Efficacy and safety of anti-interleukin 6 receptor monoclonal antibody (tocilizumab) in Colombian patients with Takayasu arteritis.

Purpose: The aim of this study was to describe the efficacy and safety of anti–interleukin 6 receptor antibody (tocilizumab [TCZ]) in patients with severe or refractory Takayasu arteritis (TA). Methods: We describe 8 Colombian patients with severe and/or refractory TA treated with TCZ during a perio...

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Autores:
Cañas Dávila, Carlos Alberto
Tipo de recurso:
Article of investigation
Fecha de publicación:
2014
Institución:
Universidad ICESI
Repositorio:
Repositorio ICESI
Idioma:
eng
OAI Identifier:
oai:repository.icesi.edu.co:10906/78520
Acceso en línea:
http://journals.lww.com/jclinrheum/Abstract/2014/04000/Efficacy_and_Safety_of_Anti_Interleukin_6_Receptor.2.aspx
http://hdl.handle.net/10906/78520
http://dx.doi.org/10.1097/RHU.0000000000000098
Palabra clave:
Arteritis de Takayasu
Tratamiento
Ciencias socio biomédicas
Biomedical sciences
Medicina
Interleukin-6
Reumatología
Rights
openAccess
License
https://creativecommons.org/licenses/by-nc-nd/4.0/
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oai_identifier_str oai:repository.icesi.edu.co:10906/78520
network_acronym_str ICESI2
network_name_str Repositorio ICESI
repository_id_str
spelling Cañas Dávila, Carlos AlbertoPhiladelphia de Lat: 33 56 00 N degrees minutes Lat: 33.9333 decimal degrees Long: 085 32 00 W degrees minutes Long: -85.5333 decimal degrees2015-10-14T21:57:27Z2015-10-14T21:57:27Z2014-04-011076-1608http://journals.lww.com/jclinrheum/Abstract/2014/04000/Efficacy_and_Safety_of_Anti_Interleukin_6_Receptor.2.aspxhttp://hdl.handle.net/10906/78520http://dx.doi.org/10.1097/RHU.0000000000000098instname: Universidad Icesireponame: Biblioteca Digitalrepourl: https://repository.icesi.edu.co/Purpose: The aim of this study was to describe the efficacy and safety of anti–interleukin 6 receptor antibody (tocilizumab [TCZ]) in patients with severe or refractory Takayasu arteritis (TA). Methods: We describe 8 Colombian patients with severe and/or refractory TA treated with TCZ during a period of at least 9 months. Clinical, radiological, biological, and associated treatments were evaluated before, during, and after TCZ infusions. Results: The median age at evaluation was 31 years (12–43 years). All patients were female and experienced clinical and biological improvement, in addition to a corticosteroid-sparing effect from a median dose of 50 mg/d at baseline (30–60 mg/d) to 6.25 mg/d (2.5–10 mg/d) at 9 months. In 4 cases, in which imaging studies were available, an improvement was observed.4 pàginasDigitalapplication/pdfengLippincott, Williams & WilkinsFacultad Ciencias de la SaludMedicinaDepartamento de Ciencias Básicas MédicasPhiladelphiaJournal of Clinical Rheumatology, Vol. 20, No. 3 -2014EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2Arteritis de TakayasuTratamientoCiencias socio biomédicasBiomedical sciencesMedicinaInterleukin-6ReumatologíaEfficacy and safety of anti-interleukin 6 receptor monoclonal antibody (tocilizumab) in Colombian patients with Takayasu arteritis.info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1Artículoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Comunidad Universidad Icesi – Investigadores203125129ORIGINALdocumento.htmldocumento.htmltext/html305http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/78520/1/documento.htmlff8fa7630f76feff8cd2dad128830693MD5110906/78520oai:repository.icesi.edu.co:10906/785202018-10-10 17:56:55.3Biblioteca Digital - Universidad icesicdcriollo@icesi.edu.co
dc.title.spa.fl_str_mv Efficacy and safety of anti-interleukin 6 receptor monoclonal antibody (tocilizumab) in Colombian patients with Takayasu arteritis.
title Efficacy and safety of anti-interleukin 6 receptor monoclonal antibody (tocilizumab) in Colombian patients with Takayasu arteritis.
spellingShingle Efficacy and safety of anti-interleukin 6 receptor monoclonal antibody (tocilizumab) in Colombian patients with Takayasu arteritis.
Arteritis de Takayasu
Tratamiento
Ciencias socio biomédicas
Biomedical sciences
Medicina
Interleukin-6
Reumatología
title_short Efficacy and safety of anti-interleukin 6 receptor monoclonal antibody (tocilizumab) in Colombian patients with Takayasu arteritis.
title_full Efficacy and safety of anti-interleukin 6 receptor monoclonal antibody (tocilizumab) in Colombian patients with Takayasu arteritis.
title_fullStr Efficacy and safety of anti-interleukin 6 receptor monoclonal antibody (tocilizumab) in Colombian patients with Takayasu arteritis.
title_full_unstemmed Efficacy and safety of anti-interleukin 6 receptor monoclonal antibody (tocilizumab) in Colombian patients with Takayasu arteritis.
title_sort Efficacy and safety of anti-interleukin 6 receptor monoclonal antibody (tocilizumab) in Colombian patients with Takayasu arteritis.
dc.creator.fl_str_mv Cañas Dávila, Carlos Alberto
dc.contributor.author.spa.fl_str_mv Cañas Dávila, Carlos Alberto
dc.subject.spa.fl_str_mv Arteritis de Takayasu
Tratamiento
Ciencias socio biomédicas
Biomedical sciences
Medicina
Interleukin-6
topic Arteritis de Takayasu
Tratamiento
Ciencias socio biomédicas
Biomedical sciences
Medicina
Interleukin-6
Reumatología
dc.subject.none.fl_str_mv Reumatología
description Purpose: The aim of this study was to describe the efficacy and safety of anti–interleukin 6 receptor antibody (tocilizumab [TCZ]) in patients with severe or refractory Takayasu arteritis (TA). Methods: We describe 8 Colombian patients with severe and/or refractory TA treated with TCZ during a period of at least 9 months. Clinical, radiological, biological, and associated treatments were evaluated before, during, and after TCZ infusions. Results: The median age at evaluation was 31 years (12–43 years). All patients were female and experienced clinical and biological improvement, in addition to a corticosteroid-sparing effect from a median dose of 50 mg/d at baseline (30–60 mg/d) to 6.25 mg/d (2.5–10 mg/d) at 9 months. In 4 cases, in which imaging studies were available, an improvement was observed.
publishDate 2014
dc.date.issued.none.fl_str_mv 2014-04-01
dc.date.accessioned.none.fl_str_mv 2015-10-14T21:57:27Z
dc.date.available.none.fl_str_mv 2015-10-14T21:57:27Z
dc.type.eng.fl_str_mv info:eu-repo/semantics/article
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.local.spa.fl_str_mv Artículo
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dc.identifier.issn.none.fl_str_mv 1076-1608
dc.identifier.other.spa.fl_str_mv http://journals.lww.com/jclinrheum/Abstract/2014/04000/Efficacy_and_Safety_of_Anti_Interleukin_6_Receptor.2.aspx
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10906/78520
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1097/RHU.0000000000000098
dc.identifier.instname.none.fl_str_mv instname: Universidad Icesi
dc.identifier.reponame.none.fl_str_mv reponame: Biblioteca Digital
dc.identifier.repourl.none.fl_str_mv repourl: https://repository.icesi.edu.co/
identifier_str_mv 1076-1608
instname: Universidad Icesi
reponame: Biblioteca Digital
repourl: https://repository.icesi.edu.co/
url http://journals.lww.com/jclinrheum/Abstract/2014/04000/Efficacy_and_Safety_of_Anti_Interleukin_6_Receptor.2.aspx
http://hdl.handle.net/10906/78520
http://dx.doi.org/10.1097/RHU.0000000000000098
dc.language.iso.eng.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Journal of Clinical Rheumatology, Vol. 20, No. 3 -2014
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.license.none.fl_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.extent.none.fl_str_mv 4 pàginas
dc.format.medium.spa.fl_str_mv Digital
dc.format.mimetype.none.fl_str_mv application/pdf
dc.coverage.spatial.none.fl_str_mv Philadelphia de Lat: 33 56 00 N degrees minutes Lat: 33.9333 decimal degrees Long: 085 32 00 W degrees minutes Long: -85.5333 decimal degrees
dc.publisher.spa.fl_str_mv Lippincott, Williams & Wilkins
dc.publisher.faculty.spa.fl_str_mv Facultad Ciencias de la Salud
dc.publisher.program.spa.fl_str_mv Medicina
dc.publisher.department.spa.fl_str_mv Departamento de Ciencias Básicas Médicas
dc.publisher.place.none.fl_str_mv Philadelphia
institution Universidad ICESI
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repository.name.fl_str_mv Biblioteca Digital - Universidad icesi
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