Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids

Chitosan hydrogels cross-linked with dicarboxylic acids were prepared. Succinic, glutaric and adipic acid were used as cross-linking agents, the goal being to compare the effect of the length of the chain on the behavior of the material obtained. The swelling properties were studied at different pHs...

Full description

Autores:
Valderruten Posso, Nora Elena
Zuluaga, Héctor Fabio
Ruiz Durantez, Eduardo
Valverde, Jonathan D.
Tipo de recurso:
Article of investigation
Fecha de publicación:
2014
Institución:
Universidad ICESI
Repositorio:
Repositorio ICESI
Idioma:
eng
OAI Identifier:
oai:repository.icesi.edu.co:10906/79907
Acceso en línea:
http://www.sciencedirect.com/science/article/pii/S1381514814001746
http://hdl.handle.net/10906/79907
http://dx.doi.org/10.1016/j.reactfunctpolym.2014.08.006
Palabra clave:
Hydrogels
Dicarboxylic acids
Drug release
Viscoelasticity
Biochemistry research
Métodos de investigación en bioquímica
Rights
openAccess
License
https://creativecommons.org/licenses/by-nc-nd/4.0/
id ICESI2_8338a837016ceb179301d64d18b048b2
oai_identifier_str oai:repository.icesi.edu.co:10906/79907
network_acronym_str ICESI2
network_name_str Repositorio ICESI
repository_id_str
spelling Valderruten Posso, Nora ElenaZuluaga, Héctor FabioRuiz Durantez, EduardoValverde, Jonathan D.2016-08-30T22:02:02Z2016-08-30T22:02:02Z2014-11-011381-5148http://www.sciencedirect.com/science/article/pii/S1381514814001746http://hdl.handle.net/10906/79907http://dx.doi.org/10.1016/j.reactfunctpolym.2014.08.006instname: Universidad Icesireponame: Biblioteca Digitalrepourl: https://repository.icesi.edu.co/Chitosan hydrogels cross-linked with dicarboxylic acids were prepared. Succinic, glutaric and adipic acid were used as cross-linking agents, the goal being to compare the effect of the length of the chain on the behavior of the material obtained. The swelling properties were studied at different pHs and temperatures, and it was discovered that these properties depend particularly on the pH of the environment. Creep-recovery and stress-relaxation studies were performed to determine mechanical properties and the chitosan/succinic acid hydrogels exhibited a completely viscous behavior. Thermal studies were carried out using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). DSC results revealed that the materials obtained are completely amorphous. Acetaminophen was used as a positive control for the release kinetics studies. Upon fitting the results to a specific mathematical model, it was determined that the release process is controlled by diffusion and relaxation of the polymer network.7 páginasengElsevierFacultad de Ciencias NaturalesQuímica con énfasis en BioquímicaDepartamento de Ciencias QuímicasReactive and Functional Polymers, Vol. 84 - 2014EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2HydrogelsDicarboxylic acidsDrug releaseViscoelasticityBiochemistry researchMétodos de investigación en bioquímicaSynthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acidsChitosaninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1Artículoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85842128ORIGINALDocumento.htmlDocumento.htmltext/html303http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/79907/1/Documento.htmlb24f2b38354fb2f704154f1de5afe093MD5110906/79907oai:repository.icesi.edu.co:10906/799072018-09-21 14:02:53.256Biblioteca Digital - Universidad icesicdcriollo@icesi.edu.co
dc.title.eng.fl_str_mv Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids
dc.title.alternative.eng.fl_str_mv Chitosan
title Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids
spellingShingle Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids
Hydrogels
Dicarboxylic acids
Drug release
Viscoelasticity
Biochemistry research
Métodos de investigación en bioquímica
title_short Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids
title_full Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids
title_fullStr Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids
title_full_unstemmed Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids
title_sort Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids
dc.creator.fl_str_mv Valderruten Posso, Nora Elena
Zuluaga, Héctor Fabio
Ruiz Durantez, Eduardo
Valverde, Jonathan D.
dc.contributor.author.spa.fl_str_mv Valderruten Posso, Nora Elena
Zuluaga, Héctor Fabio
Ruiz Durantez, Eduardo
Valverde, Jonathan D.
dc.subject.eng.fl_str_mv Hydrogels
Dicarboxylic acids
Drug release
Viscoelasticity
Biochemistry research
topic Hydrogels
Dicarboxylic acids
Drug release
Viscoelasticity
Biochemistry research
Métodos de investigación en bioquímica
dc.subject.spa.fl_str_mv Métodos de investigación en bioquímica
description Chitosan hydrogels cross-linked with dicarboxylic acids were prepared. Succinic, glutaric and adipic acid were used as cross-linking agents, the goal being to compare the effect of the length of the chain on the behavior of the material obtained. The swelling properties were studied at different pHs and temperatures, and it was discovered that these properties depend particularly on the pH of the environment. Creep-recovery and stress-relaxation studies were performed to determine mechanical properties and the chitosan/succinic acid hydrogels exhibited a completely viscous behavior. Thermal studies were carried out using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). DSC results revealed that the materials obtained are completely amorphous. Acetaminophen was used as a positive control for the release kinetics studies. Upon fitting the results to a specific mathematical model, it was determined that the release process is controlled by diffusion and relaxation of the polymer network.
publishDate 2014
dc.date.issued.none.fl_str_mv 2014-11-01
dc.date.accessioned.none.fl_str_mv 2016-08-30T22:02:02Z
dc.date.available.none.fl_str_mv 2016-08-30T22:02:02Z
dc.type.eng.fl_str_mv info:eu-repo/semantics/article
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.local.spa.fl_str_mv Artículo
dc.type.version.eng.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
format http://purl.org/coar/resource_type/c_2df8fbb1
status_str publishedVersion
dc.identifier.issn.none.fl_str_mv 1381-5148
dc.identifier.other.eng.fl_str_mv http://www.sciencedirect.com/science/article/pii/S1381514814001746
dc.identifier.uri.eng.fl_str_mv http://hdl.handle.net/10906/79907
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1016/j.reactfunctpolym.2014.08.006
dc.identifier.instname.none.fl_str_mv instname: Universidad Icesi
dc.identifier.reponame.none.fl_str_mv reponame: Biblioteca Digital
dc.identifier.repourl.none.fl_str_mv repourl: https://repository.icesi.edu.co/
identifier_str_mv 1381-5148
instname: Universidad Icesi
reponame: Biblioteca Digital
repourl: https://repository.icesi.edu.co/
url http://www.sciencedirect.com/science/article/pii/S1381514814001746
http://hdl.handle.net/10906/79907
http://dx.doi.org/10.1016/j.reactfunctpolym.2014.08.006
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartof.eng.fl_str_mv Reactive and Functional Polymers, Vol. 84 - 2014
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.eng.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.license.none.fl_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.extent.none.fl_str_mv 7 páginas
dc.publisher.spa.fl_str_mv Elsevier
dc.publisher.faculty.spa.fl_str_mv Facultad de Ciencias Naturales
dc.publisher.program.spa.fl_str_mv Química con énfasis en Bioquímica
dc.publisher.department.spa.fl_str_mv Departamento de Ciencias Químicas
institution Universidad ICESI
bitstream.url.fl_str_mv http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/79907/1/Documento.html
bitstream.checksum.fl_str_mv b24f2b38354fb2f704154f1de5afe093
bitstream.checksumAlgorithm.fl_str_mv MD5
repository.name.fl_str_mv Biblioteca Digital - Universidad icesi
repository.mail.fl_str_mv cdcriollo@icesi.edu.co
_version_ 1814094868484456448