Development of a Standardized Model for Liver Failure in Pigs: Anatomopathophysiologic Findings After Extended Liver Resection

Eighteen pigs weighing a mean 19 ± 4 kg, were divided into group 1 (n = 2), that underwent resection of the left lateral lobe, group 2 (n = 2), resection of the left median and right median lobes; and group 3 (n = 18), resection of the left lateral, left median, right median, and right lateral lobes. All animals were followed for 5 days. Liver failure (n = 8) leading to animal death within 3 days after surgery was observed in 65% of group 3, whereas no group 1 or 2 animal experienced liver insufficiency. Multivariate analysis revealed that the extent of liver resection expressed as a percentage of total body weight <2.3%, international normalized ratio > 1.6 as postoperative day 2, serum bilirubin > 4.2 on postoperative day 2, and serum lactates > 9 mmol/L after resection were independent predictors of liver failure (P < .05). The number of resected liver lobes was not a good predictor of liver failure in swine, whereas the extent of resection expressed as a percentage of total body weight was an independent predictor of early liver failure. A resected liver-to-body weight ratio >2.3% was associated with a 65% probability of developing liver insufficiency. This parameter may be useful when developing a model of liver failure after extended liver resection in swine.

• Autores: Echeverri Junca, Gabriel Jaime; De Martino, Michela; Occhipinti, Giovanna; Spada, Marco; Pagano, Duilio
• Tipo de recurso: http://purl.org/coar/resource_type/c_c94f
• Fecha de publicación: 2012
• Institución: Universidad ICESI
• Repositorio: Repositorio ICESI
• Idioma: eng
• OAI Identifier: oai:repository.icesi.edu.co:10906/78513
• Acceso en línea: http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=23&SID=4BDShD6T2KTBoAZU7Ey&page=1&doc=1; http://hdl.handle.net/10906/78513; http://dx.doi.org/10.1016/j.transproceed.2012.06.009
• Palabra clave: Insuficiencia hepática; Fisiología patológica; Higado - Cirugia; Bilirrubina; Ciencias socio biomédicas; Biomedical sciences
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-nd/4.0/