).pdf.jpgIM Thumbnailimage/jpeg12912http://repository.javeriana.edu.co/bitstream/10554/63790/3/pharmaceuticals-15-01409-v2%20%281%29.pdf.jpg3d5f215e778c8135492dd768c86021dcMD53open access10554/63790oai:repository.javeriana.edu.co:10554/637902023-03-16 03:01:07.457Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |