Aggregates of alternate amphiphilc polyanion to carry zwitterionic drug in aquedous media

The effect of amphiphilic polyanion Poly(maleic acid-alt-octadecene)sodium salt on solubility of a zwitterionic drug (ampicillin trihydrate) in aqueous media was evaluated. This polymeric salt was obtained by an equimolar reaction of parent copolymer poly Poly(maleic acid-alt-octadecene)with an aqueous solution of NaOH. The obtained amphiphilic polyanion was purified by dialysis and lyophilization and was characterized by FTIR spectroscopy. Secondly, a method for the model drug quantification by UV spectrophotometry at 37°C was standardized. Also the grade of association drug-polymer in aqueous media using ultrafiltration methodology at three levels of temperature (20, 30 and 40°C) and two levels of pH (1.2 and 7.4) was determined. Finally, the variation of aqueous solubility of ampicillin trihydrate in ultra-pure water and two buffer media with pH of 1.2 and 7.4 with an ionic strength of 0.15 M at 37°C in presence and absence of amphiphilic polyanion was evaluated. It was found that maximum solubility is reached at a pH value of 1.2 in absence of polymeric material with a value of 36 mg/mL, which diminishes dramatically to a value of 8.3mg/mL when the polyanion is added. In the other side, when the system has a pH value of 7.4, the drug solubility slightly increases from 13 to 16mg/mL in presence of polymeric material, describing that solubility of this kind of drugs is strongly influenced by aqueous media and this type of polymeric materials.

• Autores: Salamanca Mejia, Constain Hugo; Adrade, Andrés; Pineda, Diego; Quintero, Andrés
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2015
• Institución: Universidad ICESI
• Repositorio: Repositorio ICESI
• Idioma: eng
• OAI Identifier: oai:repository.icesi.edu.co:10906/81885
• Acceso en línea: http://ijpsr.com/bft-article/aggregates-of-alternate-amphiphilc-polyanion-to-carry-zwitterionic-drug-in-aqueous-media/; http://hdl.handle.net/10906/81885; http://dx.doi.org/10.13040/IJPSR.0975-8232.6(6).2360-66
• Palabra clave: Materiales poliméricos; Trihidrato de ampicilina; Métodos de investigación en bioquímica; Biochemistry research
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-nd/4.0/