Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women : A case-control study
Q2
- Autores:
-
Olaya-Galán, Nury N.
Salas-Cárdenas, Sandra P.
Rodriguez-Sarmiento, Jorge L.
Ibáñez-Pinilla, Milcíades
Monroy, Ricardo
Corredor-Figueroa, Adriana P.
Rubiano, Wilson
De la Peña, Jairo
Shen, HuaMin
Buehring, Gertrude C.
Patarroyo, Manuel A.
Gutierrez, Maria F.
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2021
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/60271
- Acceso en línea:
- https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257492
http://hdl.handle.net/10554/60271
https://doi.org/10.1371/journal.pone.0257492
- Palabra clave:
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women : A case-control study |
| title |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women : A case-control study |
| spellingShingle |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women : A case-control study |
| title_short |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women : A case-control study |
| title_full |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women : A case-control study |
| title_fullStr |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women : A case-control study |
| title_full_unstemmed |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women : A case-control study |
| title_sort |
Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women : A case-control study |
| dc.creator.fl_str_mv |
Olaya-Galán, Nury N. Salas-Cárdenas, Sandra P. Rodriguez-Sarmiento, Jorge L. Ibáñez-Pinilla, Milcíades Monroy, Ricardo Corredor-Figueroa, Adriana P. Rubiano, Wilson De la Peña, Jairo Shen, HuaMin Buehring, Gertrude C. Patarroyo, Manuel A. Gutierrez, Maria F. |
| dc.contributor.author.none.fl_str_mv |
Olaya-Galán, Nury N. Salas-Cárdenas, Sandra P. Rodriguez-Sarmiento, Jorge L. Ibáñez-Pinilla, Milcíades Monroy, Ricardo Corredor-Figueroa, Adriana P. Rubiano, Wilson De la Peña, Jairo Shen, HuaMin Buehring, Gertrude C. Patarroyo, Manuel A. Gutierrez, Maria F. |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Patología Pontificia Universidad Javeriana. Facultad de Medicina. Hospital Universitario San Ignacio |
| dc.contributor.javerianateacher.none.fl_str_mv |
Rodriguez-Sarmiento, Jorge L. |
| description |
Q2 |
| publishDate |
2021 |
| dc.date.created.none.fl_str_mv |
2021-09 |
| dc.date.accessioned.none.fl_str_mv |
2022-06-14T12:14:53Z |
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2022-06-14T12:14:53Z |
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Artículo de revista |
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257492 |
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1932-6203 |
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http://hdl.handle.net/10554/60271 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1371/journal.pone.0257492 |
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instname:Pontificia Universidad Javeriana |
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257492 http://hdl.handle.net/10554/60271 https://doi.org/10.1371/journal.pone.0257492 |
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1932-6203 instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
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eng |
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eng |
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PLoS ONE |
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16 |
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9 |
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Atribución-NoComercial 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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Colombia |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Olaya-Galán, Nury N.Salas-Cárdenas, Sandra P.Rodriguez-Sarmiento, Jorge L.Ibáñez-Pinilla, MilcíadesMonroy, RicardoCorredor-Figueroa, Adriana P.Rubiano, WilsonDe la Peña, JairoShen, HuaMinBuehring, Gertrude C.Patarroyo, Manuel A.Gutierrez, Maria F.Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de PatologíaPontificia Universidad Javeriana. Facultad de Medicina. Hospital Universitario San IgnacioRodriguez-Sarmiento, Jorge L.Colombia2022-06-14T12:14:53Z2022-06-14T12:14:53Z2021-09https://journals.plos.org/plosone/article?id=10.1371/journal.pone.02574921932-6203http://hdl.handle.net/10554/60271https://doi.org/10.1371/journal.pone.0257492instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengRisk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women : A case-control studyArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Q2Q1Viruses have been implicated in cancer development in both humans and animals. The role of viruses in cancer is typically to initiate cellular transformation through cellular DNA damage, although specific mechanisms remain unknown. Silent and long-term viral infections need to be present, in order to initiate cancer disease. In efforts to establish a causative role of viruses, first is needed to demonstrate the strength and consistency of associations in different populations. The aim of this study was to determine the association of bovine leukemia virus (BLV), a causative agent of leukemia in cattle, with breast cancer and its biomarkers used as prognosis of the severity of the disease (Ki67, HER2, hormonal receptors) in Colombian women. An unmatched, observational case–control study was conducted among women undergoing breast surgery between 2016–2018. Malignant samples (n = 75) were considered as cases and benign samples (n = 83) as controls. Nested-liquid PCR, in-situ PCR and immunohistochemistry were used for viral detection in blood and breast tissues. For the risk assessment, only BLV positive samples from breast tissues were included in the analysis. BLV was higher in cases group (61.3%) compared with controls (48.2%), with a statistically significant association between the virus and breast cancer in the unconditional logistic regression (adjusted-OR = 2.450,95%CI:1.088–5.517, p = 0.031). In this study, BLV was found in both blood and breast tissues of participants and an association between breast cancer and the virus was confirmed in Colombia, as an intermediate risk factor.https://orcid.org/0000-0002-0084-0339Revista Internacional - IndexadaSi118PLoS ONE169LICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/60271/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessORIGINALa3498.pdfa3498.pdfArtículoapplication/pdf764482http://repository.javeriana.edu.co/bitstream/10554/60271/1/a3498.pdf4541508e6a548a0ca87c508cec47f20aMD51open accessTHUMBNAILa3498.pdf.jpga3498.pdf.jpgIM Thumbnailimage/jpeg13111http://repository.javeriana.edu.co/bitstream/10554/60271/3/a3498.pdf.jpgc7d9529127e246eb108d48b02c63ff78MD53open access10554/60271oai:repository.javeriana.edu.co:10554/602712022-06-15 03:06:29.338Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |