Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses
Q1
- Autores:
-
Bogdanova, Natalia V.
Bojesen, Stig E.
Bonanni , Bernardo
Bondavalli, Davide
Borg, Ake
Brauch, Hiltrud
Brenner, Hermann
Briceño Balcázar, Ignacio
Broeks, Annegien
Brucker, Sara Y.
Brüning, Thomas
Burwinkel, Barbara
Buys, Saundra S.
Byers, Helen
Caldés, Trinidad
Caligo, Maria A.
Calvello, Mariarosaria
Campa, Daniele
Castelao, Jose E.
Chang-Claude, Jenny
Chanock, Stephen J.
Christiaens, Melissa
Christiansen, Hans
Chung, Wendy K.
Claes, Kathleen B. M.
Clarke, Christine L.
Cornelissen, Sten
Couch, Fergus J.
Cox, Angela
Cross, Simon S.
Czene, Kamila
Daly, Mary B.
Devilee, Peter
Diez, Orland
Domchek, Susan M.
Dörk, Thilo
Dwek, Miriam
Eccles, Diana M.
Ekici, Arif B.
Evans, D. Gareth
Fasching, Peter A.
Figueroa, Jonine
Foretova, Lenka
Fostira, Florentia
Friedman, Eitan
Frost, Debra
Gago-Dominguez, Manuela
Gapstur, Susan M.
Garber, Judy
García-Sáenz, José A.
Gaudet, Mia M.
Gayther, Simon A.
Giles, Graham G.
Godwin, Andrew K.
Goldberg, Mark S.
Goldgar, David E.
González-Neira, Anna
Greene, Mark H.
Gronwald, Jacek
Guénel, Pascal
Häberle, Lothar
Hahnen, Eric
Haiman, Christopher A.
Hake, Christopher R.
Hall, Per
Hamann, Ute
Harkness, Elaine F.
Heemskerk-Gerritsen, Bernadette A. M.
Hillemanns, Peter
Hogervorst, Frans B. L.
Holleczek, Bernd
Hollestelle, Antoinette
Hooning, Maartje J.
Hoover, Robert N.
Hopper, John L.
Howell, Anthony
Huebner, Hanna
Hulick, Peter J.
Imyanitov, Evgeny N.
kConFab Investigators
ABCTB Investigators
Isaacs, Claudine
Izatt, Louise
Jager, Agnes
Jakimovska, Milena
Jakubowska, Anna
James, Paul A.
Janavicius, Ramunas
Janni, Wolfgang
John, Esther M.
Jones, Michael E.
Jung, Audrey
Kaaks, Rudolf
Kapoor, Pooja Middha
Karlan, Beth Y.
Keeman, Renske
Khan, Sofia
Khusnutdinova, Elza
Kitahara, Cari M.
Ko, Yon-Dschun
Konstantopoulou, Irene
Koppert, Linetta B.
Koutros, Stella
Kristensen, Vessela N.
Laenkholm, Anne-Vibeke
Lambrechts, Diether
Larsson, Susanna C
Laurent-Puig, Pierre
Lazaro, Conxi
Lazarova, Emilija
Lejbkowicz, Flavio
Leslie, Goska
Lesueur, Fabienne
Lindblom, Annika
Lissowska, Jolanta
Lo, Wing-Yee
Loud, Jennifer T.
Lubinski, Jan
Lukomska, Alicja
MacInnis, Robert J.
Mannermaa, Arto
Manoochehri, Mehdi
Manoukian, Siranoush
Margolin, Sara
Martinez, Maria Elena
Matricardi, Laura
McGuffog, Lesley
McLean, Catriona
Mebirouk, Noura
Meindl, Alfons
Menon, Usha
Miller, Austin
Mingazheva, Elvira
Montagna, Marco
Mulligan, Anna Marie
Mulot, Claire
Muranen, Taru A.
Nathanson, Katherine L.
Neuhausen, Susan L.
Nevanlinna, Heli
Neven, Patrick
Newman, William G.
Nielsen, Finn C.
Nikitina-Zake, Liene
Nodora, Jesse
Offit, Kenneth
Olah, Edith
Olopade, Olufunmilayo I.
Olsson, Håkan
Orr, Nick
Papi, Laura
Papp, Janos
Park-Simon, Tjoung-Won
Parsons, Michael T.
Peissel, Bernard
Peixoto, Sergio V.
Peshkin, Beth
Peterlongo, Paolo
Peto, Julian
Phillips, Kelly-Anne
Piedmonte, Marion
Plaseska-Karanfilska, Dijana
Prajzendanc, Karolina
Prentice, Ross
Prokofyeva, Darya
Rack, Brigitte
Radice, Paolo
Ramus, Susan J.
Rantala, Johanna
Rashid, Muhammad U.
Rennert, Gad
Rennert, Gad
Risch, Harvey A.
Romero , Atocha
Rookus, Matti A.
Rübner, Matthias
Rüdiger, Thomas
Saloustros, Emmanouil
Sampson, Sarah
Sandler, Dale P.
Sawyer, Elinor J.
Scheuner, Maren T.
Schmutzler, Rita K.
Schneeweiss, Andreas
Schoemaker, Minouk J.
Schöttker, Ben
Schürmann, Peter
Senter, Leigha
Sharma, Priyanka
Sherman, Mark E.
Shu, Xiao-Ou
Singer, Christian F.
Smichkoska, Snezhana
Soucy, Penny
Southey, Melissa C.
Spinelli, John J.
Stone, Jennifer
Stoppa-Lyonnet, Dominique
EMBRACE Study
GEMO Study Collaborators
Swerdlow, Anthony J.
Szabova, Elena
Tamimi, Rulla M.
Tapper, William J.
Taylor, Jack A.
Teixeira, Manuel R.
Terry, Mary Beth
Thomassen, Mads
Thull, Darcy L.
Tischkowitz, Marc
Toland, Amanda E.
Tollenaar, Rob A.E.M.
Tomlinson, Ian
Torres-López, Diana María
Troester, Melissa A.
Truong, Thérèse
Tung, Nadine
Untch, Michae
Vachon, Celine M.
van den Ouweland, Ans M. W.
van der Kolk, Lizet E.
van Veen, Elke M.
vanRensburg, Elizabeth J.
Vega, Ana
Wappenschmidt, Barbara
Weinberg, Clarice R.
Weitzel, Jeffrey N.
Wildiers, Hans
Winqvist, Robert
Wolk, Alicja
Yang, Xiaohong R.
Yannoukakos, Drakoulis
Zheng, Wei
Zorn, Kristin K.
Milne, Roger L.
Kraft, Peter
Simard , Jacques
Pharoah , Paul D. P.
Michailidou, Kyriaki
Antoniou, Antonis C.
Schmidt, Marjanka K.
Chenevix-Trench, Georgia
Easton, Douglas F.
Chatterjee, Nilanjan
García-Closas, Montserrat
- Tipo de recurso:
- Letter to the editor
- Fecha de publicación:
- 2020
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/63882
- Acceso en línea:
- https://revistas.javeriana.edu.co/index.php/revPsycho/article/view/21878
http://hdl.handle.net/10554/63882
https://doi.org/10.1038/s41588-020-0609-2
- Palabra clave:
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
id |
JAVERIANA2_02990419257214d13707e0000fff71d2 |
---|---|
oai_identifier_str |
oai:repository.javeriana.edu.co:10554/63882 |
network_acronym_str |
JAVERIANA2 |
network_name_str |
Repositorio Universidad Javeriana |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses |
title |
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses |
spellingShingle |
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses |
title_short |
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses |
title_full |
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses |
title_fullStr |
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses |
title_full_unstemmed |
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses |
title_sort |
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses |
dc.creator.fl_str_mv |
Bogdanova, Natalia V. Bojesen, Stig E. Bonanni , Bernardo Bondavalli, Davide Borg, Ake Brauch, Hiltrud Brenner, Hermann Briceño Balcázar, Ignacio Broeks, Annegien Brucker, Sara Y. Brüning, Thomas Burwinkel, Barbara Buys, Saundra S. Byers, Helen Caldés, Trinidad Caligo, Maria A. Calvello, Mariarosaria Campa, Daniele Castelao, Jose E. Chang-Claude, Jenny Chanock, Stephen J. Christiaens, Melissa Christiansen, Hans Chung, Wendy K. Claes, Kathleen B. M. Clarke, Christine L. Cornelissen, Sten Couch, Fergus J. Cox, Angela Cross, Simon S. Czene, Kamila Daly, Mary B. Devilee, Peter Diez, Orland Domchek, Susan M. Dörk, Thilo Dwek, Miriam Eccles, Diana M. Ekici, Arif B. Evans, D. Gareth Fasching, Peter A. Figueroa, Jonine Foretova, Lenka Fostira, Florentia Friedman, Eitan Frost, Debra Gago-Dominguez, Manuela Gapstur, Susan M. Garber, Judy García-Sáenz, José A. Gaudet, Mia M. Gayther, Simon A. Giles, Graham G. Godwin, Andrew K. Goldberg, Mark S. Goldgar, David E. González-Neira, Anna Greene, Mark H. Gronwald, Jacek Guénel, Pascal Häberle, Lothar Hahnen, Eric Haiman, Christopher A. Hake, Christopher R. Hall, Per Hamann, Ute Harkness, Elaine F. Heemskerk-Gerritsen, Bernadette A. M. Hillemanns, Peter Hogervorst, Frans B. L. Holleczek, Bernd Hollestelle, Antoinette Hooning, Maartje J. Hoover, Robert N. Hopper, John L. Howell, Anthony Huebner, Hanna Hulick, Peter J. Imyanitov, Evgeny N. kConFab Investigators ABCTB Investigators Isaacs, Claudine Izatt, Louise Jager, Agnes Jakimovska, Milena Jakubowska, Anna James, Paul A. Janavicius, Ramunas Janni, Wolfgang John, Esther M. Jones, Michael E. Jung, Audrey Kaaks, Rudolf Kapoor, Pooja Middha Karlan, Beth Y. Keeman, Renske Khan, Sofia Khusnutdinova, Elza Kitahara, Cari M. Ko, Yon-Dschun Konstantopoulou, Irene Koppert, Linetta B. Koutros, Stella Kristensen, Vessela N. Laenkholm, Anne-Vibeke Lambrechts, Diether Larsson, Susanna C Laurent-Puig, Pierre Lazaro, Conxi Lazarova, Emilija Lejbkowicz, Flavio Leslie, Goska Lesueur, Fabienne Lindblom, Annika Lissowska, Jolanta Lo, Wing-Yee Loud, Jennifer T. Lubinski, Jan Lukomska, Alicja MacInnis, Robert J. Mannermaa, Arto Manoochehri, Mehdi Manoukian, Siranoush Margolin, Sara Martinez, Maria Elena Matricardi, Laura McGuffog, Lesley McLean, Catriona Mebirouk, Noura Meindl, Alfons Menon, Usha Miller, Austin Mingazheva, Elvira Montagna, Marco Mulligan, Anna Marie Mulot, Claire Muranen, Taru A. Nathanson, Katherine L. Neuhausen, Susan L. Nevanlinna, Heli Neven, Patrick Newman, William G. Nielsen, Finn C. Nikitina-Zake, Liene Nodora, Jesse Offit, Kenneth Olah, Edith Olopade, Olufunmilayo I. Olsson, Håkan Orr, Nick Papi, Laura Papp, Janos Park-Simon, Tjoung-Won Parsons, Michael T. Peissel, Bernard Peixoto, Sergio V. Peshkin, Beth Peterlongo, Paolo Peto, Julian Phillips, Kelly-Anne Piedmonte, Marion Plaseska-Karanfilska, Dijana Prajzendanc, Karolina Prentice, Ross Prokofyeva, Darya Rack, Brigitte Radice, Paolo Ramus, Susan J. Rantala, Johanna Rashid, Muhammad U. Rennert, Gad Rennert, Gad Risch, Harvey A. Romero , Atocha Rookus, Matti A. Rübner, Matthias Rüdiger, Thomas Saloustros, Emmanouil Sampson, Sarah Sandler, Dale P. Sawyer, Elinor J. Scheuner, Maren T. Schmutzler, Rita K. Schneeweiss, Andreas Schoemaker, Minouk J. Schöttker, Ben Schürmann, Peter Senter, Leigha Sharma, Priyanka Sherman, Mark E. Shu, Xiao-Ou Singer, Christian F. Smichkoska, Snezhana Soucy, Penny Southey, Melissa C. Spinelli, John J. Stone, Jennifer Stoppa-Lyonnet, Dominique EMBRACE Study GEMO Study Collaborators Swerdlow, Anthony J. Szabova, Elena Tamimi, Rulla M. Tapper, William J. Taylor, Jack A. Teixeira, Manuel R. Terry, Mary Beth Thomassen, Mads Thull, Darcy L. Tischkowitz, Marc Toland, Amanda E. Tollenaar, Rob A.E.M. Tomlinson, Ian Torres-López, Diana María Troester, Melissa A. Truong, Thérèse Tung, Nadine Untch, Michae Vachon, Celine M. van den Ouweland, Ans M. W. van der Kolk, Lizet E. van Veen, Elke M. vanRensburg, Elizabeth J. Vega, Ana Wappenschmidt, Barbara Weinberg, Clarice R. Weitzel, Jeffrey N. Wildiers, Hans Winqvist, Robert Wolk, Alicja Yang, Xiaohong R. Yannoukakos, Drakoulis Zheng, Wei Zorn, Kristin K. Milne, Roger L. Kraft, Peter Simard , Jacques Pharoah , Paul D. P. Michailidou, Kyriaki Antoniou, Antonis C. Schmidt, Marjanka K. Chenevix-Trench, Georgia Easton, Douglas F. Chatterjee, Nilanjan García-Closas, Montserrat |
dc.contributor.author.none.fl_str_mv |
Bogdanova, Natalia V. Bojesen, Stig E. Bonanni , Bernardo Bondavalli, Davide Borg, Ake Brauch, Hiltrud Brenner, Hermann Briceño Balcázar, Ignacio Broeks, Annegien Brucker, Sara Y. Brüning, Thomas Burwinkel, Barbara Buys, Saundra S. Byers, Helen Caldés, Trinidad Caligo, Maria A. Calvello, Mariarosaria Campa, Daniele Castelao, Jose E. Chang-Claude, Jenny Chanock, Stephen J. Christiaens, Melissa Christiansen, Hans Chung, Wendy K. Claes, Kathleen B. M. Clarke, Christine L. Cornelissen, Sten Couch, Fergus J. Cox, Angela Cross, Simon S. Czene, Kamila Daly, Mary B. Devilee, Peter Diez, Orland Domchek, Susan M. Dörk, Thilo Dwek, Miriam Eccles, Diana M. Ekici, Arif B. Evans, D. Gareth Fasching, Peter A. Figueroa, Jonine Foretova, Lenka Fostira, Florentia Friedman, Eitan Frost, Debra Gago-Dominguez, Manuela Gapstur, Susan M. Garber, Judy García-Sáenz, José A. Gaudet, Mia M. Gayther, Simon A. Giles, Graham G. Godwin, Andrew K. Goldberg, Mark S. Goldgar, David E. González-Neira, Anna Greene, Mark H. Gronwald, Jacek Guénel, Pascal Häberle, Lothar Hahnen, Eric Haiman, Christopher A. Hake, Christopher R. Hall, Per Hamann, Ute Harkness, Elaine F. Heemskerk-Gerritsen, Bernadette A. M. Hillemanns, Peter Hogervorst, Frans B. L. Holleczek, Bernd Hollestelle, Antoinette Hooning, Maartje J. Hoover, Robert N. Hopper, John L. Howell, Anthony Huebner, Hanna Hulick, Peter J. Imyanitov, Evgeny N. kConFab Investigators ABCTB Investigators Isaacs, Claudine Izatt, Louise Jager, Agnes Jakimovska, Milena Jakubowska, Anna James, Paul A. Janavicius, Ramunas Janni, Wolfgang John, Esther M. Jones, Michael E. Jung, Audrey Kaaks, Rudolf Kapoor, Pooja Middha Karlan, Beth Y. Keeman, Renske Khan, Sofia Khusnutdinova, Elza Kitahara, Cari M. Ko, Yon-Dschun Konstantopoulou, Irene Koppert, Linetta B. Koutros, Stella Kristensen, Vessela N. Laenkholm, Anne-Vibeke Lambrechts, Diether Larsson, Susanna C Laurent-Puig, Pierre Lazaro, Conxi Lazarova, Emilija Lejbkowicz, Flavio Leslie, Goska Lesueur, Fabienne Lindblom, Annika Lissowska, Jolanta Lo, Wing-Yee Loud, Jennifer T. Lubinski, Jan Lukomska, Alicja MacInnis, Robert J. Mannermaa, Arto Manoochehri, Mehdi Manoukian, Siranoush Margolin, Sara Martinez, Maria Elena Matricardi, Laura McGuffog, Lesley McLean, Catriona Mebirouk, Noura Meindl, Alfons Menon, Usha Miller, Austin Mingazheva, Elvira Montagna, Marco Mulligan, Anna Marie Mulot, Claire Muranen, Taru A. Nathanson, Katherine L. Neuhausen, Susan L. Nevanlinna, Heli Neven, Patrick Newman, William G. Nielsen, Finn C. Nikitina-Zake, Liene Nodora, Jesse Offit, Kenneth Olah, Edith Olopade, Olufunmilayo I. Olsson, Håkan Orr, Nick Papi, Laura Papp, Janos Park-Simon, Tjoung-Won Parsons, Michael T. Peissel, Bernard Peixoto, Sergio V. Peshkin, Beth Peterlongo, Paolo Peto, Julian Phillips, Kelly-Anne Piedmonte, Marion Plaseska-Karanfilska, Dijana Prajzendanc, Karolina Prentice, Ross Prokofyeva, Darya Rack, Brigitte Radice, Paolo Ramus, Susan J. Rantala, Johanna Rashid, Muhammad U. Rennert, Gad Rennert, Gad Risch, Harvey A. Romero , Atocha Rookus, Matti A. Rübner, Matthias Rüdiger, Thomas Saloustros, Emmanouil Sampson, Sarah Sandler, Dale P. Sawyer, Elinor J. Scheuner, Maren T. Schmutzler, Rita K. Schneeweiss, Andreas Schoemaker, Minouk J. Schöttker, Ben Schürmann, Peter Senter, Leigha Sharma, Priyanka Sherman, Mark E. Shu, Xiao-Ou Singer, Christian F. Smichkoska, Snezhana Soucy, Penny Southey, Melissa C. Spinelli, John J. Stone, Jennifer Stoppa-Lyonnet, Dominique EMBRACE Study GEMO Study Collaborators Swerdlow, Anthony J. Szabova, Elena Tamimi, Rulla M. Tapper, William J. Taylor, Jack A. Teixeira, Manuel R. Terry, Mary Beth Thomassen, Mads Thull, Darcy L. Tischkowitz, Marc Toland, Amanda E. Tollenaar, Rob A.E.M. Tomlinson, Ian Torres-López, Diana María Troester, Melissa A. Truong, Thérèse Tung, Nadine Untch, Michae Vachon, Celine M. van den Ouweland, Ans M. W. van der Kolk, Lizet E. van Veen, Elke M. vanRensburg, Elizabeth J. Vega, Ana Wappenschmidt, Barbara Weinberg, Clarice R. Weitzel, Jeffrey N. Wildiers, Hans Winqvist, Robert Wolk, Alicja Yang, Xiaohong R. Yannoukakos, Drakoulis Zheng, Wei Zorn, Kristin K. Milne, Roger L. Kraft, Peter Simard , Jacques Pharoah , Paul D. P. Michailidou, Kyriaki Antoniou, Antonis C. Schmidt, Marjanka K. Chenevix-Trench, Georgia Easton, Douglas F. Chatterjee, Nilanjan García-Closas, Montserrat |
dc.contributor.corporatename.spa.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana |
dc.contributor.javerianateacher.none.fl_str_mv |
Briceño Balcázar, Ignacio Torres-López, Diana María |
description |
Q1 |
publishDate |
2020 |
dc.date.created.none.fl_str_mv |
2020-05-18 |
dc.date.accessioned.none.fl_str_mv |
2023-03-22T15:44:02Z |
dc.date.available.none.fl_str_mv |
2023-03-22T15:44:02Z |
dc.type.local.spa.fl_str_mv |
Artículo de revista |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_545b |
format |
http://purl.org/coar/resource_type/c_545b |
dc.identifier.spa.fl_str_mv |
https://revistas.javeriana.edu.co/index.php/revPsycho/article/view/21878 |
dc.identifier.issn.spa.fl_str_mv |
1061-4036 / 1546-1718 (Electrónico) |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/63882 |
dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1038/s41588-020-0609-2 |
dc.identifier.instname.spa.fl_str_mv |
instname:Pontificia Universidad Javeriana |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
dc.identifier.repourl.spa.fl_str_mv |
repourl:https://repository.javeriana.edu.co |
url |
https://revistas.javeriana.edu.co/index.php/revPsycho/article/view/21878 http://hdl.handle.net/10554/63882 https://doi.org/10.1038/s41588-020-0609-2 |
identifier_str_mv |
1061-4036 / 1546-1718 (Electrónico) instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationstartpage.spa.fl_str_mv |
572 |
dc.relation.citationendpage.spa.fl_str_mv |
581 |
dc.relation.ispartofjournal.spa.fl_str_mv |
Nature Genetics |
dc.relation.citationvolume.spa.fl_str_mv |
52 |
dc.relation.citationissue.spa.fl_str_mv |
6 |
dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
dc.format.spa.fl_str_mv |
PDF |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
institution |
Pontificia Universidad Javeriana |
bitstream.url.fl_str_mv |
http://repository.javeriana.edu.co/bitstream/10554/63882/1/Genome-wide%20association%20study%20identifies%2032%20novel%20breast%20cancer%20susceptibility%20loci%20from%20overall%20and%20subtype-specific%20analyses.pdf http://repository.javeriana.edu.co/bitstream/10554/63882/2/license.txt http://repository.javeriana.edu.co/bitstream/10554/63882/3/Genome-wide%20association%20study%20identifies%2032%20novel%20breast%20cancer%20susceptibility%20loci%20from%20overall%20and%20subtype-specific%20analyses.pdf.jpg |
bitstream.checksum.fl_str_mv |
efffb4b987cf3673edb7da9c63c8c307 2070d280cc89439d983d9eee1b17df53 99690fc0a783bbcd9c1b6bccf166a912 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional - Pontificia Universidad Javeriana |
repository.mail.fl_str_mv |
repositorio@javeriana.edu.co |
_version_ |
1811671093892612096 |
spelling |
Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Bogdanova, Natalia V.Bojesen, Stig E.Bonanni , BernardoBondavalli, DavideBorg, AkeBrauch, HiltrudBrenner, HermannBriceño Balcázar, IgnacioBroeks, AnnegienBrucker, Sara Y.Brüning, ThomasBurwinkel, BarbaraBuys, Saundra S.Byers, HelenCaldés, TrinidadCaligo, Maria A.Calvello, MariarosariaCampa, DanieleCastelao, Jose E.Chang-Claude, JennyChanock, Stephen J.Christiaens, MelissaChristiansen, HansChung, Wendy K.Claes, Kathleen B. M.Clarke, Christine L.Cornelissen, StenCouch, Fergus J.Cox, AngelaCross, Simon S.Czene, KamilaDaly, Mary B.Devilee, PeterDiez, OrlandDomchek, Susan M.Dörk, ThiloDwek, MiriamEccles, Diana M.Ekici, Arif B.Evans, D. GarethFasching, Peter A.Figueroa, JonineForetova, LenkaFostira, FlorentiaFriedman, EitanFrost, DebraGago-Dominguez, ManuelaGapstur, Susan M.Garber, JudyGarcía-Sáenz, José A.Gaudet, Mia M.Gayther, Simon A.Giles, Graham G.Godwin, Andrew K.Goldberg, Mark S.Goldgar, David E.González-Neira, AnnaGreene, Mark H.Gronwald, JacekGuénel, PascalHäberle, LotharHahnen, EricHaiman, Christopher A.Hake, Christopher R.Hall, PerHamann, UteHarkness, Elaine F.Heemskerk-Gerritsen, Bernadette A. M.Hillemanns, PeterHogervorst, Frans B. L.Holleczek, BerndHollestelle, AntoinetteHooning, Maartje J.Hoover, Robert N.Hopper, John L.Howell, AnthonyHuebner, HannaHulick, Peter J.Imyanitov, Evgeny N.kConFab InvestigatorsABCTB InvestigatorsIsaacs, ClaudineIzatt, LouiseJager, AgnesJakimovska, MilenaJakubowska, AnnaJames, Paul A.Janavicius, RamunasJanni, WolfgangJohn, Esther M.Jones, Michael E.Jung, AudreyKaaks, RudolfKapoor, Pooja MiddhaKarlan, Beth Y.Keeman, RenskeKhan, SofiaKhusnutdinova, ElzaKitahara, Cari M.Ko, Yon-DschunKonstantopoulou, IreneKoppert, Linetta B.Koutros, StellaKristensen, Vessela N.Laenkholm, Anne-VibekeLambrechts, DietherLarsson, Susanna CLaurent-Puig, PierreLazaro, ConxiLazarova, EmilijaLejbkowicz, FlavioLeslie, GoskaLesueur, FabienneLindblom, AnnikaLissowska, JolantaLo, Wing-YeeLoud, Jennifer T.Lubinski, JanLukomska, AlicjaMacInnis, Robert J.Mannermaa, ArtoManoochehri, MehdiManoukian, SiranoushMargolin, SaraMartinez, Maria ElenaMatricardi, LauraMcGuffog, LesleyMcLean, CatrionaMebirouk, NouraMeindl, AlfonsMenon, UshaMiller, AustinMingazheva, ElviraMontagna, MarcoMulligan, Anna MarieMulot, ClaireMuranen, Taru A.Nathanson, Katherine L.Neuhausen, Susan L.Nevanlinna, HeliNeven, PatrickNewman, William G.Nielsen, Finn C.Nikitina-Zake, LieneNodora, JesseOffit, KennethOlah, EdithOlopade, Olufunmilayo I.Olsson, HåkanOrr, NickPapi, LauraPapp, JanosPark-Simon, Tjoung-WonParsons, Michael T.Peissel, BernardPeixoto, Sergio V.Peshkin, BethPeterlongo, PaoloPeto, JulianPhillips, Kelly-AnnePiedmonte, MarionPlaseska-Karanfilska, DijanaPrajzendanc, KarolinaPrentice, RossProkofyeva, DaryaRack, BrigitteRadice, PaoloRamus, Susan J.Rantala, JohannaRashid, Muhammad U.Rennert, GadRennert, GadRisch, Harvey A.Romero , AtochaRookus, Matti A.Rübner, MatthiasRüdiger, ThomasSaloustros, EmmanouilSampson, SarahSandler, Dale P.Sawyer, Elinor J.Scheuner, Maren T.Schmutzler, Rita K.Schneeweiss, AndreasSchoemaker, Minouk J.Schöttker, BenSchürmann, PeterSenter, LeighaSharma, PriyankaSherman, Mark E.Shu, Xiao-OuSinger, Christian F.Smichkoska, SnezhanaSoucy, PennySouthey, Melissa C.Spinelli, John J.Stone, JenniferStoppa-Lyonnet, DominiqueEMBRACE StudyGEMO Study CollaboratorsSwerdlow, Anthony J.Szabova, ElenaTamimi, Rulla M.Tapper, William J.Taylor, Jack A.Teixeira, Manuel R.Terry, Mary BethThomassen, MadsThull, Darcy L.Tischkowitz, MarcToland, Amanda E.Tollenaar, Rob A.E.M.Tomlinson, IanTorres-López, Diana MaríaTroester, Melissa A.Truong, ThérèseTung, NadineUntch, MichaeVachon, Celine M.van den Ouweland, Ans M. W.van der Kolk, Lizet E.van Veen, Elke M.vanRensburg, Elizabeth J.Vega, AnaWappenschmidt, BarbaraWeinberg, Clarice R.Weitzel, Jeffrey N.Wildiers, HansWinqvist, RobertWolk, AlicjaYang, Xiaohong R.Yannoukakos, DrakoulisZheng, WeiZorn, Kristin K.Milne, Roger L.Kraft, PeterSimard , JacquesPharoah , Paul D. P.Michailidou, KyriakiAntoniou, Antonis C.Schmidt, Marjanka K.Chenevix-Trench, GeorgiaEaston, Douglas F.Chatterjee, NilanjanGarcía-Closas, MontserratPontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética HumanaBriceño Balcázar, IgnacioTorres-López, Diana María2023-03-22T15:44:02Z2023-03-22T15:44:02Z2020-05-18https://revistas.javeriana.edu.co/index.php/revPsycho/article/view/218781061-4036 / 1546-1718 (Electrónico)http://hdl.handle.net/10554/63882https://doi.org/10.1038/s41588-020-0609-2instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengGenome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analysesArtículo de revistahttp://purl.org/coar/resource_type/c_545bQ1Q1Mujeres con Cáncer de mamaBreast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype1–3. To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 status and tumor grade. We identified 32 novel susceptibility loci (P< 5.0 × 10−8), 15 of which showed evidence for associations with at least one tumor feature (false discovery rate < 0.05). Five loci showed associations (P< 0.05) in opposite directions between luminal and non-luminal subtypes. In silico analyses showed that these five loci contained cell-specific enhancers that differed between normal luminal and basal mammary cells. The genetic correlations between five intrinsic-like subtypes ranged from 0.35 to 0.80. The proportion of genome-wide chip heritability explained by all known susceptibility loci was 54.2% for luminal A-like disease and 37.6% for triple-negative disease. The odds ratios of polygenic risk scores, which included 330 variants, for the highest 1% of quantiles compared with middle quantiles were 5.63 and 3.02 for luminal A-like and triple-negative disease, respectively. These findings provide an improved understanding of genetic predisposition to breast cancer subtypes and will inform the development of subtype-specific polygenic risk scores.https://orcid.org/0000-0001-7300-6401https://orcid.org/0000-0002-9879-9775Revista Internacional - IndexadaA1No572581Nature Genetics526ORIGINALGenome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses.pdfGenome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses.pdfArtículoapplication/pdf4491030http://repository.javeriana.edu.co/bitstream/10554/63882/1/Genome-wide%20association%20study%20identifies%2032%20novel%20breast%20cancer%20susceptibility%20loci%20from%20overall%20and%20subtype-specific%20analyses.pdfefffb4b987cf3673edb7da9c63c8c307MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/63882/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessTHUMBNAILGenome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses.pdf.jpgGenome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses.pdf.jpgIM Thumbnailimage/jpeg15895http://repository.javeriana.edu.co/bitstream/10554/63882/3/Genome-wide%20association%20study%20identifies%2032%20novel%20breast%20cancer%20susceptibility%20loci%20from%20overall%20and%20subtype-specific%20analyses.pdf.jpg99690fc0a783bbcd9c1b6bccf166a912MD53open access10554/63882oai:repository.javeriana.edu.co:10554/638822023-03-23 03:04:36.256Repositorio Institucional - Pontificia Universidad Javerianarepositorio@javeriana.edu.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 |