Effectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards : Systematic review and meta-analysis
Q1
- Autores:
-
Soto-Chávez, Maria Juliana
Muñoz, Óscar
Alzate-Granados, Juan Pablo
Lombo, Carlos
Henao-Carrillo, Diana Cristina
Gomez-Medina, Ana Maria
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2022
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/63725
- Acceso en línea:
- https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(22)00833-6/fulltext
http://hdl.handle.net/10554/63725
https://doi.org/10.1016/j.diabres.2022.110019
- Palabra clave:
- Type 2 diabetes
Inpatient management
DPP4 inhibitors
GLP-1 receptor agonist
Hypoglycemia
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Effectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards : Systematic review and meta-analysis |
| title |
Effectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards : Systematic review and meta-analysis |
| spellingShingle |
Effectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards : Systematic review and meta-analysis Type 2 diabetes Inpatient management DPP4 inhibitors GLP-1 receptor agonist Hypoglycemia |
| title_short |
Effectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards : Systematic review and meta-analysis |
| title_full |
Effectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards : Systematic review and meta-analysis |
| title_fullStr |
Effectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards : Systematic review and meta-analysis |
| title_full_unstemmed |
Effectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards : Systematic review and meta-analysis |
| title_sort |
Effectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards : Systematic review and meta-analysis |
| dc.creator.fl_str_mv |
Soto-Chávez, Maria Juliana Muñoz, Óscar Alzate-Granados, Juan Pablo Lombo, Carlos Henao-Carrillo, Diana Cristina Gomez-Medina, Ana Maria |
| dc.contributor.author.none.fl_str_mv |
Soto-Chávez, Maria Juliana Muñoz, Óscar Alzate-Granados, Juan Pablo Lombo, Carlos Henao-Carrillo, Diana Cristina Gomez-Medina, Ana Maria |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Endocrinología |
| dc.contributor.corporatename.none.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Epidemiología Clínica y Bioestadística Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Medicina Interna |
| dc.contributor.javerianateacher.none.fl_str_mv |
Muñoz, Óscar Alzate-Granados, Juan Pablo Henao-Carrillo, Diana Cristina Gomez-Medina, Ana Maria |
| dc.subject.keyword.spa.fl_str_mv |
Type 2 diabetes Inpatient management DPP4 inhibitors GLP-1 receptor agonist Hypoglycemia |
| topic |
Type 2 diabetes Inpatient management DPP4 inhibitors GLP-1 receptor agonist Hypoglycemia |
| description |
Q1 |
| publishDate |
2022 |
| dc.date.created.none.fl_str_mv |
2022-08-02 |
| dc.date.accessioned.none.fl_str_mv |
2023-03-14T12:18:02Z |
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2023-03-14T12:18:02Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_dcae04bc |
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http://purl.org/coar/resource_type/c_dcae04bc |
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https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(22)00833-6/fulltext |
| dc.identifier.issn.spa.fl_str_mv |
0168-8227 / 1872-8227 (Electrónico) |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/63725 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.diabres.2022.110019 |
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instname:Pontificia Universidad Javeriana |
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reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
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repourl:https://repository.javeriana.edu.co |
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https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(22)00833-6/fulltext http://hdl.handle.net/10554/63725 https://doi.org/10.1016/j.diabres.2022.110019 |
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0168-8227 / 1872-8227 (Electrónico) instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
1 |
| dc.relation.citationendpage.spa.fl_str_mv |
11 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Diabetes Research and Clinical Practice |
| dc.relation.citationvolume.spa.fl_str_mv |
191 |
| dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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PDF |
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application/pdf |
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2022 |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Soto-Chávez, Maria JulianaMuñoz, ÓscarAlzate-Granados, Juan PabloLombo, CarlosHenao-Carrillo, Diana CristinaGomez-Medina, Ana MariaPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. EndocrinologíaPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Epidemiología Clínica y BioestadísticaPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Medicina InternaMuñoz, ÓscarAlzate-Granados, Juan PabloHenao-Carrillo, Diana CristinaGomez-Medina, Ana Maria20222023-03-14T12:18:02Z2023-03-14T12:18:02Z2022-08-02https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(22)00833-6/fulltext0168-8227 / 1872-8227 (Electrónico)http://hdl.handle.net/10554/63725https://doi.org/10.1016/j.diabres.2022.110019instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengEffectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards : Systematic review and meta-analysisArtículo de revistahttp://purl.org/coar/resource_type/c_dcae04bcQ1Q1Background: Current guidelines recommend insulin alone for in-hospital management of diabetes, but growing information suggests that new oral or injectable agents may be as effective and safe. Methods: Systematic review and meta-analysis with evidence from randomized (RCT) and non-randomized (NRS) studies in PubMed, EMBASE and LILACS databases up to February 10, 2022, for studies including hospitalized type 2 diabetes patients, comparing dipeptidyl peptidase 4 inhibitors (DPP4i), sodium glucose co-transporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonist (GLP1Ra) with insulin alone for glycemic control and safety outcomes. Findings: 7 RCT and 3 NRTs were included. There were no differences in mean blood glucose, measurements within range or rate of hypoglycemia between DPP4i and insulin. We found a lower mean glucose for GLP1Ra plus insulin subgroup (−16.36 mg/dL, 95 % CI −27.31, −5.41; I2 = 0 %) with lower incidence of hypoglycemia < 70 mg/dL with GLP1Ra (RR 0.31, CI 95 % 0.14–0.70, I2 = 0 %). SGLT2i data was limited. Adverse events rates were similar between treatments. Conclusion: Our review suggests that inpatient management in the general ward with DPP4i and GLP1Ra is as effective and safe as management with insulin. More randomized studies are required to support these findings before they could be recommended as usual practice.https://orcid.org/0000-0003-4946-8774https://orcid.org/0000-0001-5401-0018https://orcid.org/0000-0001-8344-494Xhttps://orcid.org/0000-0002-6392-7554https://orcid.org/0000-0002-1353-148Xhttps://orcid.org/0000-0002-8907-3470Revista Internacional - IndexadaA1NoType 2 diabetesInpatient managementDPP4 inhibitorsGLP-1 receptor agonistHypoglycemia111Diabetes Research and Clinical Practice191ORIGINALEffectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards Systematic review and meta-analysis.pdfEffectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards Systematic review and meta-analysis.pdfArtículoapplication/pdf2115900http://repository.javeriana.edu.co/bitstream/10554/63725/1/Effectiveness%20and%20safety%20of%20new%20oral%20and%20injectable%20agents%20for%20in-hospital%20management%20of%20type%202%20diabetes%20in%20general%20wards%20Systematic%20review%20and%20meta-analysis.pdf0d252ad36b3d2c32b6f308d167348fa6MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/63725/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILEffectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards Systematic review and meta-analysis.pdf.jpgEffectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards Systematic review and meta-analysis.pdf.jpgIM Thumbnailimage/jpeg10123http://repository.javeriana.edu.co/bitstream/10554/63725/3/Effectiveness%20and%20safety%20of%20new%20oral%20and%20injectable%20agents%20for%20in-hospital%20management%20of%20type%202%20diabetes%20in%20general%20wards%20Systematic%20review%20and%20meta-analysis.pdf.jpg09934d36921bca830ba88f8cc6a75de7MD53open access10554/63725oai:repository.javeriana.edu.co:10554/637252023-03-20 03:06:41.549Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |