Associated factors for mortality in a COVID-19 Colombian Cohort by Epidemic wave: is the Predominance of Mu Variant relevant?

Background The third epidemic wave reported the greatest number of deaths related to SARS-CoV-2 in Colombia. In this wave, the Mu variant was predominant in 75% of the cases. Therefore, we evaluated the association between Colombia's third wave and COVID-19 all-cause inhospital mortality. Methods In this retrospective cohort, we included hospitalized patients ≥18 years with SARS-CoV-2 infection between March 2020 to September 2021 in ten hospitals from three cities in Colombia. Description analysis, survival, and multivariate Cox regression analyses were performed to evaluate the association between the third epidemic wave and in-hospital mortality. Findings A total of 25,371 patients were included. The age-stratified time-to-mortality analysis showed differences according to epidemic waves in patients ≥75 years (log-rank test p=0.012). In the multivariate Cox analysis, the third wave was not associated with increased mortality relative to the first wave (aHR 0.95; 95%CI 0.84-1.08), but there was an interaction between age ≥75 years and the third wave finding a lower HR for mortality (aHR 0.56, 95%CI 0.36- 0.86). Interpretation We did not find an increase in in-hospital mortality during the third epidemic wave in which the Mu variant was predominant in Colombia. The reduced hazard in mortality in patients ≥75 years hospitalized in the third wave could be explained by the high coverage of SARSCoV- 2 vaccination in this population and patients with underlying conditions.

• Autores: Ordoñez Blanco, Ivonne Tatiana
• Tipo de recurso: Trabajo de grado de pregrado
• Fecha de publicación: 2022
• Institución: Pontificia Universidad Javeriana
• Repositorio: Repositorio Universidad Javeriana
• Idioma: spa
• OAI Identifier: oai:repository.javeriana.edu.co:10554/63175
• Acceso en línea: http://hdl.handle.net/10554/63175
• Palabra clave: Covid 19; SARS-CoV-2; Variante Mu; Mortalidad; Ola epidémica; Covid 19; SARS-CoV-2; Mu variant; Mortality; Epidemic wave; Especialización en infectología - Tesis y disertaciones académicas; COVID-19 (Enfermedad) - Colombia; Mortalidad; Epidemias
• Rights: embargoedAccess
• License: Atribución-NoComercial-SinDerivadas 4.0 Internacional