Regional variations in Helicobacter pylori infection, gastric atrophy and gastric cancer risk : The ENIGMA study in Chile
Q2
- Autores:
-
Herrero, Rolando
Heise, Katy
Acevedo, Johanna
Cook, Paz
Gonzalez, Claudia
Gahona, Jocelyne
Cortés, Raimundo
Collado, Luis
Beltrán, María Enriqueta
Cikutovic, Marcos
Gonzalez, Paula
Leja, Marcis
Megraud, Francis
Hernandez, Maria de la Luz
Barbier, Sylvaine
Park, Jin Young
Ferreccio, Catterina
ENIGMA Chile study group
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/51907
- Acceso en línea:
- https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237515
http://hdl.handle.net/10554/51907
https://doi.org/10.1371/journal.pone.0237515
- Palabra clave:
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
| id |
JAVERIANA2_1b1ddd37cfa80b85d6e3bfeb308efa80 |
|---|---|
| oai_identifier_str |
oai:repository.javeriana.edu.co:10554/51907 |
| network_acronym_str |
JAVERIANA2 |
| network_name_str |
Repositorio Universidad Javeriana |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Regional variations in Helicobacter pylori infection, gastric atrophy and gastric cancer risk : The ENIGMA study in Chile |
| title |
Regional variations in Helicobacter pylori infection, gastric atrophy and gastric cancer risk : The ENIGMA study in Chile |
| spellingShingle |
Regional variations in Helicobacter pylori infection, gastric atrophy and gastric cancer risk : The ENIGMA study in Chile |
| title_short |
Regional variations in Helicobacter pylori infection, gastric atrophy and gastric cancer risk : The ENIGMA study in Chile |
| title_full |
Regional variations in Helicobacter pylori infection, gastric atrophy and gastric cancer risk : The ENIGMA study in Chile |
| title_fullStr |
Regional variations in Helicobacter pylori infection, gastric atrophy and gastric cancer risk : The ENIGMA study in Chile |
| title_full_unstemmed |
Regional variations in Helicobacter pylori infection, gastric atrophy and gastric cancer risk : The ENIGMA study in Chile |
| title_sort |
Regional variations in Helicobacter pylori infection, gastric atrophy and gastric cancer risk : The ENIGMA study in Chile |
| dc.creator.fl_str_mv |
Herrero, Rolando Heise, Katy Acevedo, Johanna Cook, Paz Gonzalez, Claudia Gahona, Jocelyne Cortés, Raimundo Collado, Luis Beltrán, María Enriqueta Cikutovic, Marcos Gonzalez, Paula Leja, Marcis Megraud, Francis Hernandez, Maria de la Luz Barbier, Sylvaine Park, Jin Young Ferreccio, Catterina ENIGMA Chile study group |
| dc.contributor.author.none.fl_str_mv |
Herrero, Rolando Heise, Katy Acevedo, Johanna Cook, Paz Gonzalez, Claudia Gahona, Jocelyne Cortés, Raimundo Collado, Luis Beltrán, María Enriqueta Cikutovic, Marcos Gonzalez, Paula Leja, Marcis Megraud, Francis Hernandez, Maria de la Luz Barbier, Sylvaine Park, Jin Young Ferreccio, Catterina ENIGMA Chile study group |
| dc.contributor.corporatename.none.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Preventiva y Social. Grupo de investigación de Medicina Preventiva y Social |
| dc.contributor.javerianateacher.none.fl_str_mv |
Murillo, Raul |
| description |
Q2 |
| publishDate |
2020 |
| dc.date.accessioned.none.fl_str_mv |
2020-12-04T04:40:16Z |
| dc.date.available.none.fl_str_mv |
2020-12-04T04:40:16Z |
| dc.date.created.none.fl_str_mv |
2020-09-08 |
| dc.type.local.spa.fl_str_mv |
Artículo de revista |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.identifier.spa.fl_str_mv |
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237515 |
| dc.identifier.issn.spa.fl_str_mv |
1932-6203 (Electrónico) |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/51907 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1371/journal.pone.0237515 |
| dc.identifier.instname.spa.fl_str_mv |
instname:Pontificia Universidad Javeriana |
| dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
| dc.identifier.repourl.spa.fl_str_mv |
repourl:https://repository.javeriana.edu.co |
| url |
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237515 http://hdl.handle.net/10554/51907 https://doi.org/10.1371/journal.pone.0237515 |
| identifier_str_mv |
1932-6203 (Electrónico) instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
1 |
| dc.relation.citationendpage.spa.fl_str_mv |
15 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
PLoS ONE |
| dc.relation.citationvolume.spa.fl_str_mv |
9 |
| dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
| dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| rights_invalid_str_mv |
Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
| dc.format.spa.fl_str_mv |
PDF |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.coverage.spatial.spa.fl_str_mv |
Chile |
| institution |
Pontificia Universidad Javeriana |
| bitstream.url.fl_str_mv |
http://repository.javeriana.edu.co/bitstream/10554/51907/2/license.txt http://repository.javeriana.edu.co/bitstream/10554/51907/1/journal.pone.0237515.pdf http://repository.javeriana.edu.co/bitstream/10554/51907/3/journal.pone.0237515.pdf.jpg |
| bitstream.checksum.fl_str_mv |
2070d280cc89439d983d9eee1b17df53 f747eb848f8f557a81e09674bf9075a8 6ed6ef673ff7210ab8a1a4db79b2b268 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Institucional - Pontificia Universidad Javeriana |
| repository.mail.fl_str_mv |
repositorio@javeriana.edu.co |
| _version_ |
1811671335947993088 |
| spelling |
Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Herrero, RolandoHeise, KatyAcevedo, JohannaCook, PazGonzalez, ClaudiaGahona, JocelyneCortés, RaimundoCollado, LuisBeltrán, María EnriquetaCikutovic, MarcosGonzalez, PaulaLeja, MarcisMegraud, FrancisHernandez, Maria de la LuzBarbier, SylvainePark, Jin YoungFerreccio, CatterinaENIGMA Chile study groupPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Preventiva y Social. Grupo de investigación de Medicina Preventiva y SocialMurillo, RaulChile2020-12-04T04:40:16Z2020-12-04T04:40:16Z2020-09-08https://journals.plos.org/plosone/article?id=10.1371/journal.pone.02375151932-6203 (Electrónico)http://hdl.handle.net/10554/51907https://doi.org/10.1371/journal.pone.0237515instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengRegional variations in Helicobacter pylori infection, gastric atrophy and gastric cancer risk : The ENIGMA study in ChileArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Q2Q1Background Regional variations in gastric cancer incidence are not explained by prevalence of Helicobacter pylori, the main cause of the disease, with several areas presenting high H. pylori prevalence but low gastric cancer incidence. The IARC worldwide H. pylori prevalence surveys (ENIGMA) aim at systematically describing age and sex-specific prevalence of H. pylori infection around the world and generating hypotheses to explain regional variations in gastric cancer risk. Methods We selected age- and sex-stratified population samples in two areas with different gastric cancer incidence and mortality in Chile: Antofagasta (lower rate) and Valdivia (higher rate). Participants were 1–69 years old and provided interviews and blood for anti-H. pylori antibodies (IgG, VacA, CagA, others) and atrophy biomarkers (pepsinogens). Results H. pylori seroprevalence (Age-standardized to world population) and antibodies against CagA and VacA were similar in both sites. H. pylori seroprevalence was 20% among children <10 years old, 40% among 10–19 year olds, 60% in the 20–29 year olds and close to or above 80% in those 30+ years. The comparison of the prevalence of known and potential H. pylori cofactors in gastric carcinogenesis between the high and the low risk area showed that consumption of chili products was significantly higher in Valdivia and daily non-green vegetable consumption was more common in Antofagasta. Pepsinogen levels suggestive of gastric atrophy were significantly more common and occurred at earlier ages in Valdivia, the higher risk area. In a multivariate model combining both study sites, age, chili consumption and CagA were the main risk factors for gastric atrophy. Conclusions The prevalence of H. pylori infection and its virulence factors was similar in the high and the low risk area, but atrophy was more common and occurred at younger ages in the higher risk area. Dietary factors could partly explain higher rates of atrophy and gastric cancer in Valdivia. Impact The ENIGMA study in Chile contributes to better understanding regional variations in gastric cancer incidence and provides essential information for public health interventions.https://orcid.org/0000-0001-5448-3456https://orcid.org/0000-0002-3803-8659https://orcid.org/0000-0002-7140-4219https://orcid.org/0000-0003-2491-5099Revista Internacional - Indexada115PLoS ONE9LICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/51907/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessORIGINALjournal.pone.0237515.pdfjournal.pone.0237515.pdfArtículoapplication/pdf1279157http://repository.javeriana.edu.co/bitstream/10554/51907/1/journal.pone.0237515.pdff747eb848f8f557a81e09674bf9075a8MD51open accessTHUMBNAILjournal.pone.0237515.pdf.jpgjournal.pone.0237515.pdf.jpgIM Thumbnailimage/jpeg13224http://repository.javeriana.edu.co/bitstream/10554/51907/3/journal.pone.0237515.pdf.jpg6ed6ef673ff7210ab8a1a4db79b2b268MD53open access10554/51907oai:repository.javeriana.edu.co:10554/519072020-12-24 03:02:52.443Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |