Brain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington’s disease
Q2
- Autores:
-
Junca, Estefanía
Pino, Mariana
Santamaria Garcia, Hernando
Baez, Sandra
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2022
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/63673
- Acceso en línea:
- https://link.springer.com/article/10.1007/s11136-022-03220-0
http://hdl.handle.net/10554/63673
https://doi.org/10.1007/s11136-022-03220-0
- Palabra clave:
- Huntington’s disease
Quality of life
Caregivers
Brain volumes
WHOQOL-BREF
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Brain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington’s disease |
| title |
Brain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington’s disease |
| spellingShingle |
Brain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington’s disease Huntington’s disease Quality of life Caregivers Brain volumes WHOQOL-BREF |
| title_short |
Brain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington’s disease |
| title_full |
Brain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington’s disease |
| title_fullStr |
Brain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington’s disease |
| title_full_unstemmed |
Brain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington’s disease |
| title_sort |
Brain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington’s disease |
| dc.creator.fl_str_mv |
Junca, Estefanía Pino, Mariana Santamaria Garcia, Hernando Baez, Sandra |
| dc.contributor.author.none.fl_str_mv |
Junca, Estefanía Pino, Mariana Santamaria Garcia, Hernando Baez, Sandra |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental |
| dc.contributor.javerianateacher.none.fl_str_mv |
Santamaria Garcia, Hernando |
| dc.subject.keyword.spa.fl_str_mv |
Huntington’s disease Quality of life Caregivers Brain volumes WHOQOL-BREF |
| topic |
Huntington’s disease Quality of life Caregivers Brain volumes WHOQOL-BREF |
| description |
Q2 |
| publishDate |
2022 |
| dc.date.created.none.fl_str_mv |
2022-08-17 |
| dc.date.accessioned.none.fl_str_mv |
2023-03-13T12:59:34Z |
| dc.date.available.none.fl_str_mv |
2023-03-13T12:59:34Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_6501 |
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http://purl.org/coar/resource_type/c_6501 |
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https://link.springer.com/article/10.1007/s11136-022-03220-0 |
| dc.identifier.issn.spa.fl_str_mv |
0962-9343 / 1573-2649 (Electrónico) |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/63673 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1007/s11136-022-03220-0 |
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instname:Pontificia Universidad Javeriana |
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reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
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repourl:https://repository.javeriana.edu.co |
| url |
https://link.springer.com/article/10.1007/s11136-022-03220-0 http://hdl.handle.net/10554/63673 https://doi.org/10.1007/s11136-022-03220-0 |
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0962-9343 / 1573-2649 (Electrónico) instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
171 |
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182 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Quality of Life Research |
| dc.relation.citationvolume.spa.fl_str_mv |
32 |
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Atribución-NoComercial 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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PDF |
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application/pdf |
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Pontificia Universidad Javeriana |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Junca, EstefaníaPino, MarianaSantamaria Garcia, HernandoBaez, SandraPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Psiquiatría y Salud MentalSantamaria Garcia, Hernando2023-03-13T12:59:34Z2023-03-13T12:59:34Z2022-08-17https://link.springer.com/article/10.1007/s11136-022-03220-00962-9343 / 1573-2649 (Electrónico)http://hdl.handle.net/10554/63673https://doi.org/10.1007/s11136-022-03220-0instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengBrain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington’s diseaseArtículo de revistahttp://purl.org/coar/resource_type/c_6501Q2Q1Pacientes con enfermedad de HuntingtonPurpose: Following a case–control design, as a primary objective, this study aimed to explore the relationship between quality of life (QoL) scores and gray matter (GM) volumes in patients with Huntington’s disease (HD). As a secondary objective, we assessed the relationship between QoL scores and other important behavioral, clinical and demographical variables in patients with HD and HD patients’ caregivers. Methods: We recruited 75 participants (25 HD patients, 25 caregivers, and 25 controls) and assessed their QoL using the World Health Organization Quality of Life scale-Brief Version (WHOQOL-BREF). Participants were also assessed with general cognitive functioning tests and clinical scales. In addition, we acquired MRI scans from all participants. Results: Our results showed that patients exhibited significantly lower scores in all four QoL domains (physical health, psychological wellbeing, social relationships, and relationship with the environment) compared to caregivers and controls. Caregivers showed lower scores than controls in the physical health and the environmental domains. In HD patients, lower scores in QoL domains were associated with lower GM volumes, mainly in the precuneus and the cerebellum. Moreover, in HD patients, physical disability and GM volume reduction were significant predictors of QoL decrease in all domains. For caregivers, years of formal education was the most important predictor of QoL. Conclusions: HD patients exhibit greater GM volume loss as well as lower QoL scores compared to caregivers and controls. However, caregivers displayed lower scores in QoL scores than controls, with years of education being a significant predictor. Our results reflect a first attempt to investigate the relationships among QoL, GM volumes, and other important factors in an HD and HD caregiver sample.https://orcid.org/0000-0001-9422-3579Revista Internacional - IndexadaA1NoHuntington’s diseaseQuality of lifeCaregiversBrain volumesWHOQOL-BREF171182Quality of Life Research32ORIGINALBrain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington’s disease.pdfBrain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington’s disease.pdfArtículoapplication/pdf1849802http://repository.javeriana.edu.co/bitstream/10554/63673/1/Brain%2c%20cognitive%2c%20and%20physical%20disability%20correlates%20of%20decreased%20quality%20of%20life%20in%20patients%20with%20Huntington%e2%80%99s%20disease.pdf7b74fb3375ef009e83ca8a3a95f86374MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/63673/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILBrain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington’s disease.pdf.jpgBrain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington’s disease.pdf.jpgIM Thumbnailimage/jpeg9333http://repository.javeriana.edu.co/bitstream/10554/63673/3/Brain%2c%20cognitive%2c%20and%20physical%20disability%20correlates%20of%20decreased%20quality%20of%20life%20in%20patients%20with%20Huntington%e2%80%99s%20disease.pdf.jpg04bcd7216341bfa6fad84c9e6126731dMD53open access10554/63673oai:repository.javeriana.edu.co:10554/636732023-03-19 03:04:55.525Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |