Activity of (2E)-3-(2, 3-dimetoxifenil)-1-(4-metilfenil) prop-2-en-1-ona in the presence of poli(maleic acid-co-2-vinyl-pyrrolidone) on a β-lactamase producing clinical isolate of Staphylococcus aureus
Due to the current problem of resistance to b-lactam antibiotics, it has become necessary, in search of a solution, to work with new molecules with pharmacological potential, and to use novel polymeric systems as matrices or pharmaceutical excipients. Objective: To evaluate the antibiotic activity o...
- Autores:
-
Salamanca Mejía, Constaín Hugo
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2012
- Institución:
- Universidad ICESI
- Repositorio:
- Repositorio ICESI
- Idioma:
- spa
- OAI Identifier:
- oai:repository.icesi.edu.co:10906/79855
- Acceso en línea:
- http://aprendeenlinea.udea.edu.co/revistas/index.php/iatreia/article/view/11069/10185
http://hdl.handle.net/10906/79855
- Palabra clave:
- Biología
Ecología
Conservación de la biodiversidad
Biology
Ecology
Biodiversity conservation
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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Activity of (2E)-3-(2, 3-dimetoxifenil)-1-(4-metilfenil) prop-2-en-1-ona in the presence of poli(maleic acid-co-2-vinyl-pyrrolidone) on a β-lactamase producing clinical isolate of Staphylococcus aureus |
| dc.title.alternative.spa.fl_str_mv |
Actividad del (2e)-3-(2, 3-dimetoxifenil)-1-(4-metilfenil) prop-2-en-1-ona en presencia del poli(ácido maleico-co-2-vinil-pirrolidona) sobre un aislamiento clínico de staphylococcus aureus productor de β-lactamasas |
| title |
Activity of (2E)-3-(2, 3-dimetoxifenil)-1-(4-metilfenil) prop-2-en-1-ona in the presence of poli(maleic acid-co-2-vinyl-pyrrolidone) on a β-lactamase producing clinical isolate of Staphylococcus aureus |
| spellingShingle |
Activity of (2E)-3-(2, 3-dimetoxifenil)-1-(4-metilfenil) prop-2-en-1-ona in the presence of poli(maleic acid-co-2-vinyl-pyrrolidone) on a β-lactamase producing clinical isolate of Staphylococcus aureus Biología Ecología Conservación de la biodiversidad Biology Ecology Biodiversity conservation |
| title_short |
Activity of (2E)-3-(2, 3-dimetoxifenil)-1-(4-metilfenil) prop-2-en-1-ona in the presence of poli(maleic acid-co-2-vinyl-pyrrolidone) on a β-lactamase producing clinical isolate of Staphylococcus aureus |
| title_full |
Activity of (2E)-3-(2, 3-dimetoxifenil)-1-(4-metilfenil) prop-2-en-1-ona in the presence of poli(maleic acid-co-2-vinyl-pyrrolidone) on a β-lactamase producing clinical isolate of Staphylococcus aureus |
| title_fullStr |
Activity of (2E)-3-(2, 3-dimetoxifenil)-1-(4-metilfenil) prop-2-en-1-ona in the presence of poli(maleic acid-co-2-vinyl-pyrrolidone) on a β-lactamase producing clinical isolate of Staphylococcus aureus |
| title_full_unstemmed |
Activity of (2E)-3-(2, 3-dimetoxifenil)-1-(4-metilfenil) prop-2-en-1-ona in the presence of poli(maleic acid-co-2-vinyl-pyrrolidone) on a β-lactamase producing clinical isolate of Staphylococcus aureus |
| title_sort |
Activity of (2E)-3-(2, 3-dimetoxifenil)-1-(4-metilfenil) prop-2-en-1-ona in the presence of poli(maleic acid-co-2-vinyl-pyrrolidone) on a β-lactamase producing clinical isolate of Staphylococcus aureus |
| dc.creator.fl_str_mv |
Salamanca Mejía, Constaín Hugo |
| dc.contributor.author.spa.fl_str_mv |
Salamanca Mejía, Constaín Hugo |
| dc.subject.spa.fl_str_mv |
Biología Ecología Conservación de la biodiversidad |
| topic |
Biología Ecología Conservación de la biodiversidad Biology Ecology Biodiversity conservation |
| dc.subject.eng.fl_str_mv |
Biology Ecology Biodiversity conservation |
| description |
Due to the current problem of resistance to b-lactam antibiotics, it has become necessary, in search of a solution, to work with new molecules with pharmacological potential, and to use novel polymeric systems as matrices or pharmaceutical excipients. Objective: To evaluate the antibiotic activity of ampicillin combined with a synthetic chalcone-type compound, the (2E)-3-(2,3-dimethoxyphenyl)-1-(4- methylphenyl) prop-2-en-1-one, on a clinical isolate of penicillin-resistant Staphylococcus aureus in the presence of a water soluble polymer matrix known as poly(maleic acid-co-2-vinyl-pyrrolidone). Materials and methods: The synthetic compound and the polymeric matrix were obtained by previously described methods. Tests for antibiotic activity against the strain of penicillin-resistant Staphylococcus aureus were done by the broth dilution technique which provided the minimal inhibitory concentrations of the compounds tested. Results: The chalcone-ampicillin mix shows lesser antibiotic effect than the ampicillin-sulbactam used as referent. However, when such mix is combined with the polymer matrix, antibiotic activity significantly increases as evidenced by decrease in the minimal inhibitory concentration with respect to the ampicillin-sulbactam referent. |
| publishDate |
2012 |
| dc.date.issued.none.fl_str_mv |
2012-01-01 |
| dc.date.accessioned.none.fl_str_mv |
2016-08-30T22:01:48Z |
| dc.date.available.none.fl_str_mv |
2016-08-30T22:01:48Z |
| dc.type.eng.fl_str_mv |
info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.local.none.fl_str_mv |
Artículo |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
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0121-0793 |
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http://aprendeenlinea.udea.edu.co/revistas/index.php/iatreia/article/view/11069/10185 |
| dc.identifier.uri.eng.fl_str_mv |
http://hdl.handle.net/10906/79855 |
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instname: Universidad Icesi |
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reponame: Biblioteca Digital |
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repourl: https://repository.icesi.edu.co/ |
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0121-0793 instname: Universidad Icesi reponame: Biblioteca Digital repourl: https://repository.icesi.edu.co/ |
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http://aprendeenlinea.udea.edu.co/revistas/index.php/iatreia/article/view/11069/10185 http://hdl.handle.net/10906/79855 |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.relation.ispartof.none.fl_str_mv |
Iatreia, Vol. 25, No.1 - 2012 |
| dc.rights.uri.none.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
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http://purl.org/coar/access_right/c_abf2 |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.extent.spa.fl_str_mv |
17 páginas |
| dc.coverage.spatial.eng.fl_str_mv |
Medellín de Lat: 06 15 00 N degrees minutes Lat: 6.2500 decimal degrees Long: 075 36 00 W degrees minutes Long: -75.6000 decimal degrees |
| dc.publisher.spa.fl_str_mv |
Universidad de Antioquia |
| dc.publisher.faculty.spa.fl_str_mv |
Facultad de Ciencias Naturales |
| dc.publisher.department.spa.fl_str_mv |
Departamento de Ciencias Biológicas |
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Universidad ICESI |
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Salamanca Mejía, Constaín HugoMedellín de Lat: 06 15 00 N degrees minutes Lat: 6.2500 decimal degrees Long: 075 36 00 W degrees minutes Long: -75.6000 decimal degrees2016-08-30T22:01:48Z2016-08-30T22:01:48Z2012-01-010121-0793http://aprendeenlinea.udea.edu.co/revistas/index.php/iatreia/article/view/11069/10185http://hdl.handle.net/10906/79855instname: Universidad Icesireponame: Biblioteca Digitalrepourl: https://repository.icesi.edu.co/Due to the current problem of resistance to b-lactam antibiotics, it has become necessary, in search of a solution, to work with new molecules with pharmacological potential, and to use novel polymeric systems as matrices or pharmaceutical excipients. Objective: To evaluate the antibiotic activity of ampicillin combined with a synthetic chalcone-type compound, the (2E)-3-(2,3-dimethoxyphenyl)-1-(4- methylphenyl) prop-2-en-1-one, on a clinical isolate of penicillin-resistant Staphylococcus aureus in the presence of a water soluble polymer matrix known as poly(maleic acid-co-2-vinyl-pyrrolidone). Materials and methods: The synthetic compound and the polymeric matrix were obtained by previously described methods. Tests for antibiotic activity against the strain of penicillin-resistant Staphylococcus aureus were done by the broth dilution technique which provided the minimal inhibitory concentrations of the compounds tested. Results: The chalcone-ampicillin mix shows lesser antibiotic effect than the ampicillin-sulbactam used as referent. However, when such mix is combined with the polymer matrix, antibiotic activity significantly increases as evidenced by decrease in the minimal inhibitory concentration with respect to the ampicillin-sulbactam referent.17 páginasspaUniversidad de AntioquiaFacultad de Ciencias NaturalesDepartamento de Ciencias BiológicasIatreia, Vol. 25, No.1 - 2012EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2BiologíaEcologíaConservación de la biodiversidadBiologyEcologyBiodiversity conservationActivity of (2E)-3-(2, 3-dimetoxifenil)-1-(4-metilfenil) prop-2-en-1-ona in the presence of poli(maleic acid-co-2-vinyl-pyrrolidone) on a β-lactamase producing clinical isolate of Staphylococcus aureusActividad del (2e)-3-(2, 3-dimetoxifenil)-1-(4-metilfenil) prop-2-en-1-ona en presencia del poli(ácido maleico-co-2-vinil-pirrolidona) sobre un aislamiento clínico de staphylococcus aureus productor de β-lactamasasinfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1Artículoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a852511219TEXTsalamanca_actividad _dimetoxifenil_2012.pdf.txtsalamanca_actividad _dimetoxifenil_2012.pdf.txttext/plain27133http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/79855/2/salamanca_actividad%20_dimetoxifenil_2012.pdf.txt5047aa16e8422de5cc0dc16cf5bf1525MD52ORIGINALsalamanca_actividad _dimetoxifenil_2012.pdfsalamanca_actividad _dimetoxifenil_2012.pdfapplication/pdf840221http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/79855/1/salamanca_actividad%20_dimetoxifenil_2012.pdf2299a8d328f1f585c2e707b078a018aeMD5110906/79855oai:repository.icesi.edu.co:10906/798552020-05-26 23:34:52.234Biblioteca Digital - Universidad icesicdcriollo@icesi.edu.co |