Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs

To determine whether non-steroidal anti-inflammatory drug (NSAIDs) exposure prior to intensive care unit (ICU) admission affects the development of acute kidney injury (AKI) with renal replacement therapy (RRT). An administrative database is used to establish a cohort of patients who were admitted t...

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Autores:
Oliveros, Enrique
Buitrago, Giancarlo
Tipo de recurso:
Article of investigation
Fecha de publicación:
2022
Institución:
Pontificia Universidad Javeriana
Repositorio:
Repositorio Universidad Javeriana
Idioma:
spa
OAI Identifier:
oai:repository.javeriana.edu.co:10554/63790
Acceso en línea:
https://www.mdpi.com/1424-8247/15/11/1409
http://hdl.handle.net/10554/63790
https://doi.org/10.3390/ph15111409
Palabra clave:
Nefrotoxicidad
Fármacos antiinflamatorios no esteroideos
Lesión renal aguda (IRA)
Enfermedad crítica
Control negativo
Nephrotoxicity
Non-steroidal anti-inflammatory drugs
Acute kidney injury (AKI)
Critical illness
Negative control
Rights
License
Atribución-NoComercial 4.0 Internacional
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network_name_str Repositorio Universidad Javeriana
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dc.title.spa.fl_str_mv Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs
dc.title.english.spa.fl_str_mv Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs
title Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs
spellingShingle Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs
Nefrotoxicidad
Fármacos antiinflamatorios no esteroideos
Lesión renal aguda (IRA)
Enfermedad crítica
Control negativo
Nephrotoxicity
Non-steroidal anti-inflammatory drugs
Acute kidney injury (AKI)
Critical illness
Negative control
title_short Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs
title_full Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs
title_fullStr Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs
title_full_unstemmed Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs
title_sort Acute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugs
dc.creator.fl_str_mv Oliveros, Enrique
Buitrago, Giancarlo
dc.contributor.author.none.fl_str_mv Oliveros, Enrique
Buitrago, Giancarlo
dc.contributor.corporatename.spa.fl_str_mv Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Epidemiología Clínica y Bioestadística
dc.subject.spa.fl_str_mv Nefrotoxicidad
Fármacos antiinflamatorios no esteroideos
Lesión renal aguda (IRA)
Enfermedad crítica
Control negativo
topic Nefrotoxicidad
Fármacos antiinflamatorios no esteroideos
Lesión renal aguda (IRA)
Enfermedad crítica
Control negativo
Nephrotoxicity
Non-steroidal anti-inflammatory drugs
Acute kidney injury (AKI)
Critical illness
Negative control
dc.subject.keyword.spa.fl_str_mv Nephrotoxicity
Non-steroidal anti-inflammatory drugs
Acute kidney injury (AKI)
Critical illness
Negative control
description To determine whether non-steroidal anti-inflammatory drug (NSAIDs) exposure prior to intensive care unit (ICU) admission affects the development of acute kidney injury (AKI) with renal replacement therapy (RRT). An administrative database is used to establish a cohort of patients who were admitted to the ICU. The exposure to NSAIDs that the patients had before admission to the ICU is determined. Demographic variables, comorbidities, AKI diagnoses requiring RRT, and pneumonia during the ICU stay are also measured. Multivariate logistic regression and inverse probability weighting (IPW) are used to calculate risks of exposure to NSAIDs for patients with AKI requiring RRT. In total, 96,235 patients were admitted to the ICU, of which 16,068 (16.7%) were exposed to NSAIDs. The incidence of AKI with RRT was 2.71% for being exposed to NSAIDs versus 2.24% for those not exposed (p < 0.001). For the outcome of AKI, the odds ratio weighted with IPW was 1.28 (95% CI: 1.15–1.43), and for the outcome of pneumonia as a negative control, the odds ratio was 1.07 (95% CI: 0.98–1.17). The impact of prior exposure to NSAIDs over critically ill patients in the development of AKI is calculated as 8 patients per 1000 exposures. The negative control with the same sources of bias did not show an association with NSAID exposure.
publishDate 2022
dc.date.created.none.fl_str_mv 2022-11-14
dc.date.accessioned.none.fl_str_mv 2023-03-15T20:07:30Z
dc.date.available.none.fl_str_mv 2023-03-15T20:07:30Z
dc.type.local.spa.fl_str_mv Artículo de revista
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format http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.spa.fl_str_mv https://www.mdpi.com/1424-8247/15/11/1409
dc.identifier.issn.spa.fl_str_mv 1424-8247
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10554/63790
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.3390/ph15111409
dc.identifier.instname.spa.fl_str_mv instname:Pontificia Universidad Javeriana
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional - Pontificia Universidad Javeriana
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url https://www.mdpi.com/1424-8247/15/11/1409
http://hdl.handle.net/10554/63790
https://doi.org/10.3390/ph15111409
identifier_str_mv 1424-8247
instname:Pontificia Universidad Javeriana
reponame:Repositorio Institucional - Pontificia Universidad Javeriana
repourl:https://repository.javeriana.edu.co
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.citationstartpage.spa.fl_str_mv 1
dc.relation.citationendpage.spa.fl_str_mv 10
dc.relation.ispartofjournal.spa.fl_str_mv Pharmaceuticals
dc.relation.citationvolume.spa.fl_str_mv 15
dc.relation.citationissue.spa.fl_str_mv 11
dc.rights.licence.*.fl_str_mv Atribución-NoComercial 4.0 Internacional
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
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http://creativecommons.org/licenses/by-nc/4.0/
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institution Pontificia Universidad Javeriana
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spelling Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Oliveros, EnriqueBuitrago, GiancarloPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Epidemiología Clínica y Bioestadística2023-03-15T20:07:30Z2023-03-15T20:07:30Z2022-11-14https://www.mdpi.com/1424-8247/15/11/14091424-8247http://hdl.handle.net/10554/63790https://doi.org/10.3390/ph15111409instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coTo determine whether non-steroidal anti-inflammatory drug (NSAIDs) exposure prior to intensive care unit (ICU) admission affects the development of acute kidney injury (AKI) with renal replacement therapy (RRT). An administrative database is used to establish a cohort of patients who were admitted to the ICU. The exposure to NSAIDs that the patients had before admission to the ICU is determined. Demographic variables, comorbidities, AKI diagnoses requiring RRT, and pneumonia during the ICU stay are also measured. Multivariate logistic regression and inverse probability weighting (IPW) are used to calculate risks of exposure to NSAIDs for patients with AKI requiring RRT. In total, 96,235 patients were admitted to the ICU, of which 16,068 (16.7%) were exposed to NSAIDs. The incidence of AKI with RRT was 2.71% for being exposed to NSAIDs versus 2.24% for those not exposed (p < 0.001). For the outcome of AKI, the odds ratio weighted with IPW was 1.28 (95% CI: 1.15–1.43), and for the outcome of pneumonia as a negative control, the odds ratio was 1.07 (95% CI: 0.98–1.17). The impact of prior exposure to NSAIDs over critically ill patients in the development of AKI is calculated as 8 patients per 1000 exposures. The negative control with the same sources of bias did not show an association with NSAID exposure.Q1Q1Determinar si la exposición a fármacos antiinflamatorios no esteroideos (AINE) antes del ingreso en la unidad de cuidados intensivos (UCI) afecta el desarrollo de lesión renal aguda (IRA) con terapia de reemplazo renal (TRR). Se utiliza una base de datos administrativa para establecer una cohorte de pacientes que ingresaron en la UCI. Se determina la exposición a AINE que tenían los pacientes antes del ingreso en la UCI. También se miden variables demográficas, comorbilidades, diagnósticos de FRA que requieren TRS y neumonía durante la estancia en la UCI. La regresión logística multivariante y la ponderación de probabilidad inversa (IPW) se utilizan para calcular los riesgos de exposición a los AINE para pacientes con LRA que requieren TRS. En total ingresaron en UCI 96.235 pacientes, de los cuales 16.068 (16,7%) estuvieron expuestos a AINE. La incidencia de LRA con TRS fue del 2,71% por exposición a AINE frente a 2.p < 0,001). Para el resultado de AKI, la razón de probabilidades ponderada con IPW fue de 1,28 (IC 95 %: 1,15–1,43), y para el resultado de neumonía como control negativo, la razón de probabilidades fue 1,07 (IC 95 %: 0,98–1,17). El impacto de la exposición previa a AINE en pacientes en estado crítico en el desarrollo de LRA se calcula en 8 pacientes por cada 1000 exposiciones. El control negativo con las mismas fuentes de sesgo no mostró asociación con la exposición a AINE.N/ASiPDFapplication/pdfspaNefrotoxicidadFármacos antiinflamatorios no esteroideosLesión renal aguda (IRA)Enfermedad críticaControl negativoNephrotoxicityNon-steroidal anti-inflammatory drugsAcute kidney injury (AKI)Critical illnessNegative controlAcute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugsAcute kidney injury in a cohort of critical illness patients exposed to non‐steroidal anti‐inflammatory drugsArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1110Pharmaceuticals1511ORIGINALpharmaceuticals-15-01409-v2 (1).pdfpharmaceuticals-15-01409-v2 (1).pdfArtículoapplication/pdf2207649http://repository.javeriana.edu.co/bitstream/10554/63790/1/pharmaceuticals-15-01409-v2%20%281%29.pdfdb5a0e1280d8b0a78c6d8c05c2fc1a64MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/63790/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILpharmaceuticals-15-01409-v2 (1).pdf.jpgpharmaceuticals-15-01409-v2 (1).pdf.jpgIM Thumbnailimage/jpeg12912http://repository.javeriana.edu.co/bitstream/10554/63790/3/pharmaceuticals-15-01409-v2%20%281%29.pdf.jpg3d5f215e778c8135492dd768c86021dcMD53open access10554/63790oai:repository.javeriana.edu.co:10554/637902023-03-16 03:01:07.457Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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