Evaluación del material polimérico clorhidrato de EUDRAGIT E-100 como potencial excipiente de liberación modificada de fármacos en matrices sólidas

The effect of the polymer system modified Clorhidrato Eudragit E-100, as modified release excipient potential on the dissolution profile of the drug model, 5H-dibenzo [b, f] azepine-5-carboxamide in aqueous media was determined and two systems buffer pH 1.2 and 7.4 with 0.15M ionic strength at 37 °...

Full description

Autores:
Gutiérrez Ortegón, Julie Paola
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2014
Institución:
Universidad ICESI
Repositorio:
Repositorio ICESI
Idioma:
spa
OAI Identifier:
oai:repository.icesi.edu.co:10906/76908
Acceso en línea:
http://hdl.handle.net/10906/76908
http://biblioteca2.icesi.edu.co/cgi-olib?oid=269940
Palabra clave:
Materiales poliméricos
Eudragit® E-100
Sistemas poliméricos
Perfil de disolución
Métodos de investigación en bioquímica
Producción intelectual registrada - Universidad Icesi
Biochemistry research
Dissolution Profile
Modified release system
Rights
openAccess
License
https://creativecommons.org/licenses/by-nc-nd/4.0/
Description
Summary:The effect of the polymer system modified Clorhidrato Eudragit E-100, as modified release excipient potential on the dissolution profile of the drug model, 5H-dibenzo [b, f] azepine-5-carboxamide in aqueous media was determined and two systems buffer pH 1.2 and 7.4 with 0.15M ionic strength at 37 ° C temperature In this study were obtained validation parameters of the method for the quantification the drug such as: selectivity, repeatability, reproducibility and linearity. Also were performed previous studies for determining specific parameters for obtaining the tablets of the study. Among these are hardness, moisture adsorption capacity, diameter, thickness and disintegration time. Once these characteristics are determined, were evaluated dissolution profiles for the tablets of the study and reference, these tablets were composed of Clorhidrato de Eudragit E100 and microcrystalline cellulose pH 102, respectively, together with the model drug in proportions 1:1 polymer: drug. The data obtained were analyzed by a statistical analysis (ANOVA), which established one significant effect between the dissolution medium (buffer pH 1.2, aqueous medium and buffer pH 7.4) and polymeric system, on the dissolution percentage of the drug. This study concluded that the polymer system of study, no delay of release the drug, because is observed the behavior of an immediate release dosage form.