Soluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia
Q3
- Autores:
-
Valencia, Catalina M.
Hersh, Alyssa R.
Burwick, Richard M.
Velásquez, Jesús A.
Gutiérrez-Marín, Jorge
Edna, Francisco
Silva Herrera, Jaime Luis
Trujillo-Otálvaro, Juliana
Vargas-Rodríguez, Johanna
Bernal, Yamile
Quintero, Alvaro
Rincón, Mónica
Tolosa, Jorge E.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2022
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/63743
- Acceso en línea:
- https://search-ebscohost-com.ezproxy.javeriana.edu.co/login.aspx?direct=true&AuthType=sso&db=edselp&AN=S221077892200068X&lang=es&site=eds-live&scope=site&authtype=sso&custid=s6670599
http://hdl.handle.net/10554/63743
https://doi.org/10.1016/j.preghy.2022.07.001
- Palabra clave:
- Complement membrane attack complex
Complement system proteins
Hypertension
Preeclampsia
Pregnancy
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Soluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia |
| title |
Soluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia |
| spellingShingle |
Soluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia Complement membrane attack complex Complement system proteins Hypertension Preeclampsia Pregnancy |
| title_short |
Soluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia |
| title_full |
Soluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia |
| title_fullStr |
Soluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia |
| title_full_unstemmed |
Soluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia |
| title_sort |
Soluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia |
| dc.creator.fl_str_mv |
Valencia, Catalina M. Hersh, Alyssa R. Burwick, Richard M. Velásquez, Jesús A. Gutiérrez-Marín, Jorge Edna, Francisco Silva Herrera, Jaime Luis Trujillo-Otálvaro, Juliana Vargas-Rodríguez, Johanna Bernal, Yamile Quintero, Alvaro Rincón, Mónica Tolosa, Jorge E. |
| dc.contributor.author.none.fl_str_mv |
Valencia, Catalina M. Hersh, Alyssa R. Burwick, Richard M. Velásquez, Jesús A. Gutiérrez-Marín, Jorge Edna, Francisco Silva Herrera, Jaime Luis Trujillo-Otálvaro, Juliana Vargas-Rodríguez, Johanna Bernal, Yamile Quintero, Alvaro Rincón, Mónica Tolosa, Jorge E. |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ginecología y Obstetricia |
| dc.contributor.javerianateacher.none.fl_str_mv |
Silva Herrera, Jaime Luis |
| dc.subject.keyword.spa.fl_str_mv |
Complement membrane attack complex Complement system proteins Hypertension Preeclampsia Pregnancy |
| topic |
Complement membrane attack complex Complement system proteins Hypertension Preeclampsia Pregnancy |
| description |
Q3 |
| publishDate |
2022 |
| dc.date.created.none.fl_str_mv |
2022-07-06 |
| dc.date.accessioned.none.fl_str_mv |
2023-03-14T13:12:48Z |
| dc.date.available.none.fl_str_mv |
2023-03-14T13:12:48Z |
| dc.type.local.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_6501 |
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http://purl.org/coar/resource_type/c_6501 |
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https://search-ebscohost-com.ezproxy.javeriana.edu.co/login.aspx?direct=true&AuthType=sso&db=edselp&AN=S221077892200068X&lang=es&site=eds-live&scope=site&authtype=sso&custid=s6670599 |
| dc.identifier.issn.spa.fl_str_mv |
2210-7789 / 2210-7797 (Electrónico) |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/63743 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.preghy.2022.07.001 |
| dc.identifier.instname.spa.fl_str_mv |
instname:Pontificia Universidad Javeriana |
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reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
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repourl:https://repository.javeriana.edu.co |
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2210-7789 / 2210-7797 (Electrónico) instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
92 |
| dc.relation.citationendpage.spa.fl_str_mv |
97 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Pregnancy Hypertension |
| dc.relation.citationvolume.spa.fl_str_mv |
29 |
| dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
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Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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PDF |
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application/pdf |
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Colombia |
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2015-2016 |
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Pontificia Universidad Javeriana |
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Repositorio Institucional - Pontificia Universidad Javeriana |
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1808389449832202240 |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Valencia, Catalina M.Hersh, Alyssa R.Burwick, Richard M.Velásquez, Jesús A.Gutiérrez-Marín, JorgeEdna, FranciscoSilva Herrera, Jaime LuisTrujillo-Otálvaro, JulianaVargas-Rodríguez, JohannaBernal, YamileQuintero, AlvaroRincón, MónicaTolosa, Jorge E.Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ginecología y ObstetriciaSilva Herrera, Jaime LuisColombia2015-20162023-03-14T13:12:48Z2023-03-14T13:12:48Z2022-07-06https://search-ebscohost-com.ezproxy.javeriana.edu.co/login.aspx?direct=true&AuthType=sso&db=edselp&AN=S221077892200068X&lang=es&site=eds-live&scope=site&authtype=sso&custid=s66705992210-7789 / 2210-7797 (Electrónico)http://hdl.handle.net/10554/63743https://doi.org/10.1016/j.preghy.2022.07.001instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengSoluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsiaArtículo de revistahttp://purl.org/coar/resource_type/c_6501Q3Q1Pacientes embarazadas hipertensasObjective: We sought to determine if soluble levels of C5b-9, the terminal complement complex, correlate with end-organ injury in preeclampsia. Study Design: Project COPA (Complement and Preeclampsia in the Americas), a multi-center observational study in Colombia from 2015 to 2016, enrolled hypertensive pregnant women into four groups: chronic hypertension, gestational hypertension, preeclampsia, and preeclampsia with severe features. Trained coordinators collected clinical data, blood and urine. End-organ injury was defined by serum creatinine ≥ 1.0 mg/dl, aspartate transaminase ≥ 70U/L, platelet count < 150,000/µl, or lactate dehydrogenase ≥ 500 U/L. Data were analyzed by χ2 or Fisher’s exact test with significance at P < 0.05. Main Outcome Measure: C5b-9 concentrations in plasma and urine, using enzyme linked immunosorbent assays. Results: In total, 298 hypertensive participants were enrolled. Plasma and urine C5b-9 levels were measured in all participants and stratified by quartile (Q1-4), from lowest to highest C5b-9 concentration. Participants with low plasma C5b-9 levels (Q1) were more likely to have end-organ injury compared to those with higher levels (Q2-Q4) [platelet count < 150,000/μl (20.8% vs. 8.4%, P = 0.01); elevated serum creatinine ≥ 1.0 mg/dl (14.9% vs. 4.5%, P = 0.009)]. In contrast, participants with high urinary C5b-9 levels (Q4) were more likely to have end-organ injury compared to those with lower levels (Q1-Q3) [platelet count < 150,000/μl (19.7% vs. 7.4%, P = 0.003); elevated serum creatinine ≥ 1.0 mg/dl (12.3% vs. 4.4%, P = 0.025)]. Conclusion: We identified a pattern of increased urine and low plasma C5b-9 levels in patients with preeclampsia and end-organ injury. Soluble C5b-9 levels may be used to identify complement-mediated end-organ injury in preeclampsia.https://orcid.org/0000-0001-6822-0374Revista Internacional - IndexadaA1NoComplement membrane attack complexComplement system proteinsHypertensionPreeclampsiaPregnancy9297Pregnancy Hypertension29ORIGINALSoluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia.pdfSoluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia.pdfArtículoapplication/pdf623856http://repository.javeriana.edu.co/bitstream/10554/63743/1/Soluble%20concentrations%20of%20the%20terminal%20complement%20complex%20C5b-9%20correlate%20with%20end-organ%20injury%20in%20preeclampsia.pdf454dd80d565d445421f6e60ee5f92823MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/63743/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILSoluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia.pdf.jpgSoluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia.pdf.jpgIM Thumbnailimage/jpeg9327http://repository.javeriana.edu.co/bitstream/10554/63743/3/Soluble%20concentrations%20of%20the%20terminal%20complement%20complex%20C5b-9%20correlate%20with%20end-organ%20injury%20in%20preeclampsia.pdf.jpga120d37713839079950590aba3c6979aMD53open access10554/63743oai:repository.javeriana.edu.co:10554/637432023-03-21 03:07:46.911Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |