LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS

The aim of enzyme reemplacement therapy (ERT), is to provide a foreign protein to a patient who is producing it abnormally. The protein to be  used may be purified from human fluids or tissues and from bacteria, yeast or mammalian cells in which the corresponding human gene has been introduced. Up t...

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Autores:
Sáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, Bogotá
Barrera, Luis Alejandro; Decanato de Medicina, Universidad Centroccidental “Lisandro Alvarado”. Barquisimeto, Venezuela.
Tipo de recurso:
Article of journal
Fecha de publicación:
2003
Institución:
Pontificia Universidad Javeriana
Repositorio:
Repositorio Universidad Javeriana
Idioma:
eng
OAI Identifier:
oai:repository.javeriana.edu.co:10554/31536
Acceso en línea:
http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738
http://hdl.handle.net/10554/31536
Palabra clave:
null
Hunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteins
null
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional
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oai_identifier_str oai:repository.javeriana.edu.co:10554/31536
network_acronym_str JAVERIANA2
network_name_str Repositorio Universidad Javeriana
repository_id_str
spelling Atribución-NoComercial-SinDerivadas 4.0 Internacionalinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2nullSáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, BogotáBarrera, Luis Alejandro; Decanato de Medicina, Universidad Centroccidental “Lisandro Alvarado”. Barquisimeto, Venezuela.2018-02-24T16:00:06Z2020-04-15T18:07:51Z2018-02-24T16:00:06Z2020-04-15T18:07:51Z2003-07-01http://revistas.javeriana.edu.co/index.php/scientarium/article/view/47382027-13520122-7483http://hdl.handle.net/10554/31536The aim of enzyme reemplacement therapy (ERT), is to provide a foreign protein to a patient who is producing it abnormally. The protein to be  used may be purified from human fluids or tissues and from bacteria, yeast or mammalian cells in which the corresponding human gene has been introduced. Up to now three diseases are currently being treated worldwide with ERT, Gaucher, Fabry and the combined severe human immunodeficiency. Advanced studies are in progress for the following diseases Hurler, Hunter, Pompe, Niemann-Pick B type, Morquio A,  hereditary angioderma and penfigo vulgar. One of the problems of using ERT is the its high costs, due to both the low number of patients affected world-wide and the very expensive procedures required to obtain protein expression in mammalian cells. To overcome these problems there are two possible alternatives: expression in bacteria or in yeast, however bacteria do not glycosylate proteins and most of inborn errors of  metabolism are caused by deficiency in glycosilated proteins (GP).  Yeast glycosilate proteins, but they have different pattern of   glycosylation from mammalianPDFapplication/pdfengPontificia Universidad Javerianahttp://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738/3667Universitas Scientiarum; Vol 8, No 2 (2003); 31-42Universitas Scientiarum; Vol 8, No 2 (2003); 31-42Universitas Scientiarum; Vol 8, No 2 (2003); 31-42nullHunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteinsnullLA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICASnullnullnullhttp://purl.org/coar/version/c_970fb48d4fbd8a85Artículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/article10554/31536oai:repository.javeriana.edu.co:10554/315362023-03-28 16:15:44.133Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.co
dc.title.spa.fl_str_mv LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
title LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
spellingShingle LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
null
Hunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteins
null
title_short LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
title_full LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
title_fullStr LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
title_full_unstemmed LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
title_sort LA TERAPIA DE REEMPLAZO ENZIMÁTICO EN EL TRATAMIENTO DE ENFERMEDADES GENÉTICAS
dc.creator.fl_str_mv Sáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, Bogotá
Barrera, Luis Alejandro; Decanato de Medicina, Universidad Centroccidental “Lisandro Alvarado”. Barquisimeto, Venezuela.
dc.contributor.author.none.fl_str_mv Sáenz, Homero; Instituto de Errores Innatos del Metabolismo. Pontificia Universidad Javeriana, Bogotá
Barrera, Luis Alejandro; Decanato de Medicina, Universidad Centroccidental “Lisandro Alvarado”. Barquisimeto, Venezuela.
dc.contributor.none.fl_str_mv null
dc.subject.spa.fl_str_mv null
Hunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteins
null
topic null
Hunter, Morquio A, enzyme reemplacement therapy, expression of protein, pichia pastoris, recombinant proteins
null
description The aim of enzyme reemplacement therapy (ERT), is to provide a foreign protein to a patient who is producing it abnormally. The protein to be  used may be purified from human fluids or tissues and from bacteria, yeast or mammalian cells in which the corresponding human gene has been introduced. Up to now three diseases are currently being treated worldwide with ERT, Gaucher, Fabry and the combined severe human immunodeficiency. Advanced studies are in progress for the following diseases Hurler, Hunter, Pompe, Niemann-Pick B type, Morquio A,  hereditary angioderma and penfigo vulgar. One of the problems of using ERT is the its high costs, due to both the low number of patients affected world-wide and the very expensive procedures required to obtain protein expression in mammalian cells. To overcome these problems there are two possible alternatives: expression in bacteria or in yeast, however bacteria do not glycosylate proteins and most of inborn errors of  metabolism are caused by deficiency in glycosilated proteins (GP).  Yeast glycosilate proteins, but they have different pattern of   glycosylation from mammalian
publishDate 2003
dc.date.created.none.fl_str_mv 2003-07-01
dc.date.accessioned.none.fl_str_mv 2018-02-24T16:00:06Z
2020-04-15T18:07:51Z
dc.date.available.none.fl_str_mv 2018-02-24T16:00:06Z
2020-04-15T18:07:51Z
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.hasversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.local.spa.fl_str_mv Artículo de revista
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
format http://purl.org/coar/resource_type/c_6501
dc.identifier.none.fl_str_mv http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738
dc.identifier.issn.none.fl_str_mv 2027-1352
0122-7483
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10554/31536
url http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738
http://hdl.handle.net/10554/31536
identifier_str_mv 2027-1352
0122-7483
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.uri.none.fl_str_mv http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4738/3667
dc.relation.citationissue.eng.fl_str_mv Universitas Scientiarum; Vol 8, No 2 (2003); 31-42
dc.relation.citationissue.spa.fl_str_mv Universitas Scientiarum; Vol 8, No 2 (2003); 31-42
dc.relation.citationissue.por.fl_str_mv Universitas Scientiarum; Vol 8, No 2 (2003); 31-42
dc.rights.licence.*.fl_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.spa.fl_str_mv PDF
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv null
null
null
dc.publisher.eng.fl_str_mv Pontificia Universidad Javeriana
institution Pontificia Universidad Javeriana
repository.name.fl_str_mv Repositorio Institucional - Pontificia Universidad Javeriana
repository.mail.fl_str_mv repositorio@javeriana.edu.co
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