T-Cell-Based Immunosuppressive Therapy Inhibits the Development of Natural Antibodies in Infant Baboons

Background. We set out to determine whether B-cell tolerance to A/B-incompatible alloantigens and pig xenoantigens could be achieved in infant baboons. Methods. Artery patch grafts were implanted in the abdominal aorta in 3-month-old baboons using A/B-incompatible (AB-I) allografts or wild-type pig xenografts (pig). Group 1 (Gp1) (controls, n=6) received no immunosuppressive therapy (IS) and no graft. Gp2 (n=2) received an AB-I or pig graft but no IS. Gp3 received AB-I grafts+IS (Gp3A: n=2) or pig grafts+IS (Gp3B: n=2). IS consisted of ATG, anti-CD154mAb, and mycophenolate mofetil until age 8 to 12 months. Gp4 (n=2) received IS only but no graft. Results. In Gp1, anti-A/B and cytotoxic anti-pig immunoglobulin-M increased steadily during the first year. Gp2 became sensitized to donor-specific AB-I or pig antigens within 2 weeks. Gp3 and Gp4 infants that received anti-CD154mAb made no or minimal anti-A/B and anti-pig antibodies while receiving IS.

• Autores: Echeverri Junca, Gabriel Jaime
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2012
• Institución: Universidad ICESI
• Repositorio: Repositorio ICESI
• Idioma: eng
• OAI Identifier: oai:repository.icesi.edu.co:10906/78492
• Acceso en línea: http://journals.lww.com/transplantjournal/Abstract/2012/04270/T_Cell_Based_Immunosuppressive_Therapy_Inhibits.4.aspx; http://hdl.handle.net/10906/78492; https://doi.org/10.1097/TP.0b013e3182481168
• Palabra clave: Anticuerpos; Terapia; Lactantes; Trasplantes; Órganos; Donante
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-nd/4.0/