Costimulation blockade in pig artery patch xenotransplantation - a simple model to monitor the adaptive immune response in nonhuman primates.
BACKGROUND: CD154 blockade-based immunosuppression successfully prevents both humoral and cellular adaptive immune responses in baboons receiving α1,3-galactosyltransferase gene-knockout (GTKO) pig organs. Using a GTKO pig artery transplantation model in baboons, we evaluated the efficacy of CD28/B7...
- Autores:
-
Echeverri Junca, Gabriel Jaime
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2012
- Institución:
- Universidad ICESI
- Repositorio:
- Repositorio ICESI
- Idioma:
- eng
- OAI Identifier:
- oai:repository.icesi.edu.co:10906/78507
- Acceso en línea:
- http://apps.webofknowledge.com/full_record.do?page=1&qid=1&log_event=yes&viewType=fullRecord&SID=4BDShD6T2KTBoAZU7Ey&product=UA&doc=1&search_mode=GeneralSearch
http://hdl.handle.net/10906/78507
http://dx.doi.org/10.1111/j.1399-3089.2012.00711.x
- Palabra clave:
- Ciencias socio biomédicas
Anticuerpos
Trasplante
Arteria
Xenotrasplantes
Medical sciences
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
| Summary: | BACKGROUND: CD154 blockade-based immunosuppression successfully prevents both humoral and cellular adaptive immune responses in baboons receiving α1,3-galactosyltransferase gene-knockout (GTKO) pig organs. Using a GTKO pig artery transplantation model in baboons, we evaluated the efficacy of CD28/B7 costimulatory pathway blockade in comparison with CD154 blockade. |
|---|