Physicochemical characterization of in situ drug-polymer nanocomplex formed between zwitterionic drug and ionomeric material in aqueous solution
Biocompatible polymeric materials with the potential to form functional structures, in association with different therapeutic molecules, in physiological media, represent a great potential for biological and pharmaceutical applications. Therefore, here the formation of a nano-complex between a synth...
- Autores:
-
Salamanca Mejía, Constaín Hugo
Rivera, Gustavo R.
Villada, Juan D.
Castillo, Duvan F.
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2017
- Institución:
- Universidad ICESI
- Repositorio:
- Repositorio ICESI
- Idioma:
- eng
- OAI Identifier:
- oai:repository.icesi.edu.co:10906/81447
- Acceso en línea:
- https://nebulosa.icesi.edu.co:2615/record/display.uri?eid=2-s2.0-84998865167&origin=resultslist&sort=plf-f&src=s&st1=icesi&nlo=&nlr=&nls=&sid=146634F6FFD209F746C330D4F0C3D082.wsnAw8kcdt7IPYLO0V48gA%3a110&sot=b&sdt=cl&cluster=scopubyr%2c%222017%22%2ct&sl=12&s=AFFIL%28icesi%29&relpos=2&citeCnt=0&searchTerm=
http://hdl.handle.net/10906/81447
https://doi.org/10.1016/j.msec.2016.11.097
- Palabra clave:
- Polimeros cationicos
Medicamentos
Materiales poliméricos
Farmacéutica
Métodos de investigación en bioquímica
Biodiversity conservation
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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| dc.title.spa.fl_str_mv |
Physicochemical characterization of in situ drug-polymer nanocomplex formed between zwitterionic drug and ionomeric material in aqueous solution |
| title |
Physicochemical characterization of in situ drug-polymer nanocomplex formed between zwitterionic drug and ionomeric material in aqueous solution |
| spellingShingle |
Physicochemical characterization of in situ drug-polymer nanocomplex formed between zwitterionic drug and ionomeric material in aqueous solution Polimeros cationicos Medicamentos Materiales poliméricos Farmacéutica Métodos de investigación en bioquímica Biodiversity conservation |
| title_short |
Physicochemical characterization of in situ drug-polymer nanocomplex formed between zwitterionic drug and ionomeric material in aqueous solution |
| title_full |
Physicochemical characterization of in situ drug-polymer nanocomplex formed between zwitterionic drug and ionomeric material in aqueous solution |
| title_fullStr |
Physicochemical characterization of in situ drug-polymer nanocomplex formed between zwitterionic drug and ionomeric material in aqueous solution |
| title_full_unstemmed |
Physicochemical characterization of in situ drug-polymer nanocomplex formed between zwitterionic drug and ionomeric material in aqueous solution |
| title_sort |
Physicochemical characterization of in situ drug-polymer nanocomplex formed between zwitterionic drug and ionomeric material in aqueous solution |
| dc.creator.fl_str_mv |
Salamanca Mejía, Constaín Hugo Rivera, Gustavo R. Villada, Juan D. Castillo, Duvan F. |
| dc.contributor.author.spa.fl_str_mv |
Salamanca Mejía, Constaín Hugo Rivera, Gustavo R. Villada, Juan D. Castillo, Duvan F. |
| dc.subject.spa.fl_str_mv |
Polimeros cationicos Medicamentos Materiales poliméricos Farmacéutica Métodos de investigación en bioquímica Biodiversity conservation |
| topic |
Polimeros cationicos Medicamentos Materiales poliméricos Farmacéutica Métodos de investigación en bioquímica Biodiversity conservation |
| description |
Biocompatible polymeric materials with the potential to form functional structures, in association with different therapeutic molecules, in physiological media, represent a great potential for biological and pharmaceutical applications. Therefore, here the formation of a nano-complex between a synthetic cationic polymer and model drug (ampicillin trihydrate) was studied. The formed complex was characterized by size and zeta potential measurements, using dynamic light scattering and capillary electrophoresis. Moreover, the chemical and thermodynamically stability of these complexes were studied. The ionomeric material, here referred as EuCl, was obtained by equimolar reaction between Eudragit E and HCl. The structural characterization was carried out by potentiometric titration, FTIR spectroscopy, and DSC. The effect of pH, time, polymer concentration and ampicillin/polymer molar ratio over the hydrodynamic diameter and zeta potential were established |
| publishDate |
2017 |
| dc.date.accessioned.none.fl_str_mv |
2017-05-17T22:36:36Z |
| dc.date.available.none.fl_str_mv |
2017-05-17T22:36:36Z |
| dc.date.issued.none.fl_str_mv |
2017-03-01 |
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info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Artículo |
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10.1016/j.msec.2016.11.097 |
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0928-4931 |
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http://hdl.handle.net/10906/81447 |
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https://doi.org/10.1016/j.msec.2016.11.097 |
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instname: Universidad Icesi |
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reponame: Biblioteca Digital |
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repourl: https://repository.icesi.edu.co/ |
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10.1016/j.msec.2016.11.097 0928-4931 instname: Universidad Icesi reponame: Biblioteca Digital repourl: https://repository.icesi.edu.co/ |
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eng |
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eng |
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Materials Science and Engineering: C, Vol. 72, No.1 - 2017 |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
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http://purl.org/coar/access_right/c_abf2 |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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9 páginas |
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Digital |
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Netherlands de Lat: 52 30 00 N degrees minutes Lat: 52.5000 decimal degrees Long: 005 45 00 E degrees minutes Long: 5.7500 decimal degrees |
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Elsevier |
| dc.publisher.faculty.spa.fl_str_mv |
Facultad de Ciencias Naturales |
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Química con énfasis en Bioquimica |
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Departamento de Ciencias Químicas |
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Netherlands |
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Salamanca Mejía, Constaín HugoRivera, Gustavo R.Villada, Juan D.Castillo, Duvan F.chsalamanca@icesi.edu.coNetherlands de Lat: 52 30 00 N degrees minutes Lat: 52.5000 decimal degrees Long: 005 45 00 E degrees minutes Long: 5.7500 decimal degrees2017-05-17T22:36:36Z2017-05-17T22:36:36Z2017-03-0110.1016/j.msec.2016.11.0970928-4931https://nebulosa.icesi.edu.co:2615/record/display.uri?eid=2-s2.0-84998865167&origin=resultslist&sort=plf-f&src=s&st1=icesi&nlo=&nlr=&nls=&sid=146634F6FFD209F746C330D4F0C3D082.wsnAw8kcdt7IPYLO0V48gA%3a110&sot=b&sdt=cl&cluster=scopubyr%2c%222017%22%2ct&sl=12&s=AFFIL%28icesi%29&relpos=2&citeCnt=0&searchTerm=http://hdl.handle.net/10906/81447https://doi.org/10.1016/j.msec.2016.11.097instname: Universidad Icesireponame: Biblioteca Digitalrepourl: https://repository.icesi.edu.co/Biocompatible polymeric materials with the potential to form functional structures, in association with different therapeutic molecules, in physiological media, represent a great potential for biological and pharmaceutical applications. Therefore, here the formation of a nano-complex between a synthetic cationic polymer and model drug (ampicillin trihydrate) was studied. The formed complex was characterized by size and zeta potential measurements, using dynamic light scattering and capillary electrophoresis. Moreover, the chemical and thermodynamically stability of these complexes were studied. The ionomeric material, here referred as EuCl, was obtained by equimolar reaction between Eudragit E and HCl. The structural characterization was carried out by potentiometric titration, FTIR spectroscopy, and DSC. The effect of pH, time, polymer concentration and ampicillin/polymer molar ratio over the hydrodynamic diameter and zeta potential were established9 páginasDigitalengElsevierFacultad de Ciencias NaturalesQuímica con énfasis en BioquimicaDepartamento de Ciencias QuímicasNetherlandsMaterials Science and Engineering: C, Vol. 72, No.1 - 2017EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos Todo persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2Polimeros cationicosMedicamentosMateriales poliméricosFarmacéuticaMétodos de investigación en bioquímicaBiodiversity conservationPhysicochemical characterization of in situ drug-polymer nanocomplex formed between zwitterionic drug and ionomeric material in aqueous solutioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1Artículoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Editor721405414ORIGINALdocumento.htmldocumento.htmltext/html293http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/81447/6/documento.htmlfa785873e24bec5e036a16a2face5af2MD56CC-LICENSElicense_urllicense_urltext/plain49http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/81447/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_textapplication/octet-stream0http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/81447/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/octet-stream0http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/81447/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD54LICENSElicense.txtlicense.txttext/plain1783http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/81447/5/license.txta9bf6c9d51cc761c4b473f39f5bcb2eaMD5510906/81447oai:repository.icesi.edu.co:10906/814472018-10-17 17:59:20.301Biblioteca Digital - Universidad icesicdcriollo@icesi.edu.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 |