A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis

Background: Large animals treated with immunosuppressive drugs for preclinical experiments of transplantation have increased risks of infection, which can be compounded by the induction of diabetes if islet transplantation is planned. Methods: We report our experience with severe sepsis in two young...

Full description

Autores:
Echeverri Junca, Gabriel Jaime
Tipo de recurso:
Article of investigation
Fecha de publicación:
2012
Institución:
Universidad ICESI
Repositorio:
Repositorio ICESI
Idioma:
spa
OAI Identifier:
oai:repository.icesi.edu.co:10906/78456
Acceso en línea:
http://journals.lww.com/transplantjournal/pages/results.aspx?fs=%5b%7b%22Operator%22%3a%22and%22%2c%22Field%22%3a%22Title%22%2c%22Key%22%3a%22A+Syndrome+Of+Severe+Hypoglycemia+And+Acidosis+In%22%7d%5d
http://hdl.handle.net/10906/78456
http://dx.doi.org/10.1097/TP.0b013e318272210c
Palabra clave:
Acidosis, metabolic
Hypoglycemia
Infection
Islet transplantationMonkey
Biomedical sciences
Ciencias socio biomédicas
Rights
openAccess
License
https://creativecommons.org/licenses/by-nc-nd/4.0/
Description
Summary:Background: Large animals treated with immunosuppressive drugs for preclinical experiments of transplantation have increased risks of infection, which can be compounded by the induction of diabetes if islet transplantation is planned. Methods: We report our experience with severe sepsis in two young cynomolgus monkeys and five pigs that were subjected to diabetes induction, immunosuppressive therapy, or islet allotransplantation. Results: In two monkeys and five pigs, infection was associated with a syndrome of profound hypoglycemia accompanied by severe acidosis, which was resistant to treatment. We do not believe that this syndrome has been reported previously by others. Conclusions: Despite treatment, this syndrome complicated the interpretation of blood glucose readings as a measure of islet graft function and resulted in death or the need for euthanasia in all seven animals. We tentatively suggest that the syndrome may be related to the presence of microorganisms that metabolize glucose and produce lactate.