Relationship between surface properties and in vitro drug release from a compressed matrix containing an amphiphilic polymer materia.
The performance of compressed tablet drug delivery systems made using polymeric materials depend on multiple factors, such as surface properties like contact angle, surface free energy and water absorption rate, besides the release mechanisms driven by the kind of polymer used. Hence, it should be p...
- Autores:
-
Pineda, Diego
Corre, Clara E.
Yarce, Cristhian J.
Salamanca Mejía, Constaín Hugo
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2016
- Institución:
- Universidad ICESI
- Repositorio:
- Repositorio ICESI
- Idioma:
- eng
- OAI Identifier:
- oai:repository.icesi.edu.co:10906/81450
- Acceso en línea:
- http://www.mdpi.com/1424-8247/9/3/34
http://hdl.handle.net/10906/81450
https://doi.org/10.3390/ph9030034.
- Palabra clave:
- Polímero - Anfifílico
Fármacos
Energía libre
In vitro
Termodinámica
Métodos de investigación en bioquímica
Biochemistry research
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
| Summary: | The performance of compressed tablet drug delivery systems made using polymeric materials depend on multiple factors, such as surface properties like contact angle, surface free energy and water absorption rate, besides the release mechanisms driven by the kind of polymer used. Hence, it should be possible to establish a relationship between the surface properties and the drug release kinetics. Compressed tablets with different proportions of poly(maleic acid-alt-octadecene) potassium salt (0%, 10%, 20%, 30% and 40%) were prepared. Blends of a model drug (ampicillin trihydrate) and the polymer material were analyzed by DSC. |
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