Polygenic risk modeling for prediction of epithelial ovarian cancer risk
Q1
- Autores:
-
Dareng, Eileen O.
Tyrer, Jonathan P.
Barnes, Daniel R.
Jones. Michelle R.
Yang, Xin
Aben, Katja K. H.
Adank, Muriel A.
Agata, Simona
Andrulis, Irene L.
Anton-Culver, Hoda
Antonenkova, Natalia N.
Aravantinos, Gerasimos
Arun, Banu K.
Augustinsson, Annelie
Balmaña, Judith
Bandera, Elisa V.
Barkardottir, Rosa B.
Barrowdale, Daniel
Beckmann, Matthias W.
Beeghly-Fadiel, Alicia
Benitez, Javier
Bermisheva, Marina
Bernardini, Marcus Q.
Bjorge, Line
Black, Amanda
Bogdanova, Natalia V.
Bonanni, Bernardo
Borg, Ake
Brenton, James D.
Budzilowska, Agnieszka
Butzow, Ralf
Buys, Saundra S.
Cai, Hui
Caligo, Maria A.
Campbell, Ian
Cannioto, Rikki
Cassingham, Hayley
Chang-Claude, Jenny
Chanock, Stephen J.
Chen, Kexin
Chiew, Yoke-Eng
Chung, Wendy K.
Claes, Kathleen B. M.
Colonna, Sarah
EMO Study Collaborators
GC-HBOC Study Collaborators
EMBRACE Collaborators
Cook, Linda S.
Couch, Fergus J.
Daly, Mary B.
Dao, Fanny
Davies, Eleanor
de la Hoya, Miguel
de Putter, Robin
Dennis, Joe
DePersia, Allison
Devilee, Peter
Diez, Orland
Chun Ding, Yuan
Doherty, Jennifer A.
Domchek, Susan M.
Dörk, Thilo
du Bois, Andreas
Dürst, Matthias
Eccles, Diana M.
Eliassen, Heather A.
Engel, Christoph
Evans, Gareth D.
Fasching, Peter A.
Flanagan, James M.
Fortner, Renée T.
Machackova, Eva
Friedman, Eitan
Ganz, Patricia A.
Garber, Judy
Gensini, Francesca
Giles, Graham G.
Glendon, Gord
Godwin, Andrew K.
Goodman, Marc T.
Greene, Mark H.
Gronwald, Jacek
OPAL Study Group
AOCS Group
Hahnen, Eric
Haiman, Christopher A.
Håkansson, Niclas
Hamann, Ute
Hansen, Thomas V. O.
Harris, Holly R.
Hartman, Mikael
Heitz, Florian
Hildebrandt, Michelle A. T.
Høgdall, Estrid
Høgdall, Claus K.
Hopper, John L.
Huang, Ruea-Yea
Huff, Chad
Hulick, Peter J.
Huntsman, David G.
Imyanitov, Evgeny N.
KConFab Investigators
HEBON Investigators
Isaacs, Claudine
Jakubowska, Anna
James, Paul A.
Janavicius, Ramunas
Jensen, Allan
Johannsson, Oskar Th.
John, Esther M.
Jones, Michael E.
Kang, Daehee
Karlan, Beth Y.
Karnezis, Anthony
Kelemen, Linda E.
Khusnutdinova, Elza
Kiemeney, Lambertus A.
Kim, Byoung-Gie
Kjaer, Susanne K.
Komenaka, Ian
Kupryjanczyk, Jolanta
Kurian, Allison W.
Kwong, Ava
Lambrechts, Diether
Larson, Melissa C.
Lazaro, Conxi
Le, Nhu D.
Leslie, Goska
Lester, Jenny
Lesueur, Fabienne
Levine, Douglas A.
Li, Lian
Li, Jingmei
Loud, Jennifer T.
Lu, Karen H.
Lubiński, Jan
Mai, Phuong L.
Manoukian, Siranoush
Marks, Jeffrey R.
Matsuno, Rayna Kim
Matsuo, Keitaro
May, Taymaa
McGuffog, Lesley
McLaughlin, John R.
McNeish, Iain A.
Mebirouk, Noura
Menon, Usha
Miller, Austin
Milne, Roger L.
Minlikeeva, Albina
Modugno, Francesmary
Montagna, Marco
Moysich, Kirsten B.
Munro, Elizabeth
Nathanson, Katherine L.
Neuhausen, Susan L.
Nevanlinna, Heli
Ngeow Yuen, Yie Joanne
Nielsen, Henriette Roed
Nielsen, Finn C.
Nikitina-Zake, Liene
Odunsi, Kunle
Offit, Kenneth
Olah, Edith
Olbrecht, Siel
Olopade, Olufunmilayo I.
Olson, Sara H.
Olsson, Håkan
Osorio, Ana
Papi, Laura
Park, Sue K.
Parsons, Michael T.
Pathak, Harsha
Sokilde Pedersen, Inge
Peixoto, Ana
Pejovic, Tanja
Perez-Segura, Pedro
Permuth, Jennifer B.
Peshkin, Beth
Peterlongo, Paolo
Piskorz, Anna
Prokofyeva, Darya
Radice, Paolo
Rantala, Johanna
Riggan, Marjorie J.
Risch, Harvey A.
Rodriguez-Antona, Cristina
Ross, Eric
Rossing, Mary Anne
Runnebaum, Ingo
Sandler, Dale P.
Santamariña, Marta
Soucy, Penny
Schmutzler, Rita K.
Setiawan, V. Wendy
Shan, Kang
Sieh, Weiva
Simard, Jacques
Singer, Christian F.
Sokolenko, Anna P.
Song, Honglin
Southey, Melissa C.
Steed, Helen
Stoppa-Lyonnet, Dominique
Sutphen, Rebecca
Swerdlow, Anthony J.
Tan, Yen Yen
Teixeira, Manuel R.
Teo, Soo Hwang
Terry, Kathryn L.
Terry, Mary Beth
The OCAC Consortium
The CIMBA Consortium
Thomassen, Mads
Thompson, Pamela J.
Vestrheim Thomsen, Liv Cecilie
Thull, Darcy L.
Tischkowitz, Marc
Titus, Linda
Toland, Amanda E.
Trabert, Britton
Travis, Ruth
Tung, Nadine
Tworoger, Shelley S.
Valen, Ellen
van Altena, Anne M.
van der Hout, Annemieke H.
Van Nieuwenhuysen, Els
van Rensburg, Elizabeth J.
Vega, Ana
Velez Edwards, Digna
Vierkant, Robert A.
Wang, Frances
Wappenschmidt, Barbara
Webb, Penelope M.
Weinberg, Clarice R.
Weitzel, Jeffrey N.
Wentzensen, Nicolas
White, Emily
Whittemore, Alice S.
Winham, Stacey J.
Wolk, Alicja
Woo, Yin-Ling
Wu, Anna H.
Yan, Li
Yannoukakos, Drakoulis
Zavaglia, Katia M.
Zheng, Wei
Ziogas, Argyrios
Zorn, Kristin K.
Kleibl, Zdenek
Easton, Douglas
Lawrenson, Kate
DeFazio, Anna
Sellers, Thomas A.
Ramus, Susan J.
Pearce, Celeste L.
Monteiro, Alvaro N.
Cunningham, Julie
Goode, Ellen L.
Schildkraut, Joellen M.
Berchuck, Andrew
Chenevix-Trench, Georgia
Gayther, Simon A.
Antoniou, Antonis C.
Pharoah, Paul D. P.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2022
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/61999
- Acceso en línea:
- https://www.nature.com/articles/s41431-021-00987-7
http://hdl.handle.net/10554/61999
https://doi.org/10.1038/s41431-021-00987-7
- Palabra clave:
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
id |
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oai_identifier_str |
oai:repository.javeriana.edu.co:10554/61999 |
network_acronym_str |
JAVERIANA2 |
network_name_str |
Repositorio Universidad Javeriana |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Polygenic risk modeling for prediction of epithelial ovarian cancer risk |
title |
Polygenic risk modeling for prediction of epithelial ovarian cancer risk |
spellingShingle |
Polygenic risk modeling for prediction of epithelial ovarian cancer risk |
title_short |
Polygenic risk modeling for prediction of epithelial ovarian cancer risk |
title_full |
Polygenic risk modeling for prediction of epithelial ovarian cancer risk |
title_fullStr |
Polygenic risk modeling for prediction of epithelial ovarian cancer risk |
title_full_unstemmed |
Polygenic risk modeling for prediction of epithelial ovarian cancer risk |
title_sort |
Polygenic risk modeling for prediction of epithelial ovarian cancer risk |
dc.creator.fl_str_mv |
Dareng, Eileen O. Tyrer, Jonathan P. Barnes, Daniel R. Jones. Michelle R. Yang, Xin Aben, Katja K. H. Adank, Muriel A. Agata, Simona Andrulis, Irene L. Anton-Culver, Hoda Antonenkova, Natalia N. Aravantinos, Gerasimos Arun, Banu K. Augustinsson, Annelie Balmaña, Judith Bandera, Elisa V. Barkardottir, Rosa B. Barrowdale, Daniel Beckmann, Matthias W. Beeghly-Fadiel, Alicia Benitez, Javier Bermisheva, Marina Bernardini, Marcus Q. Bjorge, Line Black, Amanda Bogdanova, Natalia V. Bonanni, Bernardo Borg, Ake Brenton, James D. Budzilowska, Agnieszka Butzow, Ralf Buys, Saundra S. Cai, Hui Caligo, Maria A. Campbell, Ian Cannioto, Rikki Cassingham, Hayley Chang-Claude, Jenny Chanock, Stephen J. Chen, Kexin Chiew, Yoke-Eng Chung, Wendy K. Claes, Kathleen B. M. Colonna, Sarah EMO Study Collaborators GC-HBOC Study Collaborators EMBRACE Collaborators Cook, Linda S. Couch, Fergus J. Daly, Mary B. Dao, Fanny Davies, Eleanor de la Hoya, Miguel de Putter, Robin Dennis, Joe DePersia, Allison Devilee, Peter Diez, Orland Chun Ding, Yuan Doherty, Jennifer A. Domchek, Susan M. Dörk, Thilo du Bois, Andreas Dürst, Matthias Eccles, Diana M. Eliassen, Heather A. Engel, Christoph Evans, Gareth D. Fasching, Peter A. Flanagan, James M. Fortner, Renée T. Machackova, Eva Friedman, Eitan Ganz, Patricia A. Garber, Judy Gensini, Francesca Giles, Graham G. Glendon, Gord Godwin, Andrew K. Goodman, Marc T. Greene, Mark H. Gronwald, Jacek OPAL Study Group AOCS Group Hahnen, Eric Haiman, Christopher A. Håkansson, Niclas Hamann, Ute Hansen, Thomas V. O. Harris, Holly R. Hartman, Mikael Heitz, Florian Hildebrandt, Michelle A. T. Høgdall, Estrid Høgdall, Claus K. Hopper, John L. Huang, Ruea-Yea Huff, Chad Hulick, Peter J. Huntsman, David G. Imyanitov, Evgeny N. KConFab Investigators HEBON Investigators Isaacs, Claudine Jakubowska, Anna James, Paul A. Janavicius, Ramunas Jensen, Allan Johannsson, Oskar Th. John, Esther M. Jones, Michael E. Kang, Daehee Karlan, Beth Y. Karnezis, Anthony Kelemen, Linda E. Khusnutdinova, Elza Kiemeney, Lambertus A. Kim, Byoung-Gie Kjaer, Susanne K. Komenaka, Ian Kupryjanczyk, Jolanta Kurian, Allison W. Kwong, Ava Lambrechts, Diether Larson, Melissa C. Lazaro, Conxi Le, Nhu D. Leslie, Goska Lester, Jenny Lesueur, Fabienne Levine, Douglas A. Li, Lian Li, Jingmei Loud, Jennifer T. Lu, Karen H. Lubiński, Jan Mai, Phuong L. Manoukian, Siranoush Marks, Jeffrey R. Matsuno, Rayna Kim Matsuo, Keitaro May, Taymaa McGuffog, Lesley McLaughlin, John R. McNeish, Iain A. Mebirouk, Noura Menon, Usha Miller, Austin Milne, Roger L. Minlikeeva, Albina Modugno, Francesmary Montagna, Marco Moysich, Kirsten B. Munro, Elizabeth Nathanson, Katherine L. Neuhausen, Susan L. Nevanlinna, Heli Ngeow Yuen, Yie Joanne Nielsen, Henriette Roed Nielsen, Finn C. Nikitina-Zake, Liene Odunsi, Kunle Offit, Kenneth Olah, Edith Olbrecht, Siel Olopade, Olufunmilayo I. Olson, Sara H. Olsson, Håkan Osorio, Ana Papi, Laura Park, Sue K. Parsons, Michael T. Pathak, Harsha Sokilde Pedersen, Inge Peixoto, Ana Pejovic, Tanja Perez-Segura, Pedro Permuth, Jennifer B. Peshkin, Beth Peterlongo, Paolo Piskorz, Anna Prokofyeva, Darya Radice, Paolo Rantala, Johanna Riggan, Marjorie J. Risch, Harvey A. Rodriguez-Antona, Cristina Ross, Eric Rossing, Mary Anne Runnebaum, Ingo Sandler, Dale P. Santamariña, Marta Soucy, Penny Schmutzler, Rita K. Setiawan, V. Wendy Shan, Kang Sieh, Weiva Simard, Jacques Singer, Christian F. Sokolenko, Anna P. Song, Honglin Southey, Melissa C. Steed, Helen Stoppa-Lyonnet, Dominique Sutphen, Rebecca Swerdlow, Anthony J. Tan, Yen Yen Teixeira, Manuel R. Teo, Soo Hwang Terry, Kathryn L. Terry, Mary Beth The OCAC Consortium The CIMBA Consortium Thomassen, Mads Thompson, Pamela J. Vestrheim Thomsen, Liv Cecilie Thull, Darcy L. Tischkowitz, Marc Titus, Linda Toland, Amanda E. Trabert, Britton Travis, Ruth Tung, Nadine Tworoger, Shelley S. Valen, Ellen van Altena, Anne M. van der Hout, Annemieke H. Van Nieuwenhuysen, Els van Rensburg, Elizabeth J. Vega, Ana Velez Edwards, Digna Vierkant, Robert A. Wang, Frances Wappenschmidt, Barbara Webb, Penelope M. Weinberg, Clarice R. Weitzel, Jeffrey N. Wentzensen, Nicolas White, Emily Whittemore, Alice S. Winham, Stacey J. Wolk, Alicja Woo, Yin-Ling Wu, Anna H. Yan, Li Yannoukakos, Drakoulis Zavaglia, Katia M. Zheng, Wei Ziogas, Argyrios Zorn, Kristin K. Kleibl, Zdenek Easton, Douglas Lawrenson, Kate DeFazio, Anna Sellers, Thomas A. Ramus, Susan J. Pearce, Celeste L. Monteiro, Alvaro N. Cunningham, Julie Goode, Ellen L. Schildkraut, Joellen M. Berchuck, Andrew Chenevix-Trench, Georgia Gayther, Simon A. Antoniou, Antonis C. Pharoah, Paul D. P. |
dc.contributor.author.none.fl_str_mv |
Dareng, Eileen O. Tyrer, Jonathan P. Barnes, Daniel R. Jones. Michelle R. Yang, Xin Aben, Katja K. H. Adank, Muriel A. Agata, Simona Andrulis, Irene L. Anton-Culver, Hoda Antonenkova, Natalia N. Aravantinos, Gerasimos Arun, Banu K. Augustinsson, Annelie Balmaña, Judith Bandera, Elisa V. Barkardottir, Rosa B. Barrowdale, Daniel Beckmann, Matthias W. Beeghly-Fadiel, Alicia Benitez, Javier Bermisheva, Marina Bernardini, Marcus Q. Bjorge, Line Black, Amanda Bogdanova, Natalia V. Bonanni, Bernardo Borg, Ake Brenton, James D. Budzilowska, Agnieszka Butzow, Ralf Buys, Saundra S. Cai, Hui Caligo, Maria A. Campbell, Ian Cannioto, Rikki Cassingham, Hayley Chang-Claude, Jenny Chanock, Stephen J. Chen, Kexin Chiew, Yoke-Eng Chung, Wendy K. Claes, Kathleen B. M. Colonna, Sarah EMO Study Collaborators GC-HBOC Study Collaborators EMBRACE Collaborators Cook, Linda S. Couch, Fergus J. Daly, Mary B. Dao, Fanny Davies, Eleanor de la Hoya, Miguel de Putter, Robin Dennis, Joe DePersia, Allison Devilee, Peter Diez, Orland Chun Ding, Yuan Doherty, Jennifer A. Domchek, Susan M. Dörk, Thilo du Bois, Andreas Dürst, Matthias Eccles, Diana M. Eliassen, Heather A. Engel, Christoph Evans, Gareth D. Fasching, Peter A. Flanagan, James M. Fortner, Renée T. Machackova, Eva Friedman, Eitan Ganz, Patricia A. Garber, Judy Gensini, Francesca Giles, Graham G. Glendon, Gord Godwin, Andrew K. Goodman, Marc T. Greene, Mark H. Gronwald, Jacek OPAL Study Group AOCS Group Hahnen, Eric Haiman, Christopher A. Håkansson, Niclas Hamann, Ute Hansen, Thomas V. O. Harris, Holly R. Hartman, Mikael Heitz, Florian Hildebrandt, Michelle A. T. Høgdall, Estrid Høgdall, Claus K. Hopper, John L. Huang, Ruea-Yea Huff, Chad Hulick, Peter J. Huntsman, David G. Imyanitov, Evgeny N. KConFab Investigators HEBON Investigators Isaacs, Claudine Jakubowska, Anna James, Paul A. Janavicius, Ramunas Jensen, Allan Johannsson, Oskar Th. John, Esther M. Jones, Michael E. Kang, Daehee Karlan, Beth Y. Karnezis, Anthony Kelemen, Linda E. Khusnutdinova, Elza Kiemeney, Lambertus A. Kim, Byoung-Gie Kjaer, Susanne K. Komenaka, Ian Kupryjanczyk, Jolanta Kurian, Allison W. Kwong, Ava Lambrechts, Diether Larson, Melissa C. Lazaro, Conxi Le, Nhu D. Leslie, Goska Lester, Jenny Lesueur, Fabienne Levine, Douglas A. Li, Lian Li, Jingmei Loud, Jennifer T. Lu, Karen H. Lubiński, Jan Mai, Phuong L. Manoukian, Siranoush Marks, Jeffrey R. Matsuno, Rayna Kim Matsuo, Keitaro May, Taymaa McGuffog, Lesley McLaughlin, John R. McNeish, Iain A. Mebirouk, Noura Menon, Usha Miller, Austin Milne, Roger L. Minlikeeva, Albina Modugno, Francesmary Montagna, Marco Moysich, Kirsten B. Munro, Elizabeth Nathanson, Katherine L. Neuhausen, Susan L. Nevanlinna, Heli Ngeow Yuen, Yie Joanne Nielsen, Henriette Roed Nielsen, Finn C. Nikitina-Zake, Liene Odunsi, Kunle Offit, Kenneth Olah, Edith Olbrecht, Siel Olopade, Olufunmilayo I. Olson, Sara H. Olsson, Håkan Osorio, Ana Papi, Laura Park, Sue K. Parsons, Michael T. Pathak, Harsha Sokilde Pedersen, Inge Peixoto, Ana Pejovic, Tanja Perez-Segura, Pedro Permuth, Jennifer B. Peshkin, Beth Peterlongo, Paolo Piskorz, Anna Prokofyeva, Darya Radice, Paolo Rantala, Johanna Riggan, Marjorie J. Risch, Harvey A. Rodriguez-Antona, Cristina Ross, Eric Rossing, Mary Anne Runnebaum, Ingo Sandler, Dale P. Santamariña, Marta Soucy, Penny Schmutzler, Rita K. Setiawan, V. Wendy Shan, Kang Sieh, Weiva Simard, Jacques Singer, Christian F. Sokolenko, Anna P. Song, Honglin Southey, Melissa C. Steed, Helen Stoppa-Lyonnet, Dominique Sutphen, Rebecca Swerdlow, Anthony J. Tan, Yen Yen Teixeira, Manuel R. Teo, Soo Hwang Terry, Kathryn L. Terry, Mary Beth The OCAC Consortium The CIMBA Consortium Thomassen, Mads Thompson, Pamela J. Vestrheim Thomsen, Liv Cecilie Thull, Darcy L. Tischkowitz, Marc Titus, Linda Toland, Amanda E. Trabert, Britton Travis, Ruth Tung, Nadine Tworoger, Shelley S. Valen, Ellen van Altena, Anne M. van der Hout, Annemieke H. Van Nieuwenhuysen, Els van Rensburg, Elizabeth J. Vega, Ana Velez Edwards, Digna Vierkant, Robert A. Wang, Frances Wappenschmidt, Barbara Webb, Penelope M. Weinberg, Clarice R. Weitzel, Jeffrey N. Wentzensen, Nicolas White, Emily Whittemore, Alice S. Winham, Stacey J. Wolk, Alicja Woo, Yin-Ling Wu, Anna H. Yan, Li Yannoukakos, Drakoulis Zavaglia, Katia M. Zheng, Wei Ziogas, Argyrios Zorn, Kristin K. Kleibl, Zdenek Easton, Douglas Lawrenson, Kate DeFazio, Anna Sellers, Thomas A. Ramus, Susan J. Pearce, Celeste L. Monteiro, Alvaro N. Cunningham, Julie Goode, Ellen L. Schildkraut, Joellen M. Berchuck, Andrew Chenevix-Trench, Georgia Gayther, Simon A. Antoniou, Antonis C. Pharoah, Paul D. P. |
dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana |
dc.contributor.javerianateacher.none.fl_str_mv |
Torres-López, Diana María |
description |
Q1 |
publishDate |
2022 |
dc.date.accessioned.none.fl_str_mv |
2022-10-04T12:28:56Z |
dc.date.available.none.fl_str_mv |
2022-10-04T12:28:56Z |
dc.date.created.none.fl_str_mv |
2022-01-14 |
dc.type.local.spa.fl_str_mv |
Artículo de revista |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
format |
http://purl.org/coar/resource_type/c_6501 |
dc.identifier.spa.fl_str_mv |
https://www.nature.com/articles/s41431-021-00987-7 |
dc.identifier.issn.spa.fl_str_mv |
1018-4813 / 1476-5438 (Electrónico) |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/61999 |
dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1038/s41431-021-00987-7 |
dc.identifier.instname.spa.fl_str_mv |
instname:Pontificia Universidad Javeriana |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
dc.identifier.repourl.spa.fl_str_mv |
repourl:https://repository.javeriana.edu.co |
url |
https://www.nature.com/articles/s41431-021-00987-7 http://hdl.handle.net/10554/61999 https://doi.org/10.1038/s41431-021-00987-7 |
identifier_str_mv |
1018-4813 / 1476-5438 (Electrónico) instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationstartpage.spa.fl_str_mv |
349 |
dc.relation.citationendpage.spa.fl_str_mv |
362 |
dc.relation.ispartofjournal.spa.fl_str_mv |
European Journal of Human Genetics |
dc.relation.citationvolume.spa.fl_str_mv |
30 |
dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Dareng, Eileen O.Tyrer, Jonathan P.Barnes, Daniel R.Jones. Michelle R.Yang, XinAben, Katja K. H.Adank, Muriel A.Agata, SimonaAndrulis, Irene L.Anton-Culver, HodaAntonenkova, Natalia N.Aravantinos, GerasimosArun, Banu K.Augustinsson, AnnelieBalmaña, JudithBandera, Elisa V.Barkardottir, Rosa B.Barrowdale, DanielBeckmann, Matthias W.Beeghly-Fadiel, AliciaBenitez, JavierBermisheva, MarinaBernardini, Marcus Q.Bjorge, LineBlack, AmandaBogdanova, Natalia V.Bonanni, BernardoBorg, AkeBrenton, James D.Budzilowska, AgnieszkaButzow, RalfBuys, Saundra S.Cai, HuiCaligo, Maria A.Campbell, IanCannioto, RikkiCassingham, HayleyChang-Claude, JennyChanock, Stephen J.Chen, KexinChiew, Yoke-EngChung, Wendy K.Claes, Kathleen B. M.Colonna, SarahEMO Study CollaboratorsGC-HBOC Study CollaboratorsEMBRACE CollaboratorsCook, Linda S.Couch, Fergus J.Daly, Mary B.Dao, FannyDavies, Eleanorde la Hoya, Miguelde Putter, RobinDennis, JoeDePersia, AllisonDevilee, PeterDiez, OrlandChun Ding, YuanDoherty, Jennifer A.Domchek, Susan M.Dörk, Thilodu Bois, AndreasDürst, MatthiasEccles, Diana M.Eliassen, Heather A.Engel, ChristophEvans, Gareth D.Fasching, Peter A.Flanagan, James M.Fortner, Renée T.Machackova, EvaFriedman, EitanGanz, Patricia A.Garber, JudyGensini, FrancescaGiles, Graham G.Glendon, GordGodwin, Andrew K.Goodman, Marc T.Greene, Mark H.Gronwald, JacekOPAL Study GroupAOCS GroupHahnen, EricHaiman, Christopher A.Håkansson, NiclasHamann, UteHansen, Thomas V. O.Harris, Holly R.Hartman, MikaelHeitz, FlorianHildebrandt, Michelle A. T.Høgdall, EstridHøgdall, Claus K.Hopper, John L.Huang, Ruea-YeaHuff, ChadHulick, Peter J.Huntsman, David G.Imyanitov, Evgeny N.KConFab InvestigatorsHEBON InvestigatorsIsaacs, ClaudineJakubowska, AnnaJames, Paul A.Janavicius, RamunasJensen, AllanJohannsson, Oskar Th.John, Esther M.Jones, Michael E.Kang, DaeheeKarlan, Beth Y.Karnezis, AnthonyKelemen, Linda E.Khusnutdinova, ElzaKiemeney, Lambertus A.Kim, Byoung-GieKjaer, Susanne K.Komenaka, IanKupryjanczyk, JolantaKurian, Allison W.Kwong, AvaLambrechts, DietherLarson, Melissa C.Lazaro, ConxiLe, Nhu D.Leslie, GoskaLester, JennyLesueur, FabienneLevine, Douglas A.Li, LianLi, JingmeiLoud, Jennifer T.Lu, Karen H.Lubiński, JanMai, Phuong L.Manoukian, SiranoushMarks, Jeffrey R.Matsuno, Rayna KimMatsuo, KeitaroMay, TaymaaMcGuffog, LesleyMcLaughlin, John R.McNeish, Iain A.Mebirouk, NouraMenon, UshaMiller, AustinMilne, Roger L.Minlikeeva, AlbinaModugno, FrancesmaryMontagna, MarcoMoysich, Kirsten B.Munro, ElizabethNathanson, Katherine L.Neuhausen, Susan L.Nevanlinna, HeliNgeow Yuen, Yie JoanneNielsen, Henriette RoedNielsen, Finn C.Nikitina-Zake, LieneOdunsi, KunleOffit, KennethOlah, EdithOlbrecht, SielOlopade, Olufunmilayo I.Olson, Sara H.Olsson, HåkanOsorio, AnaPapi, LauraPark, Sue K.Parsons, Michael T.Pathak, HarshaSokilde Pedersen, IngePeixoto, AnaPejovic, TanjaPerez-Segura, PedroPermuth, Jennifer B.Peshkin, BethPeterlongo, PaoloPiskorz, AnnaProkofyeva, DaryaRadice, PaoloRantala, JohannaRiggan, Marjorie J.Risch, Harvey A.Rodriguez-Antona, CristinaRoss, EricRossing, Mary AnneRunnebaum, IngoSandler, Dale P.Santamariña, MartaSoucy, PennySchmutzler, Rita K.Setiawan, V. WendyShan, KangSieh, WeivaSimard, JacquesSinger, Christian F.Sokolenko, Anna P.Song, HonglinSouthey, Melissa C.Steed, HelenStoppa-Lyonnet, DominiqueSutphen, RebeccaSwerdlow, Anthony J.Tan, Yen YenTeixeira, Manuel R.Teo, Soo HwangTerry, Kathryn L.Terry, Mary BethThe OCAC ConsortiumThe CIMBA ConsortiumThomassen, MadsThompson, Pamela J.Vestrheim Thomsen, Liv CecilieThull, Darcy L.Tischkowitz, MarcTitus, LindaToland, Amanda E.Trabert, BrittonTravis, RuthTung, NadineTworoger, Shelley S.Valen, Ellenvan Altena, Anne M.van der Hout, Annemieke H.Van Nieuwenhuysen, Elsvan Rensburg, Elizabeth J.Vega, AnaVelez Edwards, DignaVierkant, Robert A.Wang, FrancesWappenschmidt, BarbaraWebb, Penelope M.Weinberg, Clarice R.Weitzel, Jeffrey N.Wentzensen, NicolasWhite, EmilyWhittemore, Alice S.Winham, Stacey J.Wolk, AlicjaWoo, Yin-LingWu, Anna H.Yan, LiYannoukakos, DrakoulisZavaglia, Katia M.Zheng, WeiZiogas, ArgyriosZorn, Kristin K.Kleibl, ZdenekEaston, DouglasLawrenson, KateDeFazio, AnnaSellers, Thomas A.Ramus, Susan J.Pearce, Celeste L.Monteiro, Alvaro N.Cunningham, JulieGoode, Ellen L.Schildkraut, Joellen M.Berchuck, AndrewChenevix-Trench, GeorgiaGayther, Simon A.Antoniou, Antonis C.Pharoah, Paul D. P.Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética HumanaTorres-López, Diana María2022-10-04T12:28:56Z2022-10-04T12:28:56Z2022-01-14https://www.nature.com/articles/s41431-021-00987-71018-4813 / 1476-5438 (Electrónico)http://hdl.handle.net/10554/61999https://doi.org/10.1038/s41431-021-00987-7instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengPolygenic risk modeling for prediction of epithelial ovarian cancer riskArtículo de revistahttp://purl.org/coar/resource_type/c_6501Q1Q1Pacientes con Cáncer epitelial de ovarioPolygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individual level genotype data and a Bayesian framework with continuous shrinkage, “select and shrink for summary statistics” (S4), to summary level data for epithelial non-mucinous ovarian cancer risk prediction. We developed the models in a dataset consisting of 23,564 non-mucinous EOC cases and 40,138 controls participating in the Ovarian Cancer Association Consortium (OCAC) and validated the best models in three populations of different ancestries: prospective data from 198,101 women of European ancestries; 7,669 women of East Asian ancestries; 1,072 women of African ancestries, and in 18,915 BRCA1 and 12,337 BRCA2 pathogenic variant carriers of European ancestries. In the external validation data, the model with the strongest association for non-mucinous EOC risk derived from the OCAC model development data was the S4 model (27,240 SNPs) with odds ratios (OR) of 1.38 (95% CI: 1.28–1.48, AUC: 0.588) per unit standard deviation, in women of European ancestries; 1.14 (95% CI: 1.08–1.19, AUC: 0.538) in women of East Asian ancestries; 1.38 (95% CI: 1.21–1.58, AUC: 0.593) in women of African ancestries; hazard ratios of 1.36 (95% CI: 1.29–1.43, AUC: 0.592) in BRCA1 pathogenic variant carriers and 1.49 (95% CI: 1.35–1.64, AUC: 0.624) in BRCA2 pathogenic variant carriers. Incorporation of the S4 PRS in risk prediction models for ovarian cancer may have clinical utility in ovarian cancer prevention programs.https://orcid.org/0000-0002-9879-9775Revista Internacional - IndexadaA1No349362European Journal of Human Genetics30ORIGINALPolygenic risk modeling.pdfPolygenic risk modeling.pdfArtículoapplication/pdf3041138http://repository.javeriana.edu.co/bitstream/10554/61999/1/Polygenic%20risk%20modeling.pdfb5945353ad8b24a037e2bf06b05a128cMD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/61999/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILPolygenic risk modeling.pdf.jpgPolygenic risk modeling.pdf.jpgIM Thumbnailimage/jpeg12725http://repository.javeriana.edu.co/bitstream/10554/61999/4/Polygenic%20risk%20modeling.pdf.jpgd9e2f51da4e53a6ad60c85a002bbe040MD54open access10554/61999oai:repository.javeriana.edu.co:10554/619992023-04-05 13:23:02.766Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |