The Endothelium in Sepsis

Sepsis affects practically all aspects of endothelial cell (EC) function and is thought to be the key factor in the progression from sepsis to organ failure. Endothelial functions affected by sepsis include vasoregulation, barrier function, inflammation, and hemostasis. These are among other mechani...

Full description

Autores:
Ince, Can
De Backer, Daniel
Murray, Patrick
Hernandez, Glenn
Ospina-Tascón, Gustavo A.
Kellum, John A.
Gomez, Hernando
Nguyen, Trung
Mayeux, Philip R.
Tipo de recurso:
Article of investigation
Fecha de publicación:
2016
Institución:
Universidad ICESI
Repositorio:
Repositorio ICESI
Idioma:
eng
OAI Identifier:
oai:repository.icesi.edu.co:10906/82292
Acceso en línea:
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00024382-201603000-00005
http://hdl.handle.net/10906/82292
http://dx.doi.org/10.1097/SHK.0000000000000473
Palabra clave:
Función de barrera
Sangre
Sepsis
Endotelio
Hemostasis
Microcirculación
Inflamación
Ciencias socio biomédicas
Biomedical sciences
Rights
openAccess
License
https://creativecommons.org/licenses/by-nc-nd/4.0/
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network_acronym_str ICESI2
network_name_str Repositorio ICESI
repository_id_str
spelling Ince, CanDe Backer, DanielMurray, PatrickHernandez, GlennOspina-Tascón, Gustavo A.Kellum, John A.Gomez, HernandoNguyen, TrungMayeux, Philip R.gusospin@gmail.comPhiladelphia, Pennsylvania de Lat: 40 07 00 N degrees minutes Lat: 40.1167 decimal degrees Long: 075 00 00 W degrees minutes Long: -75.0000 decimal degrees.2017-11-16T20:07:44Z2017-11-16T20:07:44Z2016-03-011073-2322http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00024382-201603000-00005http://hdl.handle.net/10906/82292http://dx.doi.org/10.1097/SHK.0000000000000473instname: Universidad Icesireponame: Biblioteca Digitalrepourl: https://repository.icesi.edu.co/Sepsis affects practically all aspects of endothelial cell (EC) function and is thought to be the key factor in the progression from sepsis to organ failure. Endothelial functions affected by sepsis include vasoregulation, barrier function, inflammation, and hemostasis. These are among other mechanisms often mediated by glycocalyx shedding, such as abnormal nitric oxide metabolism, up-regulation of reactive oxygen species generation due to down-regulation of endothelial-associated antioxidant defenses, transcellular communication, proteases, exposure of adhesion molecules, and activation of tissue factor. This review covers current insight in EC-associated hemostatic responses to sepsis and the EC response to inflammation. The endothelial cell lining is highly heterogeneous between different organ systems and consequently also in its response to sepsis. In this context, we discuss the response of the endothelial cell lining to sepsis in the kidney, liver, and lung. Finally, we discuss evidence as to whether the EC response to sepsis is adaptive or maladaptive. This study is a result of an Acute Dialysis Quality Initiative XIV Sepsis Workgroup meeting held in Bogota, Columbia, between October 12 and 15, 2014.12 páginasDigitalapplication/pdfengLippincott Williams & WilkinsFacultad Ciencias de la SaludMedicinaDepartamento de Ciencias Básicas MédicasPhiladelphia, PennsylvaniaShock, Vol. 45, No. 3 - 2016EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2Función de barreraSangreSepsisEndotelioHemostasisMicrocirculaciónInflamaciónCiencias socio biomédicasBiomedical sciencesThe Endothelium in Sepsisinfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1Artículoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Comunidad Universidad Icesi – Investigadores453259270ORIGINALospina_endothelium_sepsis_2016.pdfospina_endothelium_sepsis_2016.pdfapplication/pdf903397http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/82292/1/ospina_endothelium_sepsis_2016.pdf3f590cc712bdcf63a965e910e07d0b31MD5110906/82292oai:repository.icesi.edu.co:10906/822922018-10-05 13:41:21.383Biblioteca Digital - Universidad icesicdcriollo@icesi.edu.co
dc.title.none.fl_str_mv The Endothelium in Sepsis
title The Endothelium in Sepsis
spellingShingle The Endothelium in Sepsis
Función de barrera
Sangre
Sepsis
Endotelio
Hemostasis
Microcirculación
Inflamación
Ciencias socio biomédicas
Biomedical sciences
title_short The Endothelium in Sepsis
title_full The Endothelium in Sepsis
title_fullStr The Endothelium in Sepsis
title_full_unstemmed The Endothelium in Sepsis
title_sort The Endothelium in Sepsis
dc.creator.fl_str_mv Ince, Can
De Backer, Daniel
Murray, Patrick
Hernandez, Glenn
Ospina-Tascón, Gustavo A.
Kellum, John A.
Gomez, Hernando
Nguyen, Trung
Mayeux, Philip R.
dc.contributor.author.spa.fl_str_mv Ince, Can
De Backer, Daniel
Murray, Patrick
Hernandez, Glenn
Ospina-Tascón, Gustavo A.
Kellum, John A.
Gomez, Hernando
Nguyen, Trung
Mayeux, Philip R.
dc.subject.spa.fl_str_mv Función de barrera
Sangre
Sepsis
Endotelio
Hemostasis
Microcirculación
Inflamación
Ciencias socio biomédicas
topic Función de barrera
Sangre
Sepsis
Endotelio
Hemostasis
Microcirculación
Inflamación
Ciencias socio biomédicas
Biomedical sciences
dc.subject.eng.fl_str_mv Biomedical sciences
description Sepsis affects practically all aspects of endothelial cell (EC) function and is thought to be the key factor in the progression from sepsis to organ failure. Endothelial functions affected by sepsis include vasoregulation, barrier function, inflammation, and hemostasis. These are among other mechanisms often mediated by glycocalyx shedding, such as abnormal nitric oxide metabolism, up-regulation of reactive oxygen species generation due to down-regulation of endothelial-associated antioxidant defenses, transcellular communication, proteases, exposure of adhesion molecules, and activation of tissue factor. This review covers current insight in EC-associated hemostatic responses to sepsis and the EC response to inflammation. The endothelial cell lining is highly heterogeneous between different organ systems and consequently also in its response to sepsis. In this context, we discuss the response of the endothelial cell lining to sepsis in the kidney, liver, and lung. Finally, we discuss evidence as to whether the EC response to sepsis is adaptive or maladaptive. This study is a result of an Acute Dialysis Quality Initiative XIV Sepsis Workgroup meeting held in Bogota, Columbia, between October 12 and 15, 2014.
publishDate 2016
dc.date.issued.none.fl_str_mv 2016-03-01
dc.date.accessioned.none.fl_str_mv 2017-11-16T20:07:44Z
dc.date.available.none.fl_str_mv 2017-11-16T20:07:44Z
dc.type.eng.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1097/SHK.0000000000000473
dc.identifier.instname.none.fl_str_mv instname: Universidad Icesi
dc.identifier.reponame.none.fl_str_mv reponame: Biblioteca Digital
dc.identifier.repourl.none.fl_str_mv repourl: https://repository.icesi.edu.co/
identifier_str_mv 1073-2322
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url http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00024382-201603000-00005
http://hdl.handle.net/10906/82292
http://dx.doi.org/10.1097/SHK.0000000000000473
dc.language.iso.eng.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Shock, Vol. 45, No. 3 - 2016
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.eng.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.license.none.fl_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.extent.spa.fl_str_mv 12 páginas
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dc.coverage.spatial.none.fl_str_mv Philadelphia, Pennsylvania de Lat: 40 07 00 N degrees minutes Lat: 40.1167 decimal degrees Long: 075 00 00 W degrees minutes Long: -75.0000 decimal degrees.
dc.publisher.eng.fl_str_mv Lippincott Williams & Wilkins
dc.publisher.faculty.spa.fl_str_mv Facultad Ciencias de la Salud
dc.publisher.program.spa.fl_str_mv Medicina
dc.publisher.department.spa.fl_str_mv Departamento de Ciencias Básicas Médicas
dc.publisher.place.eng.fl_str_mv Philadelphia, Pennsylvania
institution Universidad ICESI
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repository.name.fl_str_mv Biblioteca Digital - Universidad icesi
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