Theories of Mechanically Induced Tissue Differentiation and Adaptation in the Musculoskeletal System

It is well known that the mechanical environment affects biological tissues. The importance of theories and models that aim at explaining the role of the mechanical stimuli in process such as differentiation and adaptation of tissues is highlighted because if those theories can explain the tissue’s...

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Autores:
Suárez, Daniel R.
Tipo de recurso:
Article of journal
Fecha de publicación:
2015
Institución:
Pontificia Universidad Javeriana
Repositorio:
Repositorio Universidad Javeriana
Idioma:
eng
OAI Identifier:
oai:repository.javeriana.edu.co:10554/26024
Acceso en línea:
http://revistas.javeriana.edu.co/index.php/iyu/article/view/11283
http://hdl.handle.net/10554/26024
Palabra clave:
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional
Description
Summary:It is well known that the mechanical environment affects biological tissues. The importance of theories and models that aim at explaining the role of the mechanical stimuli in process such as differentiation and adaptation of tissues is highlighted because if those theories can explain the tissue’s response to mechanical loading and to its environment, it becomes possible to predict the consequences of mechanical stimuli on growth, adaptation and aging of tissues. This review aims to present an overview of the various theories and models on tissue differentiation and adaptation, and their mathematical implementation. Although current models are numerically well defined and are able to resemble the tissue differentiation and adaptation processes, they are limited by (1) the fact that some of their input parameters are likely to be site-and species-dependent, and (2) their verification is done by data that may make the model results redundant. However, some theories do have predictive power despite the limitations of generalization. It seems to be a matter of time until new experiments and models appear with predictive power and where rigorous verification can be performed.