A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis

Background: Large animals treated with immunosuppressive drugs for preclinical experiments of transplantation have increased risks of infection, which can be compounded by the induction of diabetes if islet transplantation is planned. Methods: We report our experience with severe sepsis in two young...

Full description

Autores:
Echeverri Junca, Gabriel Jaime
Tipo de recurso:
Article of investigation
Fecha de publicación:
2012
Institución:
Universidad ICESI
Repositorio:
Repositorio ICESI
Idioma:
spa
OAI Identifier:
oai:repository.icesi.edu.co:10906/78456
Acceso en línea:
http://journals.lww.com/transplantjournal/pages/results.aspx?fs=%5b%7b%22Operator%22%3a%22and%22%2c%22Field%22%3a%22Title%22%2c%22Key%22%3a%22A+Syndrome+Of+Severe+Hypoglycemia+And+Acidosis+In%22%7d%5d
http://hdl.handle.net/10906/78456
http://dx.doi.org/10.1097/TP.0b013e318272210c
Palabra clave:
Acidosis, metabolic
Hypoglycemia
Infection
Islet transplantationMonkey
Biomedical sciences
Ciencias socio biomédicas
Rights
openAccess
License
https://creativecommons.org/licenses/by-nc-nd/4.0/
id ICESI2_fe3d894c0f53eec06c9592534242a4ba
oai_identifier_str oai:repository.icesi.edu.co:10906/78456
network_acronym_str ICESI2
network_name_str Repositorio ICESI
repository_id_str
spelling Echeverri Junca, Gabriel Jaimegjecheverri@icesi.edu.coEstados Unidos de Lat: 38 00 00 N degrees minutes Lat: 38.0000 decimal degrees Long: 098 00 00 W degrees minutes Long: -98.0000 decimal degrees2015-10-13T21:05:50Z2015-10-13T21:05:50Z2012-12-271534-6080http://journals.lww.com/transplantjournal/pages/results.aspx?fs=%5b%7b%22Operator%22%3a%22and%22%2c%22Field%22%3a%22Title%22%2c%22Key%22%3a%22A+Syndrome+Of+Severe+Hypoglycemia+And+Acidosis+In%22%7d%5dhttp://hdl.handle.net/10906/78456http://dx.doi.org/10.1097/TP.0b013e318272210cinstname: Universidad Icesireponame: Biblioteca Digitalrepourl: https://repository.icesi.edu.co/Background: Large animals treated with immunosuppressive drugs for preclinical experiments of transplantation have increased risks of infection, which can be compounded by the induction of diabetes if islet transplantation is planned. Methods: We report our experience with severe sepsis in two young cynomolgus monkeys and five pigs that were subjected to diabetes induction, immunosuppressive therapy, or islet allotransplantation. Results: In two monkeys and five pigs, infection was associated with a syndrome of profound hypoglycemia accompanied by severe acidosis, which was resistant to treatment. We do not believe that this syndrome has been reported previously by others. Conclusions: Despite treatment, this syndrome complicated the interpretation of blood glucose readings as a measure of islet graft function and resulted in death or the need for euthanasia in all seven animals. We tentatively suggest that the syndrome may be related to the presence of microorganisms that metabolize glucose and produce lactate.5 páginasDigitalapplication/pdfspaWolters Kluwer Health, Inc.Facultad de Ciencias de la saludMedicinaCiencias Básicas MédicasEstados UnidosTransplantation, Vol. 94, No12 - 2012EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2Acidosis, metabolicHypoglycemiaInfectionIslet transplantationMonkeyBiomedical sciencesCiencias socio biomédicasA Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsisinfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1Artículoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Comunidad Universidad Icesi – Investigadores941211871191ORIGINALecheverri_syndrome_severe_2012.pdfecheverri_syndrome_severe_2012.pdfapplication/pdf326227http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/78456/1/echeverri_syndrome_severe_2012.pdf5386fa9bea03137480d6ea35e118d640MD5110906/78456oai:repository.icesi.edu.co:10906/784562018-10-23 14:00:24.283Biblioteca Digital - Universidad icesicdcriollo@icesi.edu.co
dc.title.spa.fl_str_mv A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis
title A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis
spellingShingle A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis
Acidosis, metabolic
Hypoglycemia
Infection
Islet transplantationMonkey
Biomedical sciences
Ciencias socio biomédicas
title_short A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis
title_full A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis
title_fullStr A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis
title_full_unstemmed A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis
title_sort A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis
dc.creator.fl_str_mv Echeverri Junca, Gabriel Jaime
dc.contributor.author.spa.fl_str_mv Echeverri Junca, Gabriel Jaime
dc.subject.eng.fl_str_mv Acidosis, metabolic
Hypoglycemia
Infection
Islet transplantationMonkey
Biomedical sciences
topic Acidosis, metabolic
Hypoglycemia
Infection
Islet transplantationMonkey
Biomedical sciences
Ciencias socio biomédicas
dc.subject.spa.fl_str_mv Ciencias socio biomédicas
description Background: Large animals treated with immunosuppressive drugs for preclinical experiments of transplantation have increased risks of infection, which can be compounded by the induction of diabetes if islet transplantation is planned. Methods: We report our experience with severe sepsis in two young cynomolgus monkeys and five pigs that were subjected to diabetes induction, immunosuppressive therapy, or islet allotransplantation. Results: In two monkeys and five pigs, infection was associated with a syndrome of profound hypoglycemia accompanied by severe acidosis, which was resistant to treatment. We do not believe that this syndrome has been reported previously by others. Conclusions: Despite treatment, this syndrome complicated the interpretation of blood glucose readings as a measure of islet graft function and resulted in death or the need for euthanasia in all seven animals. We tentatively suggest that the syndrome may be related to the presence of microorganisms that metabolize glucose and produce lactate.
publishDate 2012
dc.date.issued.none.fl_str_mv 2012-12-27
dc.date.accessioned.none.fl_str_mv 2015-10-13T21:05:50Z
dc.date.available.none.fl_str_mv 2015-10-13T21:05:50Z
dc.type.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.local.spa.fl_str_mv Artículo
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
format http://purl.org/coar/resource_type/c_2df8fbb1
status_str publishedVersion
dc.identifier.issn.none.fl_str_mv 1534-6080
dc.identifier.other.spa.fl_str_mv http://journals.lww.com/transplantjournal/pages/results.aspx?fs=%5b%7b%22Operator%22%3a%22and%22%2c%22Field%22%3a%22Title%22%2c%22Key%22%3a%22A+Syndrome+Of+Severe+Hypoglycemia+And+Acidosis+In%22%7d%5d
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10906/78456
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1097/TP.0b013e318272210c
dc.identifier.instname.none.fl_str_mv instname: Universidad Icesi
dc.identifier.reponame.none.fl_str_mv reponame: Biblioteca Digital
dc.identifier.repourl.none.fl_str_mv repourl: https://repository.icesi.edu.co/
identifier_str_mv 1534-6080
instname: Universidad Icesi
reponame: Biblioteca Digital
repourl: https://repository.icesi.edu.co/
url http://journals.lww.com/transplantjournal/pages/results.aspx?fs=%5b%7b%22Operator%22%3a%22and%22%2c%22Field%22%3a%22Title%22%2c%22Key%22%3a%22A+Syndrome+Of+Severe+Hypoglycemia+And+Acidosis+In%22%7d%5d
http://hdl.handle.net/10906/78456
http://dx.doi.org/10.1097/TP.0b013e318272210c
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.ispartof.none.fl_str_mv Transplantation, Vol. 94, No12 - 2012
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.license.none.fl_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.extent.spa.fl_str_mv 5 páginas
dc.format.medium.spa.fl_str_mv Digital
dc.format.mimetype.none.fl_str_mv application/pdf
dc.coverage.spatial.none.fl_str_mv Estados Unidos de Lat: 38 00 00 N degrees minutes Lat: 38.0000 decimal degrees Long: 098 00 00 W degrees minutes Long: -98.0000 decimal degrees
dc.publisher.spa.fl_str_mv Wolters Kluwer Health, Inc.
dc.publisher.faculty.spa.fl_str_mv Facultad de Ciencias de la salud
dc.publisher.program.spa.fl_str_mv Medicina
dc.publisher.department.spa.fl_str_mv Ciencias Básicas Médicas
dc.publisher.place.spa.fl_str_mv Estados Unidos
institution Universidad ICESI
bitstream.url.fl_str_mv http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/78456/1/echeverri_syndrome_severe_2012.pdf
bitstream.checksum.fl_str_mv 5386fa9bea03137480d6ea35e118d640
bitstream.checksumAlgorithm.fl_str_mv MD5
repository.name.fl_str_mv Biblioteca Digital - Universidad icesi
repository.mail.fl_str_mv cdcriollo@icesi.edu.co
_version_ 1814094861959168000