Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion
NTRODUCTION: Although the prognostic value of persistent hyperlactatemia in septic shock is unequivocal, its physiological determinants are controversial. Particularly, the role of impaired hepatic clearance has been underestimated and is only considered relevant in patients with liver ischemia or c...
- Autores:
-
Ospina Tascon, Gustavo Adolfo
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2015
- Institución:
- Universidad ICESI
- Repositorio:
- Repositorio ICESI
- Idioma:
- spa
- OAI Identifier:
- oai:repository.icesi.edu.co:10906/80817
- Acceso en línea:
- http://download.springer.com/static/pdf/413/art%253A10.1186%252Fs13054-015-0928-3.pdf?originUrl=http%3A%2F%2Fccforum.biomedcentral.com%2Farticle%2F10.1186%2Fs13054-015-0928-3&token2=exp=1479933212~acl=%2Fstatic%2Fpdf%2F413%2Fart%25253A10.1186%25252Fs13054-015-0928-3.pdf*~hmac=fcbd7ad921e1de0759841693beba713304c651f63e675a0657808968aace8856
http://hdl.handle.net/10906/80817
- Palabra clave:
- Ciencias socio biomédicas
Medical sciences
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
| Summary: | NTRODUCTION: Although the prognostic value of persistent hyperlactatemia in septic shock is unequivocal, its physiological determinants are controversial. Particularly, the role of impaired hepatic clearance has been underestimated and is only considered relevant in patients with liver ischemia or cirrhosis. Our objectives were to establish whether endotoxemia impairs whole body net lactate clearance, and to explore a potential role for total liver hypoperfusion during the early phase of septic shock. |
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