Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids
Chitosan hydrogels cross-linked with dicarboxylic acids were prepared. Succinic, glutaric and adipic acid were used as cross-linking agents, the goal being to compare the effect of the length of the chain on the behavior of the material obtained. The swelling properties were studied at different pHs...
- Autores:
-
Valderruten Posso, Nora Elena
Zuluaga, Héctor Fabio
Ruiz Durantez, Eduardo
Valverde, Jonathan D.
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2014
- Institución:
- Universidad ICESI
- Repositorio:
- Repositorio ICESI
- Idioma:
- eng
- OAI Identifier:
- oai:repository.icesi.edu.co:10906/79907
- Acceso en línea:
- http://www.sciencedirect.com/science/article/pii/S1381514814001746
http://hdl.handle.net/10906/79907
http://dx.doi.org/10.1016/j.reactfunctpolym.2014.08.006
- Palabra clave:
- Hydrogels
Dicarboxylic acids
Drug release
Viscoelasticity
Biochemistry research
Métodos de investigación en bioquímica
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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Valderruten Posso, Nora ElenaZuluaga, Héctor FabioRuiz Durantez, EduardoValverde, Jonathan D.2016-08-30T22:02:02Z2016-08-30T22:02:02Z2014-11-011381-5148http://www.sciencedirect.com/science/article/pii/S1381514814001746http://hdl.handle.net/10906/79907http://dx.doi.org/10.1016/j.reactfunctpolym.2014.08.006instname: Universidad Icesireponame: Biblioteca Digitalrepourl: https://repository.icesi.edu.co/Chitosan hydrogels cross-linked with dicarboxylic acids were prepared. Succinic, glutaric and adipic acid were used as cross-linking agents, the goal being to compare the effect of the length of the chain on the behavior of the material obtained. The swelling properties were studied at different pHs and temperatures, and it was discovered that these properties depend particularly on the pH of the environment. Creep-recovery and stress-relaxation studies were performed to determine mechanical properties and the chitosan/succinic acid hydrogels exhibited a completely viscous behavior. Thermal studies were carried out using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). DSC results revealed that the materials obtained are completely amorphous. Acetaminophen was used as a positive control for the release kinetics studies. Upon fitting the results to a specific mathematical model, it was determined that the release process is controlled by diffusion and relaxation of the polymer network.7 páginasengElsevierFacultad de Ciencias NaturalesQuímica con énfasis en BioquímicaDepartamento de Ciencias QuímicasReactive and Functional Polymers, Vol. 84 - 2014EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2HydrogelsDicarboxylic acidsDrug releaseViscoelasticityBiochemistry researchMétodos de investigación en bioquímicaSynthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acidsChitosaninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1Artículoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85842128ORIGINALDocumento.htmlDocumento.htmltext/html303http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/79907/1/Documento.htmlb24f2b38354fb2f704154f1de5afe093MD5110906/79907oai:repository.icesi.edu.co:10906/799072018-09-21 14:02:53.256Biblioteca Digital - Universidad icesicdcriollo@icesi.edu.co |
dc.title.eng.fl_str_mv |
Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids |
dc.title.alternative.eng.fl_str_mv |
Chitosan |
title |
Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids |
spellingShingle |
Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids Hydrogels Dicarboxylic acids Drug release Viscoelasticity Biochemistry research Métodos de investigación en bioquímica |
title_short |
Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids |
title_full |
Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids |
title_fullStr |
Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids |
title_full_unstemmed |
Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids |
title_sort |
Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids |
dc.creator.fl_str_mv |
Valderruten Posso, Nora Elena Zuluaga, Héctor Fabio Ruiz Durantez, Eduardo Valverde, Jonathan D. |
dc.contributor.author.spa.fl_str_mv |
Valderruten Posso, Nora Elena Zuluaga, Héctor Fabio Ruiz Durantez, Eduardo Valverde, Jonathan D. |
dc.subject.eng.fl_str_mv |
Hydrogels Dicarboxylic acids Drug release Viscoelasticity Biochemistry research |
topic |
Hydrogels Dicarboxylic acids Drug release Viscoelasticity Biochemistry research Métodos de investigación en bioquímica |
dc.subject.spa.fl_str_mv |
Métodos de investigación en bioquímica |
description |
Chitosan hydrogels cross-linked with dicarboxylic acids were prepared. Succinic, glutaric and adipic acid were used as cross-linking agents, the goal being to compare the effect of the length of the chain on the behavior of the material obtained. The swelling properties were studied at different pHs and temperatures, and it was discovered that these properties depend particularly on the pH of the environment. Creep-recovery and stress-relaxation studies were performed to determine mechanical properties and the chitosan/succinic acid hydrogels exhibited a completely viscous behavior. Thermal studies were carried out using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). DSC results revealed that the materials obtained are completely amorphous. Acetaminophen was used as a positive control for the release kinetics studies. Upon fitting the results to a specific mathematical model, it was determined that the release process is controlled by diffusion and relaxation of the polymer network. |
publishDate |
2014 |
dc.date.issued.none.fl_str_mv |
2014-11-01 |
dc.date.accessioned.none.fl_str_mv |
2016-08-30T22:02:02Z |
dc.date.available.none.fl_str_mv |
2016-08-30T22:02:02Z |
dc.type.eng.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.local.spa.fl_str_mv |
Artículo |
dc.type.version.eng.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
status_str |
publishedVersion |
dc.identifier.issn.none.fl_str_mv |
1381-5148 |
dc.identifier.other.eng.fl_str_mv |
http://www.sciencedirect.com/science/article/pii/S1381514814001746 |
dc.identifier.uri.eng.fl_str_mv |
http://hdl.handle.net/10906/79907 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1016/j.reactfunctpolym.2014.08.006 |
dc.identifier.instname.none.fl_str_mv |
instname: Universidad Icesi |
dc.identifier.reponame.none.fl_str_mv |
reponame: Biblioteca Digital |
dc.identifier.repourl.none.fl_str_mv |
repourl: https://repository.icesi.edu.co/ |
identifier_str_mv |
1381-5148 instname: Universidad Icesi reponame: Biblioteca Digital repourl: https://repository.icesi.edu.co/ |
url |
http://www.sciencedirect.com/science/article/pii/S1381514814001746 http://hdl.handle.net/10906/79907 http://dx.doi.org/10.1016/j.reactfunctpolym.2014.08.006 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.eng.fl_str_mv |
Reactive and Functional Polymers, Vol. 84 - 2014 |
dc.rights.uri.none.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.rights.accessrights.eng.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.license.none.fl_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
dc.rights.coar.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.format.extent.none.fl_str_mv |
7 páginas |
dc.publisher.spa.fl_str_mv |
Elsevier |
dc.publisher.faculty.spa.fl_str_mv |
Facultad de Ciencias Naturales |
dc.publisher.program.spa.fl_str_mv |
Química con énfasis en Bioquímica |
dc.publisher.department.spa.fl_str_mv |
Departamento de Ciencias Químicas |
institution |
Universidad ICESI |
bitstream.url.fl_str_mv |
http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/79907/1/Documento.html |
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MD5 |
repository.name.fl_str_mv |
Biblioteca Digital - Universidad icesi |
repository.mail.fl_str_mv |
cdcriollo@icesi.edu.co |
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1814094868484456448 |