Insulin glargine compared with premixed insulin for management of insulin-naïve type 2 diabetes patients uncontrolled on oral antidiabetic drugs : the open-label, randomized GALAPAGOS study
Q3
- Autores:
-
Aschner Montoya, Pablo
Sethi, Bipin
Gómez Peralta, Fernando
Landgraf, Wolfgang
Loizeau, Virginie
Dain, Marie Paule
Pilorget, Valerie
Comlekci, Abdurrahman
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2015
- Institución:
- Pontificia Universidad Javeriana
- Repositorio:
- Repositorio Universidad Javeriana
- Idioma:
- eng
- OAI Identifier:
- oai:repository.javeriana.edu.co:10554/52976
- Acceso en línea:
- https://www.sciencedirect.com/science/article/pii/S1056872715001609?via%3Dihub
http://hdl.handle.net/10554/52976
https://doi.org/10.1016/j.jdiacomp.2015.04.003
- Palabra clave:
- Galapagos
Hypoglycemia
Insulin glargine
Premixed insulin
Type 2 diabetes
- Rights
- License
- Atribución-NoComercial 4.0 Internacional
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Repositorio Universidad Javeriana |
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| dc.title.spa.fl_str_mv |
Insulin glargine compared with premixed insulin for management of insulin-naïve type 2 diabetes patients uncontrolled on oral antidiabetic drugs : the open-label, randomized GALAPAGOS study |
| title |
Insulin glargine compared with premixed insulin for management of insulin-naïve type 2 diabetes patients uncontrolled on oral antidiabetic drugs : the open-label, randomized GALAPAGOS study |
| spellingShingle |
Insulin glargine compared with premixed insulin for management of insulin-naïve type 2 diabetes patients uncontrolled on oral antidiabetic drugs : the open-label, randomized GALAPAGOS study Galapagos Hypoglycemia Insulin glargine Premixed insulin Type 2 diabetes |
| title_short |
Insulin glargine compared with premixed insulin for management of insulin-naïve type 2 diabetes patients uncontrolled on oral antidiabetic drugs : the open-label, randomized GALAPAGOS study |
| title_full |
Insulin glargine compared with premixed insulin for management of insulin-naïve type 2 diabetes patients uncontrolled on oral antidiabetic drugs : the open-label, randomized GALAPAGOS study |
| title_fullStr |
Insulin glargine compared with premixed insulin for management of insulin-naïve type 2 diabetes patients uncontrolled on oral antidiabetic drugs : the open-label, randomized GALAPAGOS study |
| title_full_unstemmed |
Insulin glargine compared with premixed insulin for management of insulin-naïve type 2 diabetes patients uncontrolled on oral antidiabetic drugs : the open-label, randomized GALAPAGOS study |
| title_sort |
Insulin glargine compared with premixed insulin for management of insulin-naïve type 2 diabetes patients uncontrolled on oral antidiabetic drugs : the open-label, randomized GALAPAGOS study |
| dc.creator.fl_str_mv |
Aschner Montoya, Pablo Sethi, Bipin Gómez Peralta, Fernando Landgraf, Wolfgang Loizeau, Virginie Dain, Marie Paule Pilorget, Valerie Comlekci, Abdurrahman |
| dc.contributor.author.none.fl_str_mv |
Aschner Montoya, Pablo Sethi, Bipin Gómez Peralta, Fernando Landgraf, Wolfgang Loizeau, Virginie Dain, Marie Paule Pilorget, Valerie Comlekci, Abdurrahman |
| dc.contributor.corporatename.none.fl_str_mv |
Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Endocrinología |
| dc.subject.keyword.spa.fl_str_mv |
Galapagos Hypoglycemia Insulin glargine Premixed insulin Type 2 diabetes |
| topic |
Galapagos Hypoglycemia Insulin glargine Premixed insulin Type 2 diabetes |
| description |
Q3 |
| publishDate |
2015 |
| dc.date.created.none.fl_str_mv |
2015-08 |
| dc.date.accessioned.none.fl_str_mv |
2021-02-17T04:08:05Z |
| dc.date.available.none.fl_str_mv |
2021-02-17T04:08:05Z |
| dc.type.local.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_6501 |
| format |
http://purl.org/coar/resource_type/c_6501 |
| dc.identifier.spa.fl_str_mv |
https://www.sciencedirect.com/science/article/pii/S1056872715001609?via%3Dihub |
| dc.identifier.issn.spa.fl_str_mv |
1056-8727 / 1873-460X (Electrónico) |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10554/52976 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1016/j.jdiacomp.2015.04.003 |
| dc.identifier.instname.spa.fl_str_mv |
instname:Pontificia Universidad Javeriana |
| dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional - Pontificia Universidad Javeriana |
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repourl:https://repository.javeriana.edu.co |
| url |
https://www.sciencedirect.com/science/article/pii/S1056872715001609?via%3Dihub http://hdl.handle.net/10554/52976 https://doi.org/10.1016/j.jdiacomp.2015.04.003 |
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1056-8727 / 1873-460X (Electrónico) instname:Pontificia Universidad Javeriana reponame:Repositorio Institucional - Pontificia Universidad Javeriana repourl:https://repository.javeriana.edu.co |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationstartpage.spa.fl_str_mv |
838 |
| dc.relation.citationendpage.spa.fl_str_mv |
845 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Journal of Diabetes and its Complications |
| dc.relation.citationvolume.spa.fl_str_mv |
29 |
| dc.relation.citationissue.spa.fl_str_mv |
6 |
| dc.rights.licence.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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PDF |
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application/pdf |
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Pontificia Universidad Javeriana |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2Aschner Montoya, PabloSethi, BipinGómez Peralta, FernandoLandgraf, WolfgangLoizeau, VirginieDain, Marie PaulePilorget, ValerieComlekci, AbdurrahmanPontificia Universidad Javeriana. Facultad de Medicina. Departamento de Endocrinología2021-02-17T04:08:05Z2021-02-17T04:08:05Z2015-08https://www.sciencedirect.com/science/article/pii/S1056872715001609?via%3Dihub1056-8727 / 1873-460X (Electrónico)http://hdl.handle.net/10554/52976https://doi.org/10.1016/j.jdiacomp.2015.04.003instname:Pontificia Universidad Javerianareponame:Repositorio Institucional - Pontificia Universidad Javerianarepourl:https://repository.javeriana.edu.coPDFapplication/pdfengInsulin glargine compared with premixed insulin for management of insulin-naïve type 2 diabetes patients uncontrolled on oral antidiabetic drugs : the open-label, randomized GALAPAGOS studyArtículo de revistahttp://purl.org/coar/resource_type/c_6501Q3Q1Aims: Demonstrate superiority of insulin glargine (±glulisine) strategy versus premixed insulin strategy for percentage of patients reaching HbA1c b7% (b53 mmol/mol) at study end without any documented symptomatic hypoglycemia (bloof glucose [BG] ≤3.1 mmol/L) in type 2 diabetes (T2DM) patients failing oral agents. Methods: This 24-week, open-label, multinational trial randomized patients to glargine OD or premix OD or BID, continuing metformin ± insulin secretagogue (IS). Second premix injection could be added any time; glulisine could be added with main meal in glargine OD patients with HbA1c ≥7% and fasting blood glucose (FBG) b7 mmol/L at week 12. IS was stopped with any second injection. Insulin titration targeted FBG ≤5.6 mmol/L. Results: Modifiedintent-to-treat population comprised 923 patients (glargine, 462; premix, 461). Baseline characteristics were similar (mean T2DM duration: 9 years; HbA1c: 8.7% (72 mmol/mol); FBG: 10.4 mmol/L). Primary endpoint was achieved by 33.2% of glargine (±glulisine) and 31.4% of premix patients. Superiority was not demonstrated, but non-inferiority was (pre-specifiedmargin: 25% of premix rate). More patients using premix achieved target (52.6% vs. 43.2%, p = 0.005); symptomatic hypoglycemia was less with glargine (1.17 vs. 2.93 events/patient–year). Conclusions: Glargine (±glulisine) and premix strategies resulted in similar percentages of well-controlled patients without hypoglycemia, with more patients achieving target HbA1c with premix whereas overall symptomatic hypoglycemia was less with glargine.N/AGalapagosHypoglycemiaInsulin glarginePremixed insulinType 2 diabetes838845Journal of Diabetes and its Complications296LICENSElicense.txtlicense.txttext/plain; charset=utf-82603http://repository.javeriana.edu.co/bitstream/10554/52976/2/license.txt2070d280cc89439d983d9eee1b17df53MD52open accessORIGINALInsulin glargine compared with premixed insulin for management of insulin-naïve type 2 diabetes patients uncontrolled on oral antidiabetic drugs_ the open-label, randomized GALAPAGOS study.pdfInsulin glargine compared with premixed insulin for management of insulin-naïve type 2 diabetes patients uncontrolled on oral antidiabetic drugs_ the open-label, randomized GALAPAGOS study.pdfArtículoapplication/pdf674512http://repository.javeriana.edu.co/bitstream/10554/52976/1/Insulin%20glargine%20compared%20with%20premixed%20insulin%20for%20management%20of%20insulin-na%c3%afve%20type%202%20diabetes%20patients%20uncontrolled%20on%20oral%20antidiabetic%20drugs_%20the%20open-label%2c%20randomized%20GALAPAGOS%20study.pdf5ef5d7babd5773872de19bc44b0e0f23MD51open accessTHUMBNAILInsulin glargine compared with premixed insulin for management of insulin-naïve type 2 diabetes patients uncontrolled on oral antidiabetic drugs_ the open-label, randomized GALAPAGOS study.pdf.jpgInsulin glargine compared with premixed insulin for management of insulin-naïve type 2 diabetes patients uncontrolled on oral antidiabetic drugs_ the open-label, randomized GALAPAGOS study.pdf.jpgIM Thumbnailimage/jpeg13386http://repository.javeriana.edu.co/bitstream/10554/52976/3/Insulin%20glargine%20compared%20with%20premixed%20insulin%20for%20management%20of%20insulin-na%c3%afve%20type%202%20diabetes%20patients%20uncontrolled%20on%20oral%20antidiabetic%20drugs_%20the%20open-label%2c%20randomized%20GALAPAGOS%20study.pdf.jpg229415eff4bc061998c2aa5d56b221a1MD53open access10554/52976oai:repository.javeriana.edu.co:10554/529762021-10-22 14:55:37.974Repositorio Institucional - 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