Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study
Q1
- Autores:
-
Wang, Minggui
Earley, Michelle
Chen, Liang
Hanson, Blake M
Yu, Yunsong
Liu, Zhengyin
Salcedo, Soraya
Cober, Eric
Li, Lanjuan
Kanj, Souha S
Gao, Hainv
Munita, Jose M
Ordoñez, Karen
Weston, Greg
Satlin, Michael J
Valderrama-Beltrán, Sandra Liliana
Marimuthu, Kalisvar
Stryjewsk, Martin E
Komarow, Lauren
Luterbach, Courtney
Marshall, Steve H
Rudin, Susan D
Manca, Claudia
Paterson, David L
Reyes, Jinnethe
Villegas, Maria V
Evans, Scott
Rebekka Arias, Carol Hill
Baum, Keri
Fries, Bettina C
Doi, Yohei
Patel, Robin
Kreiswirth, Barry N
Bonomo, Robert A
Chambers, Henry F
Fowler Jr, Vance G
Arias, Cesar A
Van Duin, David
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2021
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/61376
- Acceso en línea:
- https://login.ezproxy.javeriana.edu.co/login?url=https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip&db=edselp&AN=S1473309921003996&lang=es&site=eds-live
http://hdl.handle.net/10554/61376
https://doi.org/10.1016/S1473-3099(21)00399-6
- Palabra clave:
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study |
| title |
Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study |
| spellingShingle |
Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study |
| title_short |
Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study |
| title_full |
Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study |
| title_fullStr |
Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study |
| title_full_unstemmed |
Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study |
| title_sort |
Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study |
| dc.creator.fl_str_mv |
Wang, Minggui Earley, Michelle Chen, Liang Hanson, Blake M Yu, Yunsong Liu, Zhengyin Salcedo, Soraya Cober, Eric Li, Lanjuan Kanj, Souha S Gao, Hainv Munita, Jose M Ordoñez, Karen Weston, Greg Satlin, Michael J Valderrama-Beltrán, Sandra Liliana Marimuthu, Kalisvar Stryjewsk, Martin E Komarow, Lauren Luterbach, Courtney Marshall, Steve H Rudin, Susan D Manca, Claudia Paterson, David L Reyes, Jinnethe Villegas, Maria V Evans, Scott Rebekka Arias, Carol Hill Baum, Keri Fries, Bettina C Doi, Yohei Patel, Robin Kreiswirth, Barry N Bonomo, Robert A Chambers, Henry F Fowler Jr, Vance G Arias, Cesar A Van Duin, David |
| dc.contributor.author.none.fl_str_mv |
Wang, Minggui Earley, Michelle Chen, Liang Hanson, Blake M Yu, Yunsong Liu, Zhengyin Salcedo, Soraya Cober, Eric Li, Lanjuan Kanj, Souha S Gao, Hainv Munita, Jose M Ordoñez, Karen Weston, Greg Satlin, Michael J Valderrama-Beltrán, Sandra Liliana Marimuthu, Kalisvar Stryjewsk, Martin E Komarow, Lauren Luterbach, Courtney Marshall, Steve H Rudin, Susan D Manca, Claudia Paterson, David L Reyes, Jinnethe Villegas, Maria V Evans, Scott Rebekka Arias, Carol Hill Baum, Keri Fries, Bettina C Doi, Yohei Patel, Robin Kreiswirth, Barry N Bonomo, Robert A Chambers, Henry F Fowler Jr, Vance G Arias, Cesar A Van Duin, David |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Infectología Pontificia Universidad Javeriana. Facultad de Medicina. Hospital Universitario San Ignacio |
| dc.contributor.javerianateacher.none.fl_str_mv |
Valderrama-Beltrán, Sandra Liliana |
| description |
Q1 |
| publishDate |
2021 |
| dc.date.created.none.fl_str_mv |
2021-11-09 |
| dc.date.accessioned.none.fl_str_mv |
2022-08-17T15:23:56Z |
| dc.date.available.none.fl_str_mv |
2022-08-17T15:23:56Z |
| dc.type.local.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_6501 |
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http://purl.org/coar/resource_type/c_6501 |
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https://login.ezproxy.javeriana.edu.co/login?url=https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip&db=edselp&AN=S1473309921003996&lang=es&site=eds-live |
| dc.identifier.issn.spa.fl_str_mv |
1473-3099 / 1474-4457 (Electrónico) |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/61376 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/S1473-3099(21)00399-6 |
| dc.identifier.instname.spa.fl_str_mv |
instname:Pontificia Universidad Javeriana |
| dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
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repourl:https://repository.javeriana.edu.co |
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https://login.ezproxy.javeriana.edu.co/login?url=https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip&db=edselp&AN=S1473309921003996&lang=es&site=eds-live http://hdl.handle.net/10554/61376 https://doi.org/10.1016/S1473-3099(21)00399-6 |
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1473-3099 / 1474-4457 (Electrónico) instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
401 |
| dc.relation.citationendpage.spa.fl_str_mv |
412 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
The Lancet Infectious Diseases |
| dc.relation.citationvolume.spa.fl_str_mv |
22 |
| dc.relation.citationissue.none.fl_str_mv |
3 |
| dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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PDF |
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Pontificia Universidad Javeriana |
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Repositorio Institucional - Pontificia Universidad Javeriana |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Wang, MingguiEarley, MichelleChen, LiangHanson, Blake MYu, YunsongLiu, ZhengyinSalcedo, SorayaCober, EricLi, LanjuanKanj, Souha SGao, HainvMunita, Jose MOrdoñez, KarenWeston, GregSatlin, Michael JValderrama-Beltrán, Sandra LilianaMarimuthu, KalisvarStryjewsk, Martin EKomarow, LaurenLuterbach, CourtneyMarshall, Steve HRudin, Susan DManca, ClaudiaPaterson, David LReyes, JinnetheVillegas, Maria VEvans, ScottRebekka Arias, Carol HillBaum, KeriFries, Bettina CDoi, YoheiPatel, RobinKreiswirth, Barry NBonomo, Robert AChambers, Henry FFowler Jr, Vance GArias, Cesar AVan Duin, DavidPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. InfectologíaPontificia Universidad Javeriana. Facultad de Medicina. Hospital Universitario San IgnacioValderrama-Beltrán, Sandra Liliana2022-08-17T15:23:56Z2022-08-17T15:23:56Z2021-11-09https://login.ezproxy.javeriana.edu.co/login?url=https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip&db=edselp&AN=S1473309921003996&lang=es&site=eds-live1473-3099 / 1474-4457 (Electrónico)http://hdl.handle.net/10554/61376https://doi.org/10.1016/S1473-3099(21)00399-6instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengClinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort studyArtículo de revistahttp://purl.org/coar/resource_type/c_6501Q1Q1Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a global threat. We therefore analysed the bacterial characteristics of CRKP infections and the clinical outcomes of patients with CRKP infections across different countries. Methods In this prospective, multicentre, cohort study (CRACKLE-2), hospitalised patients with cultures positive for CRKP were recruited from 71 hospitals in Argentina, Australia, Chile, China, Colombia, Lebanon, Singapore, and the USA. The first culture positive for CRKP was included for each unique patient. Clinical data on post-hospitalisation death and readmission were collected from health records, and whole genome sequencing was done on all isolates. The primary outcome was a desirability of outcome ranking at 30 days after the index culture, and, along with bacterial characteristics and 30-day all-cause mortality (a key secondary outcome), was compared between patients from China, South America, and the USA. The desirability of outcome ranking was adjusted for location before admission, Charlson comorbidity index, age at culture, Pitt bacteremia score, and anatomical culture source through inverse probability weighting; mortality was adjusted for the same confounders, plus region where relevant, through multivariable logistic regression. This study is registered at ClinicalTrials.gov, NCT03646227, and is complete. Findings Between June 13, 2017, and Nov 30, 2018, 991 patients were enrolled, of whom 502 (51%) met the criteria for CRKP infection and 489 (49%) had positive cultures that were considered colonisation. We observed little intracountry genetic variation in CRKP. Infected patients from the USA were more acutely ill than were patients from China or South America (median Pitt bacteremia score 3 [IQR 2–6] vs 2 [0–4] vs 2 [0–4]) and had more comorbidities (median Charlson comorbidity index 3 [IQR 2–5] vs 1 [0–3] vs 1 [0–2]). Adjusted desirability of outcome ranking outcomes were similar in infected patients from China (n=246), South America (n=109), and the USA (n=130); the estimates were 53% (95% CI 42–65) for China versus South America, 50% (41–61) for the USA versus China, and 53% (41–66) for the USA versus South America. In patients with CRKP infections, unadjusted 30-day mortality was lower in China (12%, 95% CI 8–16; 29 of 246) than in the USA (23%, 16–30; 30 of 130) and South America (28%, 20–37; 31 of 109). Adjusted 30-day all-cause mortality was higher in South America than in China (adjusted odds ratio [aOR] 4·82, 95% CI 2·22–10·50) and the USA (aOR 3·34, 1·50–7·47), with the mortality difference between the USA and China no longer being significant (aOR 1·44, 0·70–2·96). Interpretation Global CRKP epidemics have important regional differences in patients’ baseline characteristics and clinical outcomes, and in bacterial characteristics. Research findings from one region might not be generalisable to other regions.https://orcid.org/0000-0003-1833-1599Revista Internacional - IndexadaNo401412The Lancet Infectious Diseases223ORIGINAL1-s2.0-S1473309921003996.pdf1-s2.0-S1473309921003996.pdfArtículoapplication/pdf1533707http://repository.javeriana.edu.co/bitstream/10554/61376/1/1-s2.0-S1473309921003996.pdffac8afe0ca6dd8b020024961ae1924abMD51embargoed access|||9999-01-01LICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/61376/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAIL1-s2.0-S1473309921003996.pdf.jpg1-s2.0-S1473309921003996.pdf.jpgIM Thumbnailimage/jpeg10922http://repository.javeriana.edu.co/bitstream/10554/61376/3/1-s2.0-S1473309921003996.pdf.jpg9ef14207a5b59b7b9553beee3304f700MD53open access10554/61376oai:repository.javeriana.edu.co:10554/613762023-01-30 20:51:29.463Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |