The Endothelium in Sepsis
Sepsis affects practically all aspects of endothelial cell (EC) function and is thought to be the key factor in the progression from sepsis to organ failure. Endothelial functions affected by sepsis include vasoregulation, barrier function, inflammation, and hemostasis. These are among other mechani...
- Autores:
-
Ince, Can
De Backer, Daniel
Murray, Patrick
Hernandez, Glenn
Ospina-Tascón, Gustavo A.
Kellum, John A.
Gomez, Hernando
Nguyen, Trung
Mayeux, Philip R.
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2016
- Institución:
- Universidad ICESI
- Repositorio:
- Repositorio ICESI
- Idioma:
- eng
- OAI Identifier:
- oai:repository.icesi.edu.co:10906/82292
- Acceso en línea:
- http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00024382-201603000-00005
http://hdl.handle.net/10906/82292
http://dx.doi.org/10.1097/SHK.0000000000000473
- Palabra clave:
- Función de barrera
Sangre
Sepsis
Endotelio
Hemostasis
Microcirculación
Inflamación
Ciencias socio biomédicas
Biomedical sciences
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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Ince, CanDe Backer, DanielMurray, PatrickHernandez, GlennOspina-Tascón, Gustavo A.Kellum, John A.Gomez, HernandoNguyen, TrungMayeux, Philip R.gusospin@gmail.comPhiladelphia, Pennsylvania de Lat: 40 07 00 N degrees minutes Lat: 40.1167 decimal degrees Long: 075 00 00 W degrees minutes Long: -75.0000 decimal degrees.2017-11-16T20:07:44Z2017-11-16T20:07:44Z2016-03-011073-2322http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00024382-201603000-00005http://hdl.handle.net/10906/82292http://dx.doi.org/10.1097/SHK.0000000000000473instname: Universidad Icesireponame: Biblioteca Digitalrepourl: https://repository.icesi.edu.co/Sepsis affects practically all aspects of endothelial cell (EC) function and is thought to be the key factor in the progression from sepsis to organ failure. Endothelial functions affected by sepsis include vasoregulation, barrier function, inflammation, and hemostasis. These are among other mechanisms often mediated by glycocalyx shedding, such as abnormal nitric oxide metabolism, up-regulation of reactive oxygen species generation due to down-regulation of endothelial-associated antioxidant defenses, transcellular communication, proteases, exposure of adhesion molecules, and activation of tissue factor. This review covers current insight in EC-associated hemostatic responses to sepsis and the EC response to inflammation. The endothelial cell lining is highly heterogeneous between different organ systems and consequently also in its response to sepsis. In this context, we discuss the response of the endothelial cell lining to sepsis in the kidney, liver, and lung. Finally, we discuss evidence as to whether the EC response to sepsis is adaptive or maladaptive. This study is a result of an Acute Dialysis Quality Initiative XIV Sepsis Workgroup meeting held in Bogota, Columbia, between October 12 and 15, 2014.12 páginasDigitalapplication/pdfengLippincott Williams & WilkinsFacultad Ciencias de la SaludMedicinaDepartamento de Ciencias Básicas MédicasPhiladelphia, PennsylvaniaShock, Vol. 45, No. 3 - 2016EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2Función de barreraSangreSepsisEndotelioHemostasisMicrocirculaciónInflamaciónCiencias socio biomédicasBiomedical sciencesThe Endothelium in Sepsisinfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1Artículoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Comunidad Universidad Icesi – Investigadores453259270ORIGINALospina_endothelium_sepsis_2016.pdfospina_endothelium_sepsis_2016.pdfapplication/pdf903397http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/82292/1/ospina_endothelium_sepsis_2016.pdf3f590cc712bdcf63a965e910e07d0b31MD5110906/82292oai:repository.icesi.edu.co:10906/822922018-10-05 13:41:21.383Biblioteca Digital - Universidad icesicdcriollo@icesi.edu.co |
dc.title.none.fl_str_mv |
The Endothelium in Sepsis |
title |
The Endothelium in Sepsis |
spellingShingle |
The Endothelium in Sepsis Función de barrera Sangre Sepsis Endotelio Hemostasis Microcirculación Inflamación Ciencias socio biomédicas Biomedical sciences |
title_short |
The Endothelium in Sepsis |
title_full |
The Endothelium in Sepsis |
title_fullStr |
The Endothelium in Sepsis |
title_full_unstemmed |
The Endothelium in Sepsis |
title_sort |
The Endothelium in Sepsis |
dc.creator.fl_str_mv |
Ince, Can De Backer, Daniel Murray, Patrick Hernandez, Glenn Ospina-Tascón, Gustavo A. Kellum, John A. Gomez, Hernando Nguyen, Trung Mayeux, Philip R. |
dc.contributor.author.spa.fl_str_mv |
Ince, Can De Backer, Daniel Murray, Patrick Hernandez, Glenn Ospina-Tascón, Gustavo A. Kellum, John A. Gomez, Hernando Nguyen, Trung Mayeux, Philip R. |
dc.subject.spa.fl_str_mv |
Función de barrera Sangre Sepsis Endotelio Hemostasis Microcirculación Inflamación Ciencias socio biomédicas |
topic |
Función de barrera Sangre Sepsis Endotelio Hemostasis Microcirculación Inflamación Ciencias socio biomédicas Biomedical sciences |
dc.subject.eng.fl_str_mv |
Biomedical sciences |
description |
Sepsis affects practically all aspects of endothelial cell (EC) function and is thought to be the key factor in the progression from sepsis to organ failure. Endothelial functions affected by sepsis include vasoregulation, barrier function, inflammation, and hemostasis. These are among other mechanisms often mediated by glycocalyx shedding, such as abnormal nitric oxide metabolism, up-regulation of reactive oxygen species generation due to down-regulation of endothelial-associated antioxidant defenses, transcellular communication, proteases, exposure of adhesion molecules, and activation of tissue factor. This review covers current insight in EC-associated hemostatic responses to sepsis and the EC response to inflammation. The endothelial cell lining is highly heterogeneous between different organ systems and consequently also in its response to sepsis. In this context, we discuss the response of the endothelial cell lining to sepsis in the kidney, liver, and lung. Finally, we discuss evidence as to whether the EC response to sepsis is adaptive or maladaptive. This study is a result of an Acute Dialysis Quality Initiative XIV Sepsis Workgroup meeting held in Bogota, Columbia, between October 12 and 15, 2014. |
publishDate |
2016 |
dc.date.issued.none.fl_str_mv |
2016-03-01 |
dc.date.accessioned.none.fl_str_mv |
2017-11-16T20:07:44Z |
dc.date.available.none.fl_str_mv |
2017-11-16T20:07:44Z |
dc.type.eng.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.local.spa.fl_str_mv |
Artículo |
dc.type.version.eng.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
status_str |
publishedVersion |
dc.identifier.issn.none.fl_str_mv |
1073-2322 |
dc.identifier.other.none.fl_str_mv |
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00024382-201603000-00005 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10906/82292 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1097/SHK.0000000000000473 |
dc.identifier.instname.none.fl_str_mv |
instname: Universidad Icesi |
dc.identifier.reponame.none.fl_str_mv |
reponame: Biblioteca Digital |
dc.identifier.repourl.none.fl_str_mv |
repourl: https://repository.icesi.edu.co/ |
identifier_str_mv |
1073-2322 instname: Universidad Icesi reponame: Biblioteca Digital repourl: https://repository.icesi.edu.co/ |
url |
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00024382-201603000-00005 http://hdl.handle.net/10906/82292 http://dx.doi.org/10.1097/SHK.0000000000000473 |
dc.language.iso.eng.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Shock, Vol. 45, No. 3 - 2016 |
dc.rights.uri.none.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.rights.accessrights.eng.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.license.none.fl_str_mv |
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
dc.rights.coar.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.format.extent.spa.fl_str_mv |
12 páginas |
dc.format.medium.spa.fl_str_mv |
Digital |
dc.format.mimetype.eng.fl_str_mv |
application/pdf |
dc.coverage.spatial.none.fl_str_mv |
Philadelphia, Pennsylvania de Lat: 40 07 00 N degrees minutes Lat: 40.1167 decimal degrees Long: 075 00 00 W degrees minutes Long: -75.0000 decimal degrees. |
dc.publisher.eng.fl_str_mv |
Lippincott Williams & Wilkins |
dc.publisher.faculty.spa.fl_str_mv |
Facultad Ciencias de la Salud |
dc.publisher.program.spa.fl_str_mv |
Medicina |
dc.publisher.department.spa.fl_str_mv |
Departamento de Ciencias Básicas Médicas |
dc.publisher.place.eng.fl_str_mv |
Philadelphia, Pennsylvania |
institution |
Universidad ICESI |
bitstream.url.fl_str_mv |
http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/82292/1/ospina_endothelium_sepsis_2016.pdf |
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3f590cc712bdcf63a965e910e07d0b31 |
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MD5 |
repository.name.fl_str_mv |
Biblioteca Digital - Universidad icesi |
repository.mail.fl_str_mv |
cdcriollo@icesi.edu.co |
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1814094878586437632 |