Placental miRNAs as potential regulators in tumour processes

Trophoblasts and cancerous cells share a number of commonalities, undertaking processes such as cell proliferation, angiogenesis, tissue invasion, evasion of apoptosis and immune control, among others that have been described as hallmarks of cancer. The Trophoblastic Thesis of Cancer sustains that despite the similarities between placental and tumour cells, trophoblasts face meticulous regulation. Epigenetic regulation by specific placental miRNAs has been described, through computational biology methods, the complete miRNA quantification Transcriptome Profiles from breast, cervix, ovary and prostate cancer available in TCGA project were compared with placental normal tissue to find overexpressed placental miRNAs. Differential expression analysis showed the C19MC miRNAs as the highly expressed miRNAs, functional annotation of these miRNAs revealed the MAPK signaling pathway as the greatly regulated pathway in placenta with a total of 45 miRNAs regulating 135 genes. MAPK signaling pathways are commonly dysregulated in tumours but carefully regulated in embryonic development, demonstrating that C19MC miRNA epigenetic regulation has a potential role in tumour progression control and cancer prognosis.

• Autores: Barbosa Rojas, Tábata Camila
• Tipo de recurso: Trabajo de grado de pregrado
• Fecha de publicación: 2020
• Institución: Pontificia Universidad Javeriana
• Repositorio: Repositorio Universidad Javeriana
• Idioma: spa
• OAI Identifier: oai:repository.javeriana.edu.co:10554/52562
• Acceso en línea: http://hdl.handle.net/10554/52562
• Palabra clave: Trophoblastic Thesis of Cancer; C19MC; MAPK; Hallmarks of cancer; Epigenetic regulation; Biología - Tesis y disertaciones académicas; Neoplasias Trofoblásticas; Epigenómica; Quinasas de Proteína Quinasa Activadas por Mitógenos
• Rights: openAccess
• License: Atribución-NoComercial-SinDerivadas 4.0 Internacional