The protozoan Trypanosoma cruzi causes Chagas’ disease, a neglected illness that remains a relevant public health concern in Latin America. In Brazil, Benznidazole is available for its treatment. This compound is effective against circulating forms of the parasite in the acute phase of the disease,...

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Autores:
Ferreira, Daniele da Silva; Universidade de Franca
Esperandim, Viviane Rodrigues; Universidade de Franca
Marçal, Maria Gabriela; Universidade de Franca
Neres, Naraya Bruna Dos Reis; Universidade de Franca
Cunha, Nayanne Larissa; Universidade de Franca
Andrade e Silva, Márcio Luís; Universidade de Franca
Cunha, Wilson Roberto; Universidade de Franca
Tipo de recurso:
Article of journal
Fecha de publicación:
2013
Institución:
Pontificia Universidad Javeriana
Repositorio:
Repositorio Universidad Javeriana
Idioma:
eng
OAI Identifier:
oai:repository.javeriana.edu.co:10554/31584
Acceso en línea:
http://revistas.javeriana.edu.co/index.php/scientarium/article/view/6187
http://hdl.handle.net/10554/31584
Palabra clave:
null
Chagas’ disease, Trypanosoma cruzi, Miconia.
null
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional
id JAVERIANA2_5158ebade706a0b3e25a73d3d2a54cdb
oai_identifier_str oai:repository.javeriana.edu.co:10554/31584
network_acronym_str JAVERIANA2
network_name_str Repositorio Universidad Javeriana
repository_id_str
spelling Atribución-NoComercial-SinDerivadas 4.0 Internacionalinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Capes, CNPq, FapespFerreira, Daniele da Silva; Universidade de FrancaEsperandim, Viviane Rodrigues; Universidade de FrancaMarçal, Maria Gabriela; Universidade de FrancaNeres, Naraya Bruna Dos Reis; Universidade de FrancaCunha, Nayanne Larissa; Universidade de FrancaAndrade e Silva, Márcio Luís; Universidade de FrancaCunha, Wilson Roberto; Universidade de Franca2018-02-24T16:00:12Z2020-04-15T18:08:00Z2018-02-24T16:00:12Z2020-04-15T18:08:00Z2013-09-10http://revistas.javeriana.edu.co/index.php/scientarium/article/view/618710.11144/Javeriana.SC18-3.npcd2027-13520122-7483http://hdl.handle.net/10554/31584PDFapplication/pdftext/htmlengPontificia Universidad Javerianahttp://revistas.javeriana.edu.co/index.php/scientarium/article/view/6187/5484http://revistas.javeriana.edu.co/index.php/scientarium/article/view/6187/6504Universitas Scientiarum; Vol 18, No 3 (2013); 243-256Universitas Scientiarum; Vol 18, No 3 (2013); 243-256Universitas Scientiarum; Vol 18, No 3 (2013); 243-256nullChagas’ disease, Trypanosoma cruzi, Miconia.nullnullnullnullhttp://purl.org/coar/version/c_970fb48d4fbd8a85Artículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleNatural products and Chagas’ disease: the action of triterpenes acids isolated from Miconia speciesThe protozoan Trypanosoma cruzi causes Chagas’ disease, a neglected illness that remains a relevant public health concern in Latin America. In Brazil, Benznidazole is available for its treatment. This compound is effective against circulating forms of the parasite in the acute phase of the disease, but its efficacy during the chronic stage is debatable. The search for new medications that can treat Chagas’ disease is therefore mandatory. Natural sources display a wide range of secondary metabolites and may play an important role in the discovery of new potential drugs. Miconia is one of the largest genus of the family Melastomataceae and includes approximately 1,000 plant species; Brazil alone is home to approximately 250 of these species, which exist in forests and savannas. Studies on the various biological activities of the Miconia species have reported promising results. Several researchers have screened these plants as well as their extracts in vitro against trypomastigote forms of T. cruzi, which displayed significant trypanocidal activity. It has been demonstrated that the presence of ursolic and oleanolic determines this biological activity.10554/31584oai:repository.javeriana.edu.co:10554/315842023-03-28 16:15:48.134Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.co
dc.title.english.eng.fl_str_mv Natural products and Chagas’ disease: the action of triterpenes acids isolated from Miconia species
dc.creator.fl_str_mv Ferreira, Daniele da Silva; Universidade de Franca
Esperandim, Viviane Rodrigues; Universidade de Franca
Marçal, Maria Gabriela; Universidade de Franca
Neres, Naraya Bruna Dos Reis; Universidade de Franca
Cunha, Nayanne Larissa; Universidade de Franca
Andrade e Silva, Márcio Luís; Universidade de Franca
Cunha, Wilson Roberto; Universidade de Franca
dc.contributor.author.none.fl_str_mv Ferreira, Daniele da Silva; Universidade de Franca
Esperandim, Viviane Rodrigues; Universidade de Franca
Marçal, Maria Gabriela; Universidade de Franca
Neres, Naraya Bruna Dos Reis; Universidade de Franca
Cunha, Nayanne Larissa; Universidade de Franca
Andrade e Silva, Márcio Luís; Universidade de Franca
Cunha, Wilson Roberto; Universidade de Franca
dc.contributor.eng.fl_str_mv Capes, CNPq, Fapesp
dc.subject.eng.fl_str_mv null
Chagas’ disease, Trypanosoma cruzi, Miconia.
null
topic null
Chagas’ disease, Trypanosoma cruzi, Miconia.
null
spellingShingle null
Chagas’ disease, Trypanosoma cruzi, Miconia.
null
description The protozoan Trypanosoma cruzi causes Chagas’ disease, a neglected illness that remains a relevant public health concern in Latin America. In Brazil, Benznidazole is available for its treatment. This compound is effective against circulating forms of the parasite in the acute phase of the disease, but its efficacy during the chronic stage is debatable. The search for new medications that can treat Chagas’ disease is therefore mandatory. Natural sources display a wide range of secondary metabolites and may play an important role in the discovery of new potential drugs. Miconia is one of the largest genus of the family Melastomataceae and includes approximately 1,000 plant species; Brazil alone is home to approximately 250 of these species, which exist in forests and savannas. Studies on the various biological activities of the Miconia species have reported promising results. Several researchers have screened these plants as well as their extracts in vitro against trypomastigote forms of T. cruzi, which displayed significant trypanocidal activity. It has been demonstrated that the presence of ursolic and oleanolic determines this biological activity.
publishDate 2013
dc.date.created.none.fl_str_mv 2013-09-10
dc.date.accessioned.none.fl_str_mv 2018-02-24T16:00:12Z
2020-04-15T18:08:00Z
dc.date.available.none.fl_str_mv 2018-02-24T16:00:12Z
2020-04-15T18:08:00Z
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.hasversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.local.spa.fl_str_mv Artículo de revista
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
format http://purl.org/coar/resource_type/c_6501
dc.identifier.none.fl_str_mv http://revistas.javeriana.edu.co/index.php/scientarium/article/view/6187
10.11144/Javeriana.SC18-3.npcd
dc.identifier.issn.none.fl_str_mv 2027-1352
0122-7483
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10554/31584
url http://revistas.javeriana.edu.co/index.php/scientarium/article/view/6187
http://hdl.handle.net/10554/31584
identifier_str_mv 10.11144/Javeriana.SC18-3.npcd
2027-1352
0122-7483
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.uri.none.fl_str_mv http://revistas.javeriana.edu.co/index.php/scientarium/article/view/6187/5484
http://revistas.javeriana.edu.co/index.php/scientarium/article/view/6187/6504
dc.relation.citationissue.eng.fl_str_mv Universitas Scientiarum; Vol 18, No 3 (2013); 243-256
dc.relation.citationissue.spa.fl_str_mv Universitas Scientiarum; Vol 18, No 3 (2013); 243-256
dc.relation.citationissue.por.fl_str_mv Universitas Scientiarum; Vol 18, No 3 (2013); 243-256
dc.rights.licence.*.fl_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.spa.fl_str_mv PDF
dc.format.mimetype.spa.fl_str_mv application/pdf
text/html
dc.coverage.none.fl_str_mv null
null
null
dc.publisher.eng.fl_str_mv Pontificia Universidad Javeriana
institution Pontificia Universidad Javeriana
repository.name.fl_str_mv Repositorio Institucional - Pontificia Universidad Javeriana
repository.mail.fl_str_mv repositorio@javeriana.edu.co
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