Development of a Standardized Model for Liver Failure in Pigs: Anatomopathophysiologic Findings After Extended Liver Resection
Eighteen pigs weighing a mean 19 ± 4 kg, were divided into group 1 (n = 2), that underwent resection of the left lateral lobe, group 2 (n = 2), resection of the left median and right median lobes; and group 3 (n = 18), resection of the left lateral, left median, right median, and right lateral lobes...
- Autores:
-
Echeverri Junca, Gabriel Jaime
De Martino, Michela
Occhipinti, Giovanna
Spada, Marco
Pagano, Duilio
- Tipo de recurso:
- http://purl.org/coar/resource_type/c_c94f
- Fecha de publicación:
- 2012
- Institución:
- Universidad ICESI
- Repositorio:
- Repositorio ICESI
- Idioma:
- eng
- OAI Identifier:
- oai:repository.icesi.edu.co:10906/78513
- Acceso en línea:
- http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=23&SID=4BDShD6T2KTBoAZU7Ey&page=1&doc=1
http://hdl.handle.net/10906/78513
http://dx.doi.org/10.1016/j.transproceed.2012.06.009
- Palabra clave:
- Insuficiencia hepática
Fisiología patológica
Higado - Cirugia
Bilirrubina
Ciencias socio biomédicas
Biomedical sciences
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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Echeverri Junca, Gabriel JaimeDe Martino, MichelaOcchipinti, GiovannaSpada, MarcoPagano, DuilioGridelli, Brunomspada@ismett.edu.coOcchipinti, GiovannaDe Martino, MichelaNew York de Lat: 43 00 00 N degrees minutes Lat: 43.0000 decimal degrees Long: 075 00 00 W degrees minutes Long: -75.0000 decimal degrees2015-10-14T21:57:26Z2015-10-14T21:57:26Z2012-09-011873-2623http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=23&SID=4BDShD6T2KTBoAZU7Ey&page=1&doc=1http://hdl.handle.net/10906/78513http://dx.doi.org/10.1016/j.transproceed.2012.06.009instname: Universidad Icesireponame: Biblioteca Digitalrepourl: https://repository.icesi.edu.co/Eighteen pigs weighing a mean 19 ± 4 kg, were divided into group 1 (n = 2), that underwent resection of the left lateral lobe, group 2 (n = 2), resection of the left median and right median lobes; and group 3 (n = 18), resection of the left lateral, left median, right median, and right lateral lobes. All animals were followed for 5 days. Liver failure (n = 8) leading to animal death within 3 days after surgery was observed in 65% of group 3, whereas no group 1 or 2 animal experienced liver insufficiency. Multivariate analysis revealed that the extent of liver resection expressed as a percentage of total body weight <2.3%, international normalized ratio > 1.6 as postoperative day 2, serum bilirubin > 4.2 on postoperative day 2, and serum lactates > 9 mmol/L after resection were independent predictors of liver failure (P < .05). The number of resected liver lobes was not a good predictor of liver failure in swine, whereas the extent of resection expressed as a percentage of total body weight was an independent predictor of early liver failure. A resected liver-to-body weight ratio >2.3% was associated with a 65% probability of developing liver insufficiency. This parameter may be useful when developing a model of liver failure after extended liver resection in swine.3 páginasDigitalapplication/pdfengElsevierFacultad Ciencias de la SaludMedicinaDepartamento de Ciencias Básicas MédicasNew YorkTransplantation Proceedings, Vol. 44, No. 7 - 2012EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribuci�n-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2Insuficiencia hepáticaFisiología patológicaHigado - CirugiaBilirrubinaCiencias socio biomédicasBiomedical sciencesDevelopment of a Standardized Model for Liver Failure in Pigs: Anatomopathophysiologic Findings After Extended Liver Resectioninfo:eu-repo/semantics/conferenceObjecthttp://purl.org/coar/resource_type/c_c94fDocumento de conferenciainfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Comunidad Universidad Icesi – Investigadores44720292032ORIGINALdocumento.htmldocumento.htmltext/html316http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/78513/1/documento.html340d3acce733d7feff4ecdb45edc88d2MD5110906/78513oai:repository.icesi.edu.co:10906/785132020-05-20 21:54:36.257Biblioteca Digital - Universidad icesicdcriollo@icesi.edu.co |
| dc.title.eng.fl_str_mv |
Development of a Standardized Model for Liver Failure in Pigs: Anatomopathophysiologic Findings After Extended Liver Resection |
| title |
Development of a Standardized Model for Liver Failure in Pigs: Anatomopathophysiologic Findings After Extended Liver Resection |
| spellingShingle |
Development of a Standardized Model for Liver Failure in Pigs: Anatomopathophysiologic Findings After Extended Liver Resection Insuficiencia hepática Fisiología patológica Higado - Cirugia Bilirrubina Ciencias socio biomédicas Biomedical sciences |
| title_short |
Development of a Standardized Model for Liver Failure in Pigs: Anatomopathophysiologic Findings After Extended Liver Resection |
| title_full |
Development of a Standardized Model for Liver Failure in Pigs: Anatomopathophysiologic Findings After Extended Liver Resection |
| title_fullStr |
Development of a Standardized Model for Liver Failure in Pigs: Anatomopathophysiologic Findings After Extended Liver Resection |
| title_full_unstemmed |
Development of a Standardized Model for Liver Failure in Pigs: Anatomopathophysiologic Findings After Extended Liver Resection |
| title_sort |
Development of a Standardized Model for Liver Failure in Pigs: Anatomopathophysiologic Findings After Extended Liver Resection |
| dc.creator.fl_str_mv |
Echeverri Junca, Gabriel Jaime De Martino, Michela Occhipinti, Giovanna Spada, Marco Pagano, Duilio |
| dc.contributor.author.spa.fl_str_mv |
Echeverri Junca, Gabriel Jaime De Martino, Michela Occhipinti, Giovanna Spada, Marco Pagano, Duilio |
| dc.subject.spa.fl_str_mv |
Insuficiencia hepática Fisiología patológica Higado - Cirugia Bilirrubina Ciencias socio biomédicas |
| topic |
Insuficiencia hepática Fisiología patológica Higado - Cirugia Bilirrubina Ciencias socio biomédicas Biomedical sciences |
| dc.subject.eng.fl_str_mv |
Biomedical sciences |
| description |
Eighteen pigs weighing a mean 19 ± 4 kg, were divided into group 1 (n = 2), that underwent resection of the left lateral lobe, group 2 (n = 2), resection of the left median and right median lobes; and group 3 (n = 18), resection of the left lateral, left median, right median, and right lateral lobes. All animals were followed for 5 days. Liver failure (n = 8) leading to animal death within 3 days after surgery was observed in 65% of group 3, whereas no group 1 or 2 animal experienced liver insufficiency. Multivariate analysis revealed that the extent of liver resection expressed as a percentage of total body weight <2.3%, international normalized ratio > 1.6 as postoperative day 2, serum bilirubin > 4.2 on postoperative day 2, and serum lactates > 9 mmol/L after resection were independent predictors of liver failure (P < .05). The number of resected liver lobes was not a good predictor of liver failure in swine, whereas the extent of resection expressed as a percentage of total body weight was an independent predictor of early liver failure. A resected liver-to-body weight ratio >2.3% was associated with a 65% probability of developing liver insufficiency. This parameter may be useful when developing a model of liver failure after extended liver resection in swine. |
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2012 |
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2012-09-01 |
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2015-10-14T21:57:26Z |
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2015-10-14T21:57:26Z |
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info:eu-repo/semantics/conferenceObject |
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http://purl.org/coar/resource_type/c_c94f |
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Documento de conferencia |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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1873-2623 |
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http://hdl.handle.net/10906/78513 |
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http://dx.doi.org/10.1016/j.transproceed.2012.06.009 |
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http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=23&SID=4BDShD6T2KTBoAZU7Ey&page=1&doc=1 http://hdl.handle.net/10906/78513 http://dx.doi.org/10.1016/j.transproceed.2012.06.009 |
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eng |
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eng |
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Transplantation Proceedings, Vol. 44, No. 7 - 2012 |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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Atribuci�n-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
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New York de Lat: 43 00 00 N degrees minutes Lat: 43.0000 decimal degrees Long: 075 00 00 W degrees minutes Long: -75.0000 decimal degrees |
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Elsevier |
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Medicina |
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New York |
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