Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial.

Background Periodontal disease (PD) is an infectious clinical entity characterized by the destruction of supporting tissues of the teeth as the result of a chronic inflammatory response in a susceptible host. It has been proposed that PD as subclinical infection may contribute to the etiology and to...

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Autores:: Contreras, Adolfo
Ramírez Escobar, Jorge Hernán
Arce, Roger

Tipo de recurso:: Article of investigation

Fecha de publicación:: 2011

Institución:: Universidad ICESI

Repositorio:: Repositorio ICESI

Idioma:: eng

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spelling	Contreras, AdolfoRamírez Escobar, Jorge HernánArce, Roger2015-10-14T21:57:26Z2015-10-14T21:57:26Z2011-02-161745-6215http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=21&SID=4BDShD6T2KTBoAZU7Ey&page=1&doc=1http://hdl.handle.net/10906/78514http://dx.doi.org/10.1186/1745-6215-12-46instname: Universidad Icesireponame: Biblioteca Digitalrepourl: https://repository.icesi.edu.co/Background Periodontal disease (PD) is an infectious clinical entity characterized by the destruction of supporting tissues of the teeth as the result of a chronic inflammatory response in a susceptible host. It has been proposed that PD as subclinical infection may contribute to the etiology and to the pathogenesis of several systemic diseases including Atherosclerosis. A number of epidemiological studies link periodontal disease/edentulism as independent risk factor for acute myocardial infarction, peripheral vascular disease, and cerebrovascular disease. Moreover, new randomized controlled clinical trials have shown an improvement on cardiovascular surrogate markers (endothelial function, sICAM, hsPCR level, fibrinogen) after periodontal treatment. Nonetheless, such trials are still limited in terms of external validity, periodontal treatment strategies, CONSORT-based design and results consistency/extrapolation. The current study is designed to evaluate if periodontal treatment with scaling and root planning plus local delivered chlorhexidine improves endothelial function and other biomarkers of cardiovascular disease in subjects with moderate to severe periodontitis.10 páginasDigitalapplication/pdfengTRIALS, Vol. 12, No. 46 - 2011EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2Enfermedad periodontalInfarto de miocardioCiencias socio biomédicasBiomedical sciencesEnfermedad cardiovascularPeriodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial.info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1Artículoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Comunidad Universidad Icesi – InvestigadoresFacultad Ciencias de la SaludMedicinaDepartamento de Ciencias Básicas Médicas1246110TEXTramirez_periodontal_treatment_2011.pdf.txtramirez_periodontal_treatment_2011.pdf.txttext/plain49729http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/78514/2/ramirez_periodontal_treatment_2011.pdf.txtce4b56db46ba52570ea647fe43db57faMD52ORIGINALramirez_periodontal_treatment_2011.pdframirez_periodontal_treatment_2011.pdfapplication/pdf485023http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/78514/1/ramirez_periodontal_treatment_2011.pdfadc6fb49f3f7f30704a4bb1d2e94d181MD5110906/78514oai:repository.icesi.edu.co:10906/785142017-10-24 20:24:20.733Biblioteca Digital - Universidad icesicdcriollo@icesi.edu.co
dc.title.spa.fl_str_mv	Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial.
title	Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial.
spellingShingle	Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial. Enfermedad periodontal Infarto de miocardio Ciencias socio biomédicas Biomedical sciences Enfermedad cardiovascular
title_short	Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial.
title_full	Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial.
title_fullStr	Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial.
title_full_unstemmed	Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial.
title_sort	Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial.
dc.creator.fl_str_mv	Contreras, Adolfo Ramírez Escobar, Jorge Hernán Arce, Roger
dc.contributor.author.spa.fl_str_mv	Contreras, Adolfo Ramírez Escobar, Jorge Hernán Arce, Roger
dc.subject.spa.fl_str_mv	Enfermedad periodontal Infarto de miocardio Ciencias socio biomédicas Biomedical sciences Enfermedad cardiovascular
topic	Enfermedad periodontal Infarto de miocardio Ciencias socio biomédicas Biomedical sciences Enfermedad cardiovascular
description	Background Periodontal disease (PD) is an infectious clinical entity characterized by the destruction of supporting tissues of the teeth as the result of a chronic inflammatory response in a susceptible host. It has been proposed that PD as subclinical infection may contribute to the etiology and to the pathogenesis of several systemic diseases including Atherosclerosis. A number of epidemiological studies link periodontal disease/edentulism as independent risk factor for acute myocardial infarction, peripheral vascular disease, and cerebrovascular disease. Moreover, new randomized controlled clinical trials have shown an improvement on cardiovascular surrogate markers (endothelial function, sICAM, hsPCR level, fibrinogen) after periodontal treatment. Nonetheless, such trials are still limited in terms of external validity, periodontal treatment strategies, CONSORT-based design and results consistency/extrapolation. The current study is designed to evaluate if periodontal treatment with scaling and root planning plus local delivered chlorhexidine improves endothelial function and other biomarkers of cardiovascular disease in subjects with moderate to severe periodontitis.
publishDate	2011
dc.date.issued.none.fl_str_mv	2011-02-16
dc.date.accessioned.none.fl_str_mv	2015-10-14T21:57:26Z
dc.date.available.none.fl_str_mv	2015-10-14T21:57:26Z
dc.type.eng.fl_str_mv	info:eu-repo/semantics/article
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dc.type.local.spa.fl_str_mv	Artículo
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dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/10906/78514
dc.identifier.doi.none.fl_str_mv	http://dx.doi.org/10.1186/1745-6215-12-46
dc.identifier.instname.none.fl_str_mv	instname: Universidad Icesi
dc.identifier.reponame.none.fl_str_mv	reponame: Biblioteca Digital
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dc.language.iso.eng.fl_str_mv	eng
language	eng
dc.relation.ispartof.none.fl_str_mv	TRIALS, Vol. 12, No. 46 - 2011
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dc.rights.accessrights.spa.fl_str_mv	info:eu-repo/semantics/openAccess
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dc.format.extent.none.fl_str_mv	10 páginas
dc.format.medium.spa.fl_str_mv	Digital
dc.format.mimetype.eng.fl_str_mv	application/pdf
dc.publisher.faculty.spa.fl_str_mv	Facultad Ciencias de la Salud
dc.publisher.program.spa.fl_str_mv	Medicina
dc.publisher.department.spa.fl_str_mv	Departamento de Ciencias Básicas Médicas
institution	Universidad ICESI
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Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial.

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