Preeclampsia association of placental nucleotide variations in eNOS, VEGFA, and FLT-1 genes in Latin American pregnant women
Q2
- Autores:
-
Macías Salas, Alejo
Sosa Macías, Martha
Barragán Zúñiga, Laura Jazel
Blanco Castañeda, Ricardo
Damiano, Alicia
García-Robles, Reggie
Ayala Ramírez, Paola
Bueno Sánchez, Julio
Giachini, Fernanda Regina
Escudero, Carlos
Galaviz-Hernández, Carlos
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2023
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/65330
- Acceso en línea:
- https://www.sciencedirect.com/science/article/abs/pii/S0143400423000437
http://hdl.handle.net/10554/65330
https://doi.org/10.1016/j.placenta.2023.02.010
- Palabra clave:
- Preeclampsia
Placenta
Nucleotide variations
eNOS
VEGFA
FLT-1
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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Repositorio Universidad Javeriana |
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| dc.title.spa.fl_str_mv |
Preeclampsia association of placental nucleotide variations in eNOS, VEGFA, and FLT-1 genes in Latin American pregnant women |
| title |
Preeclampsia association of placental nucleotide variations in eNOS, VEGFA, and FLT-1 genes in Latin American pregnant women |
| spellingShingle |
Preeclampsia association of placental nucleotide variations in eNOS, VEGFA, and FLT-1 genes in Latin American pregnant women Preeclampsia Placenta Nucleotide variations eNOS VEGFA FLT-1 |
| title_short |
Preeclampsia association of placental nucleotide variations in eNOS, VEGFA, and FLT-1 genes in Latin American pregnant women |
| title_full |
Preeclampsia association of placental nucleotide variations in eNOS, VEGFA, and FLT-1 genes in Latin American pregnant women |
| title_fullStr |
Preeclampsia association of placental nucleotide variations in eNOS, VEGFA, and FLT-1 genes in Latin American pregnant women |
| title_full_unstemmed |
Preeclampsia association of placental nucleotide variations in eNOS, VEGFA, and FLT-1 genes in Latin American pregnant women |
| title_sort |
Preeclampsia association of placental nucleotide variations in eNOS, VEGFA, and FLT-1 genes in Latin American pregnant women |
| dc.creator.fl_str_mv |
Macías Salas, Alejo Sosa Macías, Martha Barragán Zúñiga, Laura Jazel Blanco Castañeda, Ricardo Damiano, Alicia García-Robles, Reggie Ayala Ramírez, Paola Bueno Sánchez, Julio Giachini, Fernanda Regina Escudero, Carlos Galaviz-Hernández, Carlos |
| dc.contributor.author.none.fl_str_mv |
Macías Salas, Alejo Sosa Macías, Martha Barragán Zúñiga, Laura Jazel Blanco Castañeda, Ricardo Damiano, Alicia García-Robles, Reggie Ayala Ramírez, Paola Bueno Sánchez, Julio Giachini, Fernanda Regina Escudero, Carlos Galaviz-Hernández, Carlos |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ciencias Fisiológicas |
| dc.contributor.corporatename.none.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana |
| dc.contributor.javerianateacher.none.fl_str_mv |
García-Robles, Reggie Ayala Ramírez, Paola |
| dc.subject.keyword.spa.fl_str_mv |
Preeclampsia Placenta Nucleotide variations eNOS VEGFA FLT-1 |
| topic |
Preeclampsia Placenta Nucleotide variations eNOS VEGFA FLT-1 |
| description |
Q2 |
| publishDate |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2023-08-28T16:30:47Z |
| dc.date.available.none.fl_str_mv |
2023-08-28T16:30:47Z |
| dc.date.created.none.fl_str_mv |
2023-03-01 |
| dc.type.local.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_6501 |
| format |
http://purl.org/coar/resource_type/c_6501 |
| dc.identifier.spa.fl_str_mv |
https://www.sciencedirect.com/science/article/abs/pii/S0143400423000437 |
| dc.identifier.issn.spa.fl_str_mv |
0143-4004 / 1532-3102 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/65330 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.placenta.2023.02.010 |
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instname:Pontificia Universidad Javeriana |
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reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
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repourl:https://repository.javeriana.edu.co |
| url |
https://www.sciencedirect.com/science/article/abs/pii/S0143400423000437 http://hdl.handle.net/10554/65330 https://doi.org/10.1016/j.placenta.2023.02.010 |
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0143-4004 / 1532-3102 instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
1 |
| dc.relation.citationendpage.spa.fl_str_mv |
6 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Placenta |
| dc.relation.citationvolume.spa.fl_str_mv |
135 |
| dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
| dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional http://purl.org/coar/access_right/c_abf2 |
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PDF |
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application/pdf |
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Chile Colombia México |
| institution |
Pontificia Universidad Javeriana |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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Atribución-NoComercial 4.0 Internacionalhttp://purl.org/coar/access_right/c_abf2Macías Salas, AlejoSosa Macías, MarthaBarragán Zúñiga, Laura JazelBlanco Castañeda, RicardoDamiano, AliciaGarcía-Robles, ReggieAyala Ramírez, PaolaBueno Sánchez, JulioGiachini, Fernanda ReginaEscudero, CarlosGalaviz-Hernández, CarlosPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ciencias FisiológicasPontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética HumanaGarcía-Robles, ReggieAyala Ramírez, PaolaChileColombiaMéxico2023-08-28T16:30:47Z2023-08-28T16:30:47Z2023-03-01https://www.sciencedirect.com/science/article/abs/pii/S01434004230004370143-4004 / 1532-3102http://hdl.handle.net/10554/65330https://doi.org/10.1016/j.placenta.2023.02.010instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfenghttp://creativecommons.org/licenses/by-nc/4.0/Preeclampsia association of placental nucleotide variations in eNOS, VEGFA, and FLT-1 genes in Latin American pregnant womenArtículo de revistahttp://purl.org/coar/resource_type/c_6501Q2Q1Mujeres con preeclampsiaIntroduction: Preeclampsia is a leading cause of maternal and fetal morbidity in low- and middle-income countries, including those in Latin America. Placental vascular alterations are crucial in the pathophysiology of preeclampsia and few studies have evaluated nucleotide variations on genes associated with vascular regulation in the human placenta. This study aimed to evaluate whether placental nucleotide variations on eNOS, VEGFA, and FLT-1 genes are more frequently associated with preeclampsia in the Latin American population. Methods: This case-control study included placental tissue from 88 controls and 82 cases that were genotyped through Taqman probes for eNOS, VEGFA, and FLT-1 genes. The intergroup comparisons were analyzed with the Mann-Whitney U test. Genotype and allele frequencies were compared by the X2 test. The association between the nucleotide variants with preeclampsia was evaluated through logistic regression analysis. Results: A significant association was observed for VEGFA SNV rs2010963 (OR 1.95; CI 95% 1.13–3.37), after adjusting for population substructure. The allele combination T, G, G, C, C, C (rs2070744, rs1799983, rs2010963, rs3025039, rs699947 and rs4769613 respectively), showed a negative association with preeclampsia (OR 0.08; CI 95% 0.01–0.93). results. Discussion: Placental SNV rs2010963 in the VEGFA gene was a risk factor for preeclampsia, while the allele combination T, G, G, C, C, C may represent potential protective factors for preeclampsia within Latin American women.https://orcid.org/0000-0002-6804-0979https://orcid.org/0000-0002-0141-1149Revista Internacional - IndexadaA1NoPreeclampsiaPlacentaNucleotide variationseNOSVEGFAFLT-116Placenta135ORIGINALPreeclampsia association of placental nucleotide variations in eNOS, VEGFA, and FLT-1 genes in Latin American pregnant women.pdfPreeclampsia association of placental nucleotide variations in eNOS, VEGFA, and FLT-1 genes in Latin American pregnant women.pdfArtículoapplication/pdf446945http://repository.javeriana.edu.co/bitstream/10554/65330/1/Preeclampsia%20association%20of%20placental%20nucleotide%20variations%20in%20eNOS%2c%20VEGFA%2c%20and%20FLT-1%20genes%20in%20Latin%20American%20pregnant%20women.pdfe48eb5c343456735d9721018840c1f2cMD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/65330/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILPreeclampsia association of placental nucleotide variations in eNOS, VEGFA, and FLT-1 genes in Latin American pregnant women.pdf.jpgPreeclampsia association of placental nucleotide variations in eNOS, VEGFA, and FLT-1 genes in Latin American pregnant women.pdf.jpgIM Thumbnailimage/jpeg9296http://repository.javeriana.edu.co/bitstream/10554/65330/3/Preeclampsia%20association%20of%20placental%20nucleotide%20variations%20in%20eNOS%2c%20VEGFA%2c%20and%20FLT-1%20genes%20in%20Latin%20American%20pregnant%20women.pdf.jpg0bbb4d22656390df04dd8c28687cf0d1MD53open access10554/65330oai:repository.javeriana.edu.co:10554/653302024-01-10 20:53:19.86Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |