Microcirculatory alterations are associated with pulmonary dead-space fraction in moderate and severe ards
Shunt-induced hypoxemia i s considered the primary pathophysiological abnormality and main diagnostic cri- teria of acute respiratory distress syndrome (ARDS). However, increases in dead- space ventilation (VD/VT) can also contribute to gas exchange alterations in ARDS. Systemic microcirculatory alt...
- Autores:
-
Ospina Tascón, Gustavo Adolfo
De Backer, D
Salas, CE
Hernández, G
Bruhn, A
Bermúdez, WF
Valencia, JD
Madriñán, HJ
Bautista-Rincón, DF
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2015
- Institución:
- Universidad ICESI
- Repositorio:
- Repositorio ICESI
- Idioma:
- eng
- OAI Identifier:
- oai:repository.icesi.edu.co:10906/82221
- Acceso en línea:
- http://icm-experimental.springeropen.com/articles/10.1186/2197-425X-3-S1-A453
http://hdl.handle.net/10906/82221
https://doi.org/10.1186/2197-425X-3-S1-A453
- Palabra clave:
- Ciencias socio biomédicas
Hipoxemia
Sistema respiratorio - Fisiopatologia
Enfermedades pulmonares
Enfermedades respiratorias
Medical sciences
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
| Summary: | Shunt-induced hypoxemia i s considered the primary pathophysiological abnormality and main diagnostic cri- teria of acute respiratory distress syndrome (ARDS). However, increases in dead- space ventilation (VD/VT) can also contribute to gas exchange alterations in ARDS. Systemic microcirculatory alterations described during inflammatory conditions are characterized by perfusion heterogeneity and theoretically pulmonary microcirculatory heterogene ity could lead to imbalance pulmonary ventilation/perfusion relationship. Thus, we hypothesized that systemic microvascular alterations could reflect increased VD/VT in ARDS. |
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