Polygenic risk modeling for prediction of epithelial ovarian cancer risk

Q1

Autores:
Dareng, Eileen O.
Tyrer, Jonathan P.
Barnes, Daniel R.
Jones. Michelle R.
Yang, Xin
Aben, Katja K. H.
Adank, Muriel A.
Agata, Simona
Andrulis, Irene L.
Anton-Culver, Hoda
Antonenkova, Natalia N.
Aravantinos, Gerasimos
Arun, Banu K.
Augustinsson, Annelie
Balmaña, Judith
Bandera, Elisa V.
Barkardottir, Rosa B.
Barrowdale, Daniel
Beckmann, Matthias W.
Beeghly-Fadiel, Alicia
Benitez, Javier
Bermisheva, Marina
Bernardini, Marcus Q.
Bjorge, Line
Black, Amanda
Bogdanova, Natalia V.
Bonanni, Bernardo
Borg, Ake
Brenton, James D.
Budzilowska, Agnieszka
Butzow, Ralf
Buys, Saundra S.
Cai, Hui
Caligo, Maria A.
Campbell, Ian
Cannioto, Rikki
Cassingham, Hayley
Chang-Claude, Jenny
Chanock, Stephen J.
Chen, Kexin
Chiew, Yoke-Eng
Chung, Wendy K.
Claes, Kathleen B. M.
Colonna, Sarah
EMO Study Collaborators
GC-HBOC Study Collaborators
EMBRACE Collaborators
Cook, Linda S.
Couch, Fergus J.
Daly, Mary B.
Dao, Fanny
Davies, Eleanor
de la Hoya, Miguel
de Putter, Robin
Dennis, Joe
DePersia, Allison
Devilee, Peter
Diez, Orland
Chun Ding, Yuan
Doherty, Jennifer A.
Domchek, Susan M.
Dörk, Thilo
du Bois, Andreas
Dürst, Matthias
Eccles, Diana M.
Eliassen, Heather A.
Engel, Christoph
Evans, Gareth D.
Fasching, Peter A.
Flanagan, James M.
Fortner, Renée T.
Machackova, Eva
Friedman, Eitan
Ganz, Patricia A.
Garber, Judy
Gensini, Francesca
Giles, Graham G.
Glendon, Gord
Godwin, Andrew K.
Goodman, Marc T.
Greene, Mark H.
Gronwald, Jacek
OPAL Study Group
AOCS Group
Hahnen, Eric
Haiman, Christopher A.
Håkansson, Niclas
Hamann, Ute
Hansen, Thomas V. O.
Harris, Holly R.
Hartman, Mikael
Heitz, Florian
Hildebrandt, Michelle A. T.
Høgdall, Estrid
Høgdall, Claus K.
Hopper, John L.
Huang, Ruea-Yea
Huff, Chad
Hulick, Peter J.
Huntsman, David G.
Imyanitov, Evgeny N.
KConFab Investigators
HEBON Investigators
Isaacs, Claudine
Jakubowska, Anna
James, Paul A.
Janavicius, Ramunas
Jensen, Allan
Johannsson, Oskar Th.
John, Esther M.
Jones, Michael E.
Kang, Daehee
Karlan, Beth Y.
Karnezis, Anthony
Kelemen, Linda E.
Khusnutdinova, Elza
Kiemeney, Lambertus A.
Kim, Byoung-Gie
Kjaer, Susanne K.
Komenaka, Ian
Kupryjanczyk, Jolanta
Kurian, Allison W.
Kwong, Ava
Lambrechts, Diether
Larson, Melissa C.
Lazaro, Conxi
Le, Nhu D.
Leslie, Goska
Lester, Jenny
Lesueur, Fabienne
Levine, Douglas A.
Li, Lian
Li, Jingmei
Loud, Jennifer T.
Lu, Karen H.
Lubiński, Jan
Mai, Phuong L.
Manoukian, Siranoush
Marks, Jeffrey R.
Matsuno, Rayna Kim
Matsuo, Keitaro
May, Taymaa
McGuffog, Lesley
McLaughlin, John R.
McNeish, Iain A.
Mebirouk, Noura
Menon, Usha
Miller, Austin
Milne, Roger L.
Minlikeeva, Albina
Modugno, Francesmary
Montagna, Marco
Moysich, Kirsten B.
Munro, Elizabeth
Nathanson, Katherine L.
Neuhausen, Susan L.
Nevanlinna, Heli
Ngeow Yuen, Yie Joanne
Nielsen, Henriette Roed
Nielsen, Finn C.
Nikitina-Zake, Liene
Odunsi, Kunle
Offit, Kenneth
Olah, Edith
Olbrecht, Siel
Olopade, Olufunmilayo I.
Olson, Sara H.
Olsson, Håkan
Osorio, Ana
Papi, Laura
Park, Sue K.
Parsons, Michael T.
Pathak, Harsha
Sokilde Pedersen, Inge
Peixoto, Ana
Pejovic, Tanja
Perez-Segura, Pedro
Permuth, Jennifer B.
Peshkin, Beth
Peterlongo, Paolo
Piskorz, Anna
Prokofyeva, Darya
Radice, Paolo
Rantala, Johanna
Riggan, Marjorie J.
Risch, Harvey A.
Rodriguez-Antona, Cristina
Ross, Eric
Rossing, Mary Anne
Runnebaum, Ingo
Sandler, Dale P.
Santamariña, Marta
Soucy, Penny
Schmutzler, Rita K.
Setiawan, V. Wendy
Shan, Kang
Sieh, Weiva
Simard, Jacques
Singer, Christian F.
Sokolenko, Anna P.
Song, Honglin
Southey, Melissa C.
Steed, Helen
Stoppa-Lyonnet, Dominique
Sutphen, Rebecca
Swerdlow, Anthony J.
Tan, Yen Yen
Teixeira, Manuel R.
Teo, Soo Hwang
Terry, Kathryn L.
Terry, Mary Beth
The OCAC Consortium
The CIMBA Consortium
Thomassen, Mads
Thompson, Pamela J.
Vestrheim Thomsen, Liv Cecilie
Thull, Darcy L.
Tischkowitz, Marc
Titus, Linda
Toland, Amanda E.
Trabert, Britton
Travis, Ruth
Tung, Nadine
Tworoger, Shelley S.
Valen, Ellen
van Altena, Anne M.
van der Hout, Annemieke H.
Van Nieuwenhuysen, Els
van Rensburg, Elizabeth J.
Vega, Ana
Velez Edwards, Digna
Vierkant, Robert A.
Wang, Frances
Wappenschmidt, Barbara
Webb, Penelope M.
Weinberg, Clarice R.
Weitzel, Jeffrey N.
Wentzensen, Nicolas
White, Emily
Whittemore, Alice S.
Winham, Stacey J.
Wolk, Alicja
Woo, Yin-Ling
Wu, Anna H.
Yan, Li
Yannoukakos, Drakoulis
Zavaglia, Katia M.
Zheng, Wei
Ziogas, Argyrios
Zorn, Kristin K.
Kleibl, Zdenek
Easton, Douglas
Lawrenson, Kate
DeFazio, Anna
Sellers, Thomas A.
Ramus, Susan J.
Pearce, Celeste L.
Monteiro, Alvaro N.
Cunningham, Julie
Goode, Ellen L.
Schildkraut, Joellen M.
Berchuck, Andrew
Chenevix-Trench, Georgia
Gayther, Simon A.
Antoniou, Antonis C.
Pharoah, Paul D. P.
Tipo de recurso:
Article of journal
Fecha de publicación:
2022
Institución:
Pontificia Universidad Javeriana
Repositorio:
Repositorio Universidad Javeriana
Idioma:
eng
OAI Identifier:
oai:repository.javeriana.edu.co:10554/61999
Acceso en línea:
https://www.nature.com/articles/s41431-021-00987-7
http://hdl.handle.net/10554/61999
https://doi.org/10.1038/s41431-021-00987-7
Palabra clave:
Rights
License
Atribución-NoComercial 4.0 Internacional
id JAVERIANA2_9d785f202b94c0768ae9d5c25c297928
oai_identifier_str oai:repository.javeriana.edu.co:10554/61999
network_acronym_str JAVERIANA2
network_name_str Repositorio Universidad Javeriana
repository_id_str
dc.title.spa.fl_str_mv Polygenic risk modeling for prediction of epithelial ovarian cancer risk
title Polygenic risk modeling for prediction of epithelial ovarian cancer risk
spellingShingle Polygenic risk modeling for prediction of epithelial ovarian cancer risk
title_short Polygenic risk modeling for prediction of epithelial ovarian cancer risk
title_full Polygenic risk modeling for prediction of epithelial ovarian cancer risk
title_fullStr Polygenic risk modeling for prediction of epithelial ovarian cancer risk
title_full_unstemmed Polygenic risk modeling for prediction of epithelial ovarian cancer risk
title_sort Polygenic risk modeling for prediction of epithelial ovarian cancer risk
dc.creator.fl_str_mv Dareng, Eileen O.
Tyrer, Jonathan P.
Barnes, Daniel R.
Jones. Michelle R.
Yang, Xin
Aben, Katja K. H.
Adank, Muriel A.
Agata, Simona
Andrulis, Irene L.
Anton-Culver, Hoda
Antonenkova, Natalia N.
Aravantinos, Gerasimos
Arun, Banu K.
Augustinsson, Annelie
Balmaña, Judith
Bandera, Elisa V.
Barkardottir, Rosa B.
Barrowdale, Daniel
Beckmann, Matthias W.
Beeghly-Fadiel, Alicia
Benitez, Javier
Bermisheva, Marina
Bernardini, Marcus Q.
Bjorge, Line
Black, Amanda
Bogdanova, Natalia V.
Bonanni, Bernardo
Borg, Ake
Brenton, James D.
Budzilowska, Agnieszka
Butzow, Ralf
Buys, Saundra S.
Cai, Hui
Caligo, Maria A.
Campbell, Ian
Cannioto, Rikki
Cassingham, Hayley
Chang-Claude, Jenny
Chanock, Stephen J.
Chen, Kexin
Chiew, Yoke-Eng
Chung, Wendy K.
Claes, Kathleen B. M.
Colonna, Sarah
EMO Study Collaborators
GC-HBOC Study Collaborators
EMBRACE Collaborators
Cook, Linda S.
Couch, Fergus J.
Daly, Mary B.
Dao, Fanny
Davies, Eleanor
de la Hoya, Miguel
de Putter, Robin
Dennis, Joe
DePersia, Allison
Devilee, Peter
Diez, Orland
Chun Ding, Yuan
Doherty, Jennifer A.
Domchek, Susan M.
Dörk, Thilo
du Bois, Andreas
Dürst, Matthias
Eccles, Diana M.
Eliassen, Heather A.
Engel, Christoph
Evans, Gareth D.
Fasching, Peter A.
Flanagan, James M.
Fortner, Renée T.
Machackova, Eva
Friedman, Eitan
Ganz, Patricia A.
Garber, Judy
Gensini, Francesca
Giles, Graham G.
Glendon, Gord
Godwin, Andrew K.
Goodman, Marc T.
Greene, Mark H.
Gronwald, Jacek
OPAL Study Group
AOCS Group
Hahnen, Eric
Haiman, Christopher A.
Håkansson, Niclas
Hamann, Ute
Hansen, Thomas V. O.
Harris, Holly R.
Hartman, Mikael
Heitz, Florian
Hildebrandt, Michelle A. T.
Høgdall, Estrid
Høgdall, Claus K.
Hopper, John L.
Huang, Ruea-Yea
Huff, Chad
Hulick, Peter J.
Huntsman, David G.
Imyanitov, Evgeny N.
KConFab Investigators
HEBON Investigators
Isaacs, Claudine
Jakubowska, Anna
James, Paul A.
Janavicius, Ramunas
Jensen, Allan
Johannsson, Oskar Th.
John, Esther M.
Jones, Michael E.
Kang, Daehee
Karlan, Beth Y.
Karnezis, Anthony
Kelemen, Linda E.
Khusnutdinova, Elza
Kiemeney, Lambertus A.
Kim, Byoung-Gie
Kjaer, Susanne K.
Komenaka, Ian
Kupryjanczyk, Jolanta
Kurian, Allison W.
Kwong, Ava
Lambrechts, Diether
Larson, Melissa C.
Lazaro, Conxi
Le, Nhu D.
Leslie, Goska
Lester, Jenny
Lesueur, Fabienne
Levine, Douglas A.
Li, Lian
Li, Jingmei
Loud, Jennifer T.
Lu, Karen H.
Lubiński, Jan
Mai, Phuong L.
Manoukian, Siranoush
Marks, Jeffrey R.
Matsuno, Rayna Kim
Matsuo, Keitaro
May, Taymaa
McGuffog, Lesley
McLaughlin, John R.
McNeish, Iain A.
Mebirouk, Noura
Menon, Usha
Miller, Austin
Milne, Roger L.
Minlikeeva, Albina
Modugno, Francesmary
Montagna, Marco
Moysich, Kirsten B.
Munro, Elizabeth
Nathanson, Katherine L.
Neuhausen, Susan L.
Nevanlinna, Heli
Ngeow Yuen, Yie Joanne
Nielsen, Henriette Roed
Nielsen, Finn C.
Nikitina-Zake, Liene
Odunsi, Kunle
Offit, Kenneth
Olah, Edith
Olbrecht, Siel
Olopade, Olufunmilayo I.
Olson, Sara H.
Olsson, Håkan
Osorio, Ana
Papi, Laura
Park, Sue K.
Parsons, Michael T.
Pathak, Harsha
Sokilde Pedersen, Inge
Peixoto, Ana
Pejovic, Tanja
Perez-Segura, Pedro
Permuth, Jennifer B.
Peshkin, Beth
Peterlongo, Paolo
Piskorz, Anna
Prokofyeva, Darya
Radice, Paolo
Rantala, Johanna
Riggan, Marjorie J.
Risch, Harvey A.
Rodriguez-Antona, Cristina
Ross, Eric
Rossing, Mary Anne
Runnebaum, Ingo
Sandler, Dale P.
Santamariña, Marta
Soucy, Penny
Schmutzler, Rita K.
Setiawan, V. Wendy
Shan, Kang
Sieh, Weiva
Simard, Jacques
Singer, Christian F.
Sokolenko, Anna P.
Song, Honglin
Southey, Melissa C.
Steed, Helen
Stoppa-Lyonnet, Dominique
Sutphen, Rebecca
Swerdlow, Anthony J.
Tan, Yen Yen
Teixeira, Manuel R.
Teo, Soo Hwang
Terry, Kathryn L.
Terry, Mary Beth
The OCAC Consortium
The CIMBA Consortium
Thomassen, Mads
Thompson, Pamela J.
Vestrheim Thomsen, Liv Cecilie
Thull, Darcy L.
Tischkowitz, Marc
Titus, Linda
Toland, Amanda E.
Trabert, Britton
Travis, Ruth
Tung, Nadine
Tworoger, Shelley S.
Valen, Ellen
van Altena, Anne M.
van der Hout, Annemieke H.
Van Nieuwenhuysen, Els
van Rensburg, Elizabeth J.
Vega, Ana
Velez Edwards, Digna
Vierkant, Robert A.
Wang, Frances
Wappenschmidt, Barbara
Webb, Penelope M.
Weinberg, Clarice R.
Weitzel, Jeffrey N.
Wentzensen, Nicolas
White, Emily
Whittemore, Alice S.
Winham, Stacey J.
Wolk, Alicja
Woo, Yin-Ling
Wu, Anna H.
Yan, Li
Yannoukakos, Drakoulis
Zavaglia, Katia M.
Zheng, Wei
Ziogas, Argyrios
Zorn, Kristin K.
Kleibl, Zdenek
Easton, Douglas
Lawrenson, Kate
DeFazio, Anna
Sellers, Thomas A.
Ramus, Susan J.
Pearce, Celeste L.
Monteiro, Alvaro N.
Cunningham, Julie
Goode, Ellen L.
Schildkraut, Joellen M.
Berchuck, Andrew
Chenevix-Trench, Georgia
Gayther, Simon A.
Antoniou, Antonis C.
Pharoah, Paul D. P.
dc.contributor.author.none.fl_str_mv Dareng, Eileen O.
Tyrer, Jonathan P.
Barnes, Daniel R.
Jones. Michelle R.
Yang, Xin
Aben, Katja K. H.
Adank, Muriel A.
Agata, Simona
Andrulis, Irene L.
Anton-Culver, Hoda
Antonenkova, Natalia N.
Aravantinos, Gerasimos
Arun, Banu K.
Augustinsson, Annelie
Balmaña, Judith
Bandera, Elisa V.
Barkardottir, Rosa B.
Barrowdale, Daniel
Beckmann, Matthias W.
Beeghly-Fadiel, Alicia
Benitez, Javier
Bermisheva, Marina
Bernardini, Marcus Q.
Bjorge, Line
Black, Amanda
Bogdanova, Natalia V.
Bonanni, Bernardo
Borg, Ake
Brenton, James D.
Budzilowska, Agnieszka
Butzow, Ralf
Buys, Saundra S.
Cai, Hui
Caligo, Maria A.
Campbell, Ian
Cannioto, Rikki
Cassingham, Hayley
Chang-Claude, Jenny
Chanock, Stephen J.
Chen, Kexin
Chiew, Yoke-Eng
Chung, Wendy K.
Claes, Kathleen B. M.
Colonna, Sarah
EMO Study Collaborators
GC-HBOC Study Collaborators
EMBRACE Collaborators
Cook, Linda S.
Couch, Fergus J.
Daly, Mary B.
Dao, Fanny
Davies, Eleanor
de la Hoya, Miguel
de Putter, Robin
Dennis, Joe
DePersia, Allison
Devilee, Peter
Diez, Orland
Chun Ding, Yuan
Doherty, Jennifer A.
Domchek, Susan M.
Dörk, Thilo
du Bois, Andreas
Dürst, Matthias
Eccles, Diana M.
Eliassen, Heather A.
Engel, Christoph
Evans, Gareth D.
Fasching, Peter A.
Flanagan, James M.
Fortner, Renée T.
Machackova, Eva
Friedman, Eitan
Ganz, Patricia A.
Garber, Judy
Gensini, Francesca
Giles, Graham G.
Glendon, Gord
Godwin, Andrew K.
Goodman, Marc T.
Greene, Mark H.
Gronwald, Jacek
OPAL Study Group
AOCS Group
Hahnen, Eric
Haiman, Christopher A.
Håkansson, Niclas
Hamann, Ute
Hansen, Thomas V. O.
Harris, Holly R.
Hartman, Mikael
Heitz, Florian
Hildebrandt, Michelle A. T.
Høgdall, Estrid
Høgdall, Claus K.
Hopper, John L.
Huang, Ruea-Yea
Huff, Chad
Hulick, Peter J.
Huntsman, David G.
Imyanitov, Evgeny N.
KConFab Investigators
HEBON Investigators
Isaacs, Claudine
Jakubowska, Anna
James, Paul A.
Janavicius, Ramunas
Jensen, Allan
Johannsson, Oskar Th.
John, Esther M.
Jones, Michael E.
Kang, Daehee
Karlan, Beth Y.
Karnezis, Anthony
Kelemen, Linda E.
Khusnutdinova, Elza
Kiemeney, Lambertus A.
Kim, Byoung-Gie
Kjaer, Susanne K.
Komenaka, Ian
Kupryjanczyk, Jolanta
Kurian, Allison W.
Kwong, Ava
Lambrechts, Diether
Larson, Melissa C.
Lazaro, Conxi
Le, Nhu D.
Leslie, Goska
Lester, Jenny
Lesueur, Fabienne
Levine, Douglas A.
Li, Lian
Li, Jingmei
Loud, Jennifer T.
Lu, Karen H.
Lubiński, Jan
Mai, Phuong L.
Manoukian, Siranoush
Marks, Jeffrey R.
Matsuno, Rayna Kim
Matsuo, Keitaro
May, Taymaa
McGuffog, Lesley
McLaughlin, John R.
McNeish, Iain A.
Mebirouk, Noura
Menon, Usha
Miller, Austin
Milne, Roger L.
Minlikeeva, Albina
Modugno, Francesmary
Montagna, Marco
Moysich, Kirsten B.
Munro, Elizabeth
Nathanson, Katherine L.
Neuhausen, Susan L.
Nevanlinna, Heli
Ngeow Yuen, Yie Joanne
Nielsen, Henriette Roed
Nielsen, Finn C.
Nikitina-Zake, Liene
Odunsi, Kunle
Offit, Kenneth
Olah, Edith
Olbrecht, Siel
Olopade, Olufunmilayo I.
Olson, Sara H.
Olsson, Håkan
Osorio, Ana
Papi, Laura
Park, Sue K.
Parsons, Michael T.
Pathak, Harsha
Sokilde Pedersen, Inge
Peixoto, Ana
Pejovic, Tanja
Perez-Segura, Pedro
Permuth, Jennifer B.
Peshkin, Beth
Peterlongo, Paolo
Piskorz, Anna
Prokofyeva, Darya
Radice, Paolo
Rantala, Johanna
Riggan, Marjorie J.
Risch, Harvey A.
Rodriguez-Antona, Cristina
Ross, Eric
Rossing, Mary Anne
Runnebaum, Ingo
Sandler, Dale P.
Santamariña, Marta
Soucy, Penny
Schmutzler, Rita K.
Setiawan, V. Wendy
Shan, Kang
Sieh, Weiva
Simard, Jacques
Singer, Christian F.
Sokolenko, Anna P.
Song, Honglin
Southey, Melissa C.
Steed, Helen
Stoppa-Lyonnet, Dominique
Sutphen, Rebecca
Swerdlow, Anthony J.
Tan, Yen Yen
Teixeira, Manuel R.
Teo, Soo Hwang
Terry, Kathryn L.
Terry, Mary Beth
The OCAC Consortium
The CIMBA Consortium
Thomassen, Mads
Thompson, Pamela J.
Vestrheim Thomsen, Liv Cecilie
Thull, Darcy L.
Tischkowitz, Marc
Titus, Linda
Toland, Amanda E.
Trabert, Britton
Travis, Ruth
Tung, Nadine
Tworoger, Shelley S.
Valen, Ellen
van Altena, Anne M.
van der Hout, Annemieke H.
Van Nieuwenhuysen, Els
van Rensburg, Elizabeth J.
Vega, Ana
Velez Edwards, Digna
Vierkant, Robert A.
Wang, Frances
Wappenschmidt, Barbara
Webb, Penelope M.
Weinberg, Clarice R.
Weitzel, Jeffrey N.
Wentzensen, Nicolas
White, Emily
Whittemore, Alice S.
Winham, Stacey J.
Wolk, Alicja
Woo, Yin-Ling
Wu, Anna H.
Yan, Li
Yannoukakos, Drakoulis
Zavaglia, Katia M.
Zheng, Wei
Ziogas, Argyrios
Zorn, Kristin K.
Kleibl, Zdenek
Easton, Douglas
Lawrenson, Kate
DeFazio, Anna
Sellers, Thomas A.
Ramus, Susan J.
Pearce, Celeste L.
Monteiro, Alvaro N.
Cunningham, Julie
Goode, Ellen L.
Schildkraut, Joellen M.
Berchuck, Andrew
Chenevix-Trench, Georgia
Gayther, Simon A.
Antoniou, Antonis C.
Pharoah, Paul D. P.
dc.contributor.corporatename.spa.fl_str_mv Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana
dc.contributor.javerianateacher.none.fl_str_mv Torres-López, Diana María
description Q1
publishDate 2022
dc.date.accessioned.none.fl_str_mv 2022-10-04T12:28:56Z
dc.date.available.none.fl_str_mv 2022-10-04T12:28:56Z
dc.date.created.none.fl_str_mv 2022-01-14
dc.type.local.spa.fl_str_mv Artículo de revista
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_6501
format http://purl.org/coar/resource_type/c_6501
dc.identifier.spa.fl_str_mv https://www.nature.com/articles/s41431-021-00987-7
dc.identifier.issn.spa.fl_str_mv 1018-4813 / 1476-5438 (Electrónico)
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10554/61999
dc.identifier.doi.spa.fl_str_mv https://doi.org/10.1038/s41431-021-00987-7
dc.identifier.instname.spa.fl_str_mv instname:Pontificia Universidad Javeriana
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional - Pontificia Universidad Javeriana
dc.identifier.repourl.spa.fl_str_mv repourl:https://repository.javeriana.edu.co
url https://www.nature.com/articles/s41431-021-00987-7
http://hdl.handle.net/10554/61999
https://doi.org/10.1038/s41431-021-00987-7
identifier_str_mv 1018-4813 / 1476-5438 (Electrónico)
instname:Pontificia Universidad Javeriana
reponame:Repositorio Institucional - Pontificia Universidad Javeriana
repourl:https://repository.javeriana.edu.co
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationstartpage.spa.fl_str_mv 349
dc.relation.citationendpage.spa.fl_str_mv 362
dc.relation.ispartofjournal.spa.fl_str_mv European Journal of Human Genetics
dc.relation.citationvolume.spa.fl_str_mv 30
dc.rights.licence.*.fl_str_mv Atribución-NoComercial 4.0 Internacional
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.coar.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv Atribución-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0/
http://purl.org/coar/access_right/c_abf2
dc.format.spa.fl_str_mv PDF
dc.format.mimetype.spa.fl_str_mv application/pdf
institution Pontificia Universidad Javeriana
bitstream.url.fl_str_mv http://repository.javeriana.edu.co/bitstream/10554/61999/1/Polygenic%20risk%20modeling.pdf
http://repository.javeriana.edu.co/bitstream/10554/61999/2/license.txt
http://repository.javeriana.edu.co/bitstream/10554/61999/4/Polygenic%20risk%20modeling.pdf.jpg
bitstream.checksum.fl_str_mv b5945353ad8b24a037e2bf06b05a128c
2070d280cc89439d983d9eee1b17df53
d9e2f51da4e53a6ad60c85a002bbe040
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositorio Institucional - Pontificia Universidad Javeriana
repository.mail.fl_str_mv repositorio@javeriana.edu.co
_version_ 1814337637963530240
spelling Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Dareng, Eileen O.Tyrer, Jonathan P.Barnes, Daniel R.Jones. Michelle R.Yang, XinAben, Katja K. H.Adank, Muriel A.Agata, SimonaAndrulis, Irene L.Anton-Culver, HodaAntonenkova, Natalia N.Aravantinos, GerasimosArun, Banu K.Augustinsson, AnnelieBalmaña, JudithBandera, Elisa V.Barkardottir, Rosa B.Barrowdale, DanielBeckmann, Matthias W.Beeghly-Fadiel, AliciaBenitez, JavierBermisheva, MarinaBernardini, Marcus Q.Bjorge, LineBlack, AmandaBogdanova, Natalia V.Bonanni, BernardoBorg, AkeBrenton, James D.Budzilowska, AgnieszkaButzow, RalfBuys, Saundra S.Cai, HuiCaligo, Maria A.Campbell, IanCannioto, RikkiCassingham, HayleyChang-Claude, JennyChanock, Stephen J.Chen, KexinChiew, Yoke-EngChung, Wendy K.Claes, Kathleen B. M.Colonna, SarahEMO Study CollaboratorsGC-HBOC Study CollaboratorsEMBRACE CollaboratorsCook, Linda S.Couch, Fergus J.Daly, Mary B.Dao, FannyDavies, Eleanorde la Hoya, Miguelde Putter, RobinDennis, JoeDePersia, AllisonDevilee, PeterDiez, OrlandChun Ding, YuanDoherty, Jennifer A.Domchek, Susan M.Dörk, Thilodu Bois, AndreasDürst, MatthiasEccles, Diana M.Eliassen, Heather A.Engel, ChristophEvans, Gareth D.Fasching, Peter A.Flanagan, James M.Fortner, Renée T.Machackova, EvaFriedman, EitanGanz, Patricia A.Garber, JudyGensini, FrancescaGiles, Graham G.Glendon, GordGodwin, Andrew K.Goodman, Marc T.Greene, Mark H.Gronwald, JacekOPAL Study GroupAOCS GroupHahnen, EricHaiman, Christopher A.Håkansson, NiclasHamann, UteHansen, Thomas V. O.Harris, Holly R.Hartman, MikaelHeitz, FlorianHildebrandt, Michelle A. T.Høgdall, EstridHøgdall, Claus K.Hopper, John L.Huang, Ruea-YeaHuff, ChadHulick, Peter J.Huntsman, David G.Imyanitov, Evgeny N.KConFab InvestigatorsHEBON InvestigatorsIsaacs, ClaudineJakubowska, AnnaJames, Paul A.Janavicius, RamunasJensen, AllanJohannsson, Oskar Th.John, Esther M.Jones, Michael E.Kang, DaeheeKarlan, Beth Y.Karnezis, AnthonyKelemen, Linda E.Khusnutdinova, ElzaKiemeney, Lambertus A.Kim, Byoung-GieKjaer, Susanne K.Komenaka, IanKupryjanczyk, JolantaKurian, Allison W.Kwong, AvaLambrechts, DietherLarson, Melissa C.Lazaro, ConxiLe, Nhu D.Leslie, GoskaLester, JennyLesueur, FabienneLevine, Douglas A.Li, LianLi, JingmeiLoud, Jennifer T.Lu, Karen H.Lubiński, JanMai, Phuong L.Manoukian, SiranoushMarks, Jeffrey R.Matsuno, Rayna KimMatsuo, KeitaroMay, TaymaaMcGuffog, LesleyMcLaughlin, John R.McNeish, Iain A.Mebirouk, NouraMenon, UshaMiller, AustinMilne, Roger L.Minlikeeva, AlbinaModugno, FrancesmaryMontagna, MarcoMoysich, Kirsten B.Munro, ElizabethNathanson, Katherine L.Neuhausen, Susan L.Nevanlinna, HeliNgeow Yuen, Yie JoanneNielsen, Henriette RoedNielsen, Finn C.Nikitina-Zake, LieneOdunsi, KunleOffit, KennethOlah, EdithOlbrecht, SielOlopade, Olufunmilayo I.Olson, Sara H.Olsson, HåkanOsorio, AnaPapi, LauraPark, Sue K.Parsons, Michael T.Pathak, HarshaSokilde Pedersen, IngePeixoto, AnaPejovic, TanjaPerez-Segura, PedroPermuth, Jennifer B.Peshkin, BethPeterlongo, PaoloPiskorz, AnnaProkofyeva, DaryaRadice, PaoloRantala, JohannaRiggan, Marjorie J.Risch, Harvey A.Rodriguez-Antona, CristinaRoss, EricRossing, Mary AnneRunnebaum, IngoSandler, Dale P.Santamariña, MartaSoucy, PennySchmutzler, Rita K.Setiawan, V. WendyShan, KangSieh, WeivaSimard, JacquesSinger, Christian F.Sokolenko, Anna P.Song, HonglinSouthey, Melissa C.Steed, HelenStoppa-Lyonnet, DominiqueSutphen, RebeccaSwerdlow, Anthony J.Tan, Yen YenTeixeira, Manuel R.Teo, Soo HwangTerry, Kathryn L.Terry, Mary BethThe OCAC ConsortiumThe CIMBA ConsortiumThomassen, MadsThompson, Pamela J.Vestrheim Thomsen, Liv CecilieThull, Darcy L.Tischkowitz, MarcTitus, LindaToland, Amanda E.Trabert, BrittonTravis, RuthTung, NadineTworoger, Shelley S.Valen, Ellenvan Altena, Anne M.van der Hout, Annemieke H.Van Nieuwenhuysen, Elsvan Rensburg, Elizabeth J.Vega, AnaVelez Edwards, DignaVierkant, Robert A.Wang, FrancesWappenschmidt, BarbaraWebb, Penelope M.Weinberg, Clarice R.Weitzel, Jeffrey N.Wentzensen, NicolasWhite, EmilyWhittemore, Alice S.Winham, Stacey J.Wolk, AlicjaWoo, Yin-LingWu, Anna H.Yan, LiYannoukakos, DrakoulisZavaglia, Katia M.Zheng, WeiZiogas, ArgyriosZorn, Kristin K.Kleibl, ZdenekEaston, DouglasLawrenson, KateDeFazio, AnnaSellers, Thomas A.Ramus, Susan J.Pearce, Celeste L.Monteiro, Alvaro N.Cunningham, JulieGoode, Ellen L.Schildkraut, Joellen M.Berchuck, AndrewChenevix-Trench, GeorgiaGayther, Simon A.Antoniou, Antonis C.Pharoah, Paul D. P.Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética HumanaTorres-López, Diana María2022-10-04T12:28:56Z2022-10-04T12:28:56Z2022-01-14https://www.nature.com/articles/s41431-021-00987-71018-4813 / 1476-5438 (Electrónico)http://hdl.handle.net/10554/61999https://doi.org/10.1038/s41431-021-00987-7instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengPolygenic risk modeling for prediction of epithelial ovarian cancer riskArtículo de revistahttp://purl.org/coar/resource_type/c_6501Q1Q1Pacientes con Cáncer epitelial de ovarioPolygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individual level genotype data and a Bayesian framework with continuous shrinkage, “select and shrink for summary statistics” (S4), to summary level data for epithelial non-mucinous ovarian cancer risk prediction. We developed the models in a dataset consisting of 23,564 non-mucinous EOC cases and 40,138 controls participating in the Ovarian Cancer Association Consortium (OCAC) and validated the best models in three populations of different ancestries: prospective data from 198,101 women of European ancestries; 7,669 women of East Asian ancestries; 1,072 women of African ancestries, and in 18,915 BRCA1 and 12,337 BRCA2 pathogenic variant carriers of European ancestries. In the external validation data, the model with the strongest association for non-mucinous EOC risk derived from the OCAC model development data was the S4 model (27,240 SNPs) with odds ratios (OR) of 1.38 (95% CI: 1.28–1.48, AUC: 0.588) per unit standard deviation, in women of European ancestries; 1.14 (95% CI: 1.08–1.19, AUC: 0.538) in women of East Asian ancestries; 1.38 (95% CI: 1.21–1.58, AUC: 0.593) in women of African ancestries; hazard ratios of 1.36 (95% CI: 1.29–1.43, AUC: 0.592) in BRCA1 pathogenic variant carriers and 1.49 (95% CI: 1.35–1.64, AUC: 0.624) in BRCA2 pathogenic variant carriers. Incorporation of the S4 PRS in risk prediction models for ovarian cancer may have clinical utility in ovarian cancer prevention programs.https://orcid.org/0000-0002-9879-9775Revista Internacional - IndexadaA1No349362European Journal of Human Genetics30ORIGINALPolygenic risk modeling.pdfPolygenic risk modeling.pdfArtículoapplication/pdf3041138http://repository.javeriana.edu.co/bitstream/10554/61999/1/Polygenic%20risk%20modeling.pdfb5945353ad8b24a037e2bf06b05a128cMD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/61999/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILPolygenic risk modeling.pdf.jpgPolygenic risk modeling.pdf.jpgIM Thumbnailimage/jpeg12725http://repository.javeriana.edu.co/bitstream/10554/61999/4/Polygenic%20risk%20modeling.pdf.jpgd9e2f51da4e53a6ad60c85a002bbe040MD54open access10554/61999oai:repository.javeriana.edu.co:10554/619992023-04-05 13:23:02.766Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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