Thermodynamics of mixing of sodium naproxen and procaine hydrochloride in ethanol + water cosolvent mixtures

Thermodynamic functions Gibbs energy, enthalpy, and entropy of mixing of sodium naproxen and procaine hydrochloride were evaluated. Mixing quantities were calculated based on fusion calorimetric values obtained from differential scanning calorimetry measurements and equilibrium solubility values rep...

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Autores:
Mora Guerrero, Carolina Del Pilar
Vargas, Edgar F.
Delgado, Daniel R.
Martínez, Fleming
Monterroza, Diego R.
Sotomayor, Reinaldo G.
Tipo de recurso:
Article of investigation
Fecha de publicación:
2010
Institución:
Universidad ICESI
Repositorio:
Repositorio ICESI
Idioma:
eng
OAI Identifier:
oai:repository.icesi.edu.co:10906/79908
Acceso en línea:
http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0034-74182010000200003
http://hdl.handle.net/10906/79908
Palabra clave:
Biology
Ecology
Naproxeno sódico
Procaína clorhidrato
Proceso de mezcla
Cosolvencia; etanol
Termodinámica de soluciones
Rights
openAccess
License
https://creativecommons.org/licenses/by-nc-nd/4.0/
Description
Summary:Thermodynamic functions Gibbs energy, enthalpy, and entropy of mixing of sodium naproxen and procaine hydrochloride were evaluated. Mixing quantities were calculated based on fusion calorimetric values obtained from differential scanning calorimetry measurements and equilibrium solubility values reported in the literature for both drugs in ethanol + water mixtures. By means of enthalpy-entropy compensation analysis, non-linear ΔH°mix vs. ΔG°mix plots were obtained which indicates different mechanisms involved in the dissolution of these drugs according to mixtures composition. Nevertheless, the molecular and ionic events involved in the dissolution of this drug in this cosolvent system are unclear.