Relationship between surface properties and in vitro drug release from a compressed matrix containing an amphiphilic polymer materia.
The performance of compressed tablet drug delivery systems made using polymeric materials depend on multiple factors, such as surface properties like contact angle, surface free energy and water absorption rate, besides the release mechanisms driven by the kind of polymer used. Hence, it should be p...
- Autores:
-
Pineda, Diego
Corre, Clara E.
Yarce, Cristhian J.
Salamanca Mejía, Constaín Hugo
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2016
- Institución:
- Universidad ICESI
- Repositorio:
- Repositorio ICESI
- Idioma:
- eng
- OAI Identifier:
- oai:repository.icesi.edu.co:10906/81450
- Acceso en línea:
- http://www.mdpi.com/1424-8247/9/3/34
http://hdl.handle.net/10906/81450
https://doi.org/10.3390/ph9030034.
- Palabra clave:
- Polímero - Anfifílico
Fármacos
Energía libre
In vitro
Termodinámica
Métodos de investigación en bioquímica
Biochemistry research
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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| dc.title.eng.fl_str_mv |
Relationship between surface properties and in vitro drug release from a compressed matrix containing an amphiphilic polymer materia. |
| title |
Relationship between surface properties and in vitro drug release from a compressed matrix containing an amphiphilic polymer materia. |
| spellingShingle |
Relationship between surface properties and in vitro drug release from a compressed matrix containing an amphiphilic polymer materia. Polímero - Anfifílico Fármacos Energía libre In vitro Termodinámica Métodos de investigación en bioquímica Biochemistry research |
| title_short |
Relationship between surface properties and in vitro drug release from a compressed matrix containing an amphiphilic polymer materia. |
| title_full |
Relationship between surface properties and in vitro drug release from a compressed matrix containing an amphiphilic polymer materia. |
| title_fullStr |
Relationship between surface properties and in vitro drug release from a compressed matrix containing an amphiphilic polymer materia. |
| title_full_unstemmed |
Relationship between surface properties and in vitro drug release from a compressed matrix containing an amphiphilic polymer materia. |
| title_sort |
Relationship between surface properties and in vitro drug release from a compressed matrix containing an amphiphilic polymer materia. |
| dc.creator.fl_str_mv |
Pineda, Diego Corre, Clara E. Yarce, Cristhian J. Salamanca Mejía, Constaín Hugo |
| dc.contributor.author.spa.fl_str_mv |
Pineda, Diego Corre, Clara E. Yarce, Cristhian J. Salamanca Mejía, Constaín Hugo |
| dc.subject.spa.fl_str_mv |
Polímero - Anfifílico Fármacos Energía libre In vitro Termodinámica Métodos de investigación en bioquímica Biochemistry research |
| topic |
Polímero - Anfifílico Fármacos Energía libre In vitro Termodinámica Métodos de investigación en bioquímica Biochemistry research |
| description |
The performance of compressed tablet drug delivery systems made using polymeric materials depend on multiple factors, such as surface properties like contact angle, surface free energy and water absorption rate, besides the release mechanisms driven by the kind of polymer used. Hence, it should be possible to establish a relationship between the surface properties and the drug release kinetics. Compressed tablets with different proportions of poly(maleic acid-alt-octadecene) potassium salt (0%, 10%, 20%, 30% and 40%) were prepared. Blends of a model drug (ampicillin trihydrate) and the polymer material were analyzed by DSC. |
| publishDate |
2016 |
| dc.date.issued.none.fl_str_mv |
2016-06-24 |
| dc.date.accessioned.none.fl_str_mv |
2017-05-18T14:42:24Z |
| dc.date.available.none.fl_str_mv |
2017-05-18T14:42:24Z |
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info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Artículo |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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publishedVersion |
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1424-8247 |
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http://www.mdpi.com/1424-8247/9/3/34 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10906/81450 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.3390/ph9030034. |
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instname: Universidad Icesi |
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reponame: Biblioteca Digital |
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repourl: https://repository.icesi.edu.co/ |
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1424-8247 instname: Universidad Icesi reponame: Biblioteca Digital repourl: https://repository.icesi.edu.co/ |
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http://www.mdpi.com/1424-8247/9/3/34 http://hdl.handle.net/10906/81450 https://doi.org/10.3390/ph9030034. |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.isbasedon.none.fl_str_mv |
Pharmaceuticals, Vol. 9, No. 3 - 2016 |
| dc.rights.uri.none.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.license.none.fl_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
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http://purl.org/coar/access_right/c_abf2 |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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20 páginas |
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Digital |
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Basel de Lat: 47 33 30 N degrees minutes Lat: 47.5584 decimal degrees Long: 007 34 24 E degrees minutes Long: 7.5733 decimal degrees |
| dc.publisher.spa.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
| dc.publisher.faculty.spa.fl_str_mv |
Facultad de Ciencias Naturales |
| dc.publisher.program.spa.fl_str_mv |
Química Farmacéutica |
| dc.publisher.department.spa.fl_str_mv |
Departamento de Ciencias Farmacéuticas |
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Basel |
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Universidad ICESI |
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Pineda, DiegoCorre, Clara E.Yarce, Cristhian J.Salamanca Mejía, Constaín Hugochsalamanca@icesi.edu.coBasel de Lat: 47 33 30 N degrees minutes Lat: 47.5584 decimal degrees Long: 007 34 24 E degrees minutes Long: 7.5733 decimal degrees2017-05-18T14:42:24Z2017-05-18T14:42:24Z2016-06-241424-8247http://www.mdpi.com/1424-8247/9/3/34http://hdl.handle.net/10906/81450https://doi.org/10.3390/ph9030034.instname: Universidad Icesireponame: Biblioteca Digitalrepourl: https://repository.icesi.edu.co/The performance of compressed tablet drug delivery systems made using polymeric materials depend on multiple factors, such as surface properties like contact angle, surface free energy and water absorption rate, besides the release mechanisms driven by the kind of polymer used. Hence, it should be possible to establish a relationship between the surface properties and the drug release kinetics. Compressed tablets with different proportions of poly(maleic acid-alt-octadecene) potassium salt (0%, 10%, 20%, 30% and 40%) were prepared. Blends of a model drug (ampicillin trihydrate) and the polymer material were analyzed by DSC.20 páginasDigitalengMultidisciplinary Digital Publishing Institute (MDPI)Facultad de Ciencias NaturalesQuímica FarmacéuticaDepartamento de Ciencias FarmacéuticasBaselPharmaceuticals, Vol. 9, No. 3 - 2016EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos Todo persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2Polímero - AnfifílicoFármacosEnergía libreIn vitroTermodinámicaMétodos de investigación en bioquímicaBiochemistry researchRelationship between surface properties and in vitro drug release from a compressed matrix containing an amphiphilic polymer materia.info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1Artículoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Comunidad Universidad Icesi - Investigadores93120LICENSElicense.txtlicense.txttext/plain1783http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/81450/5/license.txta9bf6c9d51cc761c4b473f39f5bcb2eaMD55CC-LICENSElicense_urllicense_urltext/plain49http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/81450/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_textapplication/octet-stream0http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/81450/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/octet-stream0http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/81450/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD54ORIGINALdocumento.htmldocumento.htmlRelationship between Surfacetext/html275http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/81450/6/documento.html3b5bb9e46cbbc701146403912b33be4bMD5610906/81450oai:repository.icesi.edu.co:10906/814502022-02-11 15:53:56.625Biblioteca Digital - Universidad icesicdcriollo@icesi.edu.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 |