D-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19: A multi-national case series from different waves
Q2
- Autores:
-
Ronderos Botero, Diana Maria
Salem Omar, Alaa Mabrouk
Pengo, Martino F.
Waqas Haider, Syed
Latif, Hira
Parati, Gianfranco
Pengo, Vittorio
Canas, Alejandra
Diaz, Melissa
Villaquirán-Torres, Claudio
Contreras, Johanna
Chilimuri, Sridhar
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2023
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/65359
- Acceso en línea:
- https://www.frontiersin.org/articles/10.3389/fmed.2023.1103842/full
http://hdl.handle.net/10554/65359
https://doi.org/10.3389/fmed.2023.1103842
- Palabra clave:
- COVID-19
D-dimer
Variability
In-hospital mortality
Heterogeneity
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
D-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19: A multi-national case series from different waves |
| title |
D-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19: A multi-national case series from different waves |
| spellingShingle |
D-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19: A multi-national case series from different waves COVID-19 D-dimer Variability In-hospital mortality Heterogeneity |
| title_short |
D-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19: A multi-national case series from different waves |
| title_full |
D-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19: A multi-national case series from different waves |
| title_fullStr |
D-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19: A multi-national case series from different waves |
| title_full_unstemmed |
D-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19: A multi-national case series from different waves |
| title_sort |
D-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19: A multi-national case series from different waves |
| dc.creator.fl_str_mv |
Ronderos Botero, Diana Maria Salem Omar, Alaa Mabrouk Pengo, Martino F. Waqas Haider, Syed Latif, Hira Parati, Gianfranco Pengo, Vittorio Canas, Alejandra Diaz, Melissa Villaquirán-Torres, Claudio Contreras, Johanna Chilimuri, Sridhar |
| dc.contributor.author.none.fl_str_mv |
Ronderos Botero, Diana Maria Salem Omar, Alaa Mabrouk Pengo, Martino F. Waqas Haider, Syed Latif, Hira Parati, Gianfranco Pengo, Vittorio Canas, Alejandra Diaz, Melissa Villaquirán-Torres, Claudio Contreras, Johanna Chilimuri, Sridhar |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Neumología |
| dc.contributor.javerianateacher.none.fl_str_mv |
Canas, Alejandra Villaquirán-Torres, Claudio |
| dc.subject.keyword.spa.fl_str_mv |
COVID-19 D-dimer Variability In-hospital mortality Heterogeneity |
| topic |
COVID-19 D-dimer Variability In-hospital mortality Heterogeneity |
| description |
Q2 |
| publishDate |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2023-08-31T14:27:44Z |
| dc.date.available.none.fl_str_mv |
2023-08-31T14:27:44Z |
| dc.date.created.none.fl_str_mv |
2023-03-17 |
| dc.type.local.spa.fl_str_mv |
Artículo de revista |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.identifier.spa.fl_str_mv |
https://www.frontiersin.org/articles/10.3389/fmed.2023.1103842/full |
| dc.identifier.issn.spa.fl_str_mv |
2296-858X |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/65359 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.3389/fmed.2023.1103842 |
| dc.identifier.instname.spa.fl_str_mv |
instname:Pontificia Universidad Javeriana |
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reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
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repourl:https://repository.javeriana.edu.co |
| url |
https://www.frontiersin.org/articles/10.3389/fmed.2023.1103842/full http://hdl.handle.net/10554/65359 https://doi.org/10.3389/fmed.2023.1103842 |
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2296-858X instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
1 |
| dc.relation.citationendpage.spa.fl_str_mv |
11 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Frontiers in Medicine |
| dc.relation.citationvolume.spa.fl_str_mv |
10 |
| dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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PDF |
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application/pdf |
| dc.coverage.spatial.spa.fl_str_mv |
Colombia Estados Unidos Italia |
| dc.coverage.temporal.spa.fl_str_mv |
2020-2021 |
| institution |
Pontificia Universidad Javeriana |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Ronderos Botero, Diana MariaSalem Omar, Alaa MabroukPengo, Martino F.Waqas Haider, SyedLatif, HiraParati, GianfrancoPengo, VittorioCanas, AlejandraDiaz, MelissaVillaquirán-Torres, ClaudioContreras, JohannaChilimuri, SridharPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. NeumologíaCanas, AlejandraVillaquirán-Torres, ClaudioColombiaEstados UnidosItalia2020-20212023-08-31T14:27:44Z2023-08-31T14:27:44Z2023-03-17https://www.frontiersin.org/articles/10.3389/fmed.2023.1103842/full2296-858Xhttp://hdl.handle.net/10554/65359https://doi.org/10.3389/fmed.2023.1103842instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengD-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19: A multi-national case series from different wavesArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Q2Q1Pacientes con COVID-19Introduction: Variable D-dimer trends during hospitalization reportedly result in distinct in-hospital mortality. In this multinational case series from the first and second waves, we show the universality of such D-dimer trends. Methods: We reviewed 405 patients with COVID-19 during the first wave admitted to three institutions in the United States, Italy, and Colombia, and 111 patients admitted to the U.S. site during the second wave and 55 patients during the third wave. D-dimer was serially followed during hospitalization. Results: During the first wave, 66 (15%) patients had a persistently-low pattern, 33 (8%) had early-peaking, 70 (16%) had mid-peaking, 94 (22%) had fluctuating, 30 (7%) had late-peaking, and 112 (26%) had a persistently-high pattern. During the second and third waves, similar patterns were observed. D-dimer patterns were significantly different in terms of in-hospital mortality similarly in all waves. Patterns were then classified into low-risk patterns (persistently-low and early-peaking), where no deaths were observed in both waves, high-risk patterns (mid-peaking and fluctuating), and malignant patterns (late-peaking and persistently-high). Overall, D-dimer trends were associated with an increased risk for in-hospital mortality in the first wave (overall: HR: 1.73) and stayed the same during the second (HR: 1.67, p < 0.001) and the third (HR: 4.4, p = 0.001) waves. Conclusion: D-dimer behavior during COVID-19 hospitalization yielded universal categories with distinct mortality risks that persisted throughout all studied waves of infection. Monitoring D-dimer behavior may be useful in the management of these patients.https://orcid.org/0000-0003-3975-2835https://orcid.org/0000-0003-2297-1855https://orcid.org/0000-0002-3743-6268Revista Internacional - IndexadaA1NoCOVID-19D-dimerVariabilityIn-hospital mortalityHeterogeneity111Frontiers in Medicine10ORIGINALD-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19 A multi-national case series from different waves.pdfD-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19 A multi-national case series from different waves.pdfArtículoapplication/pdf4076255http://repository.javeriana.edu.co/bitstream/10554/65359/1/D-dimer%20trends%20elaborate%20the%20heterogeneity%20of%20risk%20in%20hospitalized%20patients%20with%20COVID-19%20A%20multi-national%20case%20series%20from%20different%20waves.pdf3b815291538e6775b1b8aa56c5155169MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/65359/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILD-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19 A multi-national case series from different waves.pdf.jpgD-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19 A multi-national case series from different waves.pdf.jpgIM Thumbnailimage/jpeg8011http://repository.javeriana.edu.co/bitstream/10554/65359/3/D-dimer%20trends%20elaborate%20the%20heterogeneity%20of%20risk%20in%20hospitalized%20patients%20with%20COVID-19%20A%20multi-national%20case%20series%20from%20different%20waves.pdf.jpge15e422c6a783eebd91a863768e99367MD53open access10554/65359oai:repository.javeriana.edu.co:10554/653592023-09-01 03:08:21.255Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |