MicroRNAs as potential liquid biopsy biomarker for patients with castration-resistant prostate cancer
Q3
- Autores:
-
Fernandez, Jose Nicolas
Chavarriaga, Julian
Ayala Ramírez, Paola
Pedraza, Adriana
Bolivar, John
Prada, Juan Guillermo
Cataño Cataño, Juan Guillermo
García-Perdomo, Herney Andres
Villanueva Congote, Juliana
Varela, Daniela
Zarante, Ignacio
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2022
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/62111
- Acceso en línea:
- https://www.dovepress.com/micrornas-as-potential-liquid-biopsy-biomarker-for-patients-with-castr-peer-reviewed-fulltext-article-RRU
http://hdl.handle.net/10554/62111
https://doi.org/10.2147/RRU.S332578
- Palabra clave:
- Rostatic neoplasm
Prostatic neoplasms
Castration-resistant
MicroRNAs
Biomarkers
Genital neoplasms
Male
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
MicroRNAs as potential liquid biopsy biomarker for patients with castration-resistant prostate cancer |
| title |
MicroRNAs as potential liquid biopsy biomarker for patients with castration-resistant prostate cancer |
| spellingShingle |
MicroRNAs as potential liquid biopsy biomarker for patients with castration-resistant prostate cancer Rostatic neoplasm Prostatic neoplasms Castration-resistant MicroRNAs Biomarkers Genital neoplasms Male |
| title_short |
MicroRNAs as potential liquid biopsy biomarker for patients with castration-resistant prostate cancer |
| title_full |
MicroRNAs as potential liquid biopsy biomarker for patients with castration-resistant prostate cancer |
| title_fullStr |
MicroRNAs as potential liquid biopsy biomarker for patients with castration-resistant prostate cancer |
| title_full_unstemmed |
MicroRNAs as potential liquid biopsy biomarker for patients with castration-resistant prostate cancer |
| title_sort |
MicroRNAs as potential liquid biopsy biomarker for patients with castration-resistant prostate cancer |
| dc.creator.fl_str_mv |
Fernandez, Jose Nicolas Chavarriaga, Julian Ayala Ramírez, Paola Pedraza, Adriana Bolivar, John Prada, Juan Guillermo Cataño Cataño, Juan Guillermo García-Perdomo, Herney Andres Villanueva Congote, Juliana Varela, Daniela Zarante, Ignacio |
| dc.contributor.author.none.fl_str_mv |
Fernandez, Jose Nicolas Chavarriaga, Julian Ayala Ramírez, Paola Pedraza, Adriana Bolivar, John Prada, Juan Guillermo Cataño Cataño, Juan Guillermo García-Perdomo, Herney Andres Villanueva Congote, Juliana Varela, Daniela Zarante, Ignacio |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana |
| dc.contributor.corporatename.none.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Cirugía y Especialidades. Urología |
| dc.contributor.javerianateacher.none.fl_str_mv |
Cataño Cataño, Juan Guillermo Ayala Ramírez, Paola Zarante, Ignacio |
| dc.subject.keyword.spa.fl_str_mv |
Rostatic neoplasm Prostatic neoplasms Castration-resistant MicroRNAs Biomarkers Genital neoplasms Male |
| topic |
Rostatic neoplasm Prostatic neoplasms Castration-resistant MicroRNAs Biomarkers Genital neoplasms Male |
| description |
Q3 |
| publishDate |
2022 |
| dc.date.accessioned.none.fl_str_mv |
2022-10-18T13:39:29Z |
| dc.date.available.none.fl_str_mv |
2022-10-18T13:39:29Z |
| dc.date.created.none.fl_str_mv |
2022-03-01 |
| dc.type.local.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.identifier.spa.fl_str_mv |
https://www.dovepress.com/micrornas-as-potential-liquid-biopsy-biomarker-for-patients-with-castr-peer-reviewed-fulltext-article-RRU |
| dc.identifier.issn.spa.fl_str_mv |
2253-2447 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/62111 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.2147/RRU.S332578 |
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instname:Pontificia Universidad Javeriana |
| dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
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repourl:https://repository.javeriana.edu.co |
| url |
https://www.dovepress.com/micrornas-as-potential-liquid-biopsy-biomarker-for-patients-with-castr-peer-reviewed-fulltext-article-RRU http://hdl.handle.net/10554/62111 https://doi.org/10.2147/RRU.S332578 |
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2253-2447 instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
63 |
| dc.relation.citationendpage.spa.fl_str_mv |
70 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Research and Reports in Urology |
| dc.relation.citationvolume.spa.fl_str_mv |
14 |
| dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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PDF |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Fernandez, Jose NicolasChavarriaga, JulianAyala Ramírez, PaolaPedraza, AdrianaBolivar, JohnPrada, Juan GuillermoCataño Cataño, Juan GuillermoGarcía-Perdomo, Herney AndresVillanueva Congote, JulianaVarela, DanielaZarante, IgnacioPontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética HumanaPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Cirugía y Especialidades. UrologíaCataño Cataño, Juan GuillermoAyala Ramírez, PaolaZarante, Ignacio2022-10-18T13:39:29Z2022-10-18T13:39:29Z2022-03-01https://www.dovepress.com/micrornas-as-potential-liquid-biopsy-biomarker-for-patients-with-castr-peer-reviewed-fulltext-article-RRU2253-2447http://hdl.handle.net/10554/62111https://doi.org/10.2147/RRU.S332578instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengMicroRNAs as potential liquid biopsy biomarker for patients with castration-resistant prostate cancerArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Q3Q3HombresPurpose: To identify micro-RNAs (miRNAs) expression profiles in peripheral blood plasma that could play a role as potential biomarkers in patients who progressed to castration-resistant prostate cancer (CRPC). Liquid biopsy analysis of miRNAs is a fast-developing field with a considerable likelihood to predict tumor progression and metastasis by targeting genes involved in oncogenesis. Patients and Methods: Differential expression analysis of miRNAs profile in CRPC patients was performed by creating small RNA libraries of circulating miRNAs using HiSeq2500 Illumina platform. A secondary analysis of aligned reads with miRNA identification and quantification was performed using miARmaSeq. Using the Bowtie algorithm, the selected variants were compared to reference nucleotide sequence GRCh38 and miRbase. Novel miRNA sequences were structurally analyzed using mirDeep2®. Results: A total of 16 patients with CRPC were included for analysis. Identified circulating miRNAs were hsa-miR-885-3p, hsa-miR -4467, hsa-miR-4686, hsa-miR-146a-3p, hsa-miR-6514-5p. Genes identified as regulated by these miRNAs were GPR56, BDNF, CTNND1, C17orf62, and DTNA. Conclusion: We explored the miRNA expression profile in patients with CRPC, identifying five miRNAs implicated in the regulation of genes involved in prostate cancer (PCa) oncogenesis and progression. We also found miRNA 855–3p in peripheral blood for the first time, which has a critical role in tumor growth mechanisms and higher expression profile than in healthy individuals.https://orcid.org/0000-0002-9675-5963https://orcid.org/0000-0002-0141-1149https://orcid.org/0000-0001-5685-8354https://orcid.org/0000-0001-8202-9744https://orcid.org/0000-0002-0700-5686https://orcid.org/0000-0002-3772-6177https://orcid.org/0000-0002-0729-6866Revista Internacional - IndexadaA2NoRostatic neoplasmProstatic neoplasmsCastration-resistantMicroRNAsBiomarkersGenital neoplasmsMale6370Research and Reports in Urology14LICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/62111/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessORIGINALRRU-332578-micrornas-as-potential-liquid-biopsy-biomarker-for-patients-.pdfRRU-332578-micrornas-as-potential-liquid-biopsy-biomarker-for-patients-.pdfArtículoapplication/pdf1048139http://repository.javeriana.edu.co/bitstream/10554/62111/1/RRU-332578-micrornas-as-potential-liquid-biopsy-biomarker-for-patients-.pdf1b6cdb933faf18b2ed1f2e31c2f9a186MD51open accessTHUMBNAILRRU-332578-micrornas-as-potential-liquid-biopsy-biomarker-for-patients-.pdf.jpgRRU-332578-micrornas-as-potential-liquid-biopsy-biomarker-for-patients-.pdf.jpgIM Thumbnailimage/jpeg11099http://repository.javeriana.edu.co/bitstream/10554/62111/4/RRU-332578-micrornas-as-potential-liquid-biopsy-biomarker-for-patients-.pdf.jpg1438b9f8b7788aff3b34215325811b66MD54open access10554/62111oai:repository.javeriana.edu.co:10554/621112023-02-26 17:32:01.752Repositorio Institucional - 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