Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion
NTRODUCTION: Although the prognostic value of persistent hyperlactatemia in septic shock is unequivocal, its physiological determinants are controversial. Particularly, the role of impaired hepatic clearance has been underestimated and is only considered relevant in patients with liver ischemia or c...
- Autores:
-
Ospina Tascon, Gustavo Adolfo
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2015
- Institución:
- Universidad ICESI
- Repositorio:
- Repositorio ICESI
- Idioma:
- spa
- OAI Identifier:
- oai:repository.icesi.edu.co:10906/80817
- Acceso en línea:
- http://download.springer.com/static/pdf/413/art%253A10.1186%252Fs13054-015-0928-3.pdf?originUrl=http%3A%2F%2Fccforum.biomedcentral.com%2Farticle%2F10.1186%2Fs13054-015-0928-3&token2=exp=1479933212~acl=%2Fstatic%2Fpdf%2F413%2Fart%25253A10.1186%25252Fs13054-015-0928-3.pdf*~hmac=fcbd7ad921e1de0759841693beba713304c651f63e675a0657808968aace8856
http://hdl.handle.net/10906/80817
- Palabra clave:
- Ciencias socio biomédicas
Medical sciences
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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| dc.title.spa.fl_str_mv |
Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion |
| title |
Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion |
| spellingShingle |
Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion Ciencias socio biomédicas Medical sciences |
| title_short |
Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion |
| title_full |
Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion |
| title_fullStr |
Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion |
| title_full_unstemmed |
Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion |
| title_sort |
Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion |
| dc.creator.fl_str_mv |
Ospina Tascon, Gustavo Adolfo |
| dc.contributor.author.spa.fl_str_mv |
Ospina Tascon, Gustavo Adolfo |
| dc.subject.spa.fl_str_mv |
Ciencias socio biomédicas Medical sciences |
| topic |
Ciencias socio biomédicas Medical sciences |
| description |
NTRODUCTION: Although the prognostic value of persistent hyperlactatemia in septic shock is unequivocal, its physiological determinants are controversial. Particularly, the role of impaired hepatic clearance has been underestimated and is only considered relevant in patients with liver ischemia or cirrhosis. Our objectives were to establish whether endotoxemia impairs whole body net lactate clearance, and to explore a potential role for total liver hypoperfusion during the early phase of septic shock. |
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2015 |
| dc.date.issued.none.fl_str_mv |
2015-04-22 |
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2016-11-23T21:09:02Z |
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2016-11-23T21:09:02Z |
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info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Artículo |
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1466-609X |
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http://download.springer.com/static/pdf/413/art%253A10.1186%252Fs13054-015-0928-3.pdf?originUrl=http%3A%2F%2Fccforum.biomedcentral.com%2Farticle%2F10.1186%2Fs13054-015-0928-3&token2=exp=1479933212~acl=%2Fstatic%2Fpdf%2F413%2Fart%25253A10.1186%25252Fs13054-015-0928-3.pdf*~hmac=fcbd7ad921e1de0759841693beba713304c651f63e675a0657808968aace8856 |
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http://hdl.handle.net/10906/80817 |
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instname: Universidad Icesi |
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spa |
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spa |
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Critical Care, 2015 |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
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http://purl.org/coar/access_right/c_abf2 |
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10 páginas |
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London de Lat: 51 30 51 N degrees minutes Lat: 51.5142 decimal degrees Long: 000 05 35 W degrees minutes Long: -0.0931 decimal degrees |
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BioMed Central |
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Facultad de Ciencias de la Salud |
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Medicina |
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Departamento Ciencias Básicas Médicas |
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Londres |
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Universidad ICESI |
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Ospina Tascon, Gustavo AdolfoLondon de Lat: 51 30 51 N degrees minutes Lat: 51.5142 decimal degrees Long: 000 05 35 W degrees minutes Long: -0.0931 decimal degrees2016-11-23T21:09:02Z2016-11-23T21:09:02Z2015-04-221466-609Xhttp://download.springer.com/static/pdf/413/art%253A10.1186%252Fs13054-015-0928-3.pdf?originUrl=http%3A%2F%2Fccforum.biomedcentral.com%2Farticle%2F10.1186%2Fs13054-015-0928-3&token2=exp=1479933212~acl=%2Fstatic%2Fpdf%2F413%2Fart%25253A10.1186%25252Fs13054-015-0928-3.pdf*~hmac=fcbd7ad921e1de0759841693beba713304c651f63e675a0657808968aace8856http://hdl.handle.net/10906/80817instname: Universidad Icesireponame: Biblioteca Digitalrepourl: https://repository.icesi.edu.co/NTRODUCTION: Although the prognostic value of persistent hyperlactatemia in septic shock is unequivocal, its physiological determinants are controversial. Particularly, the role of impaired hepatic clearance has been underestimated and is only considered relevant in patients with liver ischemia or cirrhosis. Our objectives were to establish whether endotoxemia impairs whole body net lactate clearance, and to explore a potential role for total liver hypoperfusion during the early phase of septic shock.10 páginasDigitalspaBioMed CentralFacultad de Ciencias de la SaludMedicinaDepartamento Ciencias Básicas MédicasLondresCritical Care, 2015EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos Todo persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2Ciencias socio biomédicasMedical sciencesImpairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusioninfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1Artículoinfo:eu-repo/semantics/acceptedVersionComunidad Universidad Icesi - Investigadores210TEXTospina_impairment_exogenous_2015.pdf.txtospina_impairment_exogenous_2015.pdf.txttext/plain46899http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/80817/6/ospina_impairment_exogenous_2015.pdf.txt13ddd5195bee3295001833c52e866f59MD56LICENSElicense.txtlicense.txttext/plain1783http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/80817/5/license.txta9bf6c9d51cc761c4b473f39f5bcb2eaMD55CC-LICENSElicense_urllicense_urltext/plain49http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/80817/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_textapplication/octet-stream0http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/80817/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/octet-stream0http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/80817/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD54ORIGINALospina_impairment_exogenous_2015.pdfospina_impairment_exogenous_2015.pdfapplication/pdf593012http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/80817/1/ospina_impairment_exogenous_2015.pdfbccb5af89085e714afd1e0dc30ffe986MD5110906/80817oai:repository.icesi.edu.co:10906/808172016-11-24 02:36:51.529Biblioteca Digital - Universidad icesicdcriollo@icesi.edu.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 |