Hypoxia differentially affects healthy men and women during a daytime nap with a dose-response relationship : a randomized, cross-over pilot study
Q1
- Autores:
-
Riveros-Rivera, Alain
Penzel, Thomas
Gunga, Hanns-Christian
Opatz, Oliver
Paul, Friedemann
Klug, Lars
Boschmann, Michael
Mähler, Anja
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2022
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/63757
- Acceso en línea:
- https://www.frontiersin.org/articles/10.3389/fphys.2022.899636/full
http://hdl.handle.net/10554/63757
https://doi.org/10.3389/fphys.2022.899636
- Palabra clave:
- Napping
Sleep
Hypoxia
High altitude (low air pressure)
Autonomic nervous system
Physiological stress
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Hypoxia differentially affects healthy men and women during a daytime nap with a dose-response relationship : a randomized, cross-over pilot study |
| title |
Hypoxia differentially affects healthy men and women during a daytime nap with a dose-response relationship : a randomized, cross-over pilot study |
| spellingShingle |
Hypoxia differentially affects healthy men and women during a daytime nap with a dose-response relationship : a randomized, cross-over pilot study Napping Sleep Hypoxia High altitude (low air pressure) Autonomic nervous system Physiological stress |
| title_short |
Hypoxia differentially affects healthy men and women during a daytime nap with a dose-response relationship : a randomized, cross-over pilot study |
| title_full |
Hypoxia differentially affects healthy men and women during a daytime nap with a dose-response relationship : a randomized, cross-over pilot study |
| title_fullStr |
Hypoxia differentially affects healthy men and women during a daytime nap with a dose-response relationship : a randomized, cross-over pilot study |
| title_full_unstemmed |
Hypoxia differentially affects healthy men and women during a daytime nap with a dose-response relationship : a randomized, cross-over pilot study |
| title_sort |
Hypoxia differentially affects healthy men and women during a daytime nap with a dose-response relationship : a randomized, cross-over pilot study |
| dc.creator.fl_str_mv |
Riveros-Rivera, Alain Penzel, Thomas Gunga, Hanns-Christian Opatz, Oliver Paul, Friedemann Klug, Lars Boschmann, Michael Mähler, Anja |
| dc.contributor.author.none.fl_str_mv |
Riveros-Rivera, Alain Penzel, Thomas Gunga, Hanns-Christian Opatz, Oliver Paul, Friedemann Klug, Lars Boschmann, Michael Mähler, Anja |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ciencias Fisiológicas |
| dc.contributor.javerianateacher.none.fl_str_mv |
Riveros-Rivera, Alain |
| dc.subject.keyword.spa.fl_str_mv |
Napping Sleep Hypoxia High altitude (low air pressure) Autonomic nervous system Physiological stress |
| topic |
Napping Sleep Hypoxia High altitude (low air pressure) Autonomic nervous system Physiological stress |
| description |
Q1 |
| publishDate |
2022 |
| dc.date.created.none.fl_str_mv |
2022-05-24 |
| dc.date.accessioned.none.fl_str_mv |
2023-03-14T14:24:30Z |
| dc.date.available.none.fl_str_mv |
2023-03-14T14:24:30Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://www.frontiersin.org/articles/10.3389/fphys.2022.899636/full |
| dc.identifier.issn.spa.fl_str_mv |
1664-042X |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/63757 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.3389/fphys.2022.899636 |
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instname:Pontificia Universidad Javeriana |
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reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
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repourl:https://repository.javeriana.edu.co |
| url |
https://www.frontiersin.org/articles/10.3389/fphys.2022.899636/full http://hdl.handle.net/10554/63757 https://doi.org/10.3389/fphys.2022.899636 |
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1664-042X instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
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eng |
| language |
eng |
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1 |
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14 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Frontiers in Physiology |
| dc.relation.citationvolume.spa.fl_str_mv |
13 |
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Atribución-NoComercial 4.0 Internacional |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional http://purl.org/coar/access_right/c_abf2 |
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PDF |
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application/pdf |
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Alemania |
| dc.coverage.temporal.none.fl_str_mv |
2019-2020 |
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Berlín (Alemania) |
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Pontificia Universidad Javeriana |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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Atribución-NoComercial 4.0 Internacionalhttp://purl.org/coar/access_right/c_abf2Riveros-Rivera, AlainPenzel, ThomasGunga, Hanns-ChristianOpatz, OliverPaul, FriedemannKlug, LarsBoschmann, MichaelMähler, AnjaPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ciencias FisiológicasRiveros-Rivera, AlainAlemania2019-2020Berlín (Alemania)2023-03-14T14:24:30Z2023-03-14T14:24:30Z2022-05-24https://www.frontiersin.org/articles/10.3389/fphys.2022.899636/full1664-042Xhttp://hdl.handle.net/10554/63757https://doi.org/10.3389/fphys.2022.899636instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfenghttp://creativecommons.org/licenses/by-nc/4.0/Hypoxia differentially affects healthy men and women during a daytime nap with a dose-response relationship : a randomized, cross-over pilot studyArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Q1Q1Context: The use of daytime napping as a countermeasure in sleep disturbances has been recommended but its physiological evaluation at high altitude is limited. Objective: To evaluate the neuroendocrine response to hypoxic stress during a daytime nap and its cognitive impact. Design, Subject, and Setting: Randomized, single-blind, three period cross-over pilot study conducted with 15 healthy lowlander subjects (8 women) with a mean (SD) age of 29(6) years (Clinicaltrials identifier: NCT04146857, https://clinicaltrials.gov/ct2/show/NCT04146857?cond=napping&draw=3&rank=12). Interventions: Volunteers underwent a polysomnography, hematological and cognitive evaluation around a 90 min midday nap, being allocated to a randomized sequence of three conditions: normobaric normoxia (NN), normobaric hypoxia at FiO2 14.7% (NH15) and 12.5% (NH13), with a washout period of 1 week between conditions. Results: Primary outcome was the interbeat period measured by the RR interval with electrocardiogram. Compared to normobaric normoxia, RR during napping was shortened by 57 and 206 ms under NH15 and NH13 conditions, respectively (p < 0.001). Sympathetic predominance was evident by heart rate variability analysis and increased epinephrine levels. Concomitantly, there were significant changes in endocrine parameters such as erythropoietin (∼6 UI/L) and cortisol (∼100 nmol/L) (NH13 vs. NN, p < 0.001). Cognitive evaluation revealed changes in the color-word Stroop test. Additionally, although sleep efficiency was preserved, polysomnography showed lesser deep sleep and REM sleep, and periodic breathing, predominantly in men. Conclusion: Although napping in simulated altitude does not appear to significantly affect cognitive performance, sex-dependent changes in cardiac autonomic modulation and respiratory pattern should be considered before napping is prescribed as a countermeasure.https://orcid.org/0000-0002-0011-0758Revista Internacional - IndexadaA1NoNappingSleepHypoxiaHigh altitude (low air pressure)Autonomic nervous systemPhysiological stress114Frontiers in Physiology13ORIGINALHypoxia Differentially Affects Healthy Men and Women During a Daytime Nap With a Dose-Response Relationship a Randomized, Cross-Over Pilot Study.pdfHypoxia Differentially Affects Healthy Men and Women During a Daytime Nap With a Dose-Response Relationship a Randomized, Cross-Over Pilot Study.pdfArtículoapplication/pdf1536596http://repository.javeriana.edu.co/bitstream/10554/63757/1/Hypoxia%20Differentially%20Affects%20Healthy%20Men%20and%20Women%20During%20a%20Daytime%20Nap%20With%20a%20Dose-Response%20Relationship%20a%20Randomized%2c%20Cross-Over%20Pilot%20Study.pdf7c9b7676e292142ded423aebb7b3de28MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/63757/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILHypoxia Differentially Affects Healthy Men and Women During a Daytime Nap With a Dose-Response Relationship a Randomized, Cross-Over Pilot Study.pdf.jpgHypoxia Differentially Affects Healthy Men and Women During a Daytime Nap With a Dose-Response Relationship a Randomized, Cross-Over Pilot Study.pdf.jpgIM Thumbnailimage/jpeg12776http://repository.javeriana.edu.co/bitstream/10554/63757/3/Hypoxia%20Differentially%20Affects%20Healthy%20Men%20and%20Women%20During%20a%20Daytime%20Nap%20With%20a%20Dose-Response%20Relationship%20a%20Randomized%2c%20Cross-Over%20Pilot%20Study.pdf.jpgc9c092b583a0630353a449464e967759MD53open access10554/63757oai:repository.javeriana.edu.co:10554/637572023-03-16 03:03:18.332Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |