Monocytes subsets and cytokine levels in chronic Chagas disease
Q1
- Autores:
-
González, John M.
Gómez-Olarte, Sergio
Bolaños, Natalia
Echeverry, Mariana
Rodríguez, Ayda
Cuellar, Adriana
Puerta, Concepción J.
Mariño, Alejandro
- Tipo de recurso:
- Article of data
- Fecha de publicación:
- 2019
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/56815
- Acceso en línea:
- http://hdl.handle.net/10554/56815
- Palabra clave:
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Monocytes subsets and cytokine levels in chronic Chagas disease |
| title |
Monocytes subsets and cytokine levels in chronic Chagas disease |
| spellingShingle |
Monocytes subsets and cytokine levels in chronic Chagas disease |
| title_short |
Monocytes subsets and cytokine levels in chronic Chagas disease |
| title_full |
Monocytes subsets and cytokine levels in chronic Chagas disease |
| title_fullStr |
Monocytes subsets and cytokine levels in chronic Chagas disease |
| title_full_unstemmed |
Monocytes subsets and cytokine levels in chronic Chagas disease |
| title_sort |
Monocytes subsets and cytokine levels in chronic Chagas disease |
| dc.creator.fl_str_mv |
González, John M. Gómez-Olarte, Sergio Bolaños, Natalia Echeverry, Mariana Rodríguez, Ayda Cuellar, Adriana Puerta, Concepción J. Mariño, Alejandro |
| dc.contributor.author.none.fl_str_mv |
González, John M. Gómez-Olarte, Sergio Bolaños, Natalia Echeverry, Mariana Rodríguez, Ayda Cuellar, Adriana Puerta, Concepción J. Mariño, Alejandro |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Cardiología |
| dc.contributor.javerianateacher.none.fl_str_mv |
Mariño, Alejandro |
| description |
Q1 |
| publishDate |
2019 |
| dc.date.created.none.fl_str_mv |
2019-05-01 |
| dc.date.accessioned.none.fl_str_mv |
2021-09-02T18:06:18Z |
| dc.date.available.none.fl_str_mv |
2021-09-02T18:06:18Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_beb9 |
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0022-1767 / 1550-6606 (Electrónico) |
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http://hdl.handle.net/10554/56815 |
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http://hdl.handle.net/10554/56815 |
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eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
126.26 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Journal of Immunology |
| dc.relation.citationvolume.spa.fl_str_mv |
202 |
| dc.relation.citationissue.spa.fl_str_mv |
S1 |
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Atribución-NoComercial 4.0 Internacional |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2González, John M.Gómez-Olarte, SergioBolaños, NataliaEcheverry, MarianaRodríguez, AydaCuellar, AdrianaPuerta, Concepción J.Mariño, AlejandroPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. CardiologíaMariño, Alejandro2021-09-02T18:06:18Z2021-09-02T18:06:18Z2019-05-010022-1767 / 1550-6606 (Electrónico)http://hdl.handle.net/10554/56815instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengMonocytes subsets and cytokine levels in chronic Chagas diseaseArtículo de revistahttp://purl.org/coar/resource_type/c_beb9Q1Monocytes are classified according to CD14 and CD16 expression into classical, intermediate and non classical. Variations in monocytes subsets are involved in the pathogenesis of protozoan and helminthic infections. This study assessed the relationship of monocyte subsets percentages and the level of cytokines in blood from Colombian chagasic patients. Donors included asymptomatic or indeterminate (IND), symptomatic or chronic cardiac chagasic (CCC) and heart transplant (HTCC) patients; also, non-chagasic cardiopathy patients (NCC) and healthy individuals (HI) as controls. Peripheral blood mononuclear cells (PBMCs) were isolated. Fc receptors were blocked using anti-CD16/CD32 and human AB serum. Cells were labeled with antibodies for CD14, CD16 and HLA-DR, and acquired in a flow cytometer. Cytokines were measured in plasma with a Human M1/M2 Macrophage kit. Comparisons were done with Kruskal-Wallis followed by Dunn’s post hoc test and correlations were evaluated by Spearman’s coefficient. Percentages of CD14+ CD16+ and CD14+ HLA-DR+ monocytes were higher in patients with heart involvement (CCC, HTCCC, and NCC). Percentage of intermediate monocytes (inflammatory) increased in CCC patients and was positively correlated with IL-6 concentration and negatively correlated with IL-12p40 levels. IND donors had higher percentages of classical monocytes and an increased production of CCL17, and they positively correlate. The results suggest that variations in the monocyte subsets and cytokines levels might be associated with protection (classical monocytes and CCL17) or the development (intermediate monocytes and IL-6) of chagasic myocardiopathy.https://orcid.org/0000-0002-6329-6692Revista Internacional - Indexada126.26Journal of Immunology202S1ORIGINALdummy.pdfdummy.pdfArtículoapplication/pdf25708http://repository.javeriana.edu.co/bitstream/10554/56815/1/dummy.pdfe965c7c539d6095807e50a3af2f57592MD51embargoed access|||9999-09-02LICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/56815/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILdummy.pdf.jpgdummy.pdf.jpgIM Thumbnailimage/jpeg2835http://repository.javeriana.edu.co/bitstream/10554/56815/3/dummy.pdf.jpg17ee6340be5628b4bd6ec2ddf922b276MD53open access10554/56815oai:repository.javeriana.edu.co:10554/568152022-12-07 17:53:20.882Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |