Estimation of the indomethacin solubility in ethanol + water mixtures by the extended Hildebrand solubility approach - Open Access Library

indomethacin (imc) is an analgesic drug whose physicochemical properties have not been thoroughly studied. in this work the extended hildebrand solubility approach (ehsa) was applied to evaluate the solubility of imc in ethanol + water mixtures at 298.15 k. an acceptable correlative capacity of ehsa...

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Autores:
Mora Guerrero, Carolina Del Pilar
Tipo de recurso:
Article of investigation
Fecha de publicación:
2010
Institución:
Universidad ICESI
Repositorio:
Repositorio ICESI
Idioma:
eng
OAI Identifier:
oai:repository.icesi.edu.co:10906/79875
Acceso en línea:
http://www.oalib.com/paper/1037887#.V8SkBnq2onI
http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0034-74182010000100007
http://www.scielo.org.co/pdf/rccqf/v39n1/v39n1a07.pdf
http://hdl.handle.net/10906/79875
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openAccess
License
https://creativecommons.org/licenses/by-nc-nd/4.0/
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spelling Mora Guerrero, Carolina Del Pilar2016-08-30T22:01:53Z2016-08-30T22:01:53Z2010-06-010034-7418http://www.oalib.com/paper/1037887#.V8SkBnq2onIhttp://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0034-74182010000100007http://www.scielo.org.co/pdf/rccqf/v39n1/v39n1a07.pdfhttp://hdl.handle.net/10906/79875instname: Universidad Icesireponame: Biblioteca Digitalrepourl: https://repository.icesi.edu.co/indomethacin (imc) is an analgesic drug whose physicochemical properties have not been thoroughly studied. in this work the extended hildebrand solubility approach (ehsa) was applied to evaluate the solubility of imc in ethanol + water mixtures at 298.15 k. an acceptable correlative capacity of ehsa was found using a regular polynomial model in order four (overall deviation lower than 4.1%), when the w interaction parameter is related to the solubility parameter of the mixtures. besides, the deviations obtained in the estimated solubility with respect to experimental solubility were lower compared with those obtained directly by means of an empiric regression of the experimental solubility as a function of the mixtures′ solubility parameters.Digitalapplication/pdfengUniversidad Nacional de ColombiaFacultad de Ciencias NaturalesBiologíaDepartamento de Ciencias BiológicasRevista Colombiana de Ciencias Químico Farmacéuticas, Vol. 39, No.1 - 2010EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2Estimation of the indomethacin solubility in ethanol + water mixtures by the extended Hildebrand solubility approach - Open Access LibraryMétodo extendido de Hildebrand en la estimación de la solubilidad de la indometacina en mezclas etanol + aguainfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1Artículoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Comunidad Universidad Icesi – Investigadores3917995TEXTmora_estimation_indomethacin_2010.pdf.txtmora_estimation_indomethacin_2010.pdf.txttext/plain33523http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/79875/2/mora_estimation_indomethacin_2010.pdf.txtddeb4042432faf85250b6f052565c14fMD52ORIGINALmora_estimation_indomethacin_2010.pdfmora_estimation_indomethacin_2010.pdfapplication/pdf254978http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/79875/1/mora_estimation_indomethacin_2010.pdf1fbbc6f87938d5e2da42970d5b15918aMD5110906/79875oai:repository.icesi.edu.co:10906/798752020-05-20 22:08:36.092Biblioteca Digital - Universidad icesicdcriollo@icesi.edu.co
dc.title.spa.fl_str_mv Estimation of the indomethacin solubility in ethanol + water mixtures by the extended Hildebrand solubility approach - Open Access Library
dc.title.alternative.none.fl_str_mv Método extendido de Hildebrand en la estimación de la solubilidad de la indometacina en mezclas etanol + agua
title Estimation of the indomethacin solubility in ethanol + water mixtures by the extended Hildebrand solubility approach - Open Access Library
spellingShingle Estimation of the indomethacin solubility in ethanol + water mixtures by the extended Hildebrand solubility approach - Open Access Library
title_short Estimation of the indomethacin solubility in ethanol + water mixtures by the extended Hildebrand solubility approach - Open Access Library
title_full Estimation of the indomethacin solubility in ethanol + water mixtures by the extended Hildebrand solubility approach - Open Access Library
title_fullStr Estimation of the indomethacin solubility in ethanol + water mixtures by the extended Hildebrand solubility approach - Open Access Library
title_full_unstemmed Estimation of the indomethacin solubility in ethanol + water mixtures by the extended Hildebrand solubility approach - Open Access Library
title_sort Estimation of the indomethacin solubility in ethanol + water mixtures by the extended Hildebrand solubility approach - Open Access Library
dc.creator.fl_str_mv Mora Guerrero, Carolina Del Pilar
dc.contributor.author.spa.fl_str_mv Mora Guerrero, Carolina Del Pilar
description indomethacin (imc) is an analgesic drug whose physicochemical properties have not been thoroughly studied. in this work the extended hildebrand solubility approach (ehsa) was applied to evaluate the solubility of imc in ethanol + water mixtures at 298.15 k. an acceptable correlative capacity of ehsa was found using a regular polynomial model in order four (overall deviation lower than 4.1%), when the w interaction parameter is related to the solubility parameter of the mixtures. besides, the deviations obtained in the estimated solubility with respect to experimental solubility were lower compared with those obtained directly by means of an empiric regression of the experimental solubility as a function of the mixtures′ solubility parameters.
publishDate 2010
dc.date.issued.none.fl_str_mv 2010-06-01
dc.date.accessioned.none.fl_str_mv 2016-08-30T22:01:53Z
dc.date.available.none.fl_str_mv 2016-08-30T22:01:53Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.local.none.fl_str_mv Artículo
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http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0034-74182010000100007
http://www.scielo.org.co/pdf/rccqf/v39n1/v39n1a07.pdf
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10906/79875
dc.identifier.instname.none.fl_str_mv instname: Universidad Icesi
dc.identifier.reponame.none.fl_str_mv reponame: Biblioteca Digital
dc.identifier.repourl.none.fl_str_mv repourl: https://repository.icesi.edu.co/
identifier_str_mv 0034-7418
instname: Universidad Icesi
reponame: Biblioteca Digital
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url http://www.oalib.com/paper/1037887#.V8SkBnq2onI
http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0034-74182010000100007
http://www.scielo.org.co/pdf/rccqf/v39n1/v39n1a07.pdf
http://hdl.handle.net/10906/79875
dc.language.iso.eng.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Revista Colombiana de Ciencias Químico Farmacéuticas, Vol. 39, No.1 - 2010
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
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rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
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eu_rights_str_mv openAccess
dc.format.medium.none.fl_str_mv Digital
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Nacional de Colombia
dc.publisher.faculty.none.fl_str_mv Facultad de Ciencias Naturales
dc.publisher.program.none.fl_str_mv Biología
dc.publisher.department.none.fl_str_mv Departamento de Ciencias Biológicas
publisher.none.fl_str_mv Universidad Nacional de Colombia
institution Universidad ICESI
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