Synthetic Pharmacotherapy for Systemic Lupus Erythematosus: Potential Mechanisms of Action, Efficacy, and Safety
Q3
- Autores:
-
Téllez Arévalo, Angélica María
Quaye, Abraham
Rojas-Rodríguez, Luis Carlos
Poole, Brian D.
Baracaldo-Santamaría, Daniela
Tellez Freitas, Claudia M.
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2022
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/63756
- Acceso en línea:
- https://www.mdpi.com/1648-9144/59/1/56
http://hdl.handle.net/10554/63756
https://doi.org/10.3390/medicina59010056
- Palabra clave:
- Immunosuppressant agent
Glucocorticoid
Antimalarial drug
Efficacy
Safety
Systemic lupus erythematosus
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Synthetic Pharmacotherapy for Systemic Lupus Erythematosus: Potential Mechanisms of Action, Efficacy, and Safety |
| title |
Synthetic Pharmacotherapy for Systemic Lupus Erythematosus: Potential Mechanisms of Action, Efficacy, and Safety |
| spellingShingle |
Synthetic Pharmacotherapy for Systemic Lupus Erythematosus: Potential Mechanisms of Action, Efficacy, and Safety Immunosuppressant agent Glucocorticoid Antimalarial drug Efficacy Safety Systemic lupus erythematosus |
| title_short |
Synthetic Pharmacotherapy for Systemic Lupus Erythematosus: Potential Mechanisms of Action, Efficacy, and Safety |
| title_full |
Synthetic Pharmacotherapy for Systemic Lupus Erythematosus: Potential Mechanisms of Action, Efficacy, and Safety |
| title_fullStr |
Synthetic Pharmacotherapy for Systemic Lupus Erythematosus: Potential Mechanisms of Action, Efficacy, and Safety |
| title_full_unstemmed |
Synthetic Pharmacotherapy for Systemic Lupus Erythematosus: Potential Mechanisms of Action, Efficacy, and Safety |
| title_sort |
Synthetic Pharmacotherapy for Systemic Lupus Erythematosus: Potential Mechanisms of Action, Efficacy, and Safety |
| dc.creator.fl_str_mv |
Téllez Arévalo, Angélica María Quaye, Abraham Rojas-Rodríguez, Luis Carlos Poole, Brian D. Baracaldo-Santamaría, Daniela Tellez Freitas, Claudia M. |
| dc.contributor.author.none.fl_str_mv |
Téllez Arévalo, Angélica María Quaye, Abraham Rojas-Rodríguez, Luis Carlos Poole, Brian D. Baracaldo-Santamaría, Daniela Tellez Freitas, Claudia M. |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ciencias Fisiológicas |
| dc.contributor.javerianateacher.none.fl_str_mv |
Téllez Arévalo, Angélica María |
| dc.subject.keyword.spa.fl_str_mv |
Immunosuppressant agent Glucocorticoid Antimalarial drug Efficacy Safety Systemic lupus erythematosus |
| topic |
Immunosuppressant agent Glucocorticoid Antimalarial drug Efficacy Safety Systemic lupus erythematosus |
| description |
Q3 |
| publishDate |
2022 |
| dc.date.created.none.fl_str_mv |
2022-12-27 |
| dc.date.accessioned.none.fl_str_mv |
2023-03-14T14:17:03Z |
| dc.date.available.none.fl_str_mv |
2023-03-14T14:17:03Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_dcae04bc |
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http://purl.org/coar/resource_type/c_dcae04bc |
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https://www.mdpi.com/1648-9144/59/1/56 |
| dc.identifier.issn.spa.fl_str_mv |
1010-660X / 1648-9144 (Electrónico) |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/63756 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.3390/medicina59010056 |
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instname:Pontificia Universidad Javeriana |
| dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
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repourl:https://repository.javeriana.edu.co |
| url |
https://www.mdpi.com/1648-9144/59/1/56 http://hdl.handle.net/10554/63756 https://doi.org/10.3390/medicina59010056 |
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1010-660X / 1648-9144 (Electrónico) instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
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eng |
| language |
eng |
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1 |
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47 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Medicina-Lithuania |
| dc.relation.citationvolume.spa.fl_str_mv |
59 |
| dc.relation.citationissue.spa.fl_str_mv |
1 |
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Atribución-NoComercial 4.0 Internacional |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional http://purl.org/coar/access_right/c_abf2 |
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PDF |
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Pontificia Universidad Javeriana |
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Atribución-NoComercial 4.0 Internacionalhttp://purl.org/coar/access_right/c_abf2Téllez Arévalo, Angélica MaríaQuaye, AbrahamRojas-Rodríguez, Luis CarlosPoole, Brian D.Baracaldo-Santamaría, DanielaTellez Freitas, Claudia M.Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ciencias FisiológicasTéllez Arévalo, Angélica María2023-03-14T14:17:03Z2023-03-14T14:17:03Z2022-12-27https://www.mdpi.com/1648-9144/59/1/561010-660X / 1648-9144 (Electrónico)http://hdl.handle.net/10554/63756https://doi.org/10.3390/medicina59010056instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfenghttp://creativecommons.org/licenses/by-nc/4.0/Synthetic Pharmacotherapy for Systemic Lupus Erythematosus: Potential Mechanisms of Action, Efficacy, and SafetyArtículo de revistahttp://purl.org/coar/resource_type/c_dcae04bcQ3Q2The pharmacological treatment of systemic lupus erythematosus (SLE) aims to decrease disease activity, progression, systemic compromise, and mortality. Among the pharmacological alternatives, there are chemically synthesized drugs whose efficacy has been evaluated, but which have the potential to generate adverse events that may compromise adherence and response to treatment. Therapy selection and monitoring will depend on patient characteristics and the safety profile of each drug. The aim of this review is to provide a comprehensive understanding of the most important synthetic drugs used in the treatment of SLE, including the current treatment options (mycophenolate mofetil, azathioprine, and cyclophosphamide), review their mechanism of action, efficacy, safety, and, most importantly, provide monitoring parameters that should be considered while the patient is receiving the pharmacotherapy.https://orcid.org/0000-0002-8468-8716Revista Internacional - IndexadaA2NoImmunosuppressant agentGlucocorticoidAntimalarial drugEfficacySafetySystemic lupus erythematosus147Medicina-Lithuania591LICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/63756/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessORIGINALSynthetic Pharmacotherapy for Systemic Lupus Erythematosus Potential Mechanisms of Action, Efficacy, and Safety.pdfSynthetic Pharmacotherapy for Systemic Lupus Erythematosus Potential Mechanisms of Action, Efficacy, and Safety.pdfArtículoapplication/pdf1767860http://repository.javeriana.edu.co/bitstream/10554/63756/1/Synthetic%20Pharmacotherapy%20for%20Systemic%20Lupus%20Erythematosus%20Potential%20Mechanisms%20of%20Action%2c%20Efficacy%2c%20and%20Safety.pdfdedcc732195d0195bb7d221d77b674daMD51open accessTHUMBNAILSynthetic Pharmacotherapy for Systemic Lupus Erythematosus Potential Mechanisms of Action, Efficacy, and Safety.pdf.jpgSynthetic Pharmacotherapy for Systemic Lupus Erythematosus Potential Mechanisms of Action, Efficacy, and Safety.pdf.jpgIM Thumbnailimage/jpeg11924http://repository.javeriana.edu.co/bitstream/10554/63756/3/Synthetic%20Pharmacotherapy%20for%20Systemic%20Lupus%20Erythematosus%20Potential%20Mechanisms%20of%20Action%2c%20Efficacy%2c%20and%20Safety.pdf.jpgc6915aebf9a6e29dfe37231d52a69d09MD53open access10554/63756oai:repository.javeriana.edu.co:10554/637562023-03-17 03:04:27.122Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |