A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis
Background: Large animals treated with immunosuppressive drugs for preclinical experiments of transplantation have increased risks of infection, which can be compounded by the induction of diabetes if islet transplantation is planned. Methods: We report our experience with severe sepsis in two young...
- Autores:
-
Echeverri Junca, Gabriel Jaime
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2012
- Institución:
- Universidad ICESI
- Repositorio:
- Repositorio ICESI
- Idioma:
- spa
- OAI Identifier:
- oai:repository.icesi.edu.co:10906/78456
- Acceso en línea:
- http://journals.lww.com/transplantjournal/pages/results.aspx?fs=%5b%7b%22Operator%22%3a%22and%22%2c%22Field%22%3a%22Title%22%2c%22Key%22%3a%22A+Syndrome+Of+Severe+Hypoglycemia+And+Acidosis+In%22%7d%5d
http://hdl.handle.net/10906/78456
http://dx.doi.org/10.1097/TP.0b013e318272210c
- Palabra clave:
- Acidosis, metabolic
Hypoglycemia
Infection
Islet transplantationMonkey
Biomedical sciences
Ciencias socio biomédicas
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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Echeverri Junca, Gabriel Jaimegjecheverri@icesi.edu.coEstados Unidos de Lat: 38 00 00 N degrees minutes Lat: 38.0000 decimal degrees Long: 098 00 00 W degrees minutes Long: -98.0000 decimal degrees2015-10-13T21:05:50Z2015-10-13T21:05:50Z2012-12-271534-6080http://journals.lww.com/transplantjournal/pages/results.aspx?fs=%5b%7b%22Operator%22%3a%22and%22%2c%22Field%22%3a%22Title%22%2c%22Key%22%3a%22A+Syndrome+Of+Severe+Hypoglycemia+And+Acidosis+In%22%7d%5dhttp://hdl.handle.net/10906/78456http://dx.doi.org/10.1097/TP.0b013e318272210cinstname: Universidad Icesireponame: Biblioteca Digitalrepourl: https://repository.icesi.edu.co/Background: Large animals treated with immunosuppressive drugs for preclinical experiments of transplantation have increased risks of infection, which can be compounded by the induction of diabetes if islet transplantation is planned. Methods: We report our experience with severe sepsis in two young cynomolgus monkeys and five pigs that were subjected to diabetes induction, immunosuppressive therapy, or islet allotransplantation. Results: In two monkeys and five pigs, infection was associated with a syndrome of profound hypoglycemia accompanied by severe acidosis, which was resistant to treatment. We do not believe that this syndrome has been reported previously by others. Conclusions: Despite treatment, this syndrome complicated the interpretation of blood glucose readings as a measure of islet graft function and resulted in death or the need for euthanasia in all seven animals. We tentatively suggest that the syndrome may be related to the presence of microorganisms that metabolize glucose and produce lactate.5 páginasDigitalapplication/pdfspaWolters Kluwer Health, Inc.Facultad de Ciencias de la saludMedicinaCiencias Básicas MédicasEstados UnidosTransplantation, Vol. 94, No12 - 2012EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2Acidosis, metabolicHypoglycemiaInfectionIslet transplantationMonkeyBiomedical sciencesCiencias socio biomédicasA Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsisinfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1Artículoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Comunidad Universidad Icesi – Investigadores941211871191ORIGINALecheverri_syndrome_severe_2012.pdfecheverri_syndrome_severe_2012.pdfapplication/pdf326227http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/78456/1/echeverri_syndrome_severe_2012.pdf5386fa9bea03137480d6ea35e118d640MD5110906/78456oai:repository.icesi.edu.co:10906/784562018-10-23 14:00:24.283Biblioteca Digital - Universidad icesicdcriollo@icesi.edu.co |
dc.title.spa.fl_str_mv |
A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis |
title |
A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis |
spellingShingle |
A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis Acidosis, metabolic Hypoglycemia Infection Islet transplantationMonkey Biomedical sciences Ciencias socio biomédicas |
title_short |
A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis |
title_full |
A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis |
title_fullStr |
A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis |
title_full_unstemmed |
A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis |
title_sort |
A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis |
dc.creator.fl_str_mv |
Echeverri Junca, Gabriel Jaime |
dc.contributor.author.spa.fl_str_mv |
Echeverri Junca, Gabriel Jaime |
dc.subject.eng.fl_str_mv |
Acidosis, metabolic Hypoglycemia Infection Islet transplantationMonkey Biomedical sciences |
topic |
Acidosis, metabolic Hypoglycemia Infection Islet transplantationMonkey Biomedical sciences Ciencias socio biomédicas |
dc.subject.spa.fl_str_mv |
Ciencias socio biomédicas |
description |
Background: Large animals treated with immunosuppressive drugs for preclinical experiments of transplantation have increased risks of infection, which can be compounded by the induction of diabetes if islet transplantation is planned. Methods: We report our experience with severe sepsis in two young cynomolgus monkeys and five pigs that were subjected to diabetes induction, immunosuppressive therapy, or islet allotransplantation. Results: In two monkeys and five pigs, infection was associated with a syndrome of profound hypoglycemia accompanied by severe acidosis, which was resistant to treatment. We do not believe that this syndrome has been reported previously by others. Conclusions: Despite treatment, this syndrome complicated the interpretation of blood glucose readings as a measure of islet graft function and resulted in death or the need for euthanasia in all seven animals. We tentatively suggest that the syndrome may be related to the presence of microorganisms that metabolize glucose and produce lactate. |
publishDate |
2012 |
dc.date.issued.none.fl_str_mv |
2012-12-27 |
dc.date.accessioned.none.fl_str_mv |
2015-10-13T21:05:50Z |
dc.date.available.none.fl_str_mv |
2015-10-13T21:05:50Z |
dc.type.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.local.spa.fl_str_mv |
Artículo |
dc.type.version.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
status_str |
publishedVersion |
dc.identifier.issn.none.fl_str_mv |
1534-6080 |
dc.identifier.other.spa.fl_str_mv |
http://journals.lww.com/transplantjournal/pages/results.aspx?fs=%5b%7b%22Operator%22%3a%22and%22%2c%22Field%22%3a%22Title%22%2c%22Key%22%3a%22A+Syndrome+Of+Severe+Hypoglycemia+And+Acidosis+In%22%7d%5d |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10906/78456 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1097/TP.0b013e318272210c |
dc.identifier.instname.none.fl_str_mv |
instname: Universidad Icesi |
dc.identifier.reponame.none.fl_str_mv |
reponame: Biblioteca Digital |
dc.identifier.repourl.none.fl_str_mv |
repourl: https://repository.icesi.edu.co/ |
identifier_str_mv |
1534-6080 instname: Universidad Icesi reponame: Biblioteca Digital repourl: https://repository.icesi.edu.co/ |
url |
http://journals.lww.com/transplantjournal/pages/results.aspx?fs=%5b%7b%22Operator%22%3a%22and%22%2c%22Field%22%3a%22Title%22%2c%22Key%22%3a%22A+Syndrome+Of+Severe+Hypoglycemia+And+Acidosis+In%22%7d%5d http://hdl.handle.net/10906/78456 http://dx.doi.org/10.1097/TP.0b013e318272210c |
dc.language.iso.spa.fl_str_mv |
spa |
language |
spa |
dc.relation.ispartof.none.fl_str_mv |
Transplantation, Vol. 94, No12 - 2012 |
dc.rights.uri.none.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.license.none.fl_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
dc.rights.coar.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.format.extent.spa.fl_str_mv |
5 páginas |
dc.format.medium.spa.fl_str_mv |
Digital |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.coverage.spatial.none.fl_str_mv |
Estados Unidos de Lat: 38 00 00 N degrees minutes Lat: 38.0000 decimal degrees Long: 098 00 00 W degrees minutes Long: -98.0000 decimal degrees |
dc.publisher.spa.fl_str_mv |
Wolters Kluwer Health, Inc. |
dc.publisher.faculty.spa.fl_str_mv |
Facultad de Ciencias de la salud |
dc.publisher.program.spa.fl_str_mv |
Medicina |
dc.publisher.department.spa.fl_str_mv |
Ciencias Básicas Médicas |
dc.publisher.place.spa.fl_str_mv |
Estados Unidos |
institution |
Universidad ICESI |
bitstream.url.fl_str_mv |
http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/78456/1/echeverri_syndrome_severe_2012.pdf |
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5386fa9bea03137480d6ea35e118d640 |
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MD5 |
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Biblioteca Digital - Universidad icesi |
repository.mail.fl_str_mv |
cdcriollo@icesi.edu.co |
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1814094861959168000 |