Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer
Q3
- Autores:
-
Otálora-Otálora, Beatriz Andrea
López-Kleine, Liliana
Rojas, Adriana
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2023
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/65327
- Acceso en línea:
- https://www.mdpi.com/1467-3045/45/1/29
http://hdl.handle.net/10554/65327
https://doi.org/10.3390/cimb45010029
- Palabra clave:
- Lung cancer
Pulmonary arterial hypertension
Differentially expressed genes
Transcription factors
Co-expression networks
Common connection patterns
Gene regulatory network
Coregulatory network
Fibration symmetries
Transcriptional regulatory network
Lung cancer biomarkers
Patient’s survival
Transcriptomics and bioinformatics
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer |
| title |
Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer |
| spellingShingle |
Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer Lung cancer Pulmonary arterial hypertension Differentially expressed genes Transcription factors Co-expression networks Common connection patterns Gene regulatory network Coregulatory network Fibration symmetries Transcriptional regulatory network Lung cancer biomarkers Patient’s survival Transcriptomics and bioinformatics |
| title_short |
Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer |
| title_full |
Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer |
| title_fullStr |
Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer |
| title_full_unstemmed |
Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer |
| title_sort |
Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer |
| dc.creator.fl_str_mv |
Otálora-Otálora, Beatriz Andrea López-Kleine, Liliana Rojas, Adriana |
| dc.contributor.author.none.fl_str_mv |
Otálora-Otálora, Beatriz Andrea López-Kleine, Liliana Rojas, Adriana |
| dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana |
| dc.contributor.javerianateacher.none.fl_str_mv |
Rojas, Adriana |
| dc.subject.keyword.spa.fl_str_mv |
Lung cancer Pulmonary arterial hypertension Differentially expressed genes Transcription factors Co-expression networks Common connection patterns Gene regulatory network Coregulatory network Fibration symmetries Transcriptional regulatory network Lung cancer biomarkers Patient’s survival Transcriptomics and bioinformatics |
| topic |
Lung cancer Pulmonary arterial hypertension Differentially expressed genes Transcription factors Co-expression networks Common connection patterns Gene regulatory network Coregulatory network Fibration symmetries Transcriptional regulatory network Lung cancer biomarkers Patient’s survival Transcriptomics and bioinformatics |
| description |
Q3 |
| publishDate |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2023-08-28T16:16:30Z |
| dc.date.available.none.fl_str_mv |
2023-08-28T16:16:30Z |
| dc.date.created.none.fl_str_mv |
2023-01-05 |
| dc.type.local.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_6501 |
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http://purl.org/coar/resource_type/c_6501 |
| dc.identifier.spa.fl_str_mv |
https://www.mdpi.com/1467-3045/45/1/29 |
| dc.identifier.issn.spa.fl_str_mv |
1467-3037 / 1467-3045 (Electrónico) |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/65327 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.3390/cimb45010029 |
| dc.identifier.instname.spa.fl_str_mv |
instname:Pontificia Universidad Javeriana |
| dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
| dc.identifier.repourl.spa.fl_str_mv |
repourl:https://repository.javeriana.edu.co |
| url |
https://www.mdpi.com/1467-3045/45/1/29 http://hdl.handle.net/10554/65327 https://doi.org/10.3390/cimb45010029 |
| identifier_str_mv |
1467-3037 / 1467-3045 (Electrónico) instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
434 |
| dc.relation.citationendpage.spa.fl_str_mv |
464 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Current Issues in Molecular Biology |
| dc.relation.citationvolume.spa.fl_str_mv |
45 |
| dc.relation.citationissue.spa.fl_str_mv |
1 |
| dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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PDF |
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application/pdf |
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Pontificia Universidad Javeriana |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Otálora-Otálora, Beatriz AndreaLópez-Kleine, LilianaRojas, AdrianaPontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética HumanaRojas, Adriana2023-08-28T16:16:30Z2023-08-28T16:16:30Z2023-01-05https://www.mdpi.com/1467-3045/45/1/291467-3037 / 1467-3045 (Electrónico)http://hdl.handle.net/10554/65327https://doi.org/10.3390/cimb45010029instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengLung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of CancerArtículo de revistahttp://purl.org/coar/resource_type/c_6501Q3Q2Pacientes con Cáncer de pulmónThe transcriptomic analysis of microarray and RNA-Seq datasets followed our own bioinformatic pipeline to identify a transcriptional regulatory network of lung cancer. Twenty-six transcription factors are dysregulated and co-expressed in most of the lung cancer and pulmonary arterial hypertension datasets, which makes them the most frequently dysregulated transcription factors. Co-expression, gene regulatory, coregulatory, and transcriptional regulatory networks, along with fibration symmetries, were constructed to identify common connection patterns, alignments, main regulators, and target genes in order to analyze transcription factor complex formation, as well as its synchronized co-expression patterns in every type of lung cancer. The regulatory function of the most frequently dysregulated transcription factors over lung cancer deregulated genes was validated with ChEA3 enrichment analysis. A Kaplan–Meier plotter analysis linked the dysregulation of the top transcription factors with lung cancer patients’ survival. Our results indicate that lung cancer has unique and common deregulated genes and transcription factors with pulmonary arterial hypertension, co-expressed and regulated in a coordinated and cooperative manner by the transcriptional regulatory network that might be associated with critical biological processes and signaling pathways related to the acquisition of the hallmarks of cancer, making them potentially relevant tumor biomarkers for lung cancer early diagnosis and targets for the development of personalized therapies against lung cancer.https://orcid.org/0000-0001-8528-4433Revista Internacional - IndexadaA2NoLung cancerPulmonary arterial hypertensionDifferentially expressed genesTranscription factorsCo-expression networksCommon connection patternsGene regulatory networkCoregulatory networkFibration symmetriesTranscriptional regulatory networkLung cancer biomarkersPatient’s survivalTranscriptomics and bioinformatics434464Current Issues in Molecular Biology451ORIGINALLung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer.pdfLung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer.pdfapplication/pdf6529316http://repository.javeriana.edu.co/bitstream/10554/65327/1/Lung%20Cancer%20Gene%20Regulatory%20Network%20of%20Transcription%20Factors%20Related%20to%20the%20Hallmarks%20of%20Cancer.pdf7e8605a2b10b11d3b949b52f7ca431ceMD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/65327/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILLung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer.pdf.jpgLung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer.pdf.jpgIM Thumbnailimage/jpeg12537http://repository.javeriana.edu.co/bitstream/10554/65327/3/Lung%20Cancer%20Gene%20Regulatory%20Network%20of%20Transcription%20Factors%20Related%20to%20the%20Hallmarks%20of%20Cancer.pdf.jpg23f3b251b12fefdb394952f1ebba4510MD53open access10554/65327oai:repository.javeriana.edu.co:10554/653272023-08-29 03:00:21.072Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |