Calcium, channels, intracellular signaling and autoimmunity

Calcium (Ca2+) is an important cation able to function as a second messenger in different cells of the immune system, particularly in B and T lymphocytes, macrophages, and mastocytes, among others. Recent discoveries related to the entry of Ca2+ through the store-operated calcium entry (SOCE) have opened a new investigation area about the cell destiny regulated by Ca2+ especially in B and T lymphocytes. SOCE acts through calcium-release-activated calcium (CRAC) channels. The function of CRAC depends upon two recently discovered regulators: the Ca2+ sensor in the endoplasmic reticulum or stromal interaction molecule (STIM-1) and one subunit of CRAC channels called Orai1. This review focuses on the role of Ca2+ signals in B and T lymphocytes functions, the signaling pathways leading to Ca2+ influx, and the relationship between Ca2+ signals and autoimmune diseases.

• Autores: Cañas Dávila, Carlos Alberto; Tobón J., Gabriel; Bonilla Abadía, Fabio; Izquierdo, Jorge Hernán
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2014
• Institución: Universidad ICESI
• Repositorio: Repositorio ICESI
• Idioma: spa
• OAI Identifier: oai:repository.icesi.edu.co:10906/78344
• Acceso en línea: http://www.scopus.com/inward/record.url?eid=2-s2.0-84895069810&partnerID=tZOtx3y1; http://www.reumatologiaclinica.org/es/vol-10-num-1/sumario/S1699258X13X00075/; http://hdl.handle.net/10906/78344; http://dx.doi.org/10.1016/j.reuma.2013.05.008
• Palabra clave: Calcio; Enfermedades autoinmunes; Ciencias socio biomédicas; Linfocitos T; Medical sciences
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-nd/4.0/