Neuropsychiatric symptoms and functional decline in Alzheimerʼs disease and Lewy Body Dementia
Q1
- Autores:
-
Borda, Miguel Germán
Aarsland, Dag
Tovar-Rios, Diego A
Giil, Lasse M.
Ballard, Clive
Gonzalez, Maria Camila
Brønnick, Kolbjørnk
Alves, Guido
Oppedal, Ketil
Soennesyn, Hogne
Vik-Mo, Audun Osland
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/53582
- Acceso en línea:
- https://login.ezproxy.javeriana.edu.co/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=mnh&AN=32738062&lang=es&site=eds-live
http://hdl.handle.net/10554/53582
https://doi.org/10.1111/jgs.16709
- Palabra clave:
- Dementia
Functional status
Alzheimerʼs disease
Lewy body dementia
Neuropsychiatric symptoms
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Neuropsychiatric symptoms and functional decline in Alzheimerʼs disease and Lewy Body Dementia |
| title |
Neuropsychiatric symptoms and functional decline in Alzheimerʼs disease and Lewy Body Dementia |
| spellingShingle |
Neuropsychiatric symptoms and functional decline in Alzheimerʼs disease and Lewy Body Dementia Dementia Functional status Alzheimerʼs disease Lewy body dementia Neuropsychiatric symptoms |
| title_short |
Neuropsychiatric symptoms and functional decline in Alzheimerʼs disease and Lewy Body Dementia |
| title_full |
Neuropsychiatric symptoms and functional decline in Alzheimerʼs disease and Lewy Body Dementia |
| title_fullStr |
Neuropsychiatric symptoms and functional decline in Alzheimerʼs disease and Lewy Body Dementia |
| title_full_unstemmed |
Neuropsychiatric symptoms and functional decline in Alzheimerʼs disease and Lewy Body Dementia |
| title_sort |
Neuropsychiatric symptoms and functional decline in Alzheimerʼs disease and Lewy Body Dementia |
| dc.creator.fl_str_mv |
Borda, Miguel Germán Aarsland, Dag Tovar-Rios, Diego A Giil, Lasse M. Ballard, Clive Gonzalez, Maria Camila Brønnick, Kolbjørnk Alves, Guido Oppedal, Ketil Soennesyn, Hogne Vik-Mo, Audun Osland |
| dc.contributor.author.none.fl_str_mv |
Borda, Miguel Germán Aarsland, Dag Tovar-Rios, Diego A Giil, Lasse M. Ballard, Clive Gonzalez, Maria Camila Brønnick, Kolbjørnk Alves, Guido Oppedal, Ketil Soennesyn, Hogne Vik-Mo, Audun Osland |
| dc.contributor.corporatename.none.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Envejecimiento |
| dc.subject.keyword.spa.fl_str_mv |
Dementia Functional status Alzheimerʼs disease Lewy body dementia Neuropsychiatric symptoms |
| topic |
Dementia Functional status Alzheimerʼs disease Lewy body dementia Neuropsychiatric symptoms |
| description |
Q1 |
| publishDate |
2020 |
| dc.date.created.none.fl_str_mv |
2020 |
| dc.date.accessioned.none.fl_str_mv |
2021-04-16T04:14:50Z |
| dc.date.available.none.fl_str_mv |
2021-04-16T04:14:50Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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0002-8614 / 1532-5415 |
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http://hdl.handle.net/10554/53582 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1111/jgs.16709 |
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instname:Pontificia Universidad Javeriana |
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https://login.ezproxy.javeriana.edu.co/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=mnh&AN=32738062&lang=es&site=eds-live http://hdl.handle.net/10554/53582 https://doi.org/10.1111/jgs.16709 |
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0002-8614 / 1532-5415 instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
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eng |
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eng |
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2257 |
| dc.relation.citationendpage.spa.fl_str_mv |
2263 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Journal of the American Geriatrics Society |
| dc.relation.citationvolume.spa.fl_str_mv |
68 |
| dc.relation.citationissue.spa.fl_str_mv |
10 |
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Atribución-NoComercial 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Borda, Miguel GermánAarsland, DagTovar-Rios, Diego AGiil, Lasse M.Ballard, CliveGonzalez, Maria CamilaBrønnick, KolbjørnkAlves, GuidoOppedal, KetilSoennesyn, HogneVik-Mo, Audun OslandPontificia Universidad Javeriana. Facultad de Medicina. Instituto de Envejecimiento2021-04-16T04:14:50Z2021-04-16T04:14:50Z2020https://login.ezproxy.javeriana.edu.co/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=mnh&AN=32738062&lang=es&site=eds-live0002-8614 / 1532-5415http://hdl.handle.net/10554/53582https://doi.org/10.1111/jgs.16709instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengNeuropsychiatric symptoms and functional decline in Alzheimerʼs disease and Lewy Body DementiaArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Q1Q1Background/objectives: Functional status is one of the most important markers of well-being in older adults, but the drivers of functional decline in dementia are not well known. The aim of our work was to study the association of neuropsychiatric symptoms (NPSs) with functional decline over 5 years in newly diagnosed people with Alzheimer´s disease (AD) and Lewy body dementia (LBD). Design: Secondary analysis of the Dementia Study of Western Norway longitudinal cohort study. Setting: Multicenter study conducted in memory clinics in western Norway. Participants: We included a total of 196 patients newly diagnosed with AD (n = 111) and LBD (n = 85), followed up annually for 5 years. Main Outcomes and Measures: The outcome was the rapid disability rating scale (items 1-13). Linear mixed-effects models were used for analysis with the total score of the Norwegian Neuropsychiatric Inventory (NPI) as a predictor measured either at baseline or longitudinally, adjusted for potential confounders, including cognition. Effect modification was checked by introducing interactions with NPI score and stratifying by diagnosis. Results: The total NPI score longitudinal course was associated with functional decline in both AD and LBD. At baseline, the total NPI score predicted functional decline in AD. Conclusion: NPSs were associated with the rate of functional decline in people with AD and LBD, independent of cognitive impairment. These results highlight the relevance of early detection and intervention of NPSs, which may also reduce functional decline.Revista Internacional - IndexadaDementiaFunctional statusAlzheimerʼs diseaseLewy body dementiaNeuropsychiatric symptoms22572263Journal of the American Geriatrics Society6810LICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/53582/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessORIGINALjgs.16709.pdfjgs.16709.pdfArtículoapplication/pdf690988http://repository.javeriana.edu.co/bitstream/10554/53582/4/jgs.16709.pdff39171ed32bcb77265caf45442375fdeMD54embargoed access|||9999-04-15THUMBNAILjgs.16709.pdf.jpgjgs.16709.pdf.jpgIM Thumbnailimage/jpeg9788http://repository.javeriana.edu.co/bitstream/10554/53582/5/jgs.16709.pdf.jpgddb6fe9313c1e8c584b0ed321d176284MD55open access10554/53582oai:repository.javeriana.edu.co:10554/535822021-07-14 16:31:10.618Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |