LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
The aim of enzyme reemplacement therapy (ERT), is to provide a foreign protein to a patient who is producing it abnormally. The protein to be used may be purified from human fluids or tissues and from bacteria, yeast or mammalian cells in which the corresponding human gene has been introduced. Up t...
- Autores:
-
Sáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, Bogotá
Barrera, Luis Alejandro; Decanato de Medicina, Universidad Centroccidental “Lisandro Alvarado”. Barquisimeto, Venezuela.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2003
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/31536
- Acceso en línea:
- http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738
http://hdl.handle.net/10554/31536
- Palabra clave:
- null
Hunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteins
null
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional
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Atribución-NoComercial-SinDerivadas 4.0 Internacionalinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2nullSáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, BogotáBarrera, Luis Alejandro; Decanato de Medicina, Universidad Centroccidental “Lisandro Alvarado”. Barquisimeto, Venezuela.2018-02-24T16:00:06Z2020-04-15T18:07:51Z2018-02-24T16:00:06Z2020-04-15T18:07:51Z2003-07-01http://revistas.javeriana.edu.co/index.php/scientarium/article/view/47382027-13520122-7483http://hdl.handle.net/10554/31536The aim of enzyme reemplacement therapy (ERT), is to provide a foreign protein to a patient who is producing it abnormally. The protein to be used may be purified from human fluids or tissues and from bacteria, yeast or mammalian cells in which the corresponding human gene has been introduced. Up to now three diseases are currently being treated worldwide with ERT, Gaucher, Fabry and the combined severe human immunodeficiency. Advanced studies are in progress for the following diseases Hurler, Hunter, Pompe, Niemann-Pick B type, Morquio A, hereditary angioderma and penfigo vulgar. One of the problems of using ERT is the its high costs, due to both the low number of patients affected world-wide and the very expensive procedures required to obtain protein expression in mammalian cells. To overcome these problems there are two possible alternatives: expression in bacteria or in yeast, however bacteria do not glycosylate proteins and most of inborn errors of metabolism are caused by deficiency in glycosilated proteins (GP). Yeast glycosilate proteins, but they have different pattern of glycosylation from mammalianPDFapplication/pdfengPontificia Universidad Javerianahttp://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738/3667Universitas Scientiarum; Vol 8, No 2 (2003); 31-42Universitas Scientiarum; Vol 8, No 2 (2003); 31-42Universitas Scientiarum; Vol 8, No 2 (2003); 31-42nullHunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteinsnullLA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICASnullnullnullhttp://purl.org/coar/version/c_970fb48d4fbd8a85Artículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/article10554/31536oai:repository.javeriana.edu.co:10554/315362023-03-28 16:15:44.133Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.co |
dc.title.spa.fl_str_mv |
LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS |
title |
LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS |
spellingShingle |
LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS null Hunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteins null |
title_short |
LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS |
title_full |
LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS |
title_fullStr |
LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS |
title_full_unstemmed |
LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS |
title_sort |
LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS |
dc.creator.fl_str_mv |
Sáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, Bogotá Barrera, Luis Alejandro; Decanato de Medicina, Universidad Centroccidental “Lisandro Alvarado”. Barquisimeto, Venezuela. |
dc.contributor.author.none.fl_str_mv |
Sáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, Bogotá Barrera, Luis Alejandro; Decanato de Medicina, Universidad Centroccidental “Lisandro Alvarado”. Barquisimeto, Venezuela. |
dc.contributor.none.fl_str_mv |
null |
dc.subject.spa.fl_str_mv |
null Hunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteins null |
topic |
null Hunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteins null |
description |
The aim of enzyme reemplacement therapy (ERT), is to provide a foreign protein to a patient who is producing it abnormally. The protein to be used may be purified from human fluids or tissues and from bacteria, yeast or mammalian cells in which the corresponding human gene has been introduced. Up to now three diseases are currently being treated worldwide with ERT, Gaucher, Fabry and the combined severe human immunodeficiency. Advanced studies are in progress for the following diseases Hurler, Hunter, Pompe, Niemann-Pick B type, Morquio A, hereditary angioderma and penfigo vulgar. One of the problems of using ERT is the its high costs, due to both the low number of patients affected world-wide and the very expensive procedures required to obtain protein expression in mammalian cells. To overcome these problems there are two possible alternatives: expression in bacteria or in yeast, however bacteria do not glycosylate proteins and most of inborn errors of metabolism are caused by deficiency in glycosilated proteins (GP). Yeast glycosilate proteins, but they have different pattern of glycosylation from mammalian |
publishDate |
2003 |
dc.date.created.none.fl_str_mv |
2003-07-01 |
dc.date.accessioned.none.fl_str_mv |
2018-02-24T16:00:06Z 2020-04-15T18:07:51Z |
dc.date.available.none.fl_str_mv |
2018-02-24T16:00:06Z 2020-04-15T18:07:51Z |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.hasversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.local.spa.fl_str_mv |
Artículo de revista |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
format |
http://purl.org/coar/resource_type/c_6501 |
dc.identifier.none.fl_str_mv |
http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738 |
dc.identifier.issn.none.fl_str_mv |
2027-1352 0122-7483 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/31536 |
url |
http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738 http://hdl.handle.net/10554/31536 |
identifier_str_mv |
2027-1352 0122-7483 |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.uri.none.fl_str_mv |
http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738/3667 |
dc.relation.citationissue.eng.fl_str_mv |
Universitas Scientiarum; Vol 8, No 2 (2003); 31-42 |
dc.relation.citationissue.spa.fl_str_mv |
Universitas Scientiarum; Vol 8, No 2 (2003); 31-42 |
dc.relation.citationissue.por.fl_str_mv |
Universitas Scientiarum; Vol 8, No 2 (2003); 31-42 |
dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional |
dc.rights.accessrights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.format.spa.fl_str_mv |
PDF |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
null null null |
dc.publisher.eng.fl_str_mv |
Pontificia Universidad Javeriana |
institution |
Pontificia Universidad Javeriana |
repository.name.fl_str_mv |
Repositorio Institucional - Pontificia Universidad Javeriana |
repository.mail.fl_str_mv |
repositorio@javeriana.edu.co |
_version_ |
1811671065581060096 |