Tackling variability : a multicenter study to provide a gold-standard network approach for frontotemporal dementia
Q2
- Autores:
-
Sedeno, Lucas
Piguet, Olivier
Abrevaya, Sofıa
Desmaras, Horacio
Garcıa-Cordero, Indira
Baez, Sandra
de la Fuente, Laura Alethia
Reyes, Pablo
Tu, Sicong
Mogilner, Sebastian
Lori, Nicolas
Landin-Romero, Ramon
Matallana-Eslava, Diana L.
Slachevsky, Andrea
Torralva, Teresa
Chialvo, Dante
Kumfor, Fiona
García, Adolfo M.
Manes, Facundo
Hodges, John R
Ibanez, Agustin
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2017
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/53465
- Acceso en línea:
- https://pubmed.ncbi.nlm.nih.gov/28474365/
http://hdl.handle.net/10554/53465
https://doi.org/10.1002/hbm.23627
- Palabra clave:
- Biomarkers
Frontotemporal dementia
Functional connectivity
Graph-theory and neurodegenerative diseases
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Tackling variability : a multicenter study to provide a gold-standard network approach for frontotemporal dementia |
| title |
Tackling variability : a multicenter study to provide a gold-standard network approach for frontotemporal dementia |
| spellingShingle |
Tackling variability : a multicenter study to provide a gold-standard network approach for frontotemporal dementia Biomarkers Frontotemporal dementia Functional connectivity Graph-theory and neurodegenerative diseases |
| title_short |
Tackling variability : a multicenter study to provide a gold-standard network approach for frontotemporal dementia |
| title_full |
Tackling variability : a multicenter study to provide a gold-standard network approach for frontotemporal dementia |
| title_fullStr |
Tackling variability : a multicenter study to provide a gold-standard network approach for frontotemporal dementia |
| title_full_unstemmed |
Tackling variability : a multicenter study to provide a gold-standard network approach for frontotemporal dementia |
| title_sort |
Tackling variability : a multicenter study to provide a gold-standard network approach for frontotemporal dementia |
| dc.creator.fl_str_mv |
Sedeno, Lucas Piguet, Olivier Abrevaya, Sofıa Desmaras, Horacio Garcıa-Cordero, Indira Baez, Sandra de la Fuente, Laura Alethia Reyes, Pablo Tu, Sicong Mogilner, Sebastian Lori, Nicolas Landin-Romero, Ramon Matallana-Eslava, Diana L. Slachevsky, Andrea Torralva, Teresa Chialvo, Dante Kumfor, Fiona García, Adolfo M. Manes, Facundo Hodges, John R Ibanez, Agustin |
| dc.contributor.author.none.fl_str_mv |
Sedeno, Lucas Piguet, Olivier Abrevaya, Sofıa Desmaras, Horacio Garcıa-Cordero, Indira Baez, Sandra de la Fuente, Laura Alethia Reyes, Pablo Tu, Sicong Mogilner, Sebastian Lori, Nicolas Landin-Romero, Ramon Matallana-Eslava, Diana L. Slachevsky, Andrea Torralva, Teresa Chialvo, Dante Kumfor, Fiona García, Adolfo M. Manes, Facundo Hodges, John R Ibanez, Agustin |
| dc.contributor.corporatename.none.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Envejecimiento |
| dc.subject.keyword.spa.fl_str_mv |
Biomarkers Frontotemporal dementia Functional connectivity Graph-theory and neurodegenerative diseases |
| topic |
Biomarkers Frontotemporal dementia Functional connectivity Graph-theory and neurodegenerative diseases |
| description |
Q2 |
| publishDate |
2017 |
| dc.date.created.none.fl_str_mv |
2017-05-05 |
| dc.date.accessioned.none.fl_str_mv |
2021-04-07T19:35:25Z |
| dc.date.available.none.fl_str_mv |
2021-04-07T19:35:25Z |
| dc.type.local.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_6501 |
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http://purl.org/coar/resource_type/c_6501 |
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https://pubmed.ncbi.nlm.nih.gov/28474365/ |
| dc.identifier.issn.spa.fl_str_mv |
1065-9471 / 1097-0193 (Electrónico) |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/53465 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1002/hbm.23627 |
| dc.identifier.instname.spa.fl_str_mv |
instname:Pontificia Universidad Javeriana |
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reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
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repourl:https://repository.javeriana.edu.co |
| url |
https://pubmed.ncbi.nlm.nih.gov/28474365/ http://hdl.handle.net/10554/53465 https://doi.org/10.1002/hbm.23627 |
| identifier_str_mv |
1065-9471 / 1097-0193 (Electrónico) instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
3804 |
| dc.relation.citationendpage.spa.fl_str_mv |
3822 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Human Brain Mapping |
| dc.relation.citationvolume.spa.fl_str_mv |
38 |
| dc.relation.citationissue.spa.fl_str_mv |
8 |
| dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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PDF |
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application/pdf |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Sedeno, LucasPiguet, OlivierAbrevaya, SofıaDesmaras, HoracioGarcıa-Cordero, IndiraBaez, Sandrade la Fuente, Laura AlethiaReyes, PabloTu, SicongMogilner, SebastianLori, NicolasLandin-Romero, RamonMatallana-Eslava, Diana L.Slachevsky, AndreaTorralva, TeresaChialvo, DanteKumfor, FionaGarcía, Adolfo M.Manes, FacundoHodges, John RIbanez, AgustinPontificia Universidad Javeriana. Facultad de Medicina. Instituto de Envejecimiento2021-04-07T19:35:25Z2021-04-07T19:35:25Z2017-05-05https://pubmed.ncbi.nlm.nih.gov/28474365/1065-9471 / 1097-0193 (Electrónico)http://hdl.handle.net/10554/53465https://doi.org/10.1002/hbm.23627instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengTackling variability : a multicenter study to provide a gold-standard network approach for frontotemporal dementiaArtículo de revistahttp://purl.org/coar/resource_type/c_6501Q2Q1Biomarkers represent a critical research area in neurodegeneration disease as they can contribute to studying potential disease-modifying agents, fostering timely therapeutic interventions, and alleviating associated financial costs. Functional connectivity (FC) analysis represents a promising approach to identify early biomarkers in specific diseases. Yet, virtually no study has tested whether potential FC biomarkers prove to be reliable and reproducible across different centers. As such, their implementation remains uncertain due to multiple sources of variability across studies: the numerous international centers capable conducting FC research vary in their scanning equipment and their samples’ socio-cultural background, and, more troublingly still, no gold-standard method exists to analyze FC. In this unprecedented study, we aim to address both issues by performing the first multicenter FC research in the behavioral-variant frontotemporal dementia (bvFTD), and by assessing multiple FC approaches to propose a gold-standard method for analysis. We enrolled 52 bvFTD patients and 60 controls from three international clinics (with different fMRI recording parameters), and three additional neurological patient groups. To evaluate FC, we focused on seed analysis, inter-regional connectivity, and several graph-theory approaches. Only graph-theory analysis, based on weightedmatrices, yielded consistent differences between bvFTD and controls across centers. Also, graph metrics robustly discriminated bvFTD from the other neurological conditions. The consistency of our findings across heterogeneous contexts highlights graph-theory as a potential gold-standard approach for brain network analysis in bvFTD.Revista Internacional - IndexadaBiomarkersFrontotemporal dementiaFunctional connectivityGraph-theory and neurodegenerative diseases38043822Human Brain Mapping388ORIGINALTackling Variability A Multicenter Study to.pdfTackling Variability A Multicenter Study to.pdfArtículoapplication/pdf1391414http://repository.javeriana.edu.co/bitstream/10554/53465/1/Tackling%20Variability%20%20A%20Multicenter%20Study%20to.pdf0bb474e2b5189c1b02d3ce0b21d99a96MD51embargoed access|||9999-04-03LICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/53465/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILTackling Variability A Multicenter Study to.pdf.jpgTackling Variability A Multicenter Study to.pdf.jpgIM Thumbnailimage/jpeg8705http://repository.javeriana.edu.co/bitstream/10554/53465/3/Tackling%20Variability%20%20A%20Multicenter%20Study%20to.pdf.jpg45a8e49b5f2cd2163be6a60fe297552cMD53open access10554/53465oai:repository.javeriana.edu.co:10554/534652021-07-14 16:30:57.304Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |