Potential drug delivery system: study of the association of a model nitroimidazole drug with aggregates of amphiphilic polymers on aqueous solution.

This study evaluated the association of N-hexyl-2-methyl-4-nitroimidazol, a model drug, to aggregates formed by anionic polyelectrolytes on aqueous solution. The alternating copolymers of maleic anhydride and N-vinyl-2-pyrrolidone were synthesized and then modified by reaction of the anhydride group...

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Autores:
Salamanca Mejía, Constain Hugo
Olea Carrasco, Andres Floreal
Urbano, Bruno Felipe
Tipo de recurso:
Article of investigation
Fecha de publicación:
2011
Institución:
Universidad ICESI
Repositorio:
Repositorio ICESI
Idioma:
eng
OAI Identifier:
oai:repository.icesi.edu.co:10906/79900
Acceso en línea:
http://www.revistas.usp.br/bjps/article/view/10932/12700
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400009&lng=en&nrm=iso&tlng=en
http://hdl.handle.net/10906/79900
http://dx.doi.org/10.1590/S1984-82502011000400009
Palabra clave:
Biología
Ecología
Biology
Ecology
Ácido maleico
Nitroimidazoles
Polielectrolitos
Fármacos
Rights
openAccess
License
https://creativecommons.org/licenses/by-nc-nd/4.0/
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oai_identifier_str oai:repository.icesi.edu.co:10906/79900
network_acronym_str ICESI2
network_name_str Repositorio ICESI
repository_id_str
spelling Salamanca Mejía, Constain HugoOlea Carrasco, Andres FlorealUrbano, Bruno Felipe2016-08-30T22:02:00Z2016-08-30T22:02:00Z2011-10-011984-8250http://www.revistas.usp.br/bjps/article/view/10932/12700http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400009&lng=en&nrm=iso&tlng=enhttp://hdl.handle.net/10906/79900http://dx.doi.org/10.1590/S1984-82502011000400009instname: Universidad Icesireponame: Biblioteca Digitalrepourl: https://repository.icesi.edu.co/This study evaluated the association of N-hexyl-2-methyl-4-nitroimidazol, a model drug, to aggregates formed by anionic polyelectrolytes on aqueous solution. The alternating copolymers of maleic anhydride and N-vinyl-2-pyrrolidone were synthesized and then modified by reaction of the anhydride groups with aliphatic amines and alcohols of varying length of the alkyl chain. The partition of the model drug between water and the hydrophobic microdomains provided by the copolymers was studied using the pseudo-phase model to determinate the distribution coefficient KS, and the standard free energy of transfer ∆µ°t. The results indicate that all copolymers assessed are potential pharmaceutical reservoirs of the model drug. Nevertheless, the solubility of N-hexyl-2-methyl-4-nitroimidazol on the polymeric solutions is independent from the length of the alkyl chain of the copolymer.Digitalapplication/pdfengFaculdade de Ciências Farmacêuticas da Universidade de São PauloFacultad de Ciencias NaturalesBiologíaDepartamento de Ciencias BiológicasBrazilian Journal of Pharmaceutical Sciences, Vol. 47, No, 4 - 2011EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2BiologíaEcologíaBiologyEcologyÁcido maleicoNitroimidazolesPolielectrolitosFármacosPotential drug delivery system: study of the association of a model nitroimidazole drug with aggregates of amphiphilic polymers on aqueous solution.info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1Artículoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Comunidad Universidad Icesi – Investigadores47ORIGINALdocumento.htmldocumento.htmltext/html307http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/79900/3/documento.html365a77546b372991515a14d149218852MD53TEXTsalamanca_patenting_cosmetic_2011.pdf.txtsalamanca_patenting_cosmetic_2011.pdf.txttext/plain32011http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/79900/2/salamanca_patenting_cosmetic_2011.pdf.txtf98405ef3fea7fb04ff6c6e5c71aa059MD5210906/79900oai:repository.icesi.edu.co:10906/799002022-02-21 09:04:55.813Biblioteca Digital - Universidad icesicdcriollo@icesi.edu.co
dc.title.spa.fl_str_mv Potential drug delivery system: study of the association of a model nitroimidazole drug with aggregates of amphiphilic polymers on aqueous solution.
title Potential drug delivery system: study of the association of a model nitroimidazole drug with aggregates of amphiphilic polymers on aqueous solution.
spellingShingle Potential drug delivery system: study of the association of a model nitroimidazole drug with aggregates of amphiphilic polymers on aqueous solution.
Biología
Ecología
Biology
Ecology
Ácido maleico
Nitroimidazoles
Polielectrolitos
Fármacos
title_short Potential drug delivery system: study of the association of a model nitroimidazole drug with aggregates of amphiphilic polymers on aqueous solution.
title_full Potential drug delivery system: study of the association of a model nitroimidazole drug with aggregates of amphiphilic polymers on aqueous solution.
title_fullStr Potential drug delivery system: study of the association of a model nitroimidazole drug with aggregates of amphiphilic polymers on aqueous solution.
title_full_unstemmed Potential drug delivery system: study of the association of a model nitroimidazole drug with aggregates of amphiphilic polymers on aqueous solution.
title_sort Potential drug delivery system: study of the association of a model nitroimidazole drug with aggregates of amphiphilic polymers on aqueous solution.
dc.creator.fl_str_mv Salamanca Mejía, Constain Hugo
Olea Carrasco, Andres Floreal
Urbano, Bruno Felipe
dc.contributor.author.spa.fl_str_mv Salamanca Mejía, Constain Hugo
Olea Carrasco, Andres Floreal
Urbano, Bruno Felipe
dc.subject.none.fl_str_mv Biología
Ecología
Biology
Ecology
topic Biología
Ecología
Biology
Ecology
Ácido maleico
Nitroimidazoles
Polielectrolitos
Fármacos
dc.subject.spa.fl_str_mv Ácido maleico
Nitroimidazoles
Polielectrolitos
Fármacos
description This study evaluated the association of N-hexyl-2-methyl-4-nitroimidazol, a model drug, to aggregates formed by anionic polyelectrolytes on aqueous solution. The alternating copolymers of maleic anhydride and N-vinyl-2-pyrrolidone were synthesized and then modified by reaction of the anhydride groups with aliphatic amines and alcohols of varying length of the alkyl chain. The partition of the model drug between water and the hydrophobic microdomains provided by the copolymers was studied using the pseudo-phase model to determinate the distribution coefficient KS, and the standard free energy of transfer ∆µ°t. The results indicate that all copolymers assessed are potential pharmaceutical reservoirs of the model drug. Nevertheless, the solubility of N-hexyl-2-methyl-4-nitroimidazol on the polymeric solutions is independent from the length of the alkyl chain of the copolymer.
publishDate 2011
dc.date.issued.none.fl_str_mv 2011-10-01
dc.date.accessioned.none.fl_str_mv 2016-08-30T22:02:00Z
dc.date.available.none.fl_str_mv 2016-08-30T22:02:00Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.local.none.fl_str_mv Artículo
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dc.identifier.issn.none.fl_str_mv 1984-8250
dc.identifier.ismn.none.fl_str_mv http://www.revistas.usp.br/bjps/article/view/10932/12700
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dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10906/79900
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1590/S1984-82502011000400009
dc.identifier.instname.none.fl_str_mv instname: Universidad Icesi
dc.identifier.reponame.none.fl_str_mv reponame: Biblioteca Digital
dc.identifier.repourl.none.fl_str_mv repourl: https://repository.icesi.edu.co/
identifier_str_mv 1984-8250
instname: Universidad Icesi
reponame: Biblioteca Digital
repourl: https://repository.icesi.edu.co/
url http://www.revistas.usp.br/bjps/article/view/10932/12700
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400009&lng=en&nrm=iso&tlng=en
http://hdl.handle.net/10906/79900
http://dx.doi.org/10.1590/S1984-82502011000400009
dc.language.iso.eng.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences, Vol. 47, No, 4 - 2011
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.license.none.fl_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.medium.none.fl_str_mv Digital
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Faculdade de Ciências Farmacêuticas da Universidade de São Paulo
dc.publisher.faculty.none.fl_str_mv Facultad de Ciencias Naturales
dc.publisher.program.none.fl_str_mv Biología
dc.publisher.department.none.fl_str_mv Departamento de Ciencias Biológicas
institution Universidad ICESI
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