Fungemia in Hospitalized Adult Patients with Hematological Malignancies: Epidemiology and Risk Factors
Q2
- Autores:
-
Vargas-Espíndola, Luz Alejandra
Cuervo-Maldonado, Sonia I.
Enciso-Olivera, José L.
Gómez-Rincón, Julio C.
Jiménez-Cetina, Leydy
Sánchez-Pedraza, Ricardo
García-Guzmán, Katherine
López-Mora, María José
Álvarez-Moreno, Carlos A.
Cortés, Jorge Alberto
Garzon, Javier
Martínez Vernaza, Samuel
Sierra-Parada, Claudia R.
Murillo-Sarmiento, Bryan A.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2023
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/65371
- Acceso en línea:
- https://www.mdpi.com/2309-608X/9/4/400
http://hdl.handle.net/10554/65371
https://doi.org/10.3390/jof9040400
- Palabra clave:
- Candida
Fungemia
Hematologic malignancy
Candidemia
Leukemia
Lymphoma
Myeloma
Mortality
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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Repositorio Universidad Javeriana |
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|
| dc.title.spa.fl_str_mv |
Fungemia in Hospitalized Adult Patients with Hematological Malignancies: Epidemiology and Risk Factors |
| title |
Fungemia in Hospitalized Adult Patients with Hematological Malignancies: Epidemiology and Risk Factors |
| spellingShingle |
Fungemia in Hospitalized Adult Patients with Hematological Malignancies: Epidemiology and Risk Factors Candida Fungemia Hematologic malignancy Candidemia Leukemia Lymphoma Myeloma Mortality |
| title_short |
Fungemia in Hospitalized Adult Patients with Hematological Malignancies: Epidemiology and Risk Factors |
| title_full |
Fungemia in Hospitalized Adult Patients with Hematological Malignancies: Epidemiology and Risk Factors |
| title_fullStr |
Fungemia in Hospitalized Adult Patients with Hematological Malignancies: Epidemiology and Risk Factors |
| title_full_unstemmed |
Fungemia in Hospitalized Adult Patients with Hematological Malignancies: Epidemiology and Risk Factors |
| title_sort |
Fungemia in Hospitalized Adult Patients with Hematological Malignancies: Epidemiology and Risk Factors |
| dc.creator.fl_str_mv |
Vargas-Espíndola, Luz Alejandra Cuervo-Maldonado, Sonia I. Enciso-Olivera, José L. Gómez-Rincón, Julio C. Jiménez-Cetina, Leydy Sánchez-Pedraza, Ricardo García-Guzmán, Katherine López-Mora, María José Álvarez-Moreno, Carlos A. Cortés, Jorge Alberto Garzon, Javier Martínez Vernaza, Samuel Sierra-Parada, Claudia R. Murillo-Sarmiento, Bryan A. |
| dc.contributor.author.none.fl_str_mv |
Vargas-Espíndola, Luz Alejandra Cuervo-Maldonado, Sonia I. Enciso-Olivera, José L. Gómez-Rincón, Julio C. Jiménez-Cetina, Leydy Sánchez-Pedraza, Ricardo García-Guzmán, Katherine López-Mora, María José Álvarez-Moreno, Carlos A. Cortés, Jorge Alberto Garzon, Javier Martínez Vernaza, Samuel Sierra-Parada, Claudia R. Murillo-Sarmiento, Bryan A. |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Infectología |
| dc.contributor.corporatename.none.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Medicina Interna. |
| dc.contributor.javerianateacher.none.fl_str_mv |
Garzon, Javier |
| dc.subject.keyword.spa.fl_str_mv |
Candida Fungemia Hematologic malignancy Candidemia Leukemia Lymphoma Myeloma Mortality |
| topic |
Candida Fungemia Hematologic malignancy Candidemia Leukemia Lymphoma Myeloma Mortality |
| description |
Q2 |
| publishDate |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2023-08-31T16:21:16Z |
| dc.date.available.none.fl_str_mv |
2023-08-31T16:21:16Z |
| dc.date.created.none.fl_str_mv |
2023-03-24 |
| dc.type.local.spa.fl_str_mv |
Artículo de revista |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
| format |
http://purl.org/coar/resource_type/c_6501 |
| dc.identifier.spa.fl_str_mv |
https://www.mdpi.com/2309-608X/9/4/400 |
| dc.identifier.issn.spa.fl_str_mv |
2309-608X |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/65371 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.3390/jof9040400 |
| dc.identifier.instname.spa.fl_str_mv |
instname:Pontificia Universidad Javeriana |
| dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
| dc.identifier.repourl.spa.fl_str_mv |
repourl:https://repository.javeriana.edu.co |
| url |
https://www.mdpi.com/2309-608X/9/4/400 http://hdl.handle.net/10554/65371 https://doi.org/10.3390/jof9040400 |
| identifier_str_mv |
2309-608X instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
1 |
| dc.relation.citationendpage.spa.fl_str_mv |
14 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Journal of Fungi |
| dc.relation.citationvolume.spa.fl_str_mv |
9 |
| dc.relation.citationissue.spa.fl_str_mv |
4 |
| dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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PDF |
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application/pdf |
| dc.coverage.spatial.spa.fl_str_mv |
Colombia |
| dc.coverage.temporal.spa.fl_str_mv |
2012-2019 |
| dc.coverage.city.spa.fl_str_mv |
Bogotá (Colombia) |
| institution |
Pontificia Universidad Javeriana |
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Repositorio Institucional - Pontificia Universidad Javeriana |
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repositorio@javeriana.edu.co |
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1808389263596716032 |
| spelling |
Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Vargas-Espíndola, Luz AlejandraCuervo-Maldonado, Sonia I.Enciso-Olivera, José L.Gómez-Rincón, Julio C.Jiménez-Cetina, LeydySánchez-Pedraza, RicardoGarcía-Guzmán, KatherineLópez-Mora, María JoséÁlvarez-Moreno, Carlos A.Cortés, Jorge AlbertoGarzon, JavierMartínez Vernaza, SamuelSierra-Parada, Claudia R.Murillo-Sarmiento, Bryan A.Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. InfectologíaPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Medicina Interna.Garzon, JavierColombia2012-2019Bogotá (Colombia)2023-08-31T16:21:16Z2023-08-31T16:21:16Z2023-03-24https://www.mdpi.com/2309-608X/9/4/4002309-608Xhttp://hdl.handle.net/10554/65371https://doi.org/10.3390/jof9040400instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengFungemia in Hospitalized Adult Patients with Hematological Malignancies: Epidemiology and Risk FactorsArtículo de revistahttp://purl.org/coar/resource_type/c_6501Q2Q1Pacientes con Neoplasias malignas hematológicasPacientes con FungemiaFungemia in hematologic malignancies (HM) has high mortality. This is a retrospective cohort of adult patients with HM and fungemia between 2012 and 2019 in institutions of Bogotá, Colombia. The epidemiological, clinical, and microbiological characteristics are described, and risk factors related to mortality are analyzed. One hundred five patients with a mean age of 48 years (SD 19.0) were identified, 45% with acute leukemia and 37% with lymphomas. In 42%, the HM was relapsed/refractory, 82% ECOG > 3, and 35% received antifungal prophylaxis; 57% were in neutropenia, with an average duration of 21.8 days. In 86 (82%) patients, Candida spp. was identified, and other yeasts in 18%. The most frequent of the isolates were non-albicans Candida (61%), C. tropicalis (28%), C. parapsilosis (17%), and C. krusei (12%). The overall 30-day mortality was 50%. The survival probability at day 30 in patients with leukemia vs. lymphoma/multiple myeloma (MM0 group was 59% (95% CI 46–76) and 41% (95% CI 29–58), p = 0.03, respectively. Patients with lymphoma or MM (HR 1.72; 95% CI 0.58–2.03) and ICU admission (HR 3.08; 95% CI 1.12–3.74) were associated with mortality. In conclusion, in patients with HM, non-albicans Candida species are the most frequent, and high mortality was identified; moreover, lymphoma or MM and ICU admission were predictors of mortality.https://orcid.org/0000-0001-6396-3267https://orcid.org/0000-0001-5363-5729Revista Internacional - IndexadaA1NoCandidaFungemiaHematologic malignancyCandidemiaLeukemiaLymphomaMyelomaMortality114Journal of Fungi94LICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/65371/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessORIGINALFungemia in Hospitalized Adult Patients with Hematological.pdfFungemia in Hospitalized Adult Patients with Hematological.pdfArtículoapplication/pdf847427http://repository.javeriana.edu.co/bitstream/10554/65371/1/Fungemia%20in%20Hospitalized%20Adult%20Patients%20with%20Hematological.pdf850a6afe77480537003571d3d149f325MD51open accessTHUMBNAILFungemia in Hospitalized Adult Patients with Hematological.pdf.jpgFungemia in Hospitalized Adult Patients with Hematological.pdf.jpgIM Thumbnailimage/jpeg12623http://repository.javeriana.edu.co/bitstream/10554/65371/3/Fungemia%20in%20Hospitalized%20Adult%20Patients%20with%20Hematological.pdf.jpgb51ccb174018cd14397c8fb9aa7c3e3bMD53open access10554/65371oai:repository.javeriana.edu.co:10554/653712024-01-11 11:02:36.171Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |