A comparative study on graft and overall survival rates between diabetic and nondiabetic kidney transplant patients through survival analysis
Q3
- Autores:
-
García Padilla, Paola Karina
Davila, Valentina
Hurtado Muñoz, Diana Carolina
Vargas Angel, Diana Carolina
Muñoz, Óscar
Jurado Flórez, Mayra Alejandra
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2023
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/65889
- Acceso en línea:
- https://journals.sagepub.com/doi/10.1177/20543581231199011
http://hdl.handle.net/10554/65889
https://doi.org/10.1177/20543581231199011
- Palabra clave:
- Kidney transplantation
Graft survival
Patient survival
Diabetes mellitus
Cause of death
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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oai:repository.javeriana.edu.co:10554/65889 |
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Repositorio Universidad Javeriana |
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| dc.title.spa.fl_str_mv |
A comparative study on graft and overall survival rates between diabetic and nondiabetic kidney transplant patients through survival analysis |
| title |
A comparative study on graft and overall survival rates between diabetic and nondiabetic kidney transplant patients through survival analysis |
| spellingShingle |
A comparative study on graft and overall survival rates between diabetic and nondiabetic kidney transplant patients through survival analysis Kidney transplantation Graft survival Patient survival Diabetes mellitus Cause of death |
| title_short |
A comparative study on graft and overall survival rates between diabetic and nondiabetic kidney transplant patients through survival analysis |
| title_full |
A comparative study on graft and overall survival rates between diabetic and nondiabetic kidney transplant patients through survival analysis |
| title_fullStr |
A comparative study on graft and overall survival rates between diabetic and nondiabetic kidney transplant patients through survival analysis |
| title_full_unstemmed |
A comparative study on graft and overall survival rates between diabetic and nondiabetic kidney transplant patients through survival analysis |
| title_sort |
A comparative study on graft and overall survival rates between diabetic and nondiabetic kidney transplant patients through survival analysis |
| dc.creator.fl_str_mv |
García Padilla, Paola Karina Davila, Valentina Hurtado Muñoz, Diana Carolina Vargas Angel, Diana Carolina Muñoz, Óscar Jurado Flórez, Mayra Alejandra |
| dc.contributor.author.none.fl_str_mv |
García Padilla, Paola Karina Davila, Valentina Hurtado Muñoz, Diana Carolina Vargas Angel, Diana Carolina Muñoz, Óscar Jurado Flórez, Mayra Alejandra |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Nefrología |
| dc.contributor.corporatename.none.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Medicina Interna |
| dc.contributor.javerianateacher.none.fl_str_mv |
García Padilla, Paola Karina Muñoz, Óscar |
| dc.subject.keyword.spa.fl_str_mv |
Kidney transplantation Graft survival Patient survival Diabetes mellitus Cause of death |
| topic |
Kidney transplantation Graft survival Patient survival Diabetes mellitus Cause of death |
| description |
Q3 |
| publishDate |
2023 |
| dc.date.created.none.fl_str_mv |
2023-09-14 |
| dc.date.accessioned.none.fl_str_mv |
2024-01-04T18:07:32Z |
| dc.date.available.none.fl_str_mv |
2024-01-04T18:07:32Z |
| dc.type.local.spa.fl_str_mv |
Artículo de revista |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.identifier.spa.fl_str_mv |
https://journals.sagepub.com/doi/10.1177/20543581231199011 |
| dc.identifier.issn.spa.fl_str_mv |
2054-3581 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/65889 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1177/20543581231199011 |
| dc.identifier.instname.spa.fl_str_mv |
instname:Pontificia Universidad Javeriana |
| dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
| dc.identifier.repourl.spa.fl_str_mv |
repourl:https://repository.javeriana.edu.co |
| url |
https://journals.sagepub.com/doi/10.1177/20543581231199011 http://hdl.handle.net/10554/65889 https://doi.org/10.1177/20543581231199011 |
| identifier_str_mv |
2054-3581 instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
1 |
| dc.relation.citationendpage.spa.fl_str_mv |
10 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Canadian Journal of Kidney Health and Disease |
| dc.relation.citationvolume.spa.fl_str_mv |
10 |
| dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
| dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| rights_invalid_str_mv |
Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
| dc.format.spa.fl_str_mv |
PDF |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.coverage.spatial.spa.fl_str_mv |
Colombia |
| dc.coverage.temporal.spa.fl_str_mv |
2004-2022 |
| dc.coverage.city.spa.fl_str_mv |
Bogotá (Colombia) |
| institution |
Pontificia Universidad Javeriana |
| bitstream.url.fl_str_mv |
http://repository.javeriana.edu.co/bitstream/10554/65889/1/A%20Comparative%20Study%20on%20Graft%20and%20Overall%20Survival%20Rates%20Between%20Diabetic%20and%20Nondiabetic%20Kidney%20Transplant%20Patients%20Through%20Survival%20Analysis.pdf http://repository.javeriana.edu.co/bitstream/10554/65889/2/license.txt http://repository.javeriana.edu.co/bitstream/10554/65889/3/A%20Comparative%20Study%20on%20Graft%20and%20Overall%20Survival%20Rates%20Between%20Diabetic%20and%20Nondiabetic%20Kidney%20Transplant%20Patients%20Through%20Survival%20Analysis.pdf.jpg |
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Repositorio Institucional - Pontificia Universidad Javeriana |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2García Padilla, Paola KarinaDavila, ValentinaHurtado Muñoz, Diana CarolinaVargas Angel, Diana CarolinaMuñoz, ÓscarJurado Flórez, Mayra AlejandraPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. NefrologíaPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Medicina InternaGarcía Padilla, Paola KarinaMuñoz, ÓscarColombia2004-2022Bogotá (Colombia)2024-01-04T18:07:32Z2024-01-04T18:07:32Z2023-09-14https://journals.sagepub.com/doi/10.1177/205435812311990112054-3581http://hdl.handle.net/10554/65889https://doi.org/10.1177/20543581231199011instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengA comparative study on graft and overall survival rates between diabetic and nondiabetic kidney transplant patients through survival analysisArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Q3Q2Pacientes con trasplante de riñónBackground: Patients with diabetes mellitus (DM) have worse graft and overall survival, but recent evidence suggests that the difference is no longer significant. Objective: To compare the outcomes between patients with end-stage kidney disease due to DM (ESKD-DM) and ESKD due to nondiabetic etiology (ESKD-non-DM) who underwent kidney transplantation (KT) up to 10 years of follow-up. Design: Survival analysis of a retrospective cohort. Setting and Patients: All patients who underwent KT at the Hospital Universitario San Ignacio, Colombia, between 2004 and 2022. Measurements: Overall and graft survival in ESKD-DM and ESKD-non-DM who received KT. Patients who died with functional graft were censored for the calculation of kidney graft survival. Methods: Log-rank test, Cox proportional hazards model, and competing risk analysis were used to compare overall and graft survival in patients with ESKD-DM and ESKD-non-DM who underwent KT. Results: A total of 375 patients were included: 60 (16%) with ESKD-DM and 315 (84%) with ESKD-non-DM. Median follow-up was 83.3 months. Overall survival was lower in patients with ESKD-DM at 5 (75.0% vs 90.8%, P < .001) and 10 years (55.0% vs 86.7%, P < .001). Cardiovascular death was higher in patients with diabetes (27.3% vs 8.2%, P = .021). Death-censored graft survival was similar in both groups (96.7% vs 93.3% at 5 years, P = .324). On multivariate analysis, the factors associated with global survival were DM (hazard ratio [HR] = 2.11, 95% confidence interval [CI] = 1.23-3.60, P = .006), recipient age (HR = 1.05, 95% CI = 1.02-1.08, P < .001), delayed graft function (HR = 2.07, 95% CI = 1.24-3.46, P = .005), and donor age (HR = 1.03, 95% CI = 1.01-1.05, P = .002). In the competing risk analysis, DM was associated with mortality only in the cardiovascular death group (sub-hazard ratio [SHR] = 6.06, 95% CI = 1.01-36.4, P = .049). Limitations: Change in diabetes treatment received over time and adherence to glycemic targets were not considered. The sample size is relatively small, which limits the precision of our estimates. The Kidney Donor Profile Index and the occurrence of treated acute rejection were not included in the regression models. Conclusion: Overall survival is lower in patients with diabetes, possibly due to older age and cardiovascular comorbidities. Therefore, patients with diabetes should be followed more closely to control cardiovascular risk factors. However, there is no difference in graft survival.https://orcid.org/0000-0001-9852-749Xhttps://orcid.org/0000-0001-6563-2939https://orcid.org/0000-0002-5301-8381https://orcid.org/0000-0003-0077-6119https://orcid.org/0000-0001-5401-0018https://orcid.org/0000-0001-6967-3375Revista Internacional - IndexadaA2SiKidney transplantationGraft survivalPatient survivalDiabetes mellitusCause of death110Canadian Journal of Kidney Health and Disease10ORIGINALA Comparative Study on Graft and Overall Survival Rates Between Diabetic and Nondiabetic Kidney Transplant Patients Through Survival Analysis.pdfA Comparative Study on Graft and Overall Survival Rates Between Diabetic and Nondiabetic Kidney Transplant Patients Through Survival Analysis.pdfArtículoapplication/pdf783008http://repository.javeriana.edu.co/bitstream/10554/65889/1/A%20Comparative%20Study%20on%20Graft%20and%20Overall%20Survival%20Rates%20Between%20Diabetic%20and%20Nondiabetic%20Kidney%20Transplant%20Patients%20Through%20Survival%20Analysis.pdf0659110065bcf7b1497a844a21cff7a8MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/65889/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILA Comparative Study on Graft and Overall Survival Rates Between Diabetic and Nondiabetic Kidney Transplant Patients Through Survival Analysis.pdf.jpgA Comparative Study on Graft and Overall Survival Rates Between Diabetic and Nondiabetic Kidney Transplant Patients Through Survival Analysis.pdf.jpgIM Thumbnailimage/jpeg15590http://repository.javeriana.edu.co/bitstream/10554/65889/3/A%20Comparative%20Study%20on%20Graft%20and%20Overall%20Survival%20Rates%20Between%20Diabetic%20and%20Nondiabetic%20Kidney%20Transplant%20Patients%20Through%20Survival%20Analysis.pdf.jpg4b1f3db8dc4d829e2d552ded304f879aMD53open access10554/65889oai:repository.javeriana.edu.co:10554/658892024-01-11 18:51:24.977Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |