Breast cancer risk factors and survival by tumor subtype : pooled analyses from the breast Cancer Association Consortium
Q3
- Autores:
-
Morra, Anna
Jung, Audrey Y.
Behrens, Sabine
Keeman, Renske
Ahearn, Thomas U.
Anton-Culver, Hoda
Arndt, Volker
Augustinsson, Annelie
Auvinen, Päivi
Beane Freeman, Laura E.
Becher, Heiko
Beckmann, Matthias W.
Blomqvist, Carl
Bojesen, Stig E.
Bolla, Manjeet K.
Brenner, Hermann
Briceño Balcázar, Ignacio
Brucker, Sara Y.
Camp, Nicola J.
Campa, Daniele
Canzian, Federico
Castelao, Jose E.
Chanock, Stephen J.
Choi, Ji-Yeob
Clarke, Christine L.
Couch, Fergus J.
Cox, Angela
Cross, Simon S.
Czene, Kamila
Dörk, Thilo
Dunning, Alison M.
Dwek, Miriam
Easton, Douglas F.
Eccles, Diana M.
Egan, Kathleen M.
Evans, D. Gareth
Fasching, Peter A.
Flyger, Henrik
Gago-Dominguez, Manuela
Gapstur, Susan M.
García-Sáenz, José A.
Gaudet, Mia M.
Giles, Graham G.
Grip, Mervi
Guénel, Pascal
Haiman, Christopher A.
Hakansson, Niclas
Hall, Per
Hamann, Ute
Han, Sileny N.
Hart, Steven N.
Hartman, Mikael
Heyworth, Jane S.
Hoppe, Reiner
Hopper, John L.
Hunter, David J.
Ito, Hidemi
Jager, Agnes
Jakimovska, Milena
Jakubowska, Anna
Janni, Wolfgang
Kaaks, Rudolf
Kang, Daehee
Middha Kapoor, Pooja
Kitahara, Cari M.
Koutros, Stella
Kraft, Peter
Kristensen, Vessela N.
Lacey, James V.
Lambrechts, Diether
Marchand, Loic Le
Li, Jingmei
Lindblom, Annika
Lubiński, Jan
Lush, Michael
Mannermaa, Arto
Manoochehri, Mehdi
Margolin, Sara
Mariapun, Shivaani
Matsuo, Keitaro
Mavroudis, Dimitrios
Milne, Roger L.
Muranen, Taru A.
Newman, William G.
Noh, Dong-Young
Nordestgaard, Børge G.
Obi, Nadia
Olshan, Andrew F.
Olsson, Håkan
Park-Simon, Tjoung-Won
Petridis, Christos
Pharoah, Paul D. P.
Plaseska-Karanfilska, Dijana
Presneau, Nadege
Rashid, Muhammad U.
Rennert, Gad
Rennert, Hedy S.
Rhenius, Valerie
Romero, Atocha
Saloustros, Emmanouil
Sawyer, Elinor J.
Schneeweiss, Andreas
Schwentner, Lukas
Scott, Christopher
Shah, Mitul
Shen, Chen-Yang
Shu, Xiao-Ou
Southey, Melissa C.
Stram, Daniel O.
Tamimi, Rulla M.
Tapper, William J.
Tollenaar, Rob A.E.M.
Tomlinson, Ian
Torres-López, Diana María
Troester, Melissa A.
Truong, Thérèse
Vachon, Celine M.
Wang, Qin
Wang, Sophia S.
Williams, Justin A.
Winqvist, Robert
Wolk, Alicja
Wu, Anna H.
Yoo, Keun-Young
Yu, Jyh-Cherng
Zheng, Wei
Ziogas, Argyrios
Yang, Xiaohong R.
Eliassen, Heather A.
Holmes, Michelle D.
García-Closas, Montserrat
Teo, Soo Hwang
Schmidt, Marjanka K.
Chang-Claude, Jenny
Auvinen, Peaivi K.
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2021
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/63813
- Acceso en línea:
- https://aacrjournals.org/cebp/article/30/4/623/670709/Breast-Cancer-Risk-Factors-and-Survival-by-Tumor
http://hdl.handle.net/10554/63813
https://doi.org/10.1158/1055-9965.EPI-20-0924
- Palabra clave:
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Breast cancer risk factors and survival by tumor subtype : pooled analyses from the breast Cancer Association Consortium |
| title |
Breast cancer risk factors and survival by tumor subtype : pooled analyses from the breast Cancer Association Consortium |
| spellingShingle |
Breast cancer risk factors and survival by tumor subtype : pooled analyses from the breast Cancer Association Consortium |
| title_short |
Breast cancer risk factors and survival by tumor subtype : pooled analyses from the breast Cancer Association Consortium |
| title_full |
Breast cancer risk factors and survival by tumor subtype : pooled analyses from the breast Cancer Association Consortium |
| title_fullStr |
Breast cancer risk factors and survival by tumor subtype : pooled analyses from the breast Cancer Association Consortium |
| title_full_unstemmed |
Breast cancer risk factors and survival by tumor subtype : pooled analyses from the breast Cancer Association Consortium |
| title_sort |
Breast cancer risk factors and survival by tumor subtype : pooled analyses from the breast Cancer Association Consortium |
| dc.creator.fl_str_mv |
Morra, Anna Jung, Audrey Y. Behrens, Sabine Keeman, Renske Ahearn, Thomas U. Anton-Culver, Hoda Arndt, Volker Augustinsson, Annelie Auvinen, Päivi Beane Freeman, Laura E. Becher, Heiko Beckmann, Matthias W. Blomqvist, Carl Bojesen, Stig E. Bolla, Manjeet K. Brenner, Hermann Briceño Balcázar, Ignacio Brucker, Sara Y. Camp, Nicola J. Campa, Daniele Canzian, Federico Castelao, Jose E. Chanock, Stephen J. Choi, Ji-Yeob Clarke, Christine L. Couch, Fergus J. Cox, Angela Cross, Simon S. Czene, Kamila Dörk, Thilo Dunning, Alison M. Dwek, Miriam Easton, Douglas F. Eccles, Diana M. Egan, Kathleen M. Evans, D. Gareth Fasching, Peter A. Flyger, Henrik Gago-Dominguez, Manuela Gapstur, Susan M. García-Sáenz, José A. Gaudet, Mia M. Giles, Graham G. Grip, Mervi Guénel, Pascal Haiman, Christopher A. Hakansson, Niclas Hall, Per Hamann, Ute Han, Sileny N. Hart, Steven N. Hartman, Mikael Heyworth, Jane S. Hoppe, Reiner Hopper, John L. Hunter, David J. Ito, Hidemi Jager, Agnes Jakimovska, Milena Jakubowska, Anna Janni, Wolfgang Kaaks, Rudolf Kang, Daehee Middha Kapoor, Pooja Kitahara, Cari M. Koutros, Stella Kraft, Peter Kristensen, Vessela N. Lacey, James V. Lambrechts, Diether Marchand, Loic Le Li, Jingmei Lindblom, Annika Lubiński, Jan Lush, Michael Mannermaa, Arto Manoochehri, Mehdi Margolin, Sara Mariapun, Shivaani Matsuo, Keitaro Mavroudis, Dimitrios Milne, Roger L. Muranen, Taru A. Newman, William G. Noh, Dong-Young Nordestgaard, Børge G. Obi, Nadia Olshan, Andrew F. Olsson, Håkan Park-Simon, Tjoung-Won Petridis, Christos Pharoah, Paul D. P. Plaseska-Karanfilska, Dijana Presneau, Nadege Rashid, Muhammad U. Rennert, Gad Rennert, Hedy S. Rhenius, Valerie Romero, Atocha Saloustros, Emmanouil Sawyer, Elinor J. Schneeweiss, Andreas Schwentner, Lukas Scott, Christopher Shah, Mitul Shen, Chen-Yang Shu, Xiao-Ou Southey, Melissa C. Stram, Daniel O. Tamimi, Rulla M. Tapper, William J. Tollenaar, Rob A.E.M. Tomlinson, Ian Torres-López, Diana María Troester, Melissa A. Truong, Thérèse Vachon, Celine M. Wang, Qin Wang, Sophia S. Williams, Justin A. Winqvist, Robert Wolk, Alicja Wu, Anna H. Yoo, Keun-Young Yu, Jyh-Cherng Zheng, Wei Ziogas, Argyrios Yang, Xiaohong R. Eliassen, Heather A. Holmes, Michelle D. García-Closas, Montserrat Teo, Soo Hwang Schmidt, Marjanka K. Chang-Claude, Jenny Auvinen, Peaivi K. |
| dc.contributor.author.none.fl_str_mv |
Morra, Anna Jung, Audrey Y. Behrens, Sabine Keeman, Renske Ahearn, Thomas U. Anton-Culver, Hoda Arndt, Volker Augustinsson, Annelie Auvinen, Päivi Beane Freeman, Laura E. Becher, Heiko Beckmann, Matthias W. Blomqvist, Carl Bojesen, Stig E. Bolla, Manjeet K. Brenner, Hermann Briceño Balcázar, Ignacio Brucker, Sara Y. Camp, Nicola J. Campa, Daniele Canzian, Federico Castelao, Jose E. Chanock, Stephen J. Choi, Ji-Yeob Clarke, Christine L. Couch, Fergus J. Cox, Angela Cross, Simon S. Czene, Kamila Dörk, Thilo Dunning, Alison M. Dwek, Miriam Easton, Douglas F. Eccles, Diana M. Egan, Kathleen M. Evans, D. Gareth Fasching, Peter A. Flyger, Henrik Gago-Dominguez, Manuela Gapstur, Susan M. García-Sáenz, José A. Gaudet, Mia M. Giles, Graham G. Grip, Mervi Guénel, Pascal Haiman, Christopher A. Hakansson, Niclas Hall, Per Hamann, Ute Han, Sileny N. Hart, Steven N. Hartman, Mikael Heyworth, Jane S. Hoppe, Reiner Hopper, John L. Hunter, David J. Ito, Hidemi Jager, Agnes Jakimovska, Milena Jakubowska, Anna Janni, Wolfgang Kaaks, Rudolf Kang, Daehee Middha Kapoor, Pooja Kitahara, Cari M. Koutros, Stella Kraft, Peter Kristensen, Vessela N. Lacey, James V. Lambrechts, Diether Marchand, Loic Le Li, Jingmei Lindblom, Annika Lubiński, Jan Lush, Michael Mannermaa, Arto Manoochehri, Mehdi Margolin, Sara Mariapun, Shivaani Matsuo, Keitaro Mavroudis, Dimitrios Milne, Roger L. Muranen, Taru A. Newman, William G. Noh, Dong-Young Nordestgaard, Børge G. Obi, Nadia Olshan, Andrew F. Olsson, Håkan Park-Simon, Tjoung-Won Petridis, Christos Pharoah, Paul D. P. Plaseska-Karanfilska, Dijana Presneau, Nadege Rashid, Muhammad U. Rennert, Gad Rennert, Hedy S. Rhenius, Valerie Romero, Atocha Saloustros, Emmanouil Sawyer, Elinor J. Schneeweiss, Andreas Schwentner, Lukas Scott, Christopher Shah, Mitul Shen, Chen-Yang Shu, Xiao-Ou Southey, Melissa C. Stram, Daniel O. Tamimi, Rulla M. Tapper, William J. Tollenaar, Rob A.E.M. Tomlinson, Ian Torres-López, Diana María Troester, Melissa A. Truong, Thérèse Vachon, Celine M. Wang, Qin Wang, Sophia S. Williams, Justin A. Winqvist, Robert Wolk, Alicja Wu, Anna H. Yoo, Keun-Young Yu, Jyh-Cherng Zheng, Wei Ziogas, Argyrios Yang, Xiaohong R. Eliassen, Heather A. Holmes, Michelle D. García-Closas, Montserrat Teo, Soo Hwang Schmidt, Marjanka K. Chang-Claude, Jenny Auvinen, Peaivi K. |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana |
| dc.contributor.javerianateacher.none.fl_str_mv |
Briceño Balcázar, Ignacio Torres-López, Diana María |
| description |
Q3 |
| publishDate |
2021 |
| dc.date.created.none.fl_str_mv |
2021-04-01 |
| dc.date.accessioned.none.fl_str_mv |
2023-03-16T18:38:47Z |
| dc.date.available.none.fl_str_mv |
2023-03-16T18:38:47Z |
| dc.type.local.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
| format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://aacrjournals.org/cebp/article/30/4/623/670709/Breast-Cancer-Risk-Factors-and-Survival-by-Tumor |
| dc.identifier.issn.spa.fl_str_mv |
1055-9965 / 1538-7755 (Electrónico) |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/63813 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1158/1055-9965.EPI-20-0924 |
| dc.identifier.instname.spa.fl_str_mv |
instname:Pontificia Universidad Javeriana |
| dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
| dc.identifier.repourl.spa.fl_str_mv |
repourl:https://repository.javeriana.edu.co |
| url |
https://aacrjournals.org/cebp/article/30/4/623/670709/Breast-Cancer-Risk-Factors-and-Survival-by-Tumor http://hdl.handle.net/10554/63813 https://doi.org/10.1158/1055-9965.EPI-20-0924 |
| identifier_str_mv |
1055-9965 / 1538-7755 (Electrónico) instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
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623 |
| dc.relation.citationendpage.spa.fl_str_mv |
642 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Cancer Epidemiology Biomarkers and Prevention |
| dc.relation.citationvolume.spa.fl_str_mv |
30 |
| dc.relation.citationissue.spa.fl_str_mv |
4 |
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Atribución-NoComercial 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Morra, AnnaJung, Audrey Y.Behrens, SabineKeeman, RenskeAhearn, Thomas U.Anton-Culver, HodaArndt, VolkerAugustinsson, AnnelieAuvinen, PäiviBeane Freeman, Laura E.Becher, HeikoBeckmann, Matthias W.Blomqvist, CarlBojesen, Stig E.Bolla, Manjeet K.Brenner, HermannBriceño Balcázar, IgnacioBrucker, Sara Y.Camp, Nicola J.Campa, DanieleCanzian, FedericoCastelao, Jose E.Chanock, Stephen J.Choi, Ji-YeobClarke, Christine L.Couch, Fergus J.Cox, AngelaCross, Simon S.Czene, KamilaDörk, ThiloDunning, Alison M.Dwek, MiriamEaston, Douglas F.Eccles, Diana M.Egan, Kathleen M.Evans, D. GarethFasching, Peter A.Flyger, HenrikGago-Dominguez, ManuelaGapstur, Susan M.García-Sáenz, José A.Gaudet, Mia M.Giles, Graham G.Grip, MerviGuénel, PascalHaiman, Christopher A.Hakansson, NiclasHall, PerHamann, UteHan, Sileny N.Hart, Steven N.Hartman, MikaelHeyworth, Jane S.Hoppe, ReinerHopper, John L.Hunter, David J.Ito, HidemiJager, AgnesJakimovska, MilenaJakubowska, AnnaJanni, WolfgangKaaks, RudolfKang, DaeheeMiddha Kapoor, PoojaKitahara, Cari M.Koutros, StellaKraft, PeterKristensen, Vessela N.Lacey, James V.Lambrechts, DietherMarchand, Loic LeLi, JingmeiLindblom, AnnikaLubiński, JanLush, MichaelMannermaa, ArtoManoochehri, MehdiMargolin, SaraMariapun, ShivaaniMatsuo, KeitaroMavroudis, DimitriosMilne, Roger L.Muranen, Taru A.Newman, William G.Noh, Dong-YoungNordestgaard, Børge G.Obi, NadiaOlshan, Andrew F.Olsson, HåkanPark-Simon, Tjoung-WonPetridis, ChristosPharoah, Paul D. P.Plaseska-Karanfilska, DijanaPresneau, NadegeRashid, Muhammad U.Rennert, GadRennert, Hedy S.Rhenius, ValerieRomero, AtochaSaloustros, EmmanouilSawyer, Elinor J.Schneeweiss, AndreasSchwentner, LukasScott, ChristopherShah, MitulShen, Chen-YangShu, Xiao-OuSouthey, Melissa C.Stram, Daniel O.Tamimi, Rulla M.Tapper, William J.Tollenaar, Rob A.E.M.Tomlinson, IanTorres-López, Diana MaríaTroester, Melissa A.Truong, ThérèseVachon, Celine M.Wang, QinWang, Sophia S.Williams, Justin A.Winqvist, RobertWolk, AlicjaWu, Anna H.Yoo, Keun-YoungYu, Jyh-CherngZheng, WeiZiogas, ArgyriosYang, Xiaohong R.Eliassen, Heather A.Holmes, Michelle D.García-Closas, MontserratTeo, Soo HwangSchmidt, Marjanka K.Chang-Claude, JennyAuvinen, Peaivi K.Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética HumanaBriceño Balcázar, IgnacioTorres-López, Diana María2023-03-16T18:38:47Z2023-03-16T18:38:47Z2021-04-01https://aacrjournals.org/cebp/article/30/4/623/670709/Breast-Cancer-Risk-Factors-and-Survival-by-Tumor1055-9965 / 1538-7755 (Electrónico)http://hdl.handle.net/10554/63813https://doi.org/10.1158/1055-9965.EPI-20-0924instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengBreast cancer risk factors and survival by tumor subtype : pooled analyses from the breast Cancer Association ConsortiumArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Q3Q1Mujeres con cáncer de mamaBackground: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype. Methods: We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in the Breast Cancer Association Consortium with 16,890 deaths (8,554 breast cancer specific) over 10 years. Cox regression was used to estimate associations between risk factors and 10-year all-cause mortality and breast cancer–specific mortality overall, by estrogen receptor (ER) status, and by intrinsic-like subtype. Results: There was no evidence of heterogeneous associations between risk factors and mortality by subtype (Padj > 0.30). The strongest associations were between all-cause mortality and BMI ≥30 versus 18.5–25 kg/m2 [HR (95% confidence interval (CI), 1.19 (1.06–1.34)]; current versus never smoking [1.37 (1.27–1.47)], high versus low physical activity [0.43 (0.21–0.86)], age ≥30 years versus <20 years at first pregnancy [0.79 (0.72–0.86)]; >0–<5 years versus ≥10 years since last full-term birth [1.31 (1.11–1.55)]; ever versus never use of oral contraceptives [0.91 (0.87–0.96)]; ever versus never use of menopausal hormone therapy, including current estrogen–progestin therapy [0.61 (0.54–0.69)]. Similar associations with breast cancer mortality were weaker; for example, 1.11 (1.02–1.21) for current versus never smoking. Conclusions: We confirm associations between modifiable lifestyle factors and 10-year all-cause mortality. There was no strong evidence that associations differed by ER status or intrinsic-like subtype. Impact: Given the large dataset and lack of evidence that associations between modifiable risk factors and 10-year mortality differed by subtype, these associations could be cautiously used in prognostication models to inform patient-centered care.https://orcid.org/0000-0001-7300-6401https://orcid.org/0000-0002-9879-9775Revista Internacional - IndexadaA1No623642Cancer Epidemiology Biomarkers and Prevention304ORIGINALBreast Cancer Risk Factors and Survival by Tumor Subtype Pooled Analyses from the Breast Cancer Association Consortium.pdfBreast Cancer Risk Factors and Survival by Tumor Subtype Pooled Analyses from the Breast Cancer Association Consortium.pdfArtículoapplication/pdf395620http://repository.javeriana.edu.co/bitstream/10554/63813/1/Breast%20Cancer%20Risk%20Factors%20and%20Survival%20by%20Tumor%20Subtype%20Pooled%20Analyses%20from%20the%20Breast%20Cancer%20Association%20Consortium.pdf97117add95f75a9e5ea61421206a5265MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/63813/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILBreast Cancer Risk Factors and Survival by Tumor Subtype Pooled Analyses from the Breast Cancer Association Consortium.pdf.jpgBreast Cancer Risk Factors and Survival by Tumor Subtype Pooled Analyses from the Breast Cancer Association Consortium.pdf.jpgIM Thumbnailimage/jpeg12141http://repository.javeriana.edu.co/bitstream/10554/63813/3/Breast%20Cancer%20Risk%20Factors%20and%20Survival%20by%20Tumor%20Subtype%20Pooled%20Analyses%20from%20the%20Breast%20Cancer%20Association%20Consortium.pdf.jpg701c808a8afef6cf7145c1e2c5458c46MD53open access10554/63813oai:repository.javeriana.edu.co:10554/638132023-03-20 03:06:58.507Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |